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novel approaches in schizophrenia-from risk factors and hypotheses to novel drug targets

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World Journal of Psychiatry 2021年第7期11卷 277-296页

作者： MatejĽupták Danica Michaličková Zdeněk Fišar Eva Kitzlerová Jana Hroudová Institute of Pharmacology First Faculty of MedicineCharles University and General University Hospital in PraguePrague 12800Czech Republic Department of Psychiatry First Faculty of MedicineCharles University and General University Hospital in PraguePrague 12000Czech Republic

schizophrenia is a severe psychiatric disorder characterized by emotional,behavioral and cognitive disturbances, and the treatment of schizophrenia is oftencomplicated by noncompliance and pharmacoresistance. The search for thepathophysiological mechanisms underlying schizophrenia has resulted in theproposal of several hypotheses to explain the impacts of environmental, genetic,neurodevelopmental, immune and inflammatory factors on disease onset andprogression. This review discusses the newest insights into the pathophysiologyof and risk factors for schizophrenia and notes novel approaches in antipsychotictreatment and potential diagnostic and theranostic biomarkers. The currenthypotheses focusing on neuromediators (dopamine, glutamate, and serotonin),neuroinflammation, the cannabinoid hypothesis, the gut-brain axis model, andoxidative stress are summarized. Key genetic features, including small nucleotidepolymorphisms, copy number variations, microdeletions, mutations andepigenetic changes, are highlighted. Current pharmacotherapy of schizophreniarelies mostly on dopaminergic and serotonergic antagonists/partial agonists, butnew findings in the pathophysiology of schizophrenia have allowed theexpansion of novel approaches in pharmacotherapy and the establishment ofmore reliable biomarkers. substances with promising results in preclinical andclinical studies include lumateperone, pimavanserin, xanomeline, roluperidone,agonists of trace amine-associated receptor 1, inhibitors of glycine transporters,AMPA allosteric modulators, mGLUR2-3 agonists, D-amino acid oxidase inhibitorsand cannabidiol. The use of anti-inflammatory agents as an add-on therapy ismentioned.

关键词： schizophrenia Immune system Inflammation Genetics novel antipsychotics Add-on therapy

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未来5G网络中的智能边缘计算

未来5G网络中的智能边缘计算

new species in Aspergillus section Fumigati from reclamation sites in Wyoming (U.s.A.) and revision of A. viridinutans complex

2019全国边缘计算学术研讨会

作者： Benedek kovács Tamás nyíri 爱立信

人工智能一直是移动网络中的重要组成部分。随着5G以及边缘计算技术的发展,对人工智能的需求将变得愈发强烈。本文中,我们将阐述5G网络与前几代移动通信网络相比的一个本质区别——网络边缘计算的比重会大增,同时我们会就边缘计算在5G... 详细信息

人工智能一直是移动网络中的重要组成部分。随着5G以及边缘计算技术的发展,对人工智能的需求将变得愈发强烈。本文中,我们将阐述5G网络与前几代移动通信网络相比的一个本质区别——网络边缘计算的比重会大增,同时我们会就边缘计算在5G网络里的实现做一个探讨。之后我们会列举一些此新一代网络下的典型应用,它们都需要依赖边缘计算和机器学习来实现。最后,我们将介绍一个结合了边缘计算和深度学习的参考应用——"互联之眼"。我们会讨论这个应用的关键组成部分以及其所涉及的实时多媒体处理领域的机遇与挑战。

关键词： 5G 人工智能机器学习边缘计算

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Fungal Diversity 2014年第1期64卷 253-274页

作者： Alena nováková Vit Hubka Zuzana Dudová Tetsuhiro Matsuzawa Alena Kubátová Takashi Yaguchi Miroslav Kolařík Biology Centre As CR v.v.i.Institute of Soil BiologyNa Sádkách 737005ČeskéBudějoviceCzech Republic Laboratory of Physiology and Genetics of Fungi Institute of Microbiology AS CRv.v.iVídeňská108314220 Prague 4Czech Republic Department of Botany Faculty of ScienceCharles University in PragueBenátská212801 Prague 2Czech Republic Medical Mycology Research Center Chiba University1-8-1InohanaChuo-kuChiba 260-8673Japan

