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World Journal of Radiology 2017年第6期9卷 253-268页

作者： Abhishek Mahajan sneha s Deshpande meenakshi H Thakur Department of Radiodiagnosis and Imaging Tata Memorial Hospital Tata Memorial Centre Department of Radiodiagnosis and Imaging Tata Memorial Centre

"Personalized oncology" is a multi-disciplinary science, which requires inputs from various streams for optimal patient management. Humongous progress in the treatment modalities available and the increasing need to provide functional information in addition to the morphological data; has led to leaping progress in the field of imaging. Magnetic resonance imaging has undergone tremendous progress with various newer MR techniques providing vital functional information and is becoming the cornerstone of "radiomics/radiogenomics". Diffusionweighted imaging is one such technique which capitalizes on the tendency of water protons to diffuse randomly in a given system. This technique has revolutionized oncological imaging, by giving vital qualitative and quantitative information regarding tumor biology which helps in detection, characterization and post treatment surveillance of the lesions and challenging the notion that "one size fits all". It has been applied at various sites with different clinical experience. We hereby present a brief review of this novel functional imaging tool, with its application in "personalized oncology".

关键词： Functional magnetic resonance imaging Molecular imaging Diffusion-weighted imaging Tumor biology Biomarker Radiomics

Gilbert's syndrome: High frequency of the (TA)_7 TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene

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World Journal of Gastroenterology 2006年第14期12卷 2269-2275页

作者： shabana Farheen sanghamitra sengupta Amal santra suparna Pal Gopal Krishna Dhali meenakshi Chakravorty Partha P Majumder Abhijit Chowdhury Human Genetics Unit Indian statistical Institute KolkataIndia Department of Gastroenterology Institute of Postgraduate Medical Education & Research KolkataIndia Human Genetics & Genomics Division Indian Institute of Chemical Biology KolkataIndia

AIM： To identify the variants in U rase 1 （UGT1A1） gene in Gilbert＇s syndrome （Gs） and to estimate the association between homozygosity for TA insertion and Gs in India, as well as the frequency of TA insertion and its impact among normal controls in India. METHODs： Ninety-five Gs cases and 95 normal controls were selected. Liver function and other tests were done. The promoter and all 5 exons of UGT1A1 gene were resequenced. Functional assessment of a novel trinucleotide insertion was done by in silico analysis and by estimating UGT1A1 promoter activity carried out by ludferase reporter assay of appropriate constructs in Hep G2 cell line. REsULTs： Among the Gs patients, 80% were homozygous for the TA insertion, which was several-fold higher than reports from other ethnic groups. The mean UCB level was elevated among individuals with only one copy of this insertion, which was not significantly different from those with two copies. Many new DNA variants in UGT1A1 gene were discovered, including a trinucleotide （CAT） insertion in the promoter found in a subset （10%） of Gs patients, but not among normal controls. In-silico analysis showed marked changes in the DNA-folding of the promoter and functional analysis showed a 20-fold reduction in transcription efficiency of UGT1A1 gene resulting from this insertion, thereby significantly elevating the UCB level. CONCLUsION： The genetic epidemiology of Gs is variable across ethnic interactions among UGT1A1 groups and the epistatic promoter variants modulate bilirubin glucuronidation.

关键词： Unconjugated hyperbilirubinemia UGT1A1 gene DNA resequencing Luciferase reporter assay

Oxidative stress in retinal pigment epithelium degeneration:from pathogenesis to therapeutic targets in dry age-related macular degeneration

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Neural Regeneration Research 2023年第10期18卷 2173-2181页

作者： meenakshi Maurya Kiran Bora Alexandra K.Blomfield Madeline C.Pavlovich shuo Huang Chi-Hsiu Liu Jing Chen Department of Ophthalmology Boston Children’s HospitalHarvard Medical SchoolBostonMAUSA

