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Targeting brain tumors with innovative nanocarriers:bridging the gap through the blood-brain barrier

Oncology Research 2024年第5期32卷 877-897页

作者： KARAN WADHWA PAYAL CHAUHAN sHOBHIT KUMAR RAKEsH pahwa RAVINDER VERMA RAJAT GOYAL GOVIND sINGH ARCHANA sHARMA NEHA RAO DEEPAK KAUsHIK Department of Pharmaceutical sciences Maharshi Dayanand UniversityRohtak124001India Department of Pharmaceutical Technology Meerut Institute of Engineering and Technology(MIET)NH-58Delhi-Roorkee HighwayMeerut250005India Institute of Pharmaceutical sciences Kurukshetra UniversityKurukshetra136119India Department of Pharmaceutical sciences Chaudhary Bansi Lal UniversityBhiwani127021India MM College of Pharmacy Maharishi Markandeshwar(Deemed to be University)Mullana-AmbalaHaryana133207India Delhi Pharmaceutical sciences and Research University(DIPsAR) Delhi Pharmaceutical Sciences and Research UniversityNew Delhi110017India

Background:Glioblastoma multiforme(GBM)is recognized as the most lethal and most highly invasive *** high likelihood of treatment failure arises fromthe presence of the blood-brain barrier(BBB)and stemcells around GBM,which avert the entry of chemotherapeutic drugs into the ***:Recently,several researchers have designed novel nanocarrier systems like liposomes,dendrimers,metallic nanoparticles,nanodiamonds,and nanorobot approaches,allowing drugs to infiltrate the BBB more efficiently,opening up innovative avenues to prevail over therapy problems and radiation ***:Relevant literature for this manuscript has been collected from a comprehensive and systematic search of databases,for example,PubMed,science Direct,Google scholar,and others,using specific keyword combinations,including“glioblastoma,”“brain tumor,”“nanocarriers,”and several ***:This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM *** of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.

关键词： Glioblastoma Brain tumor Blood-brain barrier Liposomes Metallic nanoparticles Nanocarriers

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三维MR指纹打印技术应用于乳腺定量成像

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国际医学放射学杂志 2019年第2期42卷 227-227页

作者： Y.Chen A.Panda s.pahwa J.I.Hamilton s.Dastmalchian D.F.Mc-Givney 李依蔓(译) 王健(校) Departments of Radiology and Biomedical Engineering Case Western Reserve University11100 Euclid AveClevelandOH 44106 不详

目的开发一种采用MR指纹技术的快速三维方法用于乳腺成像,同时对T1和T2定量测定。材料与方法在此前瞻性研究中,通过可变翻转角和磁化准备模块获取三维数据集的每个分区的MR指纹数据。

关键词： MR 乳腺成像打印技术

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MR指纹分析(MRF)技术用于腹部快速定量成像

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国际医学放射学杂志 2016年第3期 318-318页

作者： Y.Chen Y.Jiang s.pahwa D.Ma L.Lu M.D.Twieg 蓝星 Case Western Reserve University/University Hospitals Case Medical Center

摘要目的开发MR指纹分析(MRF)技术用于腹部定量成像。材料与方法本研究遵守HIPAA且经机构伦理委员会审查,所有受试者均签署知情同意书。为了实现在有明显的B0和B1磁场不均匀时的准确定量,采用稳态自由进动二维快速成像,或快速稳态进动(F... 详细信息

摘要目的开发MR指纹分析(MRF)技术用于腹部定量成像。材料与方法本研究遵守HIPAA且经机构伦理委员会审查,所有受试者均签署知情同意书。为了实现在有明显的B0和B1磁场不均匀时的准确定量,采用稳态自由进动二维快速成像,或快速稳态进动(FIsP)序列采集及Bloch-

关键词： MRF 腹部躯干 MR 指纹分析

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前列腺癌MRI纹理识别及扩散联合检查方法的开发

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国际医学放射学杂志 2017年第4期 472-472页

作者： A.C.Yu C.Badve L.E.Ponsky s.pahwa s.Dastmalchian M.Rogers 刘立恒 school of Medicine Case Western Reserve University

摘要目的开发并评估一种包含MRI纹理识别（T1、T2值测定）和标准表观扩散系数（ADC）的前列腺疾病定量特征综合提取方法。材料与方法本研究回顾性分析前期获取的140例前列腺癌病人资料。采用稳态自由进动快速成像序列获取T1、T2图和ADC...

