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Promising use of metformin in treating neurological disorders:biomarker-guided therapies

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Neural Regeneration Research 2024年第5期19卷 1045-1055页

作者： Allison Loan Charvi syal Margarita lui Ling He Jing Wang Regenerative Medicine Program Ottawa Hospital Research InstituteOttawaONCanada Department of Biology Faculty of ScienceUniversity of OttawaOttawaONCanada Department of Pediatrics and Medicine Johns Hopkins Medical SchoolBaltimoreMDUSA Department of Cellular and Molecular Medicine Faculty of MedicineUniversity of OttawaOttawaONCanada University of Ottawa Brain and Mind Research Institute OttawaONCanada

Neurological disorders are a diverse group of conditions that affect the nervous system and include neurodegenerative diseases(Alzheimer’s disease,multiple sclerosis,Parkinson’s disease,Huntington’s disease),cerebrovascular conditions(stroke),and neurodevelopmental disorders(autism spectrum disorder).Although they affect millions of individuals around the world,only a limited number of effective treatment options are available *** most neurological disorders express mitochondria-related metabolic perturbations,metformin,a biguanide type II antidiabetic drug,has attracted a lot of attention to be repurposed to treat neurological disorders by correcting their perturbed energy ***,controversial research emerges regarding the beneficial/detrimental effects of metformin on these neurological *** that most neurological disorders have complex etiology in their pathophysiology and are influenced by various risk factors such as aging,lifestyle,genetics,and environment,it is important to identify perturbed molecular functions that can be targeted by metformin in these neurological *** molecules can then be used as biomarkers to stratify subpopulations of patients who show distinct molecular/pathological properties and can respond to metformin treatment,ultimately developing targeted *** this review,we will discuss mitochondria-related metabolic perturbations and impaired molecular pathways in these neurological disorders and how these can be used as biomarkers to guide metformin-responsive treatment for the targeted therapy to treat neurological disorders.

关键词： Alzheimer’s disease Huntington’s disease metformin mitochondrial perturbation multiple sclerosis neural degenerative diseases Parkinson’s disease stroke targeted therapy

Water Tower Home transformation:bottom-up urban regeneration through a reality TV show

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Built Heritage 2024年第2期8卷 79-88页

作者： Diyu Liu lui Tam Yingchun Li College of Architecture and Urban Planning Tongji University1239 Siping RoadShanghai200092China Welsh school of Architecture Cardiff UniversityBute BuildingKing Edward VII AvenueCardiffWalesCF103NBUK

The article examines Wutopia Lab’s transformation of the Water Tower Home(shuita zhijia,also know as‘House on the House’),a top-floor unit of a residential building converted from a water tower located in a Bulinli lilong neighbourhood in *** 2015,the top-floor unit was transformed into a three-bedroom apartment,which was featured in a popular reality TV show Dream *** the concept of‘raumplan’as the primary design strategy,the design deploys various heights and platforms to re-organise the internal space while largely maintaining the exterior appearance of the *** deliberately avoided homogeneous visual control and accommodated the residents’complex functional requirements within a highly restricted *** research scrutinises various actors’involvement during the production of the reality TV show and the transformation *** highlights how the design team navigated the stakeholders’complex needs and the rigid yet ambiguous policy related to the regeneration of shanghai’s unofficial urban *** reflecting upon the various formal and informal design practices in this structure and its eventual demolition,the article illustrates the dilemmas in bottom-up regeneration of the historic urban environment in contemporary China.

关键词： Unofficial urban heritage Bottom-up Urban regeneration Raumplan Wutopia Lab Reality TV show

首发精神分裂症病人静息态脑活动的纵向改变:一项随访1年的功能MRI研究

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国际医学放射学杂志 2016年第4期 441-442页

作者： F.Li s.lui L.Yao J.Hu P.Lv X.Huang 戴群瑶 Huaxi MR Research Center Department of RadiologyWest China Hospital of Sichuan University

摘要目的探讨未经治疗的首发精神分裂症病人历经1年的抗精神病治疗后脑功能异常的变化情况以及治疗前静息态功能MRI参数与临床症状的纵向改变是否相关。材料与方法本前瞻性研究获得了伦理委员会的批准,所有参与者均签署书面知情同意书... 详细信息

摘要目的探讨未经治疗的首发精神分裂症病人历经1年的抗精神病治疗后脑功能异常的变化情况以及治疗前静息态功能MRI参数与临床症状的纵向改变是否相关。材料与方法本前瞻性研究获得了伦理委员会的批准,所有参与者均签署书面知情同意书。纳入20例未经治疗的首发精

关键词：静息态 MRI 病人精神分裂症早发性痴呆功能

sclerotherapy in a case of multiple glomuvenous malformation

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Chinese Journal of Plastic and Reconstructive surgery 2024年第2期6卷 79-82页

作者： shufen Wang sijian Wen Jiarong Liang Hui lui Xinyu Zhang Dermatology and Venereology First Clinical Medical CollegeGuangxi Medical UniversityNanningGuangxi 530021China Department of Dermatology and Venereology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530029China

In this study, we present a representative case of multiple glomuvenous malformation in a 12-year-old female patient. Approximately five years ago, the patient developed multiple blue-purple papules and plaques on her hypogastrium and right thigh, which progressively enlarged and presented tenderness. Histopathological examination confirmed the diagnosis of glomuvenous malformation. Following two injections of lauromacrogol, a significant improvement was observed in the lesions, including a resolution of tenderness. These findings suggest that sclerotherapy not only exhibits evident therapeutic efficacy but also effectively alleviates pain while addressing both aesthetic and therapeutic concerns.

