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Transcriptional changes in mesenteric and subcutaneous adipose tissue from Holstein cows in response to plane of dietary energy

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Journal of Animal science and Biotechnology 2018年第1期9卷 233-247页

作者： s.J.Moisá P.Ji J.K.Drackley s.l.rodriguez-zas J.J.loor Department of Animal sciences Auburn University Department of Animal sciences University of Illinois

Background： Dairy cows can readily overconsume dietary energy during most of the prepartum period, often leading to higher prepartal concentrations of insulin and glucose and excessive body fat deposition. The end result of these physiologic changes is greater adipose tissue lipolysis post-partum coupled with excessive hepatic lipid accumulation and compromised health. Although transcriptional regulation of the adipose response to energy availability is well established in non-ruminants, such regulation in cow adipose tissue depots remains poorly ***： Effects of ad-libitum access to high [HIGH; 1.62 Mcal/kg of dry matter（DM）] or adequate（CON; 1.35 Mcal/kg of DM） dietary energy for 8 wk on mesenteric（MAT） and subcutaneous（sAT） adipose tissue transcript profiles were assessed in non-pregnant non-lactating Holstein dairy cows using a 13,000-sequence annotated bovine oligonucleotide microarray. statistical analysis revealed 409 and 310 differentially expressed genes（DEG） due to tissue and diet. Bioinformatics analysis was conducted using the Dynamic Impact Approach（DIA） with the KEGG pathway database. Compared with sAT, MAT had more active biological processes related to adipose tissue accumulation（adiponectin secretion） and signs of pro-inflammatory processes due to adipose tissue expansion and macrophage infiltration（generation of ceramides）. Feeding the HIGH diet led to changes in m RNA expression of genes associated with cell hypertrophy（regucalcin）, activation of adipogenesis（phospholipid phosphatase 1）,insulin signaling activation（neuraminidase 1） and angiogenesis（semaphorin 4 G, plexin B1）. Further, inflammation due to HIGH was underscored by m RNA expression changes associated with oxidative stress response（coenzyme Q3, methyltransferase）, ceramide synthesis（N-acylsphingosine amidohydrolase 1）, and insulin signaling（interferon regulatory factor 1, phosphoinositide-3-kinase regulatory subunit 1, retinoic acid receptor alpha）. Activation of ribos

关键词： Adipose tissue Dairy cow Dietary energy Transcriptome

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品种和年龄对猪的基础免疫特性、血液皮质醇浓度及生长性能的影响

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饲料工业 2005年第20期 60-60页

作者： M.A.sutherland ,s.l.rodriguez-zas ,M.Ellis ,J.l.salak-Johnson

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Prepartum dietary energy intake alters adipose tissue transcriptome profiles during the periparturient period in Holstein dairy cows

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Journal of Animal science and Biotechnology 2020年第2期11卷 410-423页

作者： Andrea Minuti Massimo Bionaz Vincenzo lopreiato Nicole A.Janovick sandra l.rodriguez-zas James K.Drackley Juan J.loor Department of Animal sciences Food and NutritionFaculty of AgricultureFood and Environmental ScienceUniversitàCattolica del Sacro Cuore29122 PiacenzaItaly Animal and Rangeland sciences Oregon State UniversityCorvallisOR 97330USA Department of Animal sciences Division of Nutritional SciencesUniversity of IllinoisUrbanaIL 61801USA

