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Can Emax and platelet count truly differentiate between benign and malignant liver lesions?

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World Journal of Gastroenterology 2025年第3期31卷 120-122页

作者： Manjeet kumar Goyal Omesh Goyal Department of Gastroenterology and Human Nutrition Unit All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Gastroenterology Dayanand Medical College and HospitalLudhiana 141001PunjabIndia

This letter critically evaluates Jiang et al's article on the differentiation of benign and malignant liver lesions using Emax and platelet *** notable findings,significant methodological and interpretative limitations are *** study lacks detailed assay conditions for Emax measurement,employs inadequate statistical methods without robust multivariate analysis,and does not provide clinically relevant threshold *** nomogram's reliance on Emax as a major diagnostic contributor is questionable due to attenuation in hepatocellular carcinoma patients with ***,the study's limitations,such as selection bias and confounding factors,are not adequately *** research should adopt more rigorous methodologies,including prospective studies with larger cohorts and standardized protocols for biomarker measurement,to enhance validity and clinical applicability.

关键词： Emax Platelet count Benign liver lesions Malignant liver lesions Hepatocellular carcinoma Cirrhosis Diagnostic biomarkers shear wave elastography Methodological limitations Clinical utility

Transmission congestion management considering multiple and optimal capacity DGs

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Journal of Modern Power systems and Clean Energy 2017年第5期5卷 713-724页

作者： Rajagopal PEEsAPATI Vinod kumar YADAV niranjan kumar Department of Electrical Engineering National Institute of Technology JamshedpurJamshedpurJharkhand 831014India Department of Electrical Engineering Gautam Buddha UniversityNoida 201334India

Transmission congestion management became a grievous issue with the increase of competitiveness in the power systems. Competitiveness arises due to restructuring of the utilities along with the penetration of auxiliary services. The present study depicts a multi objective technique for achieving the optimal capacities of distributed generators(DG) such as solar, wind and biomass in order to relieve congestion in the transmission lines. Objectives like transmission congestion, real power loss, voltages and investment costs are considered to improve the technical and economical performances of the network. Multi objective particle swarm optimization algorithm is utilized to achieve the optimal sizes of unity power factor DG *** insisted methodology is practiced on IEEE-30 and IEEE-118 bus systems to check the practical *** results of the proposed approach are compared with the genetic algorithm for both single and multi-objective cases. Results revealed that the intimated method can aid independent system operator to remove the burden from lines in the contingency conditions in an optimal manner along with the improvement in voltages and a reduction in real power losses of the network.

关键词： Transmission congestion Optimal power flow Distributed generation Particle swarm optimization

Translocator protein and neurodegeneration: insights from Alzheimer’s disease

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Neural Regeneration Research 2025年第4期20卷 1090-1091页

作者： Arpit kumar Pradhan Rainer Rupprecht Gerhard Rammes Klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Graduate school of systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany Department of Psychiatry and Psychotherapy University RegensburgRegensburgGermany

The 18 kDa translocator protein(TsPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TsPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce *** main reason why TsPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TsPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TsPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TsPO knockout models,which suggest that TsPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TsPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TsPO protein.

关键词： cholesterol organs

The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review

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Acta Pharmaceutica sinica B 2021年第7期11卷 1740-1766页

作者： niranjan Das siddhartha kumar Mishra Anusha Bishayee Eunüs s.Ali Anupam Bishayee Department of Chemistry Iswar Chandra Vidyasagar CollegeBelonia-799155TripuraIndia Cancer Biology Laboratory Department of ZoologySchool of Biological SciencesDr.Harisingh Gour Central UniversitySagar-470003Madhya PradeshIndia Pine View school OspreyFL 34229USA Department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA Lake Erie College of Osteopathic Medicine BradentonFL 34211USA

