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MRI检测到的肠壁外血管侵犯可以作为直肠癌病人同步转移的独立预测因素

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国际医学放射学杂志 2015年第4期 392-392页

作者： B.sohn J.s.Lim H.Kim s.myoung J.Choi N.K.Kim 赵效新 Department of Radiology and Research Institute of Radiological science Severance Hospital Yonsei University College of Medicine 250 Seongsanno (134 Sinchon-dong)Seodaemun-gu SeoulKorea 120-752

摘要目的确定MRI检测到的肠壁外血管侵犯(EMVI)可否预测直肠癌的同步远处转移。方法筛选2011年7月—2012年12月间行直肠MRI检查的病人。447例经病理证实

关键词：血管侵犯直肠癌直肠肿瘤远处转移 MRI 病人

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Identical-video retrieval using the low-peak feature of a video's audio information

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Journal of Zhejiang University-science C(Computers and Electronics) 2010年第3期11卷 151-159页

作者： myoung-beom CHUNG Il-ju KO Department of Media Soongsil University

The recognition and retrieval of identical videos by combing through entire video files requires a great deal of time and memory space. Therefore, most current video-matching methods analyze only a part of each video's image frame information. All these methods, however, share the critical problem of erroneously categorizing identical videos as different if they have merely been altered in resolution or converted with a different codec. This paper deals instead with an identical-video-retrieval method using the low-peak feature of audio data. The low-peak feature remains relatively stable even with changes in bit-rate or codec. The proposed method showed a search success rate of 93.7% in a video matching experiment. This approach could provide a technique for recognizing identical content on video file share sites.

关键词： Video retrieval Video DNA Audio signal processing Audio feature extraction

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

THE ENERGY CONsERVATIONs AND LOWER BOUNDs FOR POssIBLE sINGULAR sOLUTIONs TO THE 3D INCOMPREssIBLE MHD EQUATIONs

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Acta Mathematica scientia 2020年第1期40卷 237-244页

作者： Jae-myoung KIM Department of Mathematics Education Andong National University AndongRepublic of Korea

In this note,we give a new proof to the energy conservation for the weak solutions of the incompressible 3D MHD ***,we give the lower bounds for possible singular solutions to the incompressible 3D MHD equations.

关键词： MHD equation lower bounds incompressible

LOCAL EXIsTENCE AND BLOW-UP CRITERION OF 3D IDEAL MAGNETOHYDRODYNAMICs EQUATIONs

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Acta Mathematica scientia 2018年第6期38卷 1759-1766页

作者： Jae-myoung KIM Center for Mathematical Analysis & Computation Yonsei University

We investigate the local existence of smooth solutions of a 3D ideal magneto-hydrodynamics （MHD） equations in a bounded domain and give a blow-up criteria to thisequations with respect to vorticists.

关键词： ideal magnetohydrodynamics equations blow-up criterion bounded domain

LOCAL REGULARITY CRITERIA OF A sUITABLE WEAK sOLUTION TO MHD EQUATIONs

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Acta Mathematica scientia 2017年第4期37卷 1033-1047页

作者： Jae-myoung KIM Department of Mathematical sciences Seoul National UniversitySeoul 08826Republic of Korea

We present a regularity condition of a suitable weak solution to the MHD equations in three dimensional space with slip boundary conditions for a velocity and magnetic vector fields. More precisely, we prove a suitable weak solution are Hslder continuous near boundary provided that the scaled mixed Lx,t^p,q-norm of the velocity vector field with 3/p ＋ 2/q 〈 2, 2 〈 q 〈 ∞ is sufficiently small near the boundary. Also, we will investigate that for this 3 2〈3 solution U ∈ Lx,t^p,q with 1 〈 3＋p ＋2/q＋≤3/2, 3 〈 p 〈 ∞, the Hausdorff dimension of its singular set is no greater than max{p, q}（3/q＋2/q- 1）.

关键词： local regularity criteria suitable weak solution MHD equations

sOME LIOUVILLE-TYPE THEOREMs FOR THE sTATIONARY 3D MAGNETO-MICROPOLAR FLUIDs

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Acta Mathematica scientia 2024年第6期44卷 2296-2306页

作者： Jae-myoung KIM seungchan KO Department of Mathematics Education Andong National UniversityGyeongdong-roAndong-si36729Gyeongsangbuk-doRepublic of Korea Department of Mathematics Inha UniversityInha-roMichuhol-gu22212Incheon-siRepublic of Korea

In this paper,we prove some Liouville-type theorems for the stationary magnetomicropolar fluids under suitable conditions in three space *** first prove that the solutions are trivial under the assumption of certain growth conditions for the mean oscillations of the *** then we show similar results assuming that the solutions are contained in L^(p)(R^(3))with p∈[2,9/2).Finally,we show the same result for lower values of p∈[1,9/4)with the further assumption that the solutions vanish at infinity.

关键词： stationary magneto-micropolar equations Liouville-type theorem