Background:The aim of the study was to investigate the effect of energy overfeeding during the dry period on adipose tissue transcriptome profiles during the periparturient period in dairy ***:Fourteen primiparous Holstein cows from a larger cohort receiving a higher-energy diet(1.62 Mcal of net energy for lactation/kg of dry matter;15%crude protein)for ad libitum intake to supply 150%(OVR)or 100%(CTR)of energy requirements from dry off until parturition were *** calving,all cows received the same lactation *** adipose tissue(sAT)biopsies were collected at−14,1,and 14d fromparturition(d)and used for transcriptome profiling using a bovine oligonucleotide *** mining of differentially expressed genes(DEG)between treatments and due to sampling time was performed using the Dynamic Impact Approach(DIA)and Ingenuity Pathway Analysis(IPA).Results:There was a strong effect of over-feeding energy on DEG with 2434(False discovery rate-corrected Ply 340 and 538 at 1 and 14 *** most-impacted and activated pathways in the Kyoto Encyclopedia of Genes and Genomes(KEGG)database that were highlighted by DIA analysis at−14 d in OVR *** included 9 associated with carbohydrate metabolism,with‘Pyruvate metabolism’,‘Glycolysis/gluconeogenesis’,and‘Pentose phosphate pathway’among the *** surprisingly,OVR led to marked activation of lipid metabolism(e.g.‘Fatty acid biosynthesis’and‘Glycerolipid metabolism’).Unexpected metabolic pathways that were activated at−14 d in OVR included several related to metabolism of amino acids(*** chain)and of cofactors and vitamins(thiamin).Among endocrine and immune system pathways,at−14 d OVR led to marked activation of‘PPAR signalling’and‘Antigen processing and presentation’.Among key pathways affected over time in OVR,a number were related to translation(*** signaling),endocrine/immune signaling(CXCR4 and IGF1),and lipid metabolism(oxidative

关键词： Periparturient cow Prepartum overfeeding subcutaneous adipose tissue Transcriptome

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The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline

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Neural Regeneration Research 2022年第11期17卷 2407-2412页

作者： Amsha s.Alsegiani Zahoor A.shah Department of Medicinal and Biological Chemistry College of Pharmacy and Pharmaceutical SciencesUniversity of ToledoToledoOHUSA

Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attra cted significant ***-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative *** is one of the critical predisposing risk factors for the development of neurodegenerative *** a healthy gut microbiota is essential for a healthy body and aging,but dys biosis could initiate many chro nic *** the underlying mechanisms of gut microbiota alterations/dys biosis will help identify biomarkers for aging-related chro nic *** review summarizes recent advances in micro biota-neurodegenerative disease research and will enhance our unde rstanding of gut microbiota dys biosis and its effects on brain aging.

关键词： brain aging cognitive decline dysbiosis fecal microbiota transplantation gut-microbiota neuroinflammation prebiotics probiotics

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血管n-3二十二碳五烯酸衍生的D系列Resolvins的生成和昼夜调节障碍增加全身性炎症与心血管病

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中华高血压杂志 2018年第3期26卷 275-275页

作者：刘莉叶鹏 Colas RA souza PR Walker ME Burton M Marques RM zasona Z Curtis AM Dalli J

昼夜机制对调节宿主反应至关重要。最近的研究发现了一种特异性促炎症消退介质（specialized proresolving mediators,sPM）的新型介质家族,其可在不干扰免疫应答的情况下终止炎症。然而关于其昼夜调节情况知之甚少。该研究调查了人体sP... 详细信息

昼夜机制对调节宿主反应至关重要。最近的研究发现了一种特异性促炎症消退介质（specialized proresolving mediators,sPM）的新型介质家族,其可在不干扰免疫应答的情况下终止炎症。然而关于其昼夜调节情况知之甚少。该研究调查了人体sPM的昼夜调节及其在控制外周血白细胞和血小板活化中的作用。

关键词：全身性炎症调节障碍心血管病昼夜碳五烯酸 n-3 十二外周血白细胞

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Facile synthesis of accordion-like porous carbon from waste PET bottles-based MIl-53(Al)and its application for high-performance Zn-ion capacitor

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Green Energy & Environment 2024年第7期9卷 1138-1150页

