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应用双期18F-FDG PET/CT预测骨肉瘤新辅助化疗后反应

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国际医学放射学杂志 2015年第5期 493-494页

作者： B.H.Byun s.H.Kim s.m.lim I.lim C.B.Kong W.s.song 曲方园 Division of Nuclear medicine Department of RadiologyCollege of MedicineThe Catholic University of Korea

摘要目的评估双期18F-FDG PET/CT预测骨肉瘤新辅助化疗(NAC)后组织学反应的能力。方法回顾性分析31例经新辅助化疗及手术治疗的骨肉瘤病人资料。经注射18FFDG,于新辅助化疗前后采集早期(60 min)及延迟期(150 min)PET信息。测量肿瘤新辅... 详细信息

摘要目的评估双期18F-FDG PET/CT预测骨肉瘤新辅助化疗(NAC)后组织学反应的能力。方法回顾性分析31例经新辅助化疗及手术治疗的骨肉瘤病人资料。经注射18FFDG,于新辅助化疗前后采集早期(60 min)及延迟期(150 min)PET信息。测量肿瘤新辅助化疗前后的sUV最大值(sUVmax),早期/延迟期sUV最大值变化(RImax)及早期/延迟

关键词：新辅助化疗 sUV 反应骨肉瘤 FDG PET

Novel N-doped multichannel carbon nanofiber architecture with porous Cos nanoprisms for high-performance potassium-ion batteries

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Rare metals 2024年第3期43卷 971-983页

作者： Jae Bong lim seung-Keun Park Department of Advanced materials Engineering Chung-Ang UniversityGyeonggi-do17546Republic of Korea Department of Intelligence Energy and Industry Chung-Ang UniversitySeoul06974Republic of Korea Western seoul Center Korea Basic Science InstituteSeoul03759Republic of Korea

Potassium-ion batteries(PIBs)have gained significant attention as an alternative to lithium-ion batteries(LIBs)due to the abundance of potassium(K)and low ***,the difficulty in finding appropriate electrode materials that can efficiently store the larger K ions has hindered their practical ***,we report a novel anode material,N-doped multichannel carbon nanofibers embedded with porous Cos nanoprisms(CsP@NmCNF),for high-performance *** CsP@NmCNF was synthesized using a two-step strategy comprising of the electrospinning of Co acetate hydroxide nanoprism/binary polymer blend and a subsequent heat *** porous Cos nanoprisms with an anisotropic morphology were well aligned along the length axis of the N-doped multichannel carbon nanofibers,thus ensuring their structural stability during the repeated charge-discharge *** addition,numerous pores facilitated the transport of electrons and ***,the CsP@NmCNF anode exhibited excellent electrochemical performance,delivering a high specific capacity of 368 mAh·g^(-1)at 0.5 A·g^(-1)after 200 cycles and excellent rate capability(232 mAh·g^(-1)at 2.0 A·g^(-1)).

关键词： K-ion batteries Cobalt sulfide multichannel structured composite Electrospinning Nanoprism Porous structure

A short overview of the lead iodide residue impact and regulation strategies in perovskite solar cells

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Journal of Energy Chemistry 2024年第3期90卷 504-510,I0012页

作者： Eng Liang lim Zhanhua Wei Xiamen Key Laboratory of Optoelectronic materials and Advanced manufacturing Institute of Luminescent Materials and Information DisplaysCollege of Materials Science and EngineeringHuaqiao UniversityXiamen 361021FujianChina

Lead iodide(PbI2) is a vital raw material for preparing perovskite solar cells(PsCs),and it not only takes part in forming the light absorption layer but also remains in the grain boundary as a *** other words,the PbI2 content in the precursor and as formed film will affect the efficiency and stability of the *** moderate residual PbI2,it passivates the bulk/surface defects of perovskite,reduces the interfacial recombination,promotes the perovskite stability,minimizes the device hysteresis,and so *** PbI2 residue will reduce the interfacial passivation effect and device *** addition to facilitating the non-radiative recombination,over PbI2 residue can also lead to electronic insulation in the grain boundary and deteriorate the device ***,the impact and regulation of PbI2 residue on the device performance and stability is still not fully ***,a comprehensive and detailed review is presented by discussing the PbI2 residue impact and its regulation strategies(i.e., elimination,facilitation and conversion of the residue PbI2) to manipulate the PbI2 content,distribution and ***,we also show future outlooks in this field,with an aim to help further the progression of high-efficiency and stable PsCs.