The Aspergillus viridinutans complex includes morphologically similar,soil-inhabiting *** its species boundaries have not been fully defined,many isolates from the complex have been isolated as opportunistic human and animal *** the present study,these species were dominant in spoil sites subjected to various types of reclamation management after coal *** species were characterised using two different PCR-fingerprinting methods,sequence data from the β-tubulin(benA)and calmodulin(caM)genes,macro-and micromorphology(optical and scanning electron microscopy),maximum growth temperatures and mating *** addition,RnA polymerase II gene(RPB2),actin(act1)and ITs sequences were deposited for the ex-type isolates of newly described *** mating experiment results,phylogenetic analyses and ascospore morphology suggested the presence of five species in the *** *** aureolus(*** aureola)was the only homothallic *** species,***,***(***)and *** ***.,were heterothallic and their morphologically distinguishable teleomorph was induced by systematic mating *** viridinutans *** to be a very rare species and was represented only by the ex-type isolate in which the MAT1-1 locus was *** viridinutans and *** were typified in accordance with the rules of the new botanical *** species outside the *** complex isolated from the reclamation sites were *** and *** as well as two new sister species,*** *** *** *** were closely related each to other and to *** new species are phylogenetically distant from all anamorphic species and resemble ***,*** and *** in micromorphology and are distinguishable from each other by the slower growth of *** on all tested ***,no isolate from the

关键词： Aspergillus fumigatus Heterothallic species MAT locus neosartorya udagawae PCR fingerprinting soil fungi

Fungal diversity notes 1611-1716: taxonomic and phylogenetic contributions on fungal genera and species emphasis in south China

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Fungal Diversity 2023年第5期122卷 161-403页

