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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés mercedes Lachén-montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease

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World Journal of Gastroenterology 2000年第1期6卷 49-52页

作者： Indaram AVK Nandi s Weissman s Lam s Bailey B Blumstein m Greenberg R Bank s Division of Gastroenterology Long Island Jewish Medical CenterAlbert Einstein College of MedicineNew YorkUSA

AIm To determine levels of cytokines incolonic mucosa of asymptomatic first degreerelatives of Crohn’s disease *** Cytokines(Interleukin(IL)1-Beta,IL-2,IL-5 and IL-8)were measured using ELIsAin biopsy samples of normal looking colonicmucosa of first degree relatives of Crohn’sdisease patients(n = 9)and from normalcontrols(n = 10)with no family history ofCrohn’s *** Asymptomatic first degree relativesof patients with Crohn’s disease had significantlyhigher levels of basal intestinal mucosalcytokines(IL-2,IL-5 and IL-8)than *** these increased cytokinelevels serve as phenotypic markers for a geneticpredisposition to developing Crohns diseaselater on,or whether they indicate early(pre-clinical)damage has yet to be further *** Asymptomatic first degreerelatives of Crohn’s disease patients have higherlevels of cytokines in their normal-lookingintestinal mucosa compared to normal controls,This supports the hypothesis that increasedcytokines may be a cause or an early event inthe inflammatory cascade of Crohns disease andare not merely a result of the inflammatoryprocess.

关键词： subject headings crohns disease cytokine/analysis intestinal mucosa

Lactate is a potentially harmful substitute for brain glucose fuel:consequences for metabolic restoration of neurotransmission

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Neural Regeneration Research 2025年第5期20卷 1403-1404页

作者： Oliver Kann Lennart soder Babak Khodaie Institute of Physiology and Pathophysiology Heidelberg UniversityHeidelbergGermany Interdisciplinary Center for Neurosciences(IZN) Heidelberg UniversityHeidelbergGermany

The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).

关键词： consequences Figure restoration

model dependent analysis of D^(+)_(s)→η^(′)l+v_(l) decays in beyond standard model

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Chinese Physics C 2024年第9期48卷 82-95页

作者： s.mahata m.mandal H.mahapatra s.Biswas s.sahoo Department of Physics National Institute of Technology Durgapur Durgapur 713209West BengalIndia

motivated by the recent experimental results of branching fractions for D^(+)_(s)→η^(′)l+v_(l) decays,which deviate from their sm predictions,we hve investigated these decays in W' model and scalar leptoquark model to determine potential signatures of new physics(NP) in semileptonic charm decays induced by c→(s,d)l+v_(l) *** recent experimental results of branching fractions for semileptonic D meson decays,new coupling parameters are predicted for the aforementioned NP *** fraction,forward-backward asymmetry,and lepton polarization asymmetry are examined by considering the predicted NP coupling *** results of branching fractions in scalar leptoquark model are found very close to the experimental results and exist around the range of 1σ *** presented a comparative study of the NP models to check their sensitivity on these *** anticipate that further research on these decays will significantly support our findings.

关键词： charm decay new physics W′boson scalar leptoquark flavour changing charged current

synergistic effect of seawater's parameters on the corrosion rate of the austenitic stainless steel 304

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Acta metallurgica sinica(English Letters) 2010年第3期23卷 161-170页

作者： s.Atashin m.Pakshir A.Yazdani Department of materials science and Engineering Shiraz University

In this article the corrosion rate of the austenitic stainless steel type 304, under the synergistic effect of environmental factors has been assessed via potentiodynamic polarization ***, velocity, pH and temperature are the factors which induce effects on the corrosion rate of the considered *** analysis is applied using the full two-level factorial experimental design method, which results in the contribution value of each parameter in changing the quantity of average corrosion rate in both individual and synergistic *** this quantitative analysis, qualitative analysis has been used to predict the variation *** two analyses show the important role of the synergistic action, which changes the variation direction of corrosion rate and the contribution percentage of each parameter in varying the value of corrosion *** both these analyses can show the magnitude and quality of each parameter＇s effect, which is remarkably valuable in marine applications.