The phytoecdysteroids(PEs)comprise a large group of biologically-active plant steroids,which have structures similar to those of insect-molting *** are distributed in plants as secondary metabolites that offer protection against phytophagus(plant-eating)*** insects consume the plants containing these chemicals,they promptly molt and undergo metabolic destruction;the insects eventually ***,ecdysteroids are a group of polyhydroxylated ketosteroids that are structurally similar to *** carbon skeleton of ecdysteroids is termed as cyclopentanoperhydro-phenanthrene with aβ-side chain at *** essential characteristics of ecdysteroids are a cis-(5β-H)junction of rings A and B,a 7-en-6-one chromophore,and a trans(14α-OH)junction of rings C and *** only synthesize PEs from mevalonic acid in the mevalonate pathway of the plant cell using acetyl-CoA as a precursor;the most common PE is *** far,over 400 PEs have been identified and reported,and a compilation of 166 PEs originating from 1998 has been previously *** the present review,we have summarized 212 new PEs reported between 1999 and *** have also critically analyzed the biological,pharmacological,and medicinal properties of PEs to understand the full impact of these phytoconstituents in health and disease.

关键词： Phytoecdysteroids secondary metabolites Antioxidant Anti-inflammatory Antimicrobial Antidiabetic Anticancer activity

A Novel Multi-objective Protection Coordination scheme for a Microgrid with Optimal Deployment of Dual-setting ROCOV Based Relays

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Protection and Control of Modern Power systems 2024年第4期9卷 23-38页

作者： Praveen kumar Gupta Priyanshul niranjan Niraj kumar Choudhary Nitin singh Ravindra kumar singh the Department of Electrical Engineering Motilal Nehru National Institute of Technology AllahabadPrayagraj 211004India

Relay coordination is crucial in electrical power systems to protect against malfunctions and damage caused by unexpected events like short *** address the challenge associated with the reverse direction of fault current,dual-setting(Ds)directional over-current relays have evolved but failed to provide proper coordination during changes of load,generation,and *** the meantime,with the increasing number of Ds relays,the total relay operating time tends to ***,this paper proposes a protection scheme based on the optimal deployment of conventional and dual-setting rate of change of voltage(Ds-ROCOV)relays in distribution *** holds true for varying network topologies and is unaffected by variations in load and *** objective of the proposed scheme is to ensure reliable and efficient protection against faults in distribution systems by minimizing the overall operating time with the optimal number of Ds-ROCOV *** proposed protection scheme’s performance is evaluated for different coordination time interval values as well as in different microgrid *** paper outlines the design and implementation of the proposed protection scheme which is validated on the modified IEEE 14-bus system using simulations in Matlab/simulink.

关键词： Coordination time interval Ds-ROCOV relay multi-objective optimization optimal-deployment protection coordination

Use of a Bioaugmented Organic soil Amendment in Combination with Gypsum for Withania somnifera Growth on sodic soil

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Pedosphere 2016年第3期26卷 299-309页

作者： Manjul GUPTA Pankaj kumar sRIVAsTAVA sHIKHA Abhishek niranjan shri Krishna TEWARI CsIR National Botanical Research Institute Rana Pratap Marg Lucknow 226001 (India) school of Environmental sciences Babasaheb Bhimrao Ambedkar University Vidya Vihar Rae Bareilly Road Lucknow 226025 (India)

Limited availability of organic matter is a problem to sustain crop growth on sodic soil. Organic soil amendments are a costeffective source of nutrients to enhance crop growth. A field study was conducted to evaluate the effect of an organic soil amendment bioaugmented with plant growth-promoting fungi(sF_(OA) ) in combination with gypsum on soil properties and growth and yield attributes of Withania somnifera, one of the most valuable crops of the traditional medicinal system in the world, on a sodic soil at the Aurawan Research Farm of CsIR-National Botanical Research Institute, Lucknow, India. The sF_(OA) used was prepared by pre-enriching farm waste vermicompost with plant growth-promoting fungi before mixing with pressmud and Azadirachta indica seed cake. The application of sF_(OA) at 10 Mg ha^(-1)after gypsum(25.0 Mg ha^(-1)) treatment significantly(P sed root length(by 96%) and biomass(by 125%) of Withania plants compared to the control without sF_(OA) and gypsum. similarly, the highest withanolide contents were observed in leaves and roots of Withania plants under 10 Mg ha^(-1)sF_(OA) and gypsum. Combined application of sF_(OA) and gypsum also improved physical, chemical and enzymatic properties of the soil, with the soil bulk density decreasing by 25%, water-holding capacity increasing by 121%, total organic C increasing by 90%, p H decreasing by 17% and alkaline phosphatase, β-glucosidase, dehydrogenase and cellulase activities increasing by 54%, 128%, 81% and 96%, respectively, compared to those of the control. These showed that application of the sF_(OA) tested in this study might reclaim sodic soil and further support Withania cultivation and results were better when the sF_(OA) was applied after gypsum treatment.

