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semantic segmentation of Lumbar vertebrae Using Meijering U-Net(MU-Net)on spine Magnetic Resonance Images

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Computer Modeling in engineering & sciences 2025年第1期142卷 733-757页

作者： Lakshmi s v v shiloah elizabeth Darmanayagam sunil Retmin Raj Cyril Department of Computer science and engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people *** to its ability to produce a detailed view of the soft tissues,including the spinal cord,nerves,intervertebral discs,and vertebrae,Magnetic Resonance Imaging is thought to be the most effective method for imaging the *** semantic segmentation of vertebrae plays a major role in the diagnostic process of lumbar *** is difficult to semantically partition the vertebrae in Magnetic Resonance Images from the surrounding variety of tissues,including muscles,ligaments,and intervertebral discs.U-Net is a powerful deep-learning architecture to handle the challenges of medical image analysis tasks and achieves high segmentation *** work proposes a modified U-Net architecture namely MU-Net,consisting of the Meijering convolutional layer that incorporates the Meijering filter to perform the semantic segmentation of lumbar vertebrae L1 to L5 and sacral vertebra ***-colour mask images were generated and used as ground truth for training the *** work has been carried out on 1312 images expanded from T1-weighted mid-sagittal MRI images of 515 patients in the Lumbar spine MRI Dataset publicly available from Mendeley *** proposed MU-Net model for the semantic segmentation of the lumbar vertebrae gives better performance with 98.79%of pixel accuracy(PA),98.66%of dice similarity coefficient(DsC),97.36%of Jaccard coefficient,and 92.55%mean Intersection over Union(mean IoU)metrics using the mentioned dataset.

关键词： Computer aided diagnosis(CAD) magnetic resonance imaging(MRI) semantic segmentation lumbar vertebrae deep learning U-Net model

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 81-100页

作者： s.sAURABH R.KIRAN D.sINGH R.vAIsH v.s.CHAUHAN school of Mechanical and Materials engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FeM), and an in-house code is developed in the MATLAB environment to solve it numerically. various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(He), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

关键词： finite element method (FeM) nonlinear Green-Lagrange inverse hyperbolic shear deformation theory (IHsDT) bio-inspired composite plate helicoidal O322

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina silvera-simón Manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Merging bound states in the continuum in an open acoustic resonator

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science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem s.Pilipchuk sibo Huang Chen shen Almas F.sadreev Yong Li Andrey e.Miroshnichenko school of Physics and electronic sciences East China Normal University Institute of Acoustics Tongji University L.v.Kirensky Institute of Physics Department of Mechanical engineering Rowan University school of engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

Upgrade of beam energy measurement system at BePC-Ⅱ

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Chinese Physics C 2016年第7期40卷 90-99页

作者：张建勇蔡啸莫晓虎郭迪舟王建力刘佰奇 M.N.Achasov A.A.Krasnov N.Yu.Muchnoi e.e.pyata e.v.Mamoshkina F.A.Harris Institute of High energy Physics Chinese Academy of SciencesBeijing 100049China Budker Institute of Nuclear Physics Siberian Branch of the Russian Academy of Sciences11 LavrentyevNovosibirsk 630090Russia Novosibirsk state University Novosibirsk 630090Russia University of Hawaii HonoluluHawaii 96822USA

The beam energy measurement system is of great importance for both BePC-II accelerator and Bes-III detector. The system is based on measuring the energies of Compton back-scattered photons. In order to meet the requirements of data taking and improve the measurement accuracy, the system has continued to be upgraded, which involves the updating of laser and optics subsystems, replacement of a view-port of the laser to the vacuum insertion subsystem, the use of an electric cooling system for a high purity germanium detector, and improvement of the data acquisition and processing subsystem. The upgrade system guarantees the smooth and efficient measurement of beam energy at BePC-II and enables accurate offline energy values for further physics analysis at Bes-III.

