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Dual PPAR delta/gamma agonist offer therapeutic potential for Alzheimer's disease

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Neural Regeneration Research 2024年第6期19卷 1175-1176页

作者： Ian steinke meenakshi singh Rajesh Amin Department of Drug Discovery and Development Auburn University

The increasing incidence of Alzheimer’s disease(AD) in the aging population, indicates the critical need for the development of novel targeted molecular therapies for ameliorating AD pathology. Moreover, clinical and preclinical evidence demonstrates that peroxisomal proliferator activating receptors(PPAR) agonists regulate energy and lipid homeostasis in models of diabetes, as well as improve spatial memory in animal models of AD(Khan et al., 2019).

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Design & Test of an Advanced Web security Analysis Tool (AWsAT)

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Journal of software Engineering and Applications 2024年第5期17卷 448-461页

作者： meenakshi s. P. Manikandaswamy Vijay Madisetti school of Cybersecurity and Privacy Georgia Institute of Technology Atlanta USA

Considering the escalating frequency and sophistication of cyber threats targeting web applications, this paper proposes the development of an automated web security analysis tool to address the accessibility gap for non-security professionals. This paper presents the design and implementation of an automated web security analysis tool, AWsAT, aimed at enabling individuals with limited security expertise to effectively assess and mitigate vulnerabilities in web applications. Leveraging advanced scanning techniques, the tool identifies common threats such as Cross-site scripting (Xss), sQL Injection, and Cross-site Request Forgery (CsRF), providing detailed reports with actionable insights. By integrating sample payloads and reference study links, the tool facilitates informed decision-making in enhancing the security posture of web applications. Through its user-friendly interface and robust functionality, the tool aims to democratize web security practices, empowering a wider audience to proactively safeguard against cyber threats.

关键词： Web security Automated Analysis Vulnerability Assessment Web scanning Cross-site scripting sQL Injection Cross-site Request Forgery

Improving the training abilities of ophthalmic educators: the Ophthalmology Foundation’s initiatives

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Annals of Eye science 2024年第1期9卷 1-3页

作者： Karl Golnik Yip Chee Chew Gabriela Palis.meenakshi swaminathan Department of Ophthalmology at the University of Cincinnati CincinnatiOHUSA. Department of Ophthalmology and Visual sciences Khoo Teck Puat HospitalSingaporeSingapore Ophthalmology Department Hospital Italiano de Buenos AiresBuenos AiresArgentina Capstone Clinic ChennaiIndia sri Ramachandra Medical College ChennaiIndia

Our goal as medical educators is for our students to learn what they need to know and competently perform ophthalmic *** addition,the students need to have good communication skills and behave professionally and ethically(1,2).Most medical educators are not taught how to teach but rather learn by role-modeling their *** can be good or bad depending on the mentor!In addition,the amount of knowledge and numbers of surgical procedures is ever increasing and yet,in most countries,the amount of time to train and become competent is not ***,our goal of creating competent ophthalmologists is ever more challenging.

关键词： Ophthalmology Foundation teaching skills feedback

Transition metal impurities in silicon:computational search for a semiconductor qubit

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npj Computational Materials 2022年第1期8卷 1674-1684页

作者： Cheng-Wei Lee meenakshi singh Adele C.Tamboli Vladan stevanović Colorado school of Mines GoldenCOUSA National Renewable Energy Laboratory GoldenCOUSA

semiconductors offer a promising platform for physical implementation of qubits,but their broad adoption is presently hindered by limited scalability and/or very low operating *** from the nitrogen-vacancy centers in diamond,our goal is to find equivalent optically active point defect centers in crystalline silicon,which could be advantageous for their scalability and integration with classical *** metal(TM)impurities in silicon are common paramagnetic deep defects,but a comprehensive theoretical study of the whole 3d series that considers generalized Koopmans’condition is *** apply the HsE06(+U)method to examine their potential as optically active spin qubits and identify seven TM impurities that have optically allowed triplet–triplet transitions within the silicon band *** results provide the first step toward silicon-based qubits with higher operating temperatures for quantum ***,these point defects could lead to spin-photon interfaces in silicon-based qubits and devices for mid-infrared free-space communications.

