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Genes & Diseases 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh Marian T.smallin Nino Mtchedlidze Isha Godwin Marco Napoli Nicole Hackel Manali s.phadke Avani A.Deshpande Xiaobo Li John H.Lockhart Jaden R.Baldwin suehelay Acevedo-Acevedo Yifeng Gao Michelle A.Reiser Keiran s.M.smalley Elsa R.Flores Andrew s.Brohl Department of Molecular Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Molecular Medicine Program H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA saveetha Medical College ChennaiTamil Nadu 602105India Tumor Biology Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA sarcoma Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

sP100 is an antiviral protein that restricts the productive stage of human papillomavirus(HPV)and multiple other viruses,and viruses in turn block sUMO-1-mediated stabilization of sP100 and promotes its degradation(Table s1).Interferon(IFN)signaling could still produce more sP100 through transcription to counteract viruses.1 Viruses also disable the transcriptional up-regulation of sP100 to achieve persistent infection in hosts.

关键词： sP100 melanoma stabilization

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用地震层析成象法确定三维构造与速度

油气藏评价与开发 1987年第4期 18-30页

作者： s.K.L.Chiu E.R.Kanasewich s.phadke 谭岩

为了从反射资料中同时获得体波的速度与界面的三维构造,我们研究了一种计算机化的地震层析成象法。组成介质的连续任意三维曲面地层将不同声特性的均匀介质分开,这种界面由多项式曲面所定义。假定弹性波在这些曲界面上透射或反射,其射... 详细信息

为了从反射资料中同时获得体波的速度与界面的三维构造,我们研究了一种计算机化的地震层析成象法。组成介质的连续任意三维曲面地层将不同声特性的均匀介质分开,这种界面由多项式曲面所定义。假定弹性波在这些曲界面上透射或反射,其射线路经满足斯奈尔定律,那么每个炮检对的射线追踪可通过求解非线性方程组来确定。这种三维射线追踪法对大量地震射线的计算,其中包括对转换相位及多次波的计算是有效的。本文阐明加阻尼的最小二乘反演法,通过使观测的旅行时与计算的旅行时之间的时差最小化,来重建层速度与界面的三维结构。合成模型的结果表明,其解能迅速地收敛于真实模型。地震层析成象法,作为深部地壳探测工程(PROEJCT LITHOPROBE)的一部分,于1981年在 Vancouver 岛已应用于所获得的可控震源地震剖面。发现该方法利用在形式上仍属于二维地震反射勘探的弯线对俯冲板块界面进行三维成象是有效的。

关键词：特征值本征值旅行时间检波点接收点射线理论射线路径射线轨迹震源组合地震层析成象射线追踪弯曲测线阻尼因子三维构造

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横向各向同性介质中P波反射数据的偏移

油气藏评价与开发 1995年第1期 83-83页

作者： s.phadke

在横向各向同性介质中波的传播受水平和垂直波速的控制。准P(qp)波波前不是椭圆的,因此,波的传播就不能用椭圆各向异性介质波动方程来描述。然而,对于与垂向呈有限夹角的范围而言,准P波的波散关系可用椭圆来近似。此近似所采用的水平速... 详细信息

在横向各向同性介质中波的传播受水平和垂直波速的控制。准P(qp)波波前不是椭圆的,因此,波的传播就不能用椭圆各向异性介质波动方程来描述。然而,对于与垂向呈有限夹角的范围而言,准P波的波散关系可用椭圆来近似。此近似所采用的水平速度不同于实际水平速度,它取决于介质的物理特性。在本文描述的方法中,地震数据用椭圆各向异性介质中45度角波动方程进行偏移采用的水平速度通过比较45度椭圆波散关系与准P波波散关系后确定。该方法已用合成数据集做了验证。

关键词：横向各向同性介质波散波动方程双曲型方程

Add-on therapy of herbal formulation rich in standardized fenugreek seed extract in type 2 diabetes mellitus patients with insulin therapy: An efficacy and safety study