Age-related macular degeneration is a primary cause of blindness in the older adult population. Past decades of research in the pathophysiology of the disease have resulted in breakthroughs in the form of anti-vascular endothelial growth factor therapies against neovascular age-related macular degeneration;however, effective treatment is not yet available for geographical atrophy in dry agerelated macular degeneration or for preventing the progression from early or mid to the late stage of age-related macular degeneration. Both clinical and experimental investigations involving human agerelated macular degeneration retinas and animal models point towards the atrophic alterations in retinal pigment epithelium as a key feature in age-related macular degeneration progression. Retinal pigment epithelium cells are primarily responsible for cellular-structural maintenance and nutrition supply to keep photoreceptors healthy and functional. The retinal pigment epithelium constantly endures a highly oxidative environment that is balanced with a cascade of antioxidant enzyme systems regulated by nuclear factor erythroid-2-related factor 2 as a main redox sensing transcription factor. Aging and accumulated oxidative stress triggers retinal pigment epithelium dysfunction and eventually death. Exposure to both environmental and genetic factors aggravates oxidative stress damage in aging retinal pigment epithelium and accelerates retinal pigment epithelium degeneration in age-related macular degeneration pathophysiology. The present review summarizes the role of oxidative stress in retinal pigment epithelium degeneration, with potential impacts from both genetic and environmental factors in age-related macular degeneration development and progression. Potential strategies to counter retinal pigment epithelium damage and protect the retinal pigment epithelium through enhancing its antioxidant capacity are also discussed, focusing on existing antioxidant nutritional supplementation

关键词： age-related macular degeneration antioxidant nuclear factor erythroid-2-related factor 2 oxidative stress retinal pigment epithelium REV-ERBα

Isolation of <i>Campylobacters</i>from Intestinal Tract of Poultry in Northern Region of India

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Advances in Microbiology 2015年第12期5卷 797-806页

作者： Chetana Vaishnavi meenakshi singh Prashant Kapoor Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India

Campylobacter is one of the most common food-borne bacterial enteropathogens. We planned to investigate the prevalence and antibiotic resistogram of Campylobacter in poultry in and around Chandigarh. Poultry samples (n = 127) were obtained from slaughter houses/retail outlets and cultured microaerophilically on Campylobacter media. The isolates were identified phenotypically and by molecular investigation. Identification of specific genes to look for resistance to nalidixic acid, ciprofloxacin, tetracyclin and streptomycin was also done. Campylobacter was isolated from 57/127 (44.9%) of the samples. The most frequent serotypes identified were B: 2, s: 27, Z5: 52 and Z7: 57. All culture isolates (100%) were reconfirmed as Campylobacter by 16s rRNA polymerase chain reaction. Molecular identification of isolates revealed the presence of C. jejuni in 45 (79.0%), C. coli in 1 (1.8%) and co-infection of C. coli and C. jejuni in 11 (19.3%). No C. lari and C. upsaliensis were detected. Antibiogram typing showed nalidixic acid resistance in 36.8%, ciprofloxacin resistance in 35.0% and 31.5% resistance for both streptomycin and tetracyclin. A high level of Campylobacter prevalence was found among the poultry with C. jejuni being the most commonly isolated species. Resistance to major antibiotics among Campylobacter isolates from poultry was also very high. The study of prevalence of Campylobacter in poultry and its resistance to major antibiotics will help to plan risk burden strategies throughout the food chain.

关键词： Antibiotic Resistance Campylobacter Molecular Investigation Phenotypic Identification Poultry serotyping

Designing of future ornamental crops: a biotechnological driven perspective

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Horticulture Research 2023年第11期10卷 253-270页

作者： Mahinder Partap Vipasha Verma meenakshi Thakur Bhavya Bhargava Floriculture Laboratory Agrotechnology DivisionCouncil of Scientific and Industrial Research(CSIR)Institute of Himalayan Bioresource Technology(IHBT)Post Box No.6176061(HP)PalampurIndia Academy of scientific and Innovative Research(AcsIR) Ghaziabad201002Uttar PradeshIndia

