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Aptamers targeting sARs-CoV-2 nucleocapsid protein exhibit potential ant1ip1 an-coronavirus activity

signal Transduction and Targeted Therapy 2024年第3期9卷 1186-1198页

作者： minghui Yang Chunhui Li Guoguo Ye Chenguang shen Huiping shi Liping Zhong Yuxin Tian mengyuan Zhao Pengfei Wu Abid hussain Tian Zhang Haiyin Yang Jun Yang Yuhua Weng Xinyue Liu Zhimin Wang Lu Gan Qianyu Zhang Yingxia Liu Ge Yang Yuanyu Huang Yongxiang Zhao school of Life science Advanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China National Clinical Research Center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public HealthSouthern Medical UniversityGuangzhou 510515China state Key Laboratory of Targeting Oncology National Center for International Research of Biotargeting TheranosticsGuangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanning 530021China CAms Key Laboratory of Antiviral Drug Research Beijing Key Laboratory of Antimicrobial AgentsInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Emerging and recurrent infectious diseases caused by human coronaviruses(HCoVs)continue to pose a significant threat to global public health *** light of this ongoing threat,the development of a broad-spectrum drug to combat HCoVs is an urgently ***,we report a series of anti-pan-coronavirus ssDNA aptamers screened using systematic Evolution of Ligands by Exponential Enrichment(sELEX).These aptamers have nanomolar affinity with the nucleocapsid protein(NP)of severe acute respiratory syndrome coronavirus 2(sARs-CoV-2)and also show excellent binding efficiency to the N proteins of both sARs,mERs,HCoV-OC43 and-NL63 with affinity KD values of 1.31 to 135.36 *** aptamer-based therapeutics exhibited potent antiviral activity against both the authentic sARs-CoV-2 prototype strain and the Omicron variant(BA.5)with EC50 values at 2.00 nm and 41.08 nm,*** protein docking analysis also evidenced that these aptamers exhibit strong affinities for N proteins of pan-coronavirus and other HCoVs(−229E and-HKU1).In conclusion,we have identified six aptamers with a high pan-coronavirus antiviral activity,which could potentially serve as an effective strategy for preventing infections by unknown coronaviruses and addressing the ongoing global health threat.

关键词： acute threat conclusion

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The secondary injury cascade after spinal cord injury: an analysis of local cytokine/chemokine regulation

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Neural Regeneration Research 2024年第6期19卷 1308-1317页

作者： Daniel J.Hellenbrand Charles m.Quinn Zachariah J.Piper Ryan T.Elder Raveena R.mishra Taylor L.marti Phoebe m.Omuro Rylie m.Roddick Jae sung Lee William L.murphy Amgad s.Hanna Department of Neurosurgery University of Wisconsin-Madison School of Medicine and Public Health Department of Biomedical Engineering University of Wisconsin-Madison Department of Orthopedics and Rehabilitation University of Wisconsin-Madison Department of materials science and Engineering University of Wisconsin-Madison Forward BIO Institute University of Wisconsin-Madison

After spinal cord injury, there is an extensive infiltration of immune cells, which exacerbates the injury and leads to further neural degeneration. Therefore, a major aim of current research involves targeting the immune response as a treatment for spinal cord injury. Although much research has been performed analyzing the complex inflammatory process following spinal cord injury, there remain major discrepancies within previous literature regarding the timeline of local cytokine regulation. The objectives of this study were to establish an overview of the timeline of cytokine regulation for 2 weeks after spinal cord injury, identify sexual dimorphisms in terms of cytokine levels, and determine local cytokines that significantly change based on the severity of spinal cord injury. Rats were inflicted with either a mild contusion, moderate contusion, severe contusion, or complete transection, 7 mm of spinal cord centered on the injury was harvested at varying times post-injury, and tissue homogenates were analyzed with a Cytokine/Chemokine 27-Plex assay. Results demonstrated pro-inflammatory cytokines including tumor necrosis factor α, interleukin-1β, and interleukin-6 were all upregulated after spinal cord injury, but returned to uninjured levels within approximately 24 hours post-injury, while chemokines including monocyte chemoattractant protein-1 remained upregulated for days post-injury. In contrast, several anti-inflammatory cytokines and growth factors including interleukin-10 and vascular endothelial growth factor were downregulated by 7 days post-injury. After spinal cord injury, tissue inhibitor of metalloproteinase-1, which specifically affects astrocytes involved in glial scar development, increased more than all other cytokines tested, reaching 26.9-fold higher than uninjured rats. After a mild injury, 11 cytokines demonstrated sexual dimorphisms; however, after a severe contusion only leptin levels were different between female and male rats. In conclus