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Asian Pacific Journal of Tropical Biomedicine 2018年第9期8卷 446-455页

作者： Amit Kandhare Uday phadke Abhay Mane Prasad Thakurdesai sunil Bhaskaran Department of scientific Affairs Indus Biotech Private Limited Ruby Hall Clinic Tulip Opp.Camp Education Society's High School

Objective: To assess the safety and efficacy of herbal formulation rich in standardized fenugreek seed extract(IND-2) add-on therapy in type 2 diabetes mellitus(T2DM) patients who were on insulin treatment in prospective, single arm, open-label, uncontrolled, multicentre ***: T2DM patients(n=30) with aged 18-80 years who were stabilized on insulin treatment with fasting blood sugar(FBs) level between 100-140 mg/dL received IND-2 capsules(700 mg, thrice a day) for 16 *** primary endpoints were an assessment of FBs at week 2, 4, 6, 8, 12 and *** end-points include post-prandial blood sugar level, glycosylated Hb(HbA1c), reduction in the dose of insulin and number of hypoglycemic attacks, and improvement in lipid profile at various *** and adverse events(AEs) were also assessed during the ***: study was completed in twenty T2DM patients, and there was no significant reduction in FBs and post-prandial blood sugar level after addon therapy of ***, add-on therapy of IND-2 significantly reduced(Ps, requirements of insulin and hypoglycemic events as compared with *** cholesterol, high-density lipoproteins-cholesterol, and low-density lipoproteincholesterol levels were significantly increased(Psafety outcomes did not differ significantly in IND-2 add-on therapy group at week ***, add-on therapy of IND-2 did not produce any serious adverse ***: The results of present investigation suggest that add-on therapy of IND-2 with insulin in T2DM patients improves glycaemic control through a decrease in levels of HbA1c and number of insulin doses needed per day without an increase in body weight and risk of ***, IND-2 may provide a safe and well-tolerated add-on therapy option for the management of T2DM.

关键词： Add-on therapy Dietary supplement Glycaemic control HbA1c standardized fenugreek seed extract Type 2 diabetes

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防爆膜设计的计算机程序

化学工业与工程 1987年第1期 69-72页

作者： P.s.phadke 刘辉岳阳石油化工总厂

为简化计算工作,本文介绍了防爆膜设计原理,除用图表外还可用HP-97计算机程序。

关键词：防爆膜破裂压力 HP 操作压力计算机程序球形封头爆破压力

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列管换热器管数的确定

化肥设计 1988年第4期 76-81页

作者： P.s.phadke 刘庆刘宇贵州化肥厂西安交大

当设计换热器时,工程师应当知道,在给定内径的外壳中所能容纳的管子总数——管数。本文用数学方法和一套图表来确定管数。并且也可用来解决大圆中放置小圆的其他问题。

关键词：换热器管列管三角形排列数学方法错列最小距离无因次热交换器最小间隙中心线

Breeding and biotechnological efforts in Jatropha curcas *** sustainable yields

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Oil Crop science 2021年第4期6卷 180-191页

作者： s.Arockiasamy Jyothirmayi Kumpatla sainath Hadole Vijay Yepuri Manoj Patil Vineeta shrivastava Chandrasekhara Rao Nagesh Kancharla saakshi Jalali Alok Varshney Neeta Madan sai Pothakani Vinod Nair sridhar Peyyala Vishwnadharaju Mudunuri Ananthan Gopal Niranjan s.Kumar Jawahar Pachiyannan satyanarayana seelamanthula J.V.Narasimham Makarand phadke Anindya B Ajit sapre santanu Dasgupta Agronomy Division Reliance Technology GroupReliance Industries LtdGhansoliNavi Mumbai400701India Jatropha Breeding station Reliance Industries LtdIDA-PeddapuramADB Road SamalkotaAndhra Pradesh533440India

