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Endos.opic treatment of biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants: Les.ons learned from single-balloon enteros.opy-assisted ERCP

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 509-514页

作者： Rodrigo Garcés-Durán Laurent Monino Pierre H Deprez Hubert Piessevaux Tom G Moreels Department of Gastroenterology and Hepatology Universitécatholique de LouvainCliniques Universitaires Saint-LucAvenue Hippocrates 101200 BrusselsBelgium

Background: Endos.opic treatment of biliopancreatic pathology is challenging due to surgically altered anatomy after Whipple's pancreaticoduodenectomy. This study aimed to evaluate the feasibility and safety of single-balloon enteros.opy-assisted endos.opic retrograde cholangiopancreatography(sBE-ERCP) to treat biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants. Methods: We retrospectively analyzed 106 sBE-ERCP procedures in 46 patients with Whipple's variants. Technical and clinical success rates and adverse events were evaluated. Results: Biliary sBE-ERCP was performed in 34 patients and pancreatic sBE-ERCP in 17, including 5 with both indications. From a total of 106 sBE-ERCP procedures, 76 were biliary indication with technical success rate of 68/76(90%) procedures and clinical success rate of 30/34(88%) patients. Mild adverse event rate was 8/76(11%), without serious adverse events. From a total of 106 sBE-ERCP procedures, 30 were pancreatic indication with technical success rate of 24/30(80%) procedures( P = 0.194 vs. biliary sBEERCP) and clinical success rate of 11/17(65%) patients( P = 0.016 vs. biliary sBE-ERCP). Mild adverse event rate was 6/30(20%)( P = 0.194 vs. biliary sBE-ERCP), without serious adverse events. After sBE-ERCP failure, endos.opic ultrasound-guided drainage, percutaneous drainage and redo surgery were alternative therapeutic options. Conclus.ons: Biliopancreatic pathology after Whipple's pancreaticoduodenectomy variants can be treated using sBE-ERCP without serious adverse events. Technical and clinical success rates are high for biliary indications, whereas clinical success rate of pancreatic indications is significantly lower. sBE-ERCP can be considered as first-line treatment option in this patient group with surgically altered anatomy.

关键词： Enteros.opy Endos.opic retrograde cholangiopancreatography Pancreaticoduodenectomy surgically altered anatomy Whipple’s procedure

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Emerging structures and dynamic mechanisms.ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms.of processive proteolysis.of substrates,the effects.of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus.on recent studies.of structural dynamic mechanisms.ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis.of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron micros.opy structure of Notch1-boundγ-secretase,molecular dynamics simulations.on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages.of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms.of various substrates byγ-*** addition,controversy over the effects.of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies.ofγ-secretase,including pathways.of substrate binding and product release,effects.of modulators.on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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Dynamic and electrical res.onses.of a curved sandwich beam with glass reinforced laminate layers and a pliable core in the presence of a piezoelectric layer under low-velocity impact

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 155-178页

作者： N.sHAHVEIsI s.FELI Department of Mechanical Engineering Razi UniversityKermanshah ***Iran

The dynamic res.onses and generated voltage in a curved sandwich beam with glass reinforced laminate(GRL)layers and a pliable core in the presence of a piezoelectric layer under low-velocity impact(LVI)are *** current study aims to carry out a dynamic analysis.on the sandwich beam when the impactor hits the top face sheet with an initial *** the layer analysis,the high-order shear deformation theory(HsDT)and Frostig's second model for the displacement fields.of the core layer are *** classical non-adhesive elastic contact theory and Hunter's principle are used to calculate the dynamic res.onses in terms.of *** order to validate the analytical method,the outcomes.of the current investigation are compared with those gained by the experimental tests carried out by other researchers for a rectangular composite plate subject to the *** element(FE)simulations are conducted by means.of the ABAQUs *** effects.of the parameters such as foam modulus,layer material,fiber angle,impactor mass,and its velocity on the generated voltage are reviewed.