摘要目的开发并评估一种包含MRI纹理识别（T1、T2值测定）和标准表观扩散系数（ADC）的前列腺疾病定量特征综合提取方法。材料与方法本研究回顾性分析前期获取的140例前列腺癌病人资料。采用稳态自由进动快速成像序列获取T1、T2图和ADC图。由2位研究者根据临床影像表现,分别在周围带肿瘤区和正常表现外周带（NPZ）勾画兴趣区（ROI）。同时记录每个ROI的T1、T2和ADC值。将上述定量

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MR成像引导穿刺检测男性前列腺癌的成本效益

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国际医学放射学杂志 2017年第6期 724-724页

作者： s.pahwa N.K.schiltz L.E.Ponsky Z.Lu M.A.Griswold V.Gulani 刘会佳 Department of Radiology University Hospitals Case Medical Center

摘要目的评估多参数MR成像对临床怀疑前列腺癌病人经MRI引导穿刺活检术发现前列腺癌的价值。材料与方法对于直肠指诊结果异常或前列腺特异性抗原(PsA)升

关键词： MRI MR 穿刺活检成本效益前列腺癌

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Effect of Eu3+,Bi3+,and Li+ doping on luminescent property of GdNbO4

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Journal of Rare Earths 2024年第1期42卷 66-75页

作者： s.W.Wi Y.s.Lee Department of Physics and Integrative Institute of Basic sciences Soongsil University

We investigated the emission properties of Eu3+-doped GdNbO4-based oxide phosphors,aiming at improving the Eu3+emission by codoping of Bi3+and Li+.Eu3+singly doped,Eu3+and Bi3+doubly doped,and Eu3+,Bi3+,and Li+triply doped GdNbO4were prepared using a high-temperature solid-state reaction *** red-orange emissions from Eu3+in the singly doped samples are significantly improved by the codoping of Bi3+,mainly due to the energy transfer from Bi3+to Eu3+.The additional codoping of Li+is found to increase the Eu3+emission *** improvement might be attributed to the increase in the photoluminescent quantum yield originating from larger grain sizes and better crystallinity.A detailed analysis of the X-ray diffraction pattern and the asymmetric ratio estimated from the photoluminescence spectra show that the local lattice environment around Eu3+in GdNbO4does not change significantly with the codoping of Bi3+and Li+.Our results indicate that Li+doping is a promising way to improve the emission properties of rare-earth ion-doped GdNbO4phosphors.

关键词： Eu 3+ GdNbO 4 Codoping of Li + Photoluminescence sensitizer Rare earths

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First evidence for chiral wobbling of triaxial nuclei

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Nuclear science and Techniques 2024年第7期35卷 4-7页

作者： s.Frauendorf Department of Physics and Astronomy University of Notre DameNotre DameIN 46556USA

Chirality(Greek“handiness”)is a property of many com-plex *** molecules exist in two forms,one being the mirror image of the *** for our hands,it is impossible to make the images identical by a suitable *** two forms are called left-handed and *** have the same binding energy,because the electro-magnetic interaction,which holds the molecule together,does not change under a *** properties that are insensitive to the geometry are also the *** different geometry is the reason why the left-handed form turns the polarization plane of transmitted light in one direction by some angle while the right-handed form turns it in the oppo-site direction by the same ***,the geometrical differences between the two species may have other *** two species of the carvon molecule shown in Fig.1 taste quite differently.

关键词： turns Chiral mirror

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Tribological behavior of lubricant-impregnated porous polyimide

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Friction 2024年第4期12卷 711-725页

作者： Jinbang LI Ningning ZHOU Janet s.s.WONG school of Mechanical Engineering and Mechanics Ningbo UniversityNingbo 315211China Beijing Key Laboratory of Long-life Technology of Precise Rotation and Transmission Mechanisms Beijing Institute of Control EngineeringBeijing 100029China Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK

