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Chinese Physics C 2022年第11期46卷 177-194页

作者： Yu.E.Penionzhkevich V.V.samarin s.m.lukyanov V.A.maslov m.A.Naumenko Flerov Laboratory of Nuclear Reactions Joint Institute for Nuclear ResearchDubna 141980Russia Department of Experimental methods in Nuclear Physics National Research Nuclear UniversityMoscow 115409Russia Department of Nuclear Physics Dubna State UniversityDubna 141982Russia

The results of experiments on measuring the energy spectra of alpha particles in reactions with heavy ions are *** measurements were performed using the high-resolution magnetic analyzer mAVR with beams of ^(48)Ca(280 meV)and ^(56)Fe(320 and 400 meV)on ^(181)Ta and ^(238)U targets at an angle of 0°.A strong dependence of the double differential cross sections for production of alpha particles on the atomic number of the target nucleus was observed,which indicates that fast alpha particles are mainly emitted from the target nucleus;this conclusion was also confirmed by calculations within the time-dependent schrödinger equation *** analysis of the obtained experimental data was carried out within the model of moving sources modified to consider the kinematic limits for two-body and three-body exit channels.

关键词： alpha particle energy spectra two-and three-body kinematic limits model of moving sources time-dependent schrodinger equation

Reactions induced by 30 meV 3He beam on 9Be:cluster transfer reactions

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Chinese Physics C 2024年第1期48卷 61-70页

作者： B.A.Urazbekov T.Issatayev s.m.lukyanov A.Azhibekov A.s.Denikin K.mendibayev D.m.Janseitov Yu E.Penionzhkevich K.A.Kuterbekov T.K.Zholdybayev Gumiliyev Eurasian National University 2 Satpayev StrAstanaKazakhstan Institute of Nuclear Physics 1 Ibragimov StrAlmatyKazakhstan Bogolubov Laboratory of Theoretical Physics JINR20 Joliot Curie StrDubnaRussia Flerov Laboratory of Nuclear Reactions JINR20 Joliot Curie StrDubnaRussia Korkyt-ata state University 29A Aiteke-Byi StrKyzylordaKazakhstan Dubna state University 19 Universitetskaya StrDubnaRussia Al-Farabi Kazakh National University AlmatyKazakhstan

An experiment was conducted for studying the cluster structure of Be induced by He ions at an energy of 30 *** results of the nuclear reaction^(3)He+^(9)Be,the differential cross sections for the exit channels–elastic,inelastic,α+^(8)Be,^(6)He+^(6)Be,^(6)Li+^(6)Li,and^(7)Be+^(5)He–were *** and inelastic scattering data were treated within both the optical model and coupled channel method.A new set of optical potentials was considered for the elastic *** deformation parameter was established for the transition 3/2→5/*** transfer reactions were analyzed via the coupled reaction channel *** nuclear reactions with the exit channels^(6)He+^(6)Be,^(6)Li+^(6)Li,and^(7)Be+^(5)He were complemented by two-step transfer *** contribution of each reaction mechanism were shown and compared with the findings of other authors.

关键词： cluster transfer reaction mechanisms coupled equations

study of one-step and two-step neutron transfer in the reaction ^(6)Li+^(9)Be

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Chinese Physics C 2024年第11期48卷 96-105页

作者： A.K.Azhibekov s.m.lukyanov Yu.E.Penionzhkevich B.A.Urazbekov m.A.Naumenko V.V.samarin T.Issatayev V.A.maslov K.mendibayev D.Aznabayev T.K.Zholdybayev A.Temirzhanov Joint Institute for Nuclear Research DubnaRussia Korkyt Ata Kyzylorda University KyzylordaKazakhstan National Research Nuclear University mEPhI MoscowRussia L.N.Gumilyov Eurasian National University AstanaKazakhstan Dubna state University DubnaRussia Institute of Nuclear Physics AlmatyKazakhstan satbayev University AlmatyKazakhstan