关键词： analytical model piezoelectric layer curved sandwich beam glass reinforced laminate(GRL) pliable core low-velocity impact(LVI) classical non-adhesive elastic contact theory

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MXenes for Bioinspired soft Actuators:Advancements in Angle-Independent structural Colors and Beyond

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Nano-Micro Letters 2024年第8期16卷 18-34页

作者： siavash Iravani Rajender s.Varma Independent Researcher W Nazar STBoostan AveIsfahanIran Centre of Excellence for Research in sustainable Chemistry Department of ChemistryFederal University of São CarlosSão CarlosSP 13565‑905Brazil

soft actuators have garnered substantial attention in current years in view of their potential appliances in diverse domains like robotics,biomedical devices,and biomimetic *** actuators mimic the natural movements.of living organisms,aiming to attain enhanced flexibility,adaptability,and *** the other hand,angle-independent structural color has been achieved through innovative design strategies and engineering *** carefully controlling the size,shape,and arrangement of nanostructures,researchers have been able to create materials exhibiting consistent colors regardless.of the viewing *** promising class.of materials that holds great potential for bioinspired soft actuators is MXenes in view of their exceptional mechanical,electrical,and optical *** integration of MXenes for bioinspired soft actuators with angle-independent structural color offers exciting *** material compatibility issues,improving color reproducibility,scalability,durability,power supply efficiency,and cost-effectiveness will play vital roles in advancing these *** perspective appraises the development of bioinspired MXene-centered soft actuators with angleindependent structural color in soft robotics.

关键词： MXenes MXene-based composites Bioinspired soft robotics Angle-independent structural color

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Influence of railway wheel tread damage on wheel-rail impact loads and the durability of wheelsets

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Railway Engineering science 2024年第1期32卷 20-35页

作者： Michele Maglio Tore Verners.on Jens C.o.Nielsen Anders Ekberg Elena Kabo CHARMEC Department of Mechanical and Maritime SciencesChalmers University of TechnologySE‑41296 GothenburgSweden

Dynamic wheel-rail contact forces induced by a severe form of wheel tread damage have been measured by a wheel impact load detector during full-scale field tests at different vehicle *** on laser scanning,the measured three-dimens.onal damage geometry is employed in simulations.of dynamic vehicle-track interaction to calibrate and verify a simulation *** relation between the magnitude of the impact load and various.operational parameters,such as vehicle speed,lateral position of wheel-rail contact,track stiffness and position of impact within a sleeper bay,is *** calibrated model is later employed in simulations featuring other forms.of tread damage;their effects.on impact load and subsequent fatigue impact on bearings,wheel webs and subsurface initiated rolling contact fatigue of the wheel tread are *** results quantify the effects.of wheel tread defects and are valuable in a shift towards condition-based maintenance of running gear,and for general assessment of the severity of different types.of railway wheel tread damage.

关键词： Wheel tread damage Rolling contact fatigue cluster Field measurements Dynamic vehicle-track interaction Wheel-rail impact load Wheelset durability

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Tensor force impact on shell evolution in neutron-rich si and Ni isotopes

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Chinese Physics C 2024年第4期48卷 95-106页

作者： s.V.sidorov A.s.Kornilova T.Yu.Tretyakova Faculty of Physics Lomonosov Moscow State UniversityMoscow 119991Russia s.obeltsyn Institute of Nuclear Physics Lomonosov Moscow State UniversityMoscow 119991Russia

The influence of the tensor interaction of nucleons.on the characteristics.of neutron-rich silicon and nickel isotopes was studied in this *** forces are considered within the framework of the Hartree-Fock approach with the skyrme *** addition of a tensor component of interaction is s.own to improve the description of the splittings between different single-particle states and decrease nucleon-nucleon pairing correlations in silicon and nickel *** attention was directed toward the role of isovector tensor forces relevant to the interaction of like nucleons.

关键词： nuclear shell model tensor interaction silicon isotopes nickel isotopes

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Are dogs not susceptible to retroviral infections?