关键词： astrocytes chemokines cytokines inflammation macrophages microglia secondary damage spinal cord injury

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Comparison of the Anatomy and Adaptability of Reconstructed Teeth with Natural Teeth:An Innovative Approach in Forensic Dentistry

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Journal of Forensic science and medicine 2024年第1期10卷 47-54页

作者： supraja s P m Tejaswi Ravikanth manyam mohan Kumar Pasupuleti swetha P Ramesh Kumar Budumuru Department of Oral and maxillofacial Pathology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia Vishnu Dental College BhimavaramAndhra PradeshIndia Department of Periodontics and Implantology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia Department of Oral medicine and Radiology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia

Background:Forensic tooth reconstruction is the technique of reconstructing the morphology of a missing tooth from the intra-alveolar morphology of dental sockets from skeletal *** and Objectives:The aim and objective of the study are to compare and investigate whether the anatomy and adaptability of reconstructed teeth simulate with the natural tooth and to investigate whether the dental materials have potential in reconstruction of *** and methods:An in vitro experimental study was undertaken on a human *** to the Fédération Dentaire Internationale,charting will be done based on the number of teeth *** entire study will be conducted in three phases using dental *** 1 comprised preparation for negative replica,where an impression will be taken,Phase 2 comprised preparation of a positive replica or cast,and Phase 3 comprised tooth reconstruction using the flowable ***:The specimen tooth(which had been taken from its socket)and the newly constructed tooth were compared,and when the length of the newly constructed root was measured using digital vernier calipers,there was a disparity of 0.5-1 *** cone-beam computed tomography radiographs demonstrated the necessary ***:The present study demonstrated that dental information can be obtained even when teeth are absent postmortem by making an attempt to recreate the teeth using dental materials while documenting the intra-alveolar anatomy of the dental root socket.

关键词： Adaptability anatomy reconstruction teeth

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smILE soft X-ray Imager flight model CCD370 pre-flight device characterisation

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Earth and Planetary Physics 2024年第1期8卷 25-38页

作者： s.Parsons D.J.Hall O.Hetherington T.W.Buggey T.Arnold m.W.J.Hubbard A.Holland Centre for Electronic Imaging the Open UniversityMilton KeynesMK76AAUK

Throughout the smILE mission the satellite will be bombarded by radiation which gradually damages the focal plane devices and degrades their *** order to understand the changes of the CCD370s within the soft X-ray Imager,an initial characterisation of the devices has been carried out to give a baseline performance *** CCDs have been characterised,the two flight devices and the flight spa *** has been carried out at the Open University in a bespo ke cleanroom measure ment *** results show that there is a cluster of bright pixels in the flight spa re which increases in size with tempe *** at the nominal ope rating tempe rature(-120℃) it is within the procure ment ***,the devices meet the specifications when ope rating at -120℃ in 6 × 6 binned frame transfer science *** se rial charge transfer inefficiency degrades with temperature in full frame *** any charge losses are recovered when binning/frame transfer is implemented.

关键词： CCD soft X-ray imager characterisation smILE

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Effects of multiple shapes for steady flow with transformer oil+Fe_(3)O_(4)+TiO_(2) between two stretchable rotating disks

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Applied mathematics and mechanics(English Edition) 2024年第2期45卷 373-388页

作者： m.RAHmAN m.TURKYILmAZOGLU Z.mUsHTAQ Department of mathematics Mirpur University of Science and TechnologyMirpur 10250Pakistan Department of mathematics Hacettepe UniversityBeytepeAnkara 06532Turkiye