关键词： Glomuvenous malformation sclerotherapy

Molecularly engineered lignin to polyphenol via organocatalysis as an active sunscreen ingredient

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Journal of Bioresources and Bioproducts 2024年第2期9卷 197-210页

作者： Yuanlong Guo Pengcheng Liu Lei Deng Changwei lui Michael North Gang Hu Qitian Huang Zongbao Kent Zhao Haibo Xie Department of Polymeric Materials&Engineering Guizhou UniversityGuiyang 550025China KZJ New Materials Group Guizhou Co.Ltd. Guizhou 551200China Green Chemistry Centre of Excellence Department of ChemistryUniversity of YorkYork YO105DDUK Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China

Phenolation is one of the effective strategies to synthesize lignin-based polyphenols,improve lignin’s properties,and extend its value-added applications in biological,medicinal and cosmetic ***,by taking the structural feature advantage of lignin,an effective and green strategy was developed to molecularly engineer lignin into a robust lignin-3-(2-hydroxyphenyl)propionate ester(LPPE)derivative via a transesterification reaction between 3,4-dihydrocoumarin(DHC)and the aliphatic hydroxyls in lignin under *** strategy is optimized and the novel derivative was systematically characterized by ^(1)H,^(13)C and ^(31)P nuclear magnetic resonance(NMR)and Fourier transform infrared(FT-IR)*** findings indicated that the successful introduction of 3-(2-hydroxyphenyl)propionate groups using a OH groups/DHC/organic base mo-lar ratio of 1꞉1꞉0.3 at 120℃ for 6 h increased the content of phenolic hydroxyl groups from 1.7931 to 3.0179 mmol/g,and the LPPE exhibited excellent ultraviolet-absorbing and antioxidant per-formance with up to 90%free radical scavenging activity within 20 min using 5 mg/mL of *** addition,good biocompatibility and a high sun protection factor(sPF)value of 40.9 were achieved at 5%(w)dosage of LPPE in the cream,indicating its significant application potential in sunscreen.

关键词： Phenolation of lignin Organocatalysis 3,4-dihydrocoumarin Antioxidant sunscreen cream

smooth muscle cell-specific genetic targeting by Myh11-driven Cre(ER)knockin mice

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science China(Life sciences) 2024年第10期67卷 2280-2282页

作者： Enci Wang Ximeng Han Haixiao Wang Kathy O.lui Bin Zhou Lixin Wang Department of Vascular surgery Zhongshan HospitalFudan UniversityShanghai 200032China Department of Cardiology Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Pediatric Research Institute The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China Department of Chemical Pathology and Li Ka Shing Institute of Health SciencesPrince of Wales HospitalThe Chinese University of Hong KongHong Kong 999077China New Cornerstone Investigator Institute State Key Laboratory of Cell BiologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Department of Vascular surgery(Xiamen) Zhongshan hospitalFudan UniversityXiamen 361015China

Dear editor,site specific recombinases have been widely used for genome engineering in cardiovascular research(Fu et al.,2024;Huang et al.,2023;Xue et al.,2022).In particular,Cre is the most broadly used recombinase for cell type-specific lineage tracing and gene manipulation in *** smooth muscle cell(sMC)-specific targeting,several sMC promoters including Myh11(smooth muscle myosin heavy chain),Acta2(smooth muscle a-2 actin),and sM22a(Tagln)have been used to drive Cre or CreER.

关键词： cardiovascular manipulation

Quantitative and qualitative subgenomic RNA profiles of sARs-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng Grace lui Lowell Ling Agnes s.Y.Leung Chit Chow siaw shi Boon Wendy C.s.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David shu Cheong Hui Paul Kay sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club school of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The sARs-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus sARs-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq subgenomic RNA(sgRNA)

Introducing the Hong Kong Medical Journal and its important role in the timely dissemination of COVID-19 related knowledge

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Chinese Medical Journal 2024年第3期137卷 253-254页

作者： Rashid N lui Kenneth KW Li Martin Cs Wong Hong Kong Medical Journal Hong Kong SARChina The JC school of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong Kong SARChina

Hong Kong Medical Journal(HKMJ)is the flagship general medical journal in the Hong Kong special Administrative Region,China,with an international *** are committed to publishing and promoting high-quality *** by our Editor-in-Chief,Professor Martin Cs Wong,our Editorial Board is pleased to collaborate with *** Wang,the Editor-in-Chief of the Chinese Medical Journal(CMJ),as well as the editors of CMJ to enhance the visibility of our respective journals and foster a collaborate environment that brings forth ideas and knowledge to our readers.

关键词： journal knowledge visibility

全面抗战时期温台地区道教会的基层管理与经费改革

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宗教学研究 2024年第4期 52-57页

作者：吕珊珊西南大学历史文化学院

全面抗战爆发后,道教会负责动员道教徒参与抗战活动和筹募经费等工作。在前期的组织管理中,道教会面临道众抵抗与经费不足的困境。因此,道教会根据地方实际情况,改革经费征收模式,通过征收经忏捐与规范经忏的方式,扩大经费来源。在此过... 详细信息

全面抗战爆发后,道教会负责动员道教徒参与抗战活动和筹募经费等工作。在前期的组织管理中,道教会面临道众抵抗与经费不足的困境。因此,道教会根据地方实际情况,改革经费征收模式,通过征收经忏捐与规范经忏的方式,扩大经费来源。在此过程中,地方道教会利用这一特殊时期,初步掌握对道教徒及其经忏业务的管理权,改变以往地方道教界“松散”的形态,对所辖境内的道教徒实施从人到财产全方位的统合与管控。道教会所采取的经费改革,逐步冲击传统道教界的运行秩序,走向现代组织化的管理模式。

关键词：道教会经费征收经忏温台地区

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