关键词： Lead iodide Residue Regulation Perovskite solar cells Efficiency stability

Reconfigurable transmissive metasurface with a combination of scissor and rotation actuators for independently controlling beam scanning and polarization conversion

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microsystems & Nanoengineering 2024年第2期10卷 173-180页

作者： Chhunheng Lor Ratanak Phon sungjoon lim Intelligent semiconductor Engineering Chung-Ang UniversityHeukseok-DongDongjak-GuSeoul06974Republic of Korea school of Electrical and Electronic Engineering Chung-Ang UniversityHeukseok-DongDongjak-GuSeoul06974Republic of Korea

Polarization conversion and beam scanning metasurfaces are commonly used to reduce polarization mismatch and direct electromagnetic waves in a specific direction to improve the strength of a wireless ***,identifying suitable active and mechanically reconfigurable metasurfaces for polarization conversion and beam scanning is a considerable challenge,and the reported metasurfaces have narrow scanning ranges,are expensive,and cannot be independently *** this paper,we propose a reconfigurable transmissive metasurface combined with a scissor and rotation actuator for independently controlling beam scanning and polarization conversion *** metasurface is constructed with rotatable unit cells(UCs)that can switch the polarization state between right-handed(RHCP)and left-handed circular polarization(LHCP)by flipping the UCs to reverse their phase ***,independent beam scanning is achieved using the scissor actuator to linearly change the distance between the *** and experimental results confirm that the proposed metasurface can perform beam scanning in the range of 28°for both the positive and negative regions of a radiation pattern(RHCP and LHCP beams)at an operational frequency of 10.5 GHz.

关键词： beam rotation controlling

Detection and defending the Xss attack using novel hybrid stacking ensemble learning-based DNN approach

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Digital Communications and Networks 2024年第3期10卷 716-727页

作者： muralitharan Krishnan Yongdo lim seethalakshmi Perumal Gayathri Palanisamy Ims Sungkyunkwan UniversitySuwon16419South Korea Department of mathematics Sungkyunkwan UniversitySuwon16419South Korea Department of Information Technology Madras Institute of TechnologyChennaiIndia Department of mathematics PSG College of Arts and ScienceTamilnaduIndia

Existing web-based security applications have failed in many situations due to the great intelligence of *** web applications,Cross-site scripting(Xss)is one of the dangerous assaults experienced while modifying an organization's or user's *** avoid these security challenges,this article proposes a novel,all-encompassing combination of machine learning(NB,sVm,k-NN)and deep learning(RNN,CNN,LsTm)frameworks for detecting and defending against Xss attacks with high accuracy and *** on the representation,a novel idea for merging stacking ensemble with web applications,termed“hybrid stacking”,is *** order to implement the aforementioned methods,four distinct datasets,each of which contains both safe and unsafe content,are *** hybrid detection method can adaptively identify the attacks from the URL,and the defense mechanism inherits the advantages of URL encoding with dictionary-based mapping to improve prediction accuracy,accelerate the training process,and effectively remove the unsafe Jscript/Javascript keywords from the *** simulation results show that the proposed hybrid model is more efficient than the existing detection *** produces more than 99.5%accurate Xss attack classification results(accuracy,precision,recall,f1_score,and Receiver Operating Characteristic(ROC))and is highly resistant to Xss *** order to ensure the security of the server's information,the proposed hybrid approach is demonstrated in a real-time environment.

关键词： machine learning Deep neural networks Classification stacking ensemble Xss attack URL encoding Jscript/Javascript Web security

Alterations of protein homeostasis in Alzheimer's disease:beyond Procrustean bed of endoplasmic reticulum stress and unfolded protein response

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Neural Regeneration Research 2024年第8期19卷 1645-1646页

作者： Dmitry lim Alexei Verkhratsky Department of Pharmaceutical sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achucarro Center for Neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoSpain&Department of NeurosciencesUniversity of the Basque Country UPV/EHU and CIBERNEDLeioaSpain Department of stem Cell Biology State Research Institute Centre for Innovative MedicineVilniusLithuania Department of Forensic Analytical Toxicology School of Forensic MedicineChina Medical UniversityShenyangLiaoning ProvinceChina

Alzheimer’s disease(AD)is a major age-related form of dementia with a number of cases exponentially growing,causing enormous social and economic impact on individuals and *** hallmarks of AD,evident in postmortem AD brains,include a massive loss of the grey matter in the neocortex,extracellular deposition of amyloid-β(Aβ)in the form of senile plaques and cerebrovascular amyloid angiopathy,and intra-neuronal accumulation of neurofibrillary tangles,formed by hyper-phosphorylated tau protein.