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Animal Diseases 2024年第3期4卷 217-223页

作者： Jorge Casseb João Henrique Campos Luciano Rodrigo Lopes Laboratory of Investigation in Dermatology and Immunodefciencies Department of DermatologyUniversity of São Paulo Medical SchoolSão PauloSPBrazil Igen-Institute of Immunogenetics São PauloSPBrazil Bioinformatics and Biomedical Data science Divis.on Health Informatics DepartmentUniversidade Federal de São Paulo–UNIFESP.Rua Botucatu 862Prédio Leal PradotérreoVila ClementinoCEP 04023-062São PauloSPBrazil

Retroviruses have been proven to cause infections and diseases in a series.of mammalian hosts but not in ***,this letter discussed the dog susceptibility to retrovirus infection,encompassing arguments to understand why dogs may have not been infected by retroviruses thus *** potential resistance of retrovirus in dogs enables this provocative s.ort communication to discuss this question,looking at some evolutive *** lineage of canids has s.own,throughout its evolutionary his.ory,a smaller accumulation of retroviruses in canid genomes,classifed as endogenous *** this context,the genomes.of canids seem to ofer obstacles,which have been evolutionarily conserved,in the face of retroviral infection.

关键词： Retrovirus dogs Endogenous retrovirus

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The emerging role of exercise as a cancer treatment

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Journal of s.ort and Health science 2024年第4期13卷 443-444页

作者： Kerry s.Courneya Faculty of Kines.ology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmontonAlbertaT6G 2H9Canada

over the past few decades,exercise oncology has emerged as an important subfield within exercise *** that time,substantial progress has been made in understanding the role of exercise in people newly diagnosed with ca... 详细信息

关键词： cancer treatment exercise

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A Review on the Recent Trends.of Image steganography for VANET Applications

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Computers, Materials & Continua 2024年第3期78卷 2865-2892页

作者： Arshiya s.Ansari Department of Information Technology College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia

Image steganography is a technique of concealing confidential information within an image without dramatically changing its.outside *** vehicular ad hoc networks(VANETs),which enable vehicles to communicate with one another and with roadside infrastructure to enhance safety and traffic flow provide a range of value-added services,as they are an essential component of modern smart trans.ortation *** steganography has been suggested by many authors for secure,reliable message transfer between terminal/hope to terminal/hope and also to secure it from attack for privacy *** paper aims to determine whether using steganography is possible to improve data security and secrecy in VANET applications and to analyze effective steganography techniques for incorporating data into images while minimizing visual quality *** to simulations in literature and real-world studies,Image steganography proved to be an effectivemethod for secure communication on VANETs,even in difficult network *** this research,we also explore a variety of steganography approaches for vehicular ad-hoc network trans.ortation systems like vector embedding,statistics,spatial domain(sD),trans.orm domain(TD),dis.ortion,masking,and *** study possibly shall help researchers to improve vehicle networks’ability to communicate securely and lay the door for innovative steganography methods.

关键词： steganography image steganography image steganography techniques information exchange data embedding and extracting vehicular ad hoc network(VANET) trans.ortation system

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^(4)He monolayer on graphene:a quantum Monte Carlo study

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Communications in Theoretical Physics 2024年第9期76卷 149-157页

作者： s Yu M Boninsegni Department of Physics University of AlbertaEdmontonAlbertaT6G 2H5Canada

We revisit the problem of adsorption of a single^(4)He layer on graphene,focusing on the commensurate(C_(1/3))crystalline phase,specifically on whether it may possess a nonzero superfluid res.onse,and on the existence of superfluid phases,either(metastable)liquid or vacancy-doped *** make use of canonical quantum Monte Carlo simulations at zero and finite temperature,based on a realistic micros.opic model of the *** results confirm the absence of any superfluid res.onse in the commensurate crystal,and that no thermodynamically stable uniform phase exists at lower *** evidence of a possibly long-lived,metastable superfluid phase at C_(1/3)coverage is ***,the results.of ground-state projection methods and finite-temperature simulations are entirely consistent.

关键词： superfluidity low-dimens.onal systems quantum Monte Carlo helium supersolids

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