关键词： stainless steel 304 Environmental parameters seawater corrosion synergistic effect

Fluid dynamics analysis and pyrolysis of brewer’s spent grain in a spouted bed reactor

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Particuology 2019年第1期17卷 199-207页

作者： marcos A.s. Barrozo Lidja D.m.s. Borel Taísa s. Lira Carlos H. Ataíde school of Chemical Engineering Federal University of UberlandiaBrazil Department of Engineering and Technologies Federal University of Espirito SantoBrazil

Brewer’s spent grain (BsG) is a large-scale agroindustrial waste that could be more efficiently utilized. This waste is composed of lignocellulosic material and so may serve as a good source of biomass for thermochemical conversion. The present study investigated the fluid dynamics behavior of mixtures of sand and BsG in a spouted bed to assess the viability of the thermochemical conversion of this biomass via fast pyrolysis. Fluid dynamics analyses were performed while varying the mass fraction of BsG (6–80%) and the static bed height (6.6–13.4 cm). Empirical equations for predicting the minimum spouting conditions and the mixing index were obtained using a regression technique, and the selected fluid dynamics parameters were employed in the spouted bed pyrolysis. The bio-oil resulting from this process was rich in phenolic compounds, various nitrogenated compounds (representing precursors for pharmaceuticals) and long-chain hydrocarbons. The products obtained from the analytical and spouted bed pyrolysis processes were also compared.

关键词： Brewer’s spent grain Agroindustrial residue spouted bed Fast pyrolysis Particle mixing

Theoretical study of structural and electronic properties of oligo(thiophene-phenylene)s in comparison with oligothiophenes and oligophenylenes

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Chinese Chemical Letters 2008年第1期19卷 123-126页

作者： H.Zgou s.m.Bouzzine s.Bouzakraoui m.Hamidi m.Bouachrine Unité de Recherche sur les macromolécules et modélisation Faculté des Sciences et TechniquesB.P.509 Boutalamine5200 ErrachidiaMorocco Unité de Chimie Théorique AppliquéeFaculté des Sciences et TechniquesB.P.509 Boutalamine5200 ErrachidiaMorocco Unité de Chimie Théorique Appliquée Faculté des Sciences et TechniquesB.P.509 Boutalamine5200 ErrachidiaMorocco Unité de Recherche sur les macromolécules et modélisation Faculté des Sciences et TechniquesB.P.509 Boutalamine5200 ErrachidiaMorocco

In this work, a quantum-chemical investigation on the structural and opto-electronic properties of oligo（thiophene-phenylene）（4TP） is carried out. The results are discussed in comparison with the properties of corresponding oligothiophene （8T） and oligophenylene （8P）. As the opto-electronic properties of this type of conducting polymers are governed by their electronic band gap, we shall also present a comparison among HOmO, LUmO and band gap energies of these three materials.

关键词： Conjugated polymers Oligothiophene Oligophenylene Oligo(thiophene-phenylene) DFT

A setup for a scenario-Driven Water Balance at Landscape scale—Assessment with AKWA-m~-Embedded in a model Framework for Land-Use Planning’s Decision support in mountainous southwest China

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Journal of Earth science 2010年第6期21卷 974-978页

作者： Andreas Wahren Karin Berkhoff Albrecht münch sylvia herrmann Karl-Heinz Feger Insitute of soil science and site Ecology Technische Universitt Dresden Dr. Dittrich & Partner Hydro-Consult GmbH Institute of Environmental Planning Leibniz University Hannover

Land-cover changes cause a loss of natural vegetation in many parts of the world. In the Xishuangbanna （西双版纳） district （Yunnan （云南） Province）, rubber plantations replace tropical rainforests covering already an area of about 10% of the study area （2007）. There, land-use allocation is mostly driven by economic considerations. Thus, local planning authorities need decision support for land-use planning issues, which integrate socio-economic and ecological aspects. Within the NabanFrame, an agro-economic, ecological and social model was applied, which, altogether, interacted with a land allocation model via defined interfaces. Effects on the water cycle, ecological conditions as well as socio-economic should be considered by integrating the spatially distributed rainfali-runoff and water balance model AKWA-m in the model setup.

关键词： land-use water balance model rubber integrated land-use planning land-use prognosis.

modeling slow deformation of polygonal particles using DEm

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Particuology 2008年第6期6卷 506-514页

作者： Andrés A. Pea Pedro G. Lind Hans J. herrmann Institute for Computational Physics Universitt Stuttgart Computational Physics IfB HIF E12 ETH Hnggerberg CH-8093 Zrich Switzerland Departamento de Física Universidade Federal do Ceará

We introduce two improvements in the numerical scheme to simulate collision and slow shearing of irregular particles. First, we propose an alternative approach based on simple relations to compute the frictional contact forces. The approach improves efficiency and accuracy of the Discrete Element method （DEm） when modeling the dynamics of the granular packing. We determine the proper upper limit for the integration step in the standard numerical scheme using a wide range of material parameters. To this end, we study the kinetic energy decay in a stress controlled test between two particles. second, we show that the usual way of defining the contact plane between two polygonal particles is, in general, not unique which leads to discontinuities in the direction of the contact plane while particles move. To solve this drawback, we introduce an accurate definition for the contact plane based on the shape of the overlap area between touching particles, which evolves continuously in time.

关键词： Granular media Discrete element method slow deformation Contact forces