With a basis in human appreciation of beauty and aesthetic values,the new era of ornamental crops is based on implementing innovative technologies and transforming symbols into tangible *** advances in plant biotechnology have attracted considerable scientific and industrial interest,particularly in terms ofmodifying desired plant traits and developing future ornamental *** utilizing omics approaches,genomic data,genetic engineering,and gene editing tools,scientists have successively explored the underlying molecular mechanism and potential gene(s)behind trait regulation such as floral induction,plant architecture,stress resistance,plasticity,adaptation,and phytoremediation in ornamental crop *** signs of progress lay a theoretical and practical foundation for designing and enhancing the efficiency of ornamental plants for a wide range of *** this review,we briefly summarized the existing literature and advances in biotechnological approaches for the improvement of vital traits in ornamental *** future ornamental plants,such as light-emitting plants,biotic/abiotic stress detectors,and pollution abatement,and the introduction of new ornamental varieties via domestication of wild species are also discussed.

关键词： crops ornamental utilizing

Effect of AgI on Conduction Mechanism in silver-Vanadate superionic Glasses

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New Journal of Glass and Ceramics 2011年第3期1卷 112-118页

作者： Poonam sharma D.K. Kanchan meenakshi Pant Manish s. Jayswal Nirali Gondaliya 不详

A quaternary super-ionic glass system xAgI: (95-x) [Ag2O:2V2O5]: 5TeO2, where 40 ≤ x ≤ 65 in steps of 5, has been pre- pared by melt quenching technique. The prepared glass samples are characterized by X-ray, FTIR and DsC studies. As revealed by the FTIR spectra, the oxyanion network is not affected by the addition of AgI. The frequency dependence of the electrical conductivity for various glass compositions at different temperatures has been analyzed in terms of Jon- scher’s universal power law. The measurements reveal that the conductivity increases from σ = 7.62 × 10–7 s/cm to 1.15 × 10–4 s/cm with increasing AgI content. The temperature dependent conductivity obeys the Arrhenius relationship. The impedance and modulus studies indicate the non-debye type of the frequency dispersion for all the glass samples.

关键词： Conductivity Glass Transition Temperature Infrared spectra Impedance Modulus

Dynamic Impact Absorption Behaviour of Glass Coated with Carbon Nanotubes

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Journal of surface Engineered Materials and Advanced Technology 2013年第4期3卷 257-261页

作者： Prashant Jindal meenakshi Goyal Navin Kumar Indian Institute of Technology Roopnagar Punjab India. University Institute of Chemical Engi- neering & Technology Panjab University Chandigarh India University Institute of Engineering & Technology Panjab University Chandigarh India

Boro-silicate glass samples were coated with chemically treated multi-walled carbon nanotubes (MWCNTs) to study the resistance offered by the coatings under the high strain rate impact. Impact testing of these glass samples was performed on split Hopkinson Pressure Bar (sHPB), where strain rates were varied from 500/s to 3300/s. However, the comparisons were limited to samples subjected to a strain rate of 2300/s to 3000/s so that the effect of only variable deposits of coatings on the stress-strain behavior of glass can be studied. Variable deposits (0.1 mg to 0.8 mg) of MWCNTs were coated uniformly on glass samples having a disc shape with a fixed surface area (79 mm2) to observe the effect of the coating on the impact absorption capacity of glass. It was observed that the small thickness of about 25 μm formed due to the fact that 0.2 mg of MWCNTs deposit spread over the surface increased the impact absorption capacity of the glass pieces by nearly 70%. However, beyond this amount when the deposit was increased to 0.4 mg, the coating thickness got doubled to nearly 49 μm and this led to a fall in absorption capacity which remained static till 0.8 mg deposit. However, even this decrease in capacity was able to absorb 30% more impact than offered by pure glass sample.