关键词： laser HPGe detector beam energy measurement

Processes underlying the laser photochromic effect in colloidal plasmonic nanoparticle aggregates

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Chinese Physics B 2020年第3期29卷 412-419页

作者： A e ershov v s Gerasimov I L Isaev A P Gavrilyuk s v Karpov Institute of Computational Modeling sB RAs 660036KrasnoyarskRussia siberian Federal University Krasnoyarsk660041Russia Kirensky Institute of Physics Federal Research Center KSC SB RAS660036KrasnoyarskRussia siberian state University of science and Technology Krasnoyarsk 660014Russia

We have studied the dynamic and static processes occurring in disordered multiparticle colloidal Ag aggregates with natural structure and affecting their plasmonic absorption spectra under pico-and nanosecond pulsed laser radiations, as well as the physical origin responsible for these processes. We have shown that depending on the duration of the laser pulse,the mechanisms of laser modification of such aggregates can be associated both with changes in the resonant properties of the particles due to their heating and melting(picosecond irradiation mode) and with the particle shifts in the resonant domains of the aggregates(nanosecond pulses) which depend on the wavelength, intensity, and polarization of the *** mechanisms result in formation of a narrow dip in the plasmonic absorption spectrum of the aggregates near the laser radiation wavelength and affect the shape and position of the dip. The effect of polydispersity of nanoparticle aggregates on laser photochromic reaction has been studied.

关键词： nanoparticle surface plasmon resonance photochromic process pulsed laser radiation

structural evolution-enabled BiFeO3 modulated by strontium doping with enhanced dielectric,optical and superparamagnetic properties by a modified sol-gel method

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Chinese Physics B 2023年第3期32卷 521-530页

作者： sharon v s veena Gopalan e Malini K A Department of Physics vimala College Thrissur-9 KeralaIndia

Multiferroic(BFO)nanoparticles doped with strontium with the general formula Bi1-xsrx FeO3(x=0,0.3,0.5,0.7)were synthesized using a modified sol-gel auto-combustion *** structural,electrical,optical,and magnetic properties of the samples are *** structural analysis,carried out using the x-ray powder diffraction technique,shows a structural transition from rhombohedral(R-3c)to cubic(Pm-3m)for the doping amount of strontium(sr)equal to x=*** analysis of the prepared samples were carried out using scanning electron microscopy(seM).Frequency-dependent dielectric constant and ac conductivity were *** doped samples,with improved dielectric properties,can be used to fabricate different optoelectronic *** dielectric dispersion and broad relaxation were exhibited by all the ***–Cole plots were employed as an effective tool to study the dispersion parameters,namely,the optical dielectric constant,static dielectric constant,relaxation time,and spreading *** activation energy was calculated from the relaxation peaks and Cole–Cole plots,which were found to be compatible with each *** bandgap of the samples was calculated using diffuse reflectance spectral(DRs)*** and strong photoluminescence in the IR region was observed in the samples,similar to ZnO,which was reported for the first ***-temperature and low-temperature magnetization studies point towards the superparamagnetic nature of the samples,with an improvement in magnetic properties with *** antiferromagnetic behavior of bulk bismuth ferrite transforms to superparamagnetic in nature for both pure and sr-substituted bismuth ferrite nanoparticles due to the close dimensions of crystallite size with magnetic domains leading to the break-down of the frustrated spin cycloidal moment.

关键词： multiferroics sol-gel process x-ray spectra optical and dielectric properties

Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena stanojevic Ivana stevanovic Milica Ninkovic Tihomir v.Ilic Nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

Restructuring of plasmonic nanoparticle aggregates with arbitrary particle size distribution in pulsed laser fields

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Chinese Physics B 2016年第11期25卷 563-570页

作者： A e ershov A P Gavrilyuk s v Karpov s P Polyutov Institute of Computational Modeling Russian Academy of SciencesKrasnoyarsk 660036Russia L.v.Kirensky Institute of Physics of the Russian Academy of sciences Krasnoyarsk 660036Russia siberian Federal University Krasnoyarsk 660028Russia siberian state Aerospace University Krasnoyarsk 660037Russia

We have studied processes of interaction of pulsed laser radiation with resonant groups of plasmonic nanoparticles（resonant domains） in large colloidal nanoparticle aggregates having different interparticle gaps and particle size *** processes are responsible for the origin of nonlinear optical effects and photochromic reactions in multiparticle *** describe photo-induced transformations in resonant domains and alterations in their absorption spectra remaining after the pulse action,we introduce the factor of spectral *** on calculation of changes in thermodynamic,mechanical,and optical characteristics of the domains,the histograms of the spectrum photomodification factor have been obtained for various interparticle gaps,an average particle size,and the degree of *** in spectra have been analyzed depending on the intensity of laser radiation and various combinations of size characteristics of *** obtained results can be used to predict manifestation of photochromic effects in composite materials containing different plasmonic nanoparticle aggregates in pulsed laser fields.

关键词： resonant arbitrary pulsed dipole manifestation alterations extinction remaining aggregate colloidal