关键词： Transition centers allowed

Oxidative stress in retinal pigment epithelium degeneration:from pathogenesis to therapeutic targets in dry age-related macular degeneration

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Neural Regeneration Research 2023年第10期18卷 2173-2181页

作者： meenakshi Maurya Kiran Bora Alexandra K.Blomfield Madeline C.Pavlovich shuo Huang Chi-Hsiu Liu Jing Chen Department of Ophthalmology Boston Children’s HospitalHarvard Medical SchoolBostonMAUSA

Age-related macular degeneration is a primary cause of blindness in the older adult population. Past decades of research in the pathophysiology of the disease have resulted in breakthroughs in the form of anti-vascular endothelial growth factor therapies against neovascular age-related macular degeneration;however, effective treatment is not yet available for geographical atrophy in dry agerelated macular degeneration or for preventing the progression from early or mid to the late stage of age-related macular degeneration. Both clinical and experimental investigations involving human agerelated macular degeneration retinas and animal models point towards the atrophic alterations in retinal pigment epithelium as a key feature in age-related macular degeneration progression. Retinal pigment epithelium cells are primarily responsible for cellular-structural maintenance and nutrition supply to keep photoreceptors healthy and functional. The retinal pigment epithelium constantly endures a highly oxidative environment that is balanced with a cascade of antioxidant enzyme systems regulated by nuclear factor erythroid-2-related factor 2 as a main redox sensing transcription factor. Aging and accumulated oxidative stress triggers retinal pigment epithelium dysfunction and eventually death. Exposure to both environmental and genetic factors aggravates oxidative stress damage in aging retinal pigment epithelium and accelerates retinal pigment epithelium degeneration in age-related macular degeneration pathophysiology. The present review summarizes the role of oxidative stress in retinal pigment epithelium degeneration, with potential impacts from both genetic and environmental factors in age-related macular degeneration development and progression. Potential strategies to counter retinal pigment epithelium damage and protect the retinal pigment epithelium through enhancing its antioxidant capacity are also discussed, focusing on existing antioxidant nutritional supplementation

关键词： age-related macular degeneration antioxidant nuclear factor erythroid-2-related factor 2 oxidative stress retinal pigment epithelium REV-ERBα

Facile synthesis and characterization of acetate intercalated Co-La layered double hydroxide

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Journal of Rare Earths 2017年第5期35卷 474-479页

作者： meenakshi Pokhriyal sitharaman Uma Rajamani Nagarajan Materials Chemistry Group Department of Chemistry University of Delhi

Layered double hydroxide（LDH） comprising of Co^2＋ and La^3＋-ions with acetate counter anion was successfully synthesized by hydrogen peroxide catalyzed hydrolysis reaction and characterized extensively. The observed reflections in the powder X-ray diffraction pattern could be indexed in P3 space group with a=0.316 nm and c=2.97 nm. Lattice fringes of distances corresponding to the peaks observed in X-ray diffraction pattern were observed in high resolution transmission electron microscopic images. UV-visible diffuse reflectance spectroscopy results confirmed the presence of Co（OH）6 along with the presence of charge-transfer band due to the interlayer carboxylate anion. Magnetization measurements at room temperature indicated high spin configuration of Co^2＋-ion in the sample exhibiting paramagnetic behavior. The mixed metal oxide from calcination was used to reconstruct the parent layered structure. Intercalation experiments with other organic anions in Co-La LDH proved be successful.

关键词： layered acetate interlayer hydroxide hydrolysis anion calcination carboxylate reconstruct intercalation

Assessment of groundwater quality with special emphasis on nitrate contamination in parts of Gautam Budh Nagar district,Uttar Pradesh, India

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Acta Geochimica 2019年第5期38卷 703-717页

作者： Meenu Agarwal meenakshi singh Jakir Hussain Galgotias University Plot No.2Sector 17-A Yamuna ExpresswayGreater NoidaGautam Budh NagarUttar PradeshIndia National River Water Quality Laboratory Central Water CommissionNew Delhi 110016India