In this study,we examine the effects of various shapes of nanoparticles in a steady flow of hybrid nanofluids between two stretchable rotating *** steady flow of hybrid nanofluids with transformer oil as the base fluid and Fe_(3)O_(4)+TiO_(2)as the hybrid nanofluid is *** shapes of Fe_(3)O_(4)+TiO_(2)hybrid nanofluids,including sphere,brick,blade,cylinder,and platelet,are *** shape exists in the same volume of a *** leading equations(partial differential equations(PDEs))are transformed to the nonlinear ordinary differential equations(ODEs)with the help of similarity *** system of equations takes the form of ODEs depending on the boundary conditions,whose solutions are computed numerically by the bvp4c mATLAB *** outputs are compared with the previous findings,and an intriguing pattern is discovered,such that the tangential velocity is increased for the rotation parameter,while it is decreased by the stretching values because of the lower *** the reaction rate parameter,the concentration boundary layer becomes shorter,and the activation energy component increases the rate at which mass transfers come to the higher disk but have the opposite effect on the bottom *** ranges of various parameters taken into account are Pr=6.2,Re=2,m=1.0,φ_(1)=φ_(2)=0.03,K=0.5,s=-0.1,Br=0.3,sc=2.0,α_(1)=0.2,γ=0.1,E_(n)=2.0,and q=1.0,and the rotation factor K is within the range of 0 to 1.

关键词： transformer oil Brinkman number skin friction coefficient double rotating disk Nusselt number sherwood number

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Identifying genetic susceptibility to Aspergillus fumigatus infection using collaborative cross mice and RNA-seq approach

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Animal models and Experimental medicine 2024年第1期7卷 36-47页

作者： Roa'a H.s.Yosief Iqbal m.Lone Aharon Nachshon Heinz Himmelbauer Irit Gat-Viks Fuad A.Iraqi Department of Clinical microbiology and Immunology Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael school of molecular Cell Biology and Biotechnology George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Institute of Computational Biology Department of BiotechnologyUniversity of Natural Resources and Life SciencesMuthgasse 181190 ViennaAustria

Background:Aspergillus fumigatus(Af)is one of the most ubiquitous fungi and its infection potency is suggested to be strongly controlled by the host genetic *** aim of this study was to search for candidate genes associated with host susceptibility to Aspergillus fumigatus(Af)using an RNAseq approach in CC lines and hepatic gene ***:We studied 31 male mice from 25 CC lines at 8 weeks old;the mice were infected with *** tissues were extracted from these mice 5 days post-infection,and next-generation RNA-sequencing(RNAseq)was *** GENE-E analysis platform was used to generate a clustered heat map ***:significant variation in body weight changes between CC lines was *** gene expression revealed 12 top prioritized candidate genes differ-entially expressed in resistant versus susceptible mice based on body weight ***,three candidate genes are located within genomic intervals of the previ-ously mapped quantitative trait loci(QTL),including Gm16270 and stox1 on chromo-some 10 and Gm11033 on chromosome ***:Our findings emphasize the CC mouse model's power in fine mapping the genetic components underlying susceptibility towards *** a next step,eQTL analysis will be performed for our RNA-seq *** candidate genes from our study will be further assessed with a human cohort with aspergillosis.

关键词： aspergillus fumigatus infection collaborative cross(CC)mice gene expression profile gene-network host susceptibility quantitative trait loci(QTL)mapping RNA-seq

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mitigating Urban Heat Island Effects: A Review of Innovative Pavement Technologies and Integrated solutions

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structural Durability & Health monitoring 2024年第5期18卷 525-551页

作者： s.F.Ismael A.H.Alias N.A.Haron B.B.Zaidan Abdulrahman m.Abdulghani Department of Civil Engineering Faculty of EngineeringUniversiti Putra MalaysiaSerdang43400Malaysia Central Region Heavy Civil DivisionGranite ConstructionWoodlandsTexas77381USA sP Jain school of Global management LidcombeSydneyNSW2141Australia Department of Communication Technology and Network Faculty of Computer Science and Information TechnologyUniversiti Putra MalaysiaSerdang43400Malaysia

In this review paper,we present a thorough investigation into the role of pavement technologies in advancing urban *** analysis traverses the historical evolution of these technologies,meticulously evaluating their socio-economic and environmental impacts,with a particular emphasis on their role in mitigating the urban heat island *** evaluation of pavement types and variables inﬂuencing pavement performance to be used in the multi-criteria decision-making(mCDm)framework to choose the optimal pavement application are at the heart of our *** serves to assess a spectrum of pavement options,revealing insights into the most effective and sustainable *** highlighting both the existing challenges and potential innovative solutions within theﬁeld,this paper aims to offer a directional compass for future urban planning and infrastructural *** review not only synthesizes the current state of knowledge but also aims to chart a course for future exploration,emphasizing the critical need for innovative and environmentally sensitive pavement tech-nologies in the creation of resilient and sustainable urban environments.