Porous materials impregnated with lubricants can be used in conditions where limited lubricant is *** this work,three porous polyimides(PPI)with different densities were ***(PAO)impregnated PPI(iPPI)discs were rubbed against steel and sapphire *** operando observations of the iPPI-sapphire contacts show that oil is released under an applied load,forming a meniscus around *** at the outlet is created at high sliding *** amount of released oil increases with increasing PPI *** moduli,E*,estimated based on the actual contact size show that trapped oil in iPPIs contributes to load *** higher speeds,tribological rehydration of the contact occurs in low density iPPI,with that E*rises with *** high density PPIs,high speeds give a constantly high E*which is limited by the viscoelastic properties of the PPI network and possibly the rate of oil *** of iPPI-steel contacts is governed by the mechanical properties of the PPI,the flow of the lubricant,and the roughness of the PPI *** low-and medium-density(highly porous,high roughness)PPIs,large amount of oil is released,and lubrication is mainly via lubricant restricted in the contact in the pores and possibly tribological *** high density(low porosity)PPI,with lower roughness,hydrodynamic lubrication is achieved which gives the lowest *** results show that polymeric porous materials for effective lubrication require the optimization of its surface roughness,stiffness,oil flow,and oil retentions.

关键词： polyimide porous material friction mechanism polymer limited lubrication

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Enhancing fatigue performance of AZ31 magnesium alloy components fabricated by cold metal transfer-based wire arc directed energy deposition through LPB

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Journal of Magnesium and Alloys 2024年第4期12卷 1638-1662页

作者： shambhu Kumar Manjhi srikanth Bontha A.s.s.Balan Department of Mechanical Engineering National Institute of Technology KarnatakaSurathkalSrinivasanagarMangaloreKarnataka 575025India

Cold Metal Transfer-Based Wire Arc Directed Energy Deposition(CMT-WA-DED)presents a promising avenue for the rapid fabrication of components crucial to automotive,shipbuilding,and aerospace ***,the susceptibility to fatigue of CMT-WA-DED-produced AZ31 Mg alloy components has impeded their widespread adoption for critical load-bearing *** this study,a comprehensive investigation into the fatigue behaviour of WA-DED-fabricated AZ31 Mg alloy has been carried out and compared to commercially available wrought AZ31 *** findings indicate that the as-deposited parts exhibit a lower fatigue life than wrought Mg alloy,primarily due to poor surface finish,tensile residual stress,porosity,and coarse grain microstructure inherent in the WA-DED *** Plasticity Burnishing(LPB)treatment is applied to mitigate these issues,which induce significant plastic deformation on the *** treatment resulted in a remarkable improvement of fatigue life by 42%,accompanied by a reduction in surface roughness,grain refinement and enhancement of compressive residual stress ***,during cyclic deformation,WA-DED specimens exhibited higher plasticity and dislocation density compared to both wrought and WA-DED+LPB specimens.A higher fraction of Low Angle Grain Boundaries(LAGBs)in WA-DED specimens contributed to multiple crack initiation sites and convoluted crack paths,ultimately leading to premature *** contrast,wrought and WA-DED+LPB specimens displayed a higher percentage of High Angle Grain Boundaries(HAGBs),which hindered dislocation movement and resulted in fewer crack initiation sites and less complex crack paths,thereby extending fatigue *** findings underscore the effectiveness of LPB as a post-processing technique to enhance the fatigue performance of WA-DED-fabricated AZ31 Mg alloy *** study highlights the importance of LPB surface treatment on AZ31 Mg components produced by CMT-WA-DED to remove surface d

关键词： Wire arc additive manufacturing AZ31 Mg alloy Low plasticity burnishing Low cycle fatigue test strain amplitude

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Ren-integrable and ren-symmetric integrable systems

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Communications in Theoretical Physics 2024年第3期76卷 62-69页

作者： s Y Lou school of Physical science and Technology Ningbo UniversityNingbo315211China

A new type of symmetry,ren-symmetry,describing anyon physics and corresponding topological physics,is ***-symmetry is a generalization of super-symmetry which is widely applied in super-symmetric physics such as super-symmetric quantum mechanics,super-symmetric gravity,super-symmetric string theory,super-symmetric integrable systems and so *** and Grassmann numbers are,in some sense,dual conceptions,and it turns out that these conceptions coincide for the ren situation,that is,a similar conception of ren-number(R-number)is devised for *** particular,some basic results of the R-number and ren-symmetry are exposed which allow one to derive,in principle,some new types of integrable systems including ren-integrable models and ren-symmetric integrable *** examples of ren-integrable KdV-type systems and ren-symmetric KdV equations are explicitly given.

关键词： symmetries integrable systems anyon physics extended supersymmetry ren-symmetry

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