Jatropha is a non-edible,important bioenergy plant,which can grow in marginalized *** seeds possess about 36%oil and this would be converted into biodiesel or *** provides an option for sustainable feed and fuel production due to its inherent qualities including hardy nature,drought tolerance and surviving with limited amount of water,tolerance to unfavorable conditions and excessive ***,heterozygosity,low productivity and poor understanding of its genome are the major impediments to elite line ***,classical breeding and advanced technological investments remain limited owing to long juvenile phase and breeding *** technologies that lead to identification of elite genotypes and development of high yielding elite Jatropha lines and effective methods of detoxification of seeds needs immediate *** tissue culture system,doubled haploids(DH)and genomic tools are increasingly made available to improve the seed yield and its oil quantity through the development of geminivirus disease resistant *** application of advanced,sequencing technologies has presented a repertoire of genomic information for this important yet orphan *** the present investigation,we highlight the achievements made in Jatropha towards development of high yielding,virus resistant elite lines and hybrids with yield potential ranging from 3 to 5 tons per hectare in a year,which is a first ever report in the *** also developed potential biotechnological tools such as genetic transformation,genome editing and next generation genomics tools including linkage maps and QTLs for accelerating breeding efforts through marker assisted *** of our concerted and continuous efforts during the past 15 years,we have overcome all the obstacles and developed high yielding,disease resistant hybrids/lines,advanced cultivation technologies with thorough knowledge on Agronomy of the Jatropha *** Jatropha cultivat

关键词： Breeding Hybrids Micropropagation Transformation sequencing Mapping QTLs CRIsPR

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Disruption of NAD^+ binding site in glyceraldehyde 3-phosphate dehydrogenase affects its intranuclear interactions

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World Journal of Biological Chemistry 2015年第4期6卷 366-378页

作者： Manali phadke Natalia Krynetskaia Anurag Mishra Carlos Barrero salim Merali scott A Gothe Evgeny Krynetskiy Temple University school of Pharmacy Jayne Haines Center for Pharmacogenomics and Drug safety Temple University

AIM:To characterize phosphorylation of human glyceraldehyde 3-phosphate dehydrogenase(GAPDH),and mobility of GAPDH in cancer cells treated with chemotherapeutic agents. METHODs:We used proteomics analysis to detect and characterize phosphorylation sites within human GAPDH. site-specific mutagenesis and alanine scanning was then performed to evaluate functional significance of phosphorylation sites in the GAPDH polypeptide chain. Enzymatic properties of mutated GAPDH variants were assessed using kinetic studies. Intranuclear dynamics parameters(diffusion coefficient and the immobile fraction) were estimated using fluorescence recovery after photobleaching(FRAP) experiments and confocal microscopy. Molecular modeling experiments were performed to estimate the effects of mutations on NAD+ cofactor ***:Using MALDI-TOF analysis,we identified novel phosphorylation sites within the NAD+ binding center of GAPDH at Y94,s98,and T99. Using polyclonal antibody specific to phospho-T99-containing peptide within GAPDH,we demonstrated accumulation of phospho-T99-GAPDH inthe nuclear fractions of A549,HCT116,and sW48 cancer cel s after cytotoxic stress. We performed site-mutagenesis,and estimated enzymatic properties,intranuclear distribution,and intranuclear mobility of GAPDH mutated variants. site-mutagenesis at positions s98 and T99 in the NAD+ binding center reduced enzymatic activity of GAPDH due to decreased affinity to NAD+(Km = 741 ± 257 μmol/L in T99 I vs 57 ± 11.1 μmol/L in wild type GAPDH. Molecular modeling experiments revealed the effect of mutations on NAD+ binding with GAPDH. FRAP(fluorescence recovery after photo bleaching) analysis showed that mutations in NAD+ binding center of GAPDH abrogated its intranuclear interactions. CONCLUsION:Our results suggest an important functional role of phosphorylated amino acids in the NAD+ binding center in GAPDH interactions with its intranuclear partners.

关键词： NAD+ Binding site Fluorescence recovery after phot