关键词： Pavement sustainability urban heat island environmental impact of pavements innovative pavement solutions economic and social implications sustainable development in urban areas

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不同国家黄油和黄油乳脂理化性质的比较评价

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中国油脂 2024年第7期49卷 29-39页

作者：邹孝强蒋邦智郑磊胡纪洁潘月超王钦民 ImAD Khan mUDAssAR hussain 江南大学食品学院食品科学与资源挖掘国家重点实验室国家功能食品工程技术研究中心粮食发酵与食品生物制造国家工程研究中心江苏无锡214122 伽力森食品生物科技(江苏)有限公司江苏泰州225700

为帮助食品生产商和消费者选择适用于不同应用途径的黄油,并为生产更受消费者喜爱的黄油替代品提供理论支持,选取了11个国家的黄油并提取黄油乳脂,对黄油及黄油乳脂的理化性质进行了系统的比较评价。结果表明:11个国家黄油中的脂肪、水... 详细信息

为帮助食品生产商和消费者选择适用于不同应用途径的黄油,并为生产更受消费者喜爱的黄油替代品提供理论支持,选取了11个国家的黄油并提取黄油乳脂,对黄油及黄油乳脂的理化性质进行了系统的比较评价。结果表明:11个国家黄油中的脂肪、水分、蛋白质含量和滑动熔点分别为82.97%~86.40%、12.84%~16.14%、0.45%~0.78%、31.5~33.9℃,酸值(KOH)和过氧化值分别不超过0.32 mg/g、0.029 g/100 g。中国黄油的L值最高(86.87),而新西兰黄油的b值最高(35.28)。所有黄油共检出29种脂肪酸和42种甘油三酯,蛋白质主要由αs1-酪蛋白、β-酪蛋白、κ-酪蛋白、α-乳白蛋白和Adipophilin组成。爱尔兰黄油的不饱和脂肪酸含量最高(35.65%),固体脂肪含量(sFC)较低,而美国、荷兰和澳大利亚黄油的饱和脂肪酸和sFC含量较高。不同国家的黄油和黄油乳脂的晶体均为均匀精细的球晶,其中美国黄油和黄油乳脂的晶体均呈现部分聚集,且绝大多数晶体主要由β′型晶体组成。质地和流变学分析表明,爱尔兰黄油和黄油乳脂的硬度最低,所有黄油和黄油乳脂都表现出良好的黏弹性和剪切变稀性能。综上,不同国家黄油在基本理化性质、脂肪酸和甘油酯组成、sFC及硬度等方面存在差异,在食品工业中需要根据成品、加工工艺等有针对性地选择黄油,在新型人造奶油的构建中,也可依据各黄油特点进行定向研究。

关键词：黄油黄油乳脂理化性质晶体质构流变

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One-neutron stripping process in the^(209)Bi(^(6)Li,^(5)Li)^(210)Bi*reaction reaction

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Nuclear science and Techniques 2024年第6期35卷 120-129页