Progressive developments in industrial and agricultural activities are causing a critical stress on groundwater quality in developing *** objective of this paper is to assess and evaluate the contamination level of groundwater caused by leachate in 11 villages of the Gautam Budh Nagar district in Uttar Pradesh,*** systematically sampled 22 groundwater samples and 13 leachate samples to ascertain the source of pollution on groundwater *** standard analytical methods given by the American Public Health Association(APHA)(standard methods for examination of water and wastewater,23rd ***,AWWA,WPCF,Washington,2017)were used for quantitative estimation of hydrochemical parameters of collected *** results of the analysis of groundwater samples indicate that pH values range from 7.31 to *** mean magnesium concentration in groundwater samples is 58.93±21.44 mg/*** of the groundwater samples taken,approximately 41%and 73%of samples analysis results have been found beyond the acceptable limit with respect to the parameters of turbidity and total dissolved solids,respectively,according to the Bureau of Indian standards(Indian standard specification for drinking water(Is:10500).BIs,Manak Bhawan,New Delhi,2012)for drinking *** 95.4%of groundwater samples and 92.3%of leachate samples have high nitrate concentrations above the standard limit of BIs(45 mg/L),*** Piper plot shows that 50%of the samples belong to the Ca^2+-Mg^2+-HCO3^-*** and Durov's diagrams indicate that the mean concentrations of ions are in the order of Na^+>Mg^2+>Ca^2+>K^+(for cations)and HCO3^->NO3^->C1^->sO42^->CO32^->F-(for anions)in groundwater of the study *** spatial variation of the hydrochemical parameters shows that groundwater is heavily contaminated with respect to *** results indicate that the groundwater of villages Achheja,Bisrakh road,Dujana,Badalpur and sadopur is not suitable for drinking.

关键词： Leachate Hydrochemical parameters Piper plot Ternary and Durov's diagram spatial variation

Designing of future ornamental crops: a biotechnological driven perspective

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Horticulture Research 2023年第11期10卷 253-270页

作者： Mahinder Partap Vipasha Verma meenakshi Thakur Bhavya Bhargava Floriculture Laboratory Agrotechnology DivisionCouncil of Scientific and Industrial Research(CSIR)Institute of Himalayan Bioresource Technology(IHBT)Post Box No.6176061(HP)PalampurIndia Academy of scientific and Innovative Research(AcsIR) Ghaziabad201002Uttar PradeshIndia

With a basis in human appreciation of beauty and aesthetic values,the new era of ornamental crops is based on implementing innovative technologies and transforming symbols into tangible *** advances in plant biotechnology have attracted considerable scientific and industrial interest,particularly in terms ofmodifying desired plant traits and developing future ornamental *** utilizing omics approaches,genomic data,genetic engineering,and gene editing tools,scientists have successively explored the underlying molecular mechanism and potential gene(s)behind trait regulation such as floral induction,plant architecture,stress resistance,plasticity,adaptation,and phytoremediation in ornamental crop *** signs of progress lay a theoretical and practical foundation for designing and enhancing the efficiency of ornamental plants for a wide range of *** this review,we briefly summarized the existing literature and advances in biotechnological approaches for the improvement of vital traits in ornamental *** future ornamental plants,such as light-emitting plants,biotic/abiotic stress detectors,and pollution abatement,and the introduction of new ornamental varieties via domestication of wild species are also discussed.

关键词： crops ornamental utilizing

Peptidomimetic inhibitor of L-plastin reduces osteoclastic bone resorption in aging female mice

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Bone Research 2021年第2期9卷 213-222页

作者： Hanan Aljohani Joseph P.stains sunipa Majumdar Deepa srinivasan Linda senbanjo meenakshi A.Chellaiah Department of Oncology and Diagnostic sciences School of DentistryUniversity of MarylandBaltimoreMDUSA Department of Oral Medicine and Diagnostics sciences King Saud UniversitySchool of DentistryRiyadhKingdom of Saudi Arabia Department of Orthopedics University of Maryland School of MedicineBaltimoreMDUSA

L-plastin(LPL)was identified as a potential regulator of the actin-bundling process involved in forming nascent sealing zones(NsZs),which are precursor zones for mature sealing ***-fused cell-penetrating small molecular weight LPL peptide(TATMARGsVsDEE,denoted as an inhibitory LPL peptide)attenuated the formation of NsZs and impaired bone resorption in vitro in ***,the genetic deletion of LPL in mice demonstrated decreased eroded perimeters and increased trabecular bone *** the present study,we hypothesized that targeting LPL with the inhibitory LPL peptide in vivo could reduce osteoclast function and increase bone density in a mice model of low bone *** injected aging C57BL/6 female mice(36 weeks old)subcutaneously with the inhibitory and scrambled peptides of LPL for 14 ***-CT and histomorphometry analyses demonstrated an increase in trabecular bone density of femoral and tibial bones with no change in cortical thickness in mice injected with the inhibitory LPL peptide.A reduction in the serum levels of CTX-1 peptide suggests that the increase in bone density is associated with a decrease in osteoclast *** changes in bone formation rate and mineral apposition rate,and the serum levels of P1NP indicate that the inhibitory LPL peptide does not affect osteoblast *** study shows that the inhibitory LPL peptide can block osteoclast function without impairing the function of *** peptide could be developed as a prospective therapeutic agent to treat osteoporosis.

关键词： function. sealing impaired