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Residual feed intake phenotype and gender affect the expression of key genes of the lipogenesis pathway in subcutaneous adipose tissue of beef cattle

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Journal of Animal science and Biotechnology 2019年第1期10卷 208-217页

作者： Clare mckenna Richard K.Porter Kate A.Keogh sinead M.Waters Mark McGee David A.Kenny Animal and Bioscience Research Department Teagasc Grange school of Biochemistry & Immunology Trinity College Dublin

Background: Feed accounts for up to 75% of costs in beef production systems,thus any improvement in feed efficiency(FE) will benefit the profitability of this *** feed intake(RFI) is a measure of FE that is independent of level of *** tissue(AT) is a major endocrine organ and the primary metabolic energy *** modulates a variety of processes related to FE such as lipid metabolism and glucose homeostasis and thus measures of inter-animal variation in adiposity are frequently included in the calculation of the RFI *** aim of this study was to determine the effect of phenotypic RFI status and gender on the expression of key candidate genes related to processes involved in energy metabolism within *** matter intake(DMI) and average daily gain(ADG) were measured over a period of 70 d for 52 purebred simmental heifers(n = 24) and bulls(n = 28) with an initial BW±sD of 372±39.6 kg and 387±50.6 kg,*** feed intake was calculated and animals were ranked within gender by RFI into high(inefficient; n = 9 heifers and n = 8 bulls)and low(efficient; n = 9 heifers and n = 8 bulls) ***: Average daily gain ±sD and daily DMI ±sD for heifers and bul s were 1.2±0.4 kg and 9.1±0.5 kg,and 1.8±0.3 kg and 9.5±1 kg *** RFI heifers and bulls consumed 10% and 15% more(P s,*** had a higher expression of all genes measured than bulls(P s detected for HMGCs2(P s tended to have lower expression of HMGCs2 than low RFI bulls(P s high RFI heifers had higher expression than low RFI heifers(P s(P sLC2 A4 expression was consistently higher in subcutaneous AT of low RFI animals across ***: The findings of this study indicate that low RFI cattle exhibit upregulation of the molecular mechanisms governing glucose metabolism in adipose tiss

关键词： Adipose Cattle RFI sLC2A4

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solution‑Processed Thin Film Transparent Photovoltaics:Present Challenges and Future Development

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Nano-Micro Letters 2025年第2期17卷 566-600页

作者： Tianle Liu Munerah M.s.Almutairi Jie Ma Aisling stewart Zhaohui Xing Mengxia Liu Bo Hou Yuljae Cho UM-sJTU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China school of Physics and Astronomy Cardiff UniversityCardiff CF243AAWalesUK Department of Electrical and Computer Engineering Yale UniversityNew HavenCT 06511USA Energy sciences Institute Yale UniversityWest HavenCT 06516USA Future Photovoltaics Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is essential for modern society to sustain economic *** soaring demand for the electrical energy,together with an awareness of the environmental impact of fossil fuels,has been driving a shift towards the utilization of solar ***,traditional solar energy solutions often require extensive spaces for a panel installation,limiting their practicality in a dense urban *** overcome the spatial constraint,researchers have developed transparent photovoltaics(TPV),enabling windows and facades in vehicles and buildings to generate electric *** TPV advancements are focused on improving both transparency and power output to rival commercially available silicon solar *** this review,we first briefly introduce wavelength-and non-wavelengthselective strategies to achieve *** of merit and theoretical limits of TPVs are discussed to comprehensively understand the status of current TPV *** we highlight recent progress in different types of TPVs,with a particular focus on solution-processed thin-film photovoltaics(PVs),including colloidal quantum dot PVs,metal halide perovskite PVs and organic *** applications of TPVs are also reviewed,with emphasis on agrivoltaics,smart windows and ***,current challenges and future opportunities in TPV research are pointed out.

关键词： Transparent semiconductors solution-processable transparent solar cell Emerging solar cell materials Buildingintegrated photovoltaics

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Increased food intake after starvation enhances sleep in Drosophila melanogaster

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Journal of Genetics and Genomics 2017年第6期44卷 319-326页

作者： Josue M.Regalado mckenna B.Cortez Jeremy Grubbs Jared A.Link Alexander van der Linden Yong Zhang Department of Biology University of Nevada-Reno

Feeding and sleep are highly conserved,interconnected behaviors essential for *** has been shown to potently suppress sleep across species;however,whether satiety promotes sleep is still *** we use the fruit fly,Drosophila melanogaster,as a model organism to address the interaction between feeding and *** first monitored the sleep of flies that had been starved for 24 h and found that sleep amount increased in the first 4 h after flies were given *** sleep after starvation was due to an increase in sleep bout number and average sleep bout *** of translin or adipokinetic hormone,which fail to suppress sleep during starvation,still exhibited a sleep increase after starvation,suggesting that sleep increase after starvation is not a consequence of sleep loss during *** also found that feeding activity and food consumption were higher in the first 10-30 min after *** food consumption in starved flies to 30 min was sufficient to increase sleep for 1 *** flies ingested a comparable amount of food at differing sucrose concentrations,sleep increase after starvation on a lower sucrose concentration was *** together,our results suggest that increased food intake after starvation enhances sleep and reveals a novel relationship between feeding and sleep.