作者： Gao-Long Zhang Zhen-Wei Jiao Guang-Xin Zhang E.N.Cardozo B.Paes shi-Peng Hu Jian-Qiang Qian Daniele mengoni Wei-Wei Qu Cong-Bo Li Yun Zheng Huan-Qiao Zhang Hui-Bin sun Nan Wang Chun-Lei Zhang J.J.Valiente-Dobón D.Testov m.mazzocco A.Gozzelino C.Parascandolo D.Pierroutsakou m.La Commara A.Goasduff D.Bazzacco D.R.Napoli F.Galtarossa F.Recchia A.Illana s.Bakes I.Zanon s.Aydin Gde Angelis m.siciliano R.menegazzo s.m.Lenzi s.Akkoyun L.F.Canto J.Lubian school of Physics Beihang UniversityBeijing 100191China sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340 NiteróiRio de JaneiroBrazil Laboratorio TANDAR Comisión Nacional de Energía AtómicaBKNA1650 San MartíınArgentina Institute for Advanced study in Nuclear Energy and safety Shenzhen UniversityShenzhen 518060China shenzhen Key Laboratory of Research and manufacture of High Purity Germanium materials and Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPaduaItaly Dipartimento di fisica Astronomia dell’Universita di padova PaduaItaly state Key Laboratory of Radiation medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key Laboratory of Beam Technology and material modification of ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Laboratori Nazionali di Legnaro INFN35020 LegnaroItaly INFN Sezione di Napoli80126 NaplesItaly Dipartimento di Farmacia Universitàdi Napoli“Federico II”80131 NaplesItaly Department of Natural and mathematical sciences Faculty of EngineeringTarsus University33480 MersinTurkey Physics Division Argonne National LaboratoryLemontILUSA Department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroRio de Janeiro CP 6852821941-972Brazil

One-neutron stripping process between^(6)Li and^(209)Bi was studied at 28,30,and 34 meV using the in-beamγ-ray spectroscopy ***γ-γcoincident analysis clearly identified twoγ-rays feeding the ground and long-lived isomeric states,which were employed to determine the cross *** one-neutron stripping cross sections were similar to the cross sections of complete fusion in the^(6)Li+^(209)Bi system,but the one-neutron stripping cross sections decreased more gradually at the sub-barrier region.A coupled-reaction-channel calculation was performed to study the detailed reaction mechanism of the one-neutron stripping process in^(6)*** calculations indicated that the first excited state of 5 Li is critical in the actual one-neutron transfer mechanism,and the valence proton of 209Bi can be excited to the low-lying excited state in(^(6)Li,^(5)Li)reaction,unlike in the(d,p)reaction.

关键词： Transfer reaction Weakly bound nuclei Cross section

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Old-growth mixed dipterocarp forests show variable losses and gains in aboveground biomass and standing carbon over forty years

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Forest Ecosystems 2024年第1期11卷 14-23页

作者： sisira Ediriweera Champika Bandara Tithira Lakkana shanika Jayasinghe David Woodbury Arun Dayanandan B.m.P.singhakumara Xiangcheng mi I.A.U.N.Gunatilleke C.V.s.Gunatilleke mark sAshton Department of science and Technology Uva Wellassa UniversityBadullaSri Lanka The Forest school Yale School of the EnvironmentYale UniversityNew HavenCT06511USA Department of Forestry and Environmental science University of Sri JayewardenepuraNugegodaSri Lanka state Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing100093China Botany Department University of PeradeniyaPeradeniyaSri Lanka

Background:No studies have documented long-term trends in aboveground biomass(AGB)for mixed-dipterocarp forests(mDF),the dominant rain forest type in tropical wet equatorial *** our study,we sought to document such trends over forty years across three sites representing lowland to lower montane ***:To do this,we established fifty 100 m×25 m plots in 1978 across three sites sampled along an elevation gradient,identified as mature old-growth *** measured trees for diameter at breast height that we identified to species and *** took wood samples to calculate species wood-specific *** re-measured plots in 1998 and again in ***:We show standing AGB for all sites combined to be 517.52 mg·ha^(-1)in 1978,but this declined by 17%over 40 years to 430.11 mg·ha^(-1).No differences exist among sites in AGB primarily because of considerable within site variation;but interactions of time with site show declines across sites were not uniform,one remained about the *** few species represented a high proportion of the AGB with the top five species comprising between 34%and 65%,depending upon site and year *** species,mesua nagassarium,represented a disproportionately large amount of AGB and decline over time,particularly at the low elevation ***:Our results are directly relevant to estimating AGB and standing carbon sequestered in *** study is the first to demonstrate varying but overall,declining trends in amounts of AGB among forests making predictions of biomass and standing carbon in mDF difficult over wide regions.

关键词： Western ghats shorea spp. southeast Asia sri Lanka Tropical rain forest Wood specific gravity

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