作者： Indunil C.senanayake Walter Rossi Marco Leonardi Alex Weir Mark McHugh Kunhiraman C.Rajeshkumar Rajnish K.Verma samantha C.Karunarathna saowaluck Tibpromma nikhil Ashtekar sreejith K.Ashtamoorthy sanjay Raveendran Gurmeet Kour Aishwarya singh saúl De la Peña-Lastra Antonio Mateos Miroslav Kolařík Vladimír Antonín HanaŠevčíková Fernando Esteve-Raventós Ellen Larsson Fermín Pancorbo Gabriel Moreno Alberto Altés Yolanda Turégano Tian-Ye Du Li Lu Qi-Rui Li Ji-Chuan Kang sugantha Gunaseelan Kezhocuyi Kezo Malarvizhi Kaliyaperumal Jizhen Fu Milan C.samarakoon Yusufjon Gafforov shakhnoza Teshaboeva Pradeep C.Kunjan Arya Chamaparambath Adam Flakus Javier Etayo Pamela Rodriguez-Flakus Mikhail P.Zhurbenko nimali Ide silva Danushka s.Tennakoon KPDeepna Latha Patinjareveettil Manimohan KnAnil Raj Mark s.Calabon Abdollah Ahmadpour Zeinab Heidarian Zahra Alavi Fatemeh Alavi Youbert Ghosta Razmig Azizi Mei Luo Min-Ping Zhao nuwan D.Kularathnage Li Hua Yun-Hui Yang Chun-Fang Liao Hai-Jun Zhao Anis s.Lestari subashini C.Jayasiri Feng-Ming Yu Lei Lei Jian-Wei Liu Omid Karimi song-Ming Tang Ya-Ru sun Yong Wang Ming Zeng Zin H.Htet Benedetto T.Linaldeddu Artur Alves Alan J.L.Phillips Carlo Bregant Lucio Montecchio AndréDe Kesel Vincent P.Hustad Andrew n.Miller Anna G.Fedosova Viktor Kučera Mubashar Raza Muzammil Hussain Yan-Peng Chen Vinodhini Thiyagaraja Deecksha Gomdola Achala R.Rathnayaka Asha J.Dissanayake nakarin suwannarach sinang Hongsanan sajeewa s.n.Maharachchikumbura Lakmali s.Dissanayake nalin n.Wijayawardene Rungtiwa Phookamsak saisamorn Lumyong E.B.Gareth Jones neelamanie Yapa Dhanushka n.Wanasinghe ning Xie Mingkwan Doilom Ishara s.Manawasinghe Jian-Kui(Jack)Liu Qi Zhao Biao Xu Kevin D.Hyde Jiage song Innovative Institute for Plant Health/Key Laboratory of Green Prevention and Control On Fruits and Vegetables in south China Ministry of Agriculture and Rural AffairsZhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225GuangdongChina Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Guangdong Provincial Key Laboratory for Plant Epigenetics College of Life Science and OceanographyShenzhen University3688Nanhai AvenueNanshanShenzhen 518055GuangdongChina sect.Environmental sciences Department MeSVAUniversity of L’AquilaVia Vetoio67100 CoppitoAQItaly Department of Environmental Biology SUNY-ESF241 Illick Hall1 Forestry DriveSyracuseNY 13210USA national Fungal Culture Collection of India MACS Agharkar Research InstitutePuneMaharashtra 411004India Department of Plant Pathology Punjab Agricultural UniversityLudhianaPunjab 141004India Center for Yunnan Plateau Biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujing 655011YunnanChina Department of Forest Ecology Kerala Forest Research InstitutePeechiThrissurKerala 680653India Department of Botany The American CollegeTallakkulamMaduraiTamil Nadu 625002India Department of Zoology Savitribai Phule Pune UniversityGaneshkhind RdGaneshkhindPuneMaharashtra 411007India University of santiago de Compostela 15782 Santiago de CompostelaSpain sociedad Micológica Extremeña C/Sagitario 1410001 CáceresSpain Institute of Microbiology of the Czech Academy of sciences Vídeňská108314220 Prague 4Czech Republic Department of Botany Moravian MuseumZelnýtrh 665937 BrnoCzech Republic Department of Life sciences(Botany Unit) University of Alcalá28805 Alcaláde HenaresMadridSpain Biological and Enviromental sciences University of Gothemburgand Gothemburg Global Biodiversity CentreBox 46140530 GöteborgSweden Madrid Mycological society Real Jardín BotánicoC/Claudio Moyano 128014 MadridSpain state Ke

This article is the 15th contribution in the Fungal Diversity notes series,wherein 115 taxa from three phyla,nine classes,28 orders,48 families,and 64 genera are *** taxa described and illustrated in the present study include a new family,five new genera,61 new species,five new combinations,one synonym,one new variety and 31 records on new hosts or new geographical *** *** introduced and accommodated in *** new genera introduced in this study are Ageratinicola,Kevinia,Pseudomultiseptospora(Parabambusicolaceae),Marasmiellomycena,and Vizzinia(Porotheleaceae).newly described species are Abrothallus altoandinus,Ageratinicola kunmingensis,Allocryptovalsa aceris,Allophoma yuccae,Apiospora cannae,***,***,Boeremia wisteriae,Calycina papaeana,Clypeo-coccum lichenostigmoides,Coniochaeta riskali-shoyakubovii,Cryphonectria kunmingensis,Diaporthe angustiapiculata,***,***,Diatrypella guangdongense,Dothiorella franceschinii,Endocalyx phoenicis,Epicoc-cum terminosporum,Fulvifomes karaiensis,***,Ganoderma ghatensis,Hysterobrevium baoshanense,Inocybe avellaneorosea,***,Jahnula oblonga,Kevinia lignicola,Kirschsteiniothelia guangdongensis,Laboulbenia caprina,***,***,***,***,***,***,***,***,Laccaria rubriporus,Lasiodiplodia morindae,Lyophyllum agnijum,Marasmiellomycena pseudoomphaliiformis,Melomastia beihaiensis,nemania guangdongensis,nigrograna thailandica,nigrospora ficuum,Oxydothis chinensis,***,Petriella thailandica,Phaeoacremonium chinensis,Phialocephala chinensis,Phytophthora debattistii,Polyplosphaeria nigrospora,Pronectria loweniae,seriascoma acutispora,setoseptoria bambusae,stictis anomianthi,Tarzetta tibetensis,Tarzetta urceolata,Tetraploa obpyriformis,Trichoglossum beninense,and Tricoderma *** provide an emendation for Urnula ailaoshanensis Agaricus duplocingulatoides *** i