关键词： Alzheimer homeostasis cortex

A review of understanding electrocatalytic reactions in energy conversion and energy storage systems via scanning electrochemical microscopy

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Journal of Energy Chemistry 2024年第4期91卷 155-177页

作者： Jihye Park Jong Hwan lim Jin-Hyuk Kang Jiheon lim Ho Won Jang Hosun shin sun Hwa Park Interdisciplinary materials measurement Institute Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Department of material science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Applied measurement science University of Science and TechnologyDaejeon 34113Republic of Korea

To address climate change and promote environmental sustainability,electrochemical energy conversion and storage systems emerge as promising alternative to fossil fuels,catering to the escalating demand for *** optimal energy efficiency and cost competitiveness in these systems requires the strategic design of electrocatalysts,coupled with a thorough comprehension of the underlying mechanisms and degradation behavior occurring during the electrocatalysis *** electrochemical microscopy(sECm),an analytical technique for studying surface electrochemically,stands out as a powerful tool offering electrochemical *** possesses remarkable spatiotemporal resolution,enabling the visualization of the localized electrochemical activity and surface *** review compiles crucial research findings and recent breakthroughs in electrocatalytic processes utilizing the sECm methodology,specifically focusing on applications in electrolysis,fuel cells,and metal–oxygen batteries within the realm of energy conversion and storage *** with an overview of each energy system,the review introduces the fundamental principles of sECm,and aiming to provide new perspectives and broadening the scope of applied research by describing the major research categories within sECm.

关键词： scanning electrochemical microscopy Electrocatalyst Electrocatalysis Water splitting Fuel cell metal-oxygen battery

Probing the endoplasmic reticulummitochondria interaction in Alzheimer's disease:searching far and wide

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Neural Regeneration Research 2024年第10期19卷 2103-2104页

作者： Giulia Dematteis Laura Tapella Dmitry lim Department of Pharmaceutical sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly

Alzheimer's disease(AD)is the most frequent,form of dementia in elderly people and is an incurable disease with an exponentially growing number of *** deposition of amyloid-β(Aβ)plaques and intraneuronal formation o... 详细信息

关键词： Alzheimer Aβ reticulum

structural engineering of antimicrobials for optimal broad-spectrum activity

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Green Chemical Engineering 2024年第4期5卷 473-482页

作者： Arunmozhiarasi Armugam Diane s.W.lim siti Nurhanna Riduan shook Pui Chan Jerome Asugan Yugen Zhang Institute of Bioengineering and Bioimaging Institute of sustainability for Chemicals Energy and Environment(ISCE2) Agency for Science Technology and Research (A*STAR) Diploma in Biomedical science School of Chemical and Life SciencesSingapore Polytechnic

Antimicrobial materials are a crucial component in eradicating and managing the spread of infectious *** are expected to act on a broad-spectrum of microbes, including emerging pathogens which could cause the next Disease X. Herein, we reassessed a series of antimicrobial imidazolium polymers on our shelves and uncovered extended functionality through dual modes of action. By redesigning their structures, a truly broadspectrum antimicrobial material with optimized activity against bacteria(G +ve, G-ve) and fungi, as well as enveloped and non-enveloped viruses was developed. We demonstrated that the imidazolium polymer exhibits dual modes of function against microbes: targeting the microbial membrane and binding DNA. The latter DNA binding affinity was found to be key against non-enveloped viruses. With this insight, we designed small molecule compounds that exhibited optimum broad-spectrum antimicrobial activity and excellent efficacy against EsKAPE group of pathogens that are responsible for some of the deadliest nosocomial infections worldwide. Our results could also shed light on the design of broad-spectrum antimicrobial compounds against Disease X.

关键词： Broad-spectrum Antimicrobial Polyimidazolium structure-function membrane active