This paper presents the results of experiments conducted to measure the cross-sections for elastic scattering and nucleon transfer channels in the ^(6)Li+^(9)Be reaction at an incident energy of 68 meV:^(9)Be(^(6)Li,^(6)Li)^(9)Be,^(9)Be(^(6)Li,7Li)8Be,^(9)Be(^(6)Li,7Li)^(8)Be_(2+),^(9)Be(^(6)Li,^(8)Li)^(7)Be,and ^(9)Be(^(6)Li,^(7)Be)^(8)*** objective of the study is to elucidate the manifestation of the cluster structure of ^(9)*** analysis of the contributions of the one-step and two-step neutron transfer mechanisms is performed using the distorted wave Born approximation method with the Fresco *** agreement between the calculations and the experimental data is obtained for the channels of elastic scattering ^(9)Be(^(6)Li,^(6)Li)^(9)Be,neutron ^(9)Be(^(6)Li,^(7)Li)^(8)Be,and proton transfer ^(9)Be(^(6)Li,^(7)Be)^(8)Li,as well as for the transfer of two neutrons ^(9)Be(^(6)Li,^(8)Li)^(7)*** dineutron cluster transfer mechanism makes a dominant contribution to the ^(9)Be(^(6)Li,^(8)Li)^(7)Be reaction channel at forward angles.

关键词： elastic scattering neutron and proton transfer reaction mechanisms DWBA Fresco code

some Insights into Cluster structure of ^(9)Be from ^(3)He + ^(9)Be Reaction

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World Journal of Nuclear science and Technology 2015年第4期5卷 265-273页

作者： s.m.lukyanov m.N.Harakeh m.A.Naumenko Yi Xu W.H.Trzaska V.Burjan V.Kroha J.mrazek V.Glagolev s.Piskoi E.I.Voskoboynik s.V.Khlebnikov Yu.E.Penionzhkevich N.K.skobelev Yu.G.sobolev G.P.Tyurin K.Kuterbekov Yu.Tuleushev Flerov Laboratory of Nuclear Reactions DubnaRussian Federation KVI-CART University of GroningenGroningenThe Netherlands Nuclear Physics Institute RezCzech Republic Department of Physics University of JyvaskylaJyvaskylaFinland Khlopin Institute St.PetersburgRussian Federation National Research Nuclear University“mEPhI” MoscowRussian Federation Eurasian Gumilev University AstanaKazakhstan Nuclear Physics Institute AlmatyKazakhstan

The study of inelastic scattering and multi-nucleon transfer reactions was performed by bombarding a 9Be target with a 3He beam at the incident energy of 30 meV. Angular distributions for 9Be(3He, 3He) 9Be, 9Be (3He, 3He) 8Be, 9Be (3He, 7Be) 5He, 9Be (3He, 6Li) 6Li and 9Be (3He, 7Li) 5Li reaction channels were measured. Experimental angular distributions for the corresponding ground states (g.s.) were analyzed within the framework of the optical model, the coupled-channel approach and the distorted-wave Born approximation. Cross sections for channels leading to unbound 5Heg.s., 5Lig.s. and 8Be systems were obtained from singles measurements where the relationship between the energy and the scattering angle of the observed stable ejectile was constrained by two-body kinematics. Information on the cluster structure of 9Be was obtained from the transfer channels. It was concluded that cluster transfer was an important mechanism in the investigated nuclear reaction channels. In the present work an attempt was made to estimate the relative strengths of the interesting (n + 8Be) and (α + 5He) cluster configurations in 9Be. The contributions of different exit channels have been determined confirming that the (α + 5He) configuration plays an important role. The configuration of 8Be consisting of two bound helium clusters (5He + 6He) is significantly suppressed, whereas the two-body configurations (n + 8Be) and (α + 5He) including unbound 8Be and 5He are found more probable.

关键词： Nuclear Reaction mechanism Cluster structure DWBA

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： mackenzie m.spicer Jianqi Yang Daniel Fu Alison N.DeVore marisol Lauffer Nilufer s.Atasoy Deniz Atasoy Rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGs6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGs6fl/fl;APP_(sWE) mice and used retroviral approaches to examine the impact of RGs6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(sWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGs6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(sWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGs6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGs6-expressing ***,RGs6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(sWE) mice,identifying RGs6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGs6)

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.G.Cassiano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNs)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong miao michael s.Wolfe Computational medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-Em structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CImA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Predicting maximum Lifespan Limits at mean menopausal Age

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Journal of mathematical Research with Applications 2025年第1期 133-142页

作者： m.sUmATHI s.ANTONY CARLA Department of mathematics N.M.S.S.Vellaichamy Nadar College Research scholar (Part-time) Madurai Kamaraj University

The age at which a woman enters natural menopause has also been associated to death from any cause. menopause is a natural component of aging that happens between the ages of 45 and 55, with the average menopausal age being 51. Previous research has revealed the age at which women reach menopause, but there is no evidence to support the link between menopause and longevity. We made a study in assessing the limits of maximum lifespan at menopausal age in our previous article. In this paper, we aim to predict the maximum lifespan of women at mean menopausal age.

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