作者： Jiaxin li shuai Zhang Yumeng Hua Yichao lin Xin Wen Ewa Mijowska Tao Tang Xuecheng Chen Rodney s.Ruoff Faculty of Chemical Technology and Engineering West Pomeranian University of TechnologyPiastow Ave.4271-065SzczecinPoland Key state Key laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China school of safety Engineering China University of Mining and TechnologyXuzhou221116China Institute of Advanced Electrical Materials Qingdao University of Science and TechnologyQingdao266042China Institute for Basic science Center for Multiple Dimensional Carbon Materials Ulsan44919Republic of Korea Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)Ulsan44919Republic of Korea Department of Materials science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan44919Republic of Korea school of Energy and Chemical Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan44919Republic of Korea

It is of great scientific and economic value to recycle waste poly(ethylene terephthalate)(PET)into high-value PET-based metal organic frameworks(MOFs)and further convert it into porous carbon for green energy storage *** the present study,a facile and costeffective hydrothermal process was developed to direct recycle waste PET bottles into MIl-53(Al)with a 100% conversation,then the MOFderived porous carbon was assembled into electrodes for high-performance *** results indicated that the as-synthesized carbon exhibited high ssA of 1712 m^(2)g^(-1)and unique accordion-like structure with hierarchical *** to these advantageous characters,the assembled three-electrode supercapacitor displayed high specific capacitances of 391 F g^(-1)at the current density of 0.5 A g^(-1)and good rate capability of 73.6% capacitance retention at 20 A g^(-1)in 6 mol l^(-1)KOH ***,the assembled zinc ion capacitor still revealed outstanding capacitance of 335 F g^(-1)at 0.1 A g^(-1),excellent cycling stability of 92.2% capacitance retention after 10000 cycles and ultra-high energy density of 150.3 Wh kg^(-1)at power density of 90 W kg^(-1)in 3 mol l^(-1)ZnsO_(4)*** is believed that the current work provides a facile and effective strategy to recycle PET waste into high-valuable MOF,and further expands the applications of MOF-derived carbons for high-performance energy storage devices,so it is conducive to both pollution alleviation and sustainable economic development.

关键词： PET Recycling Porous carbon supercapacitor Energy storage

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small interfering RNAs based therapies for intracerebral hemorrhage: challenges and progress in drug delivery systems

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Neural Regeneration Research 2022年第8期17卷 1717-1725页

作者： Daniyah A.Almarghalani sai H.s.Boddu Mohammad Ali Akhila Kondaka Devin Ta Rayyan A.shah Zahoor A.shah Department of Pharmacology and Experimental Therapeutics College of Pharmacy and Pharmaceutical SciencesUniversity of ToledoToledoOHUSA Department of Medicinal and Biological Chemistry College of Pharmacy and Pharmaceutical SciencesUniversity of ToledoToledoOHUSA Department of Pharmaceutical sciences College of Pharmacy and Health SciencesAjman UniversityAjmanUnited Arab Emirates

Intracerebral hemorrhage(ICH)is a subtype of stroke associated with higher rates of ***,no effective drug treatment is available for *** molecular pathways following ICH are complicated and *** acid therapeutics such as gene knockdown by small interfering RNAs(siRNAs)have been developed in recent years to modulate ICH’s destructive pathways and mitigate its ***,siRNAs delivery to the central nervous system is challenging and faces many *** barriers to systemic delivery of siRNA limit the use of naked siRNA;therefore,siRNA-vectors developed to protect and deliver these therapies into the specific-target areas of the brain,or cell types seem quite *** delivery of siRNA via nanoparticles emerged as a viable and effective alternative therapeutic tool for central nervous system-related *** review discusses the obstacles to siRNA delivery,including the advantages and disadvantages of viral and nonviral ***,we provide a comprehensive overview of recent progress in nanotherapeutics areas,primarily focusing on the delivery system of siRNA for ICH treatment.

关键词： intracerebral hemorrhage lipid-based nanoparticle nanoparticles nanotechnology nonviral vectors peptide-mediated nanoparticle polymer-based nanoparticle siRNA therapeutics siRNA-barriers viral vectors

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