关键词： medicinal crop plant growth-promoting fungi soil property soil reclamation vermicompost

A checklist of the macrofungi of North East India

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studies in Fungi 2022年第1期7卷 1-24页

作者： niranjan Roy Dhruva kumar Jha Arun kumar Dutta Department of Botany Gauhati UniversityGopinath Bordoloi NagarJalukbariGuwahati-781014AssamIndia

A literature-based checklist of macrofungi occurring in North East India is *** consists of 733 species of macrofungi distributed over 267 genera under 21 orders and 94 *** relevant information provided herein is based on 86 papers and six doctoral *** geographical distribution of the reports covers eight states of North East *** order Agaricales has the highest number of species(330 spp.)followed by Polyporales(126 spp.).The three most represented genera are Russula(38 spp.),Amanita(22 spp.)and Lactarius(23 spp.).This list covers only a part of the actual diversity of macrofungi occurring in the entire North East Indian region as detailed survey on macrofungi of this region is yet to be completed.

关键词： East distribution herein

Effect of Inclined Tension Crack on Rock slope stability by ssR Technique

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Intelligent Automation & soft Computing 2023年第4期36卷 1205-1214页

作者： Ch.Venkat Ramana niranjan Ramchandra Thote Arun kumar singh Visvesvaraya National Institute of Technology Nagpur440010India

The tension cracks and joints in rock or soil slopes affect their failure *** of rock or soil slope failure is one of the most challenging tasks in the earth *** actual slopes consist of inhomogeneous materials,complex morphology,and erratic *** studies concerning the failure of rock slopes primarily focused on determining Factor of safety(Fos)and Critical slip surface(Css).In this article,the effect of inclined tension crack on a rock slope failure is studied numerically with shear strength Reduction Factor(sRF)*** inclined Tension Crack(TC)inﬂuences the magnitude and location of the rock slope’s Critical shear strength Reduction Factor(CsRF).Certainly,inclined cracks are more prone to cause the failure of the slope than the vertical ***,all tension cracks do not lead to failure of the slope *** effect of the crest distance of the tension crack is also *** numerical results do not show any signiﬁcant change in the magnitude of CsRF unless the tip of the TC is very near to the crest of the *** is also replaced with a joint,and the results differ from the corresponding *** results are discussed regarding shear stress and Critical slip surface(Css).

关键词： Crest distance critical shear strength reduction factor critical slip surface inclined tension crack joint

Effect of process parameters on depth of penetration and topography of AZ91 magnesium alloy in abrasive water jet cutting

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Journal of Magnesium and Alloys 2018年第4期6卷 366-374页

作者： C A niranjan s srinivas M Ramachandra Department of Mechanical Engineering BMS College of EngineeringBengaluru-India

In the present study,the influence of dynamic process parameters such as water pressure,traverse speed and abrasive mass flow rate on depth of penetration and surface topography in high strength AZ91 magnesium alloy were investigated using Abrasive Water Jet(AWJ)cutting *** parameters were varied at 3 levels and influences of each parameter on penetration ability were identified using analysis of variance(ANOVA).Contribution of water pressure and traverse speed on jet penetration found higher compared to abrasive mass flow *** projector was used to measure depth of *** features and topography of cut surfaces were examined using scanning Electron Microscopy(sEM).Micro cutting and ploughing were observed on the top and bottom portion of the cut which were similar to that of modes of deformation in other ductile materials like aluminium and *** roughness of cut surfaces was measured using Taylor Hobson surface roughness *** roughness found higher at higher traverse speeds and lower at lower traverse *** study also highlights the suitability of AWJ cutting technology for cutting magnesium and its alloys.

关键词： AZ91 magnesium alloy Depth of penetration Profile projector Topography