关键词： Agaricomycetes Ascomycota Basidiomycota Dothideomycetes Eurotiomycetes Fungal diversity Geoglossomycetes Geographical distribution Host records Incertae sedis Laboulbeniomycetes Lecanoromycetes Leotiomycetes novel taxa new combination Oomycota Peronosporea Pezizomycetes Phylogeny sordariomycetes south Chinese fungi Taxonomy

Changes in the Regulating Ecosystem service on the Contaminated site Used for Energy Purposes

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Open Journal of Ecology 2020年第9期10卷 597-611页

作者： Jarmila Makovníková Beata Houšková Pálka Boris Širáň Miloš national Agricultural and Food Centre/soil science and Conservation Research Institute Bratislava Sovakia

soil cleaning, the ability of the soil to immobilize the risk elements, belongs to important agroecosystem services in terms of protection of the hydrosphere and plant production from contamination. Dynamic monitoring of selected indicators of soil quality was realized in a special network of site on soil used for planting fast growing willow (salix viminalis). Monitoring of the study site Kuchyňa (Mollic Fluvisol) is running since 2010 year. The fast-growing willow was planted on an area of about 43 hectares. study site Kuchyňa belonged to the degraded contaminated sites, at the time of planting (the total contents of the risk elements were as follows: Cd 1.016 mg∙span>kgsup>−1sup>, Zn 199.000 mg∙span>kgsup>−1sup>, ni 51.500 mg∙span>kgsup>−1sup>) There were positive changes in the total content of cadmium, zinc and nickel (in 2018 year), the zinc content decreased by 27% compared to 2010, the nickel content was lower by 23% and the Cd content by 57% in comparison to 2010 year, these elements have a declining trend during the monitored period. The remediation ability of the willow in relation to the risk elements was manifested by the accumulation of these elements in the wood mass and by their decrease in the soil below the limit value. The regulatory ecosystem service, the potential for the immobilisation of the risk elements, was evaluated based on the sum of the assessment of the contamination potential and the sorption potential of soil. The decrease of the total content of risk elements in the soil below the limit value was manifested in the increase of the potential o

关键词： soil Cleaning Willow Crops for Bioenergy Risk Elements soil Quality Indicators

乙烷氧化脱氢用ni/Al_2O_3催化剂中活性镍物种前驱体(英文)

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催化学报 2013年第10期34卷 1905-1913页

作者： Lucie smoláková árka Botková Libor apek Peter Priecel Agnieszka soltysek Martin Kout Lenka Matějová Department of Physical Chemistry Faculty of Chemical TechnologyUniversity of Pardubice nanotechnology Centre V B-Technical University of Ostrava

ni/Al2O3 catalysts for oxidative dehydrogenation(ODH) of ethane were prepared by impregnation of Al2O3 with nickel acetate or nickel nitrate,and by mechanical mixing of niO and *** ni-based catalysts were characterized by n2 adsorption-desorption,X-ray diffraction,diffuse reflectance UV-visible diffuse reflectance spectroscopy,and temperature-programmed reduction of *** results showed that formation of crystalline niO particles with a size of nm and/or non-stoichiometric niO species in the ni/Al2O3 catalysts led to more active species in ODH of ethane under the investigated reaction *** contrast,tetrahedral ni species present in the catalysts led to higher selectivity for *** of large crystalline niO particles(22-32 nm) over ni/Al2O3 catalysts decreased the selectivity for ethene.