关键词： Glass Coatings Impact Behaviour strength Mechanical Properties

The Effect of Mixed Iodide salts on the Conductivity Behavior in Ag2O-V2O5-B2O3 superionic Glass system

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New Journal of Glass and Ceramics 2011年第3期1卷 125-129页

作者： Poonam sharma D.K. Kanchan Nirali Gondaliya meenakshi Pant Manish s. Jayswal 不详

A superionic mixed metal iodide glass system [(PbI2 –CuI ) - Ag2O- V2O5- B2O3] has been prepared by splat quenching technique. The prepared glass samples are characterized by X-ray diffraction (XRD) and differential scanning calo- rimetry (DsC). The effect of mixed metal iodide salts concentration on electrical properties has been investigated by the complex impedance spectroscopy (CIs). AC conductivity analysis is carried out in the frequency range of 2MHz-1Hz at different temperatures and an enhancement in the conductivity with iodide salts is the main feature of the observed re- sults with an anomaly at 20 mole % of PbI2 –CuI.

关键词： Iodide salts Ag-Ion Conductors XRD Impedance

Low Prevalence of Campylobacteriosis in the Northern Region of India

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Advances in Microbiology 2015年第3期5卷 155-165页

作者： Chetana Vaishnavi meenakshi singh Jarnail singh Thakur Babu Ram Thapa Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India Department of Community Medicine (school of Public Health) Postgraduate Institute of Medical Education and Research Chandigarh India

Campylobacter is one of the most common bacterial enteropathogens of food borne origin in industrialized countries with C. jejuni being the most common species followed by C. coli. The prevalence of Campylobacters in and around Chandigarh, India was studied by phenotypic and genotypic methods. Fecal samples from 1145 diarrheal patients and 102 healthy subjects from hospital and community were cultured on Campylobacter media and identified by Gram stain, biochemical investigations and serotyping. Molecular identification of Campylobacter isolates was done using specific primers to unique regions of 16s rRNA, Campylobacter jejuni (hipO), Campylobacter coli (aspK), Campylobacter lari (glyA) and Campylobacter upsaliensis (lpxA) genes. Identification of specific genes to look for resistance to nalidixic acid, ciprofloxacin, tetracyclin and streptomycin was also done. Campylobacters were isolated from 2.6% of patients with diarrhea. Campylobacteriosis was more prevalent in children ≤5 years old and during summer season. The most frequent serotypes were s:27, B:2, Z5:52 and V:32. All the Campylobacters isolated by culture were confirmed genotypically by identification of 16s rRNA, hipO and aspK genes. Of the 30 isolates, 27 were C. jejuni and 3 were C. coli. No C. lari or C. upsaliensis were detected. Antibiotic resistance was 40% for nalidixic acid, 23.3% for ciprofloxacin, 50% for tetracyclin and 20% for streptomycin. Campylobacter prevalence is low in the region with C. jejuni being the most common species. A high degree of resistance was found for nalidixic acid and tetracyclin but moderate for ciprofloxacin and streptomycin.

关键词： Antibiotic Resistance Campylobacter Diarrheas Molecular Investigation Phenotypes serotyping

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化学镀镍槽热损失的最小化(英文)

电镀与涂饰 2010年第7期29卷 27-29页

作者： K. N. srinivasan T. selvaganapathy R. meenakshi s. John Central Electrochemical Research Institute Karaikudi Tamilnadu-630006 India Annamalai University Annamalai Nagar Tamilnadu-608002 India A.V.V.M sri Pushpam College Poondi Thanjavur Tamilnadu-613503 India

在不使用电能的情况下，化学镀依靠含有还原剂的水溶液中金属离子的催化还原，从而实现金属的沉积。其成功与否，很大程度上取决于温度的维护。温度升高，沉积速度加快，因此，应当避免热量散失到周围环境中。本文估算了包裹不同隔热材... 详细信息

在不使用电能的情况下，化学镀依靠含有还原剂的水溶液中金属离子的催化还原，从而实现金属的沉积。其成功与否，很大程度上取决于温度的维护。温度升高，沉积速度加快，因此，应当避免热量散失到周围环境中。本文估算了包裹不同隔热材料的化学镀镍液的散热量。结果表明，采用棉花作为隔热材料，热损失可降至最低，从而提高并维持一定的沉积速率。

关键词：镍磷合金化学镀热损失隔热材料