关键词： Drosophila Feeding sleep starvation satiety

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Use of methotrexate in inflammatory bowel disease in 2014: A User's Guide

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2014年第3期5卷 113-121页

作者： Arun swaminath Raja Taunk Garrett lawlor IBD Program NorthShore Hospital SystemLenox Hill HospitalNew YorkNY 10075United States Division of Gastroenterology Lenox Hill HospitalNew YorkNY 10075United States NY Harbor Veteran’s Affairs Healthcare system Brooklyn CampusBrooklynNY 11201United States

Methotrexate has been used an immunomodulator in many autoimmune diseases,including inflammatory bowel disease. However,many physicians are unfamiliar or uncomfortable with its use in the management of inflammatory bowel disease. We summarize the data for use of methotrexate in common clinical scenarios:(1) steroid dependant Crohn's disease(CD);(2) maintenance of remission in steroid free CD;(3) azathioprine failures in CD;(4) in combination therapy with Anti-TNF agents in CD;(5) decreasing antibody formation to Anti-TNF therapy in CD;(6) management of fistulizing disease in CD; and(7) as well as induction and maintenance of remission in ulcerative colitis. An easy to use algorithm is provided for the busy clinician to access and safely prescribe methotrexate for their inflammatory bowel disease patients.

关键词： Methotrexate Inflammatory bowel disease Crohn’s disease Ulcerative colitis Immunomodulators Methotrexate user’s guide

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卫星姿态对磁层中性原子成像探测的影响

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科技创新导报 2014年第24期11卷 76-78页

作者：路立 susan mckenna-lawlor Jan Balaz 史建魁杨垂柏罗静中国科学院空间科学与应用研究中心北京100190 space Technology Ireland National University of Ireland Institute of Experimental Physics KosiceSlovakia

适于磁层中性原子威像探测的一般是运行在磁层高度的极轨自旋稳定卫星。利用设置在不同仰角方向的探测器通过卫星自旋进行方位角扫描以实现二维中性原子成像探测。这样以来,卫星自旋轴的取向就是我们选择中性原子二维图像的仰角和方位... 详细信息

适于磁层中性原子威像探测的一般是运行在磁层高度的极轨自旋稳定卫星。利用设置在不同仰角方向的探测器通过卫星自旋进行方位角扫描以实现二维中性原子成像探测。这样以来,卫星自旋轴的取向就是我们选择中性原子二维图像的仰角和方位角分布的依据。为了提高角分辨,我们总是希望把垂直于自旋轴方向的探测器时准主要成像位置。考虑卫星在极区的最佳遥测位置,我们选择卫星自旋轴垂直于轨道面将最有利于中性原子的成像探测。对于三轴稳定卫星,我们可以利用多组硅条探测器设计二维中性原子成像仪。

关键词：能量中性原子自旋稳定三轴稳定

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIs) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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Restless head syndrome:A retrospective study

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World Journal of Methodology 2025年第1期15卷 51-59页

作者： sanjay Prakash Varoon Vadodaria Niraj Chawda Chetsi s shah Anurag Prakash Department of Neurology Smt.B.K.Shah Medical Institute and Research CentreSumandeep VidyapeethVadodara 391760GujarātIndia Department of Medicine Smt.B.K.Shah Medical Institute and Research CentreSumandeep VidyapeethVadodara 391760GujarātIndia Department of Medicine Parul Institute of Medical Sciences and Research CentreParul University WaghodiaVadodara 391760India

BACKGROUND Restless legs syndrome(RLs)is characterized by an urge to move with an unpleasant sensation in the lower *** typically affects the ***,it can also affect several other body regions,such as the arms,abdomen,face,neck,head,and genital *** are only a few reports of the RLs variant affecting the *** To assess the epidemiological,clinical,and other aspects of the RLs variant affecting the *** We conducted a retrospective study of 17 adult patients(>18 years)who met the RLs criteria and simultaneously experienced RLs-like symptoms in the *** The median age at which symptoms appeared was 41.6 *** and females were equally affected(1.1:1).All 17 patients had uncomfortable sensations in the lower *** or disturbed sleep was the most common comorbidity(n=16,88.2%).However,headache was the most common presenting or primary symptom(n=10,70.5%).Dizziness or an abnormal sensation in the head was the second most common presenting symptom(5 patients,29.4%).Other presenting features were leg pain,backache,and generalized body *** patients responded favorably to dopaminergic *** If RLs-related unpleasant sensations and pain are felt in the head,they may be misinterpreted as headache,dizziness,or psychosomatic *** and headaches in a subset of patients may be two phenotypic manifestations of the same disorder.

关键词： Restless legs syndrome Restless head syndrome Dopamine Headache Migraine Tension-type headache

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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha R samarasinghe Taniya s Nagpal Michele L Barbeau Charys M Martin Division of General surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MsK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MsK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of MsK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement MsK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy Exercise Online learning

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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

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如何延长汽车电池的寿命和可靠性?——大幅降低汽车电气故障的精密电池检测和传感技术

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电子技术应用 2011年第3期37卷 6-7页

作者： David mckenna ADI公司

为了减少汽车故障,需要精确地检测电池的电压、电流和温度。以铅酸电池为例,分析了常用的分立电池检测方案和采用集成器件的解决方案,并对汽车传感器在汽车中的应用前景作出了预测。

关键词：电池检测铅酸电池传感器 ADuC703x

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