关键词： Alumina Ethane Oxidative dehydrogenation nickel species

scald Burns in Children. An Analysis with special Attention to the Roma Ethnic Group in East slovakia

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International Journal of Clinical Medicine 2015年第1期6卷 44-49页

作者： Eugen Frisman Oliver Rácz Jozefina Petrovicová Ján slávik Iveta Cimboláková Clinic of Burns and Reconstructive surgery 1st Private Hospital Kosice-Saca Slovakia Department of Pathophysiology Medical School Safárik University Kosice Slovakia Faculty of Healthcare Miskolc University Miskolc Hungary Department of Medical Informatics Medical School Safárik University Kosice Slovakia Department of Anaesthesiology and Intensive Care Medicine 1st Private Hospital Kosice-Saca Slovakia

Objectives: A retrospective analysis of scald burns in children in a region with a significant prevalence of Roma ethnicity living in poor socioeconomic situation. Patients: During 3 year period 273 children were admitted to the Clinic of Burns and Reconstructive surgery of our hospital;201 of them were with scald burns accounting for 73.6% of all pediatric burn admissions. More than half (58.7%) of the 201 children with scald burns were of Roma ethnicity. Results: The average BsAB of the children with scald burns was 10.8%;mean length of hospital stay 11.5 days. 58.7% of the children with scald burns was of Roma ethnicity. The non-scald admissions of children had a similar pattern but these children were older and with an even higher prevalence of Roma patients (75%), a slightly lower average BsAB (9.8%) and a significantly longer need of hospital treatment (average 15.7 days). Conclusion: The frequency of scald burn injuries in very young Roma children in our region is very high. Prevention of scald burns is possible only through targeted and well-organized education of this vulnerable population.

关键词： scald Burns Pediatric Burns Roma Ethnicity

Monitoring of soil Bulk Density in Context with Its small-scale spatial Heterogeneity

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Journal of Geoscience and Environment Protection 2021年第5期9卷 138-151页

作者： Miloš Širáň Jarmila Makovníková national Agricultural and Food Centre Soil Science and Conservation Research Institute Bratislava Slovakia

The main aim of soil monitoring system is to obtain the knowledge of the most current state and development of soil properties according to concrete threats to soil. To determine the significant changes of soil properties in time, it is important to know spatial variability of concrete soil parameter for concrete site. Only those time changes of the soil parameter are significant, which exceed its spatial variability at the site. The main aim of the study has been focused on the evaluation of small-scale site heterogeneity of equilibrium soil bulk density and the integration of impact of this heterogeneity in evaluation of degradation process of soil compaction in time. As site variation coefficients have considerably varied at standard sampling with five repetitions during monitoring period, one-time detail spatial variability mapping of soil bulk density was realized at 17 repetitions on five selected monitoring sites with different soil type, texture and use. This increase in the number of sampling points helped us to specify and stabilize the values of variation coefficients (between minimum and maximum by standard sampling) as well as the extent of confidence intervals. standard deviations at the chosen monitoring sites moved from 0.039 to 0.118 g·cmsup>-3span>sup> in topsoil and from 0.031 to 0.067 g·cmsup>-3span>sup>span style="font-family:Verdana;"> in subsoil and expressed as variation coefficient 2.9% - 9.2% and 2.0% - 4.9%, respectively. The intervals of significant time changes of soil bulk density for the sites and depths were determined on the base of its site confidence interval (9

关键词： soil Monitoring soil Bulk Density spatial site and Time Variability significant Time Change

Heavy metal retention by soil mineral phases during a potential soil contamination by sewage sludge

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Chinese Journal Of Geochemistry 2006年第B8期25卷 194-195页

作者： Péter sipos Tibor németh Viktória kováics Kis Ilona Mohai Institute for Geochemical Research Hungarian Academy of Sciences Budapest Hungary Research Institute for Technical Physics and Materials science Hungarian Academy of Sciences Budapest Hungary Institute of Materials and Environmental Chemistry Chemical Research Center Hungarian Academy of Sciences Budapest Hungary