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A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment

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Bioactive Materials 2024年第2期32卷 206-221页

作者： Valentina Marotti Yining Xu Cécilia Bohns.michalowski Wunan Zhang Inês Domingues Hafsa Ameraoui Tom G.Moreels Pieter Baatsen Matthias Van Hul Giulio G.Muccioli Patrice D.Cani Mireille Alhouayek Alessio Malfanti Ana Beloqui UCLouvain Universit´e catholique de LouvainLouvain Drug Research InstituteAdvanced Drug Delivery and Biomaterials1200 BrusselsBelgium UCLouvain Universit´e catholique de LouvainLouvain Drug Research InstituteBioanalysis and Pharmacology of Bioactive Lipids1200 BrusselsBelgium UCLouvain Universit´e catholique de LouvainInstitute of Experimental and Clinical ResearchLaboratory of Hepato-Gastroenterology1200 BrusselsBelgium Cliniques universitaires saint-Luc Department of Hepato-GastroenterologyBrusselsBelgium EM-platform VIB Bio Imaging CoreKU LeuvenCampus GasthuisbergHerestraat 493000 LeuvenBelgium UCLouvain Universit´e catholique de LouvainLouvain Drug Research InstituteMetabolism and Nutrition Group1200 BrusselsBelgium UCLouvain Institute of Experimental and Clinical Research1200 BrusselsBelgium WEL Research Institute Avenue Pasteur61300 WavreBelgium

Current treatments for inflammatory bowel disease(IBD)treatment consist of anti-inflammatory *** this study,we sought to induce the physiological secretion of glucagon-like peptide 2,a peptide with intestinal growth-promoting activity,via nanoparticles while simultaneously providing with immunomodulation by tailoring the nanoparticle *** this end,we developed hybrid lipid hyaluronate-KPV conjugated nanoparticles loaded with teduglutide for combination therapy in *** nanocarriers induced(or did not induce)immunosuppression depending on the presence(or absence)of a hyaluronan-KPV *** strategy holds promise as a nanoparticle platform for combined mucosal healing and immunomodulation in IBD treatment.

关键词： Nanocarrier GLP-2 Teduglutide KPV Inflammatory bowel disease

Evaluation of Transition Points between Different solid Phases in Aqueous Media

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Journal of Analytical sciences, Methods and Instrumentation 2014年第3期4卷 87-94页

作者： Anna M.Michalowska-Kaczmarczyk Tadeusz michalowski Department of Oncology The University Hospital in CracowCracowPoland Faculty of Engineering and Chemical Technology Technical University of CracowCracowPoland

A uniform procedure is suggested for calculation of the pHt value(s) separating equilibrium solid phases in pH scale, at an excess of the precipitating agent. The pHt value, related to pairs of precipitates formed from the species ??and ?, fulfils the relation , where F is a constant value involving pKso’s for solubility products (Kso’s) of these precipitates, and the equilibrium data, related to the species composing these precipitates.

关键词： Electrolytic systems Precipitates pH-Intervals

Calculation of solubility of Oxyquinolinates

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Journal of Analytical sciences, Methods and Instrumentation 2014年第3期4卷 71-79页

The solubilities (s, mol/L) of different oxyquinolinates (oxinates, MeL2) are calculated using the formulae obtained according to elementary algebra, with the use of Excel spreadsheets. The calculations are involved with solution of algebraic equation of the third degree, obtained on the basis of concentration balances. The root of this equation, , is then inserted into the charge balance, and resolved according to zeroing procedure. In principle, the calculations are related to aqueous media. Nonetheless, the extension on liquid-liquid extraction systems is also proposed.

关键词： solubility Oxyquinolinates

Linear Dependence of Balances for Non-Redox Electrolytic systems

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American Journal of Analytical Chemistry 2014年第17期5卷 1285-1289页

作者： Anna M. Michalowska-Kaczmarczyk Tadeusz michalowski Department of Oncology The University Hospital in CracowCracowPoland Faculty of Engineering and Chemical Technology Technical University of CracowCracowPoland

Two complex dynamic non-redox systems are considered as examples, providing interdependent linear equations. A simple and efficient linear combination method that leads the system of equations to the identity, 0 = 0, is used for this purpose. These examples are clear confirmations of the general property differentiating non-redox and redox electrolytic systems. This property is involved with linear dependence or independence of 2·f(O)-f(H) on charge and elemental/core balances for elements/cores ≠H, O, where f(H) and?f(O) are elemental balances for H and O, respectively.

关键词： Titration Liebig-Denigès Method Complexonometric Detemination of Zinc

Inflection Points on some s-shaped Curves

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Journal of Analytical sciences, Methods and Instrumentation 2014年第1期4卷 27-30页

作者： Anna MMichalowska-Kaczmarczyk Tadeusz michalowski Agustin G.Asuero Department of Oncology The University Hospital in CracowCracowPoland Faculty of Engineering and Chemical Technology Technical University of CracowCracowPoland Department of Analytical Chemistry The University of SevilleSevilleSpain

This paper refers to inflection point—the fundamental property of s-shaped curves. In this paper, the inflection points are related to pH titration curve pH = pH(V), and to the curve s = s(pH) involved with surface t... 详细信息

关键词： pH Titration surface Tension