检索结果-南通市图书馆

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Understanding activity of butyrate at a cellular level

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

Microglial dysfunction and genetic risk for neurodegenerative disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay Penney Department of Biomedical sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations *** tremendous progress has been made,our understanding of the mechanisms that underlie the development of these diseases remains far from com *** troubling,despite the growing emotional and financial toll being to ken by neurodegenerative disorders,existing treatment options are limited almost exclusively to those that help manage symptoms but that lack the ability to alter the progression of the disease(Liu et al.,2022).

关键词： degenerative diseases

Viscosity,NMR Diffusometry and Light scattering Data for Aqueous and Aqueous-salt solutions of Poly(1-butyl-3-vinylimidazolium bromide)

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer science 2025年第2期43卷 380-391页

作者： Petr A.Korchak Polina s.Yarchenko Evgenia A.safonova Alina s.Koneva Alexey I.Victorov st.Petersburg state University St.Petersburg 199034Russia

Poly(1-butyl-3-vinylimidazolium bromide)is a polymerized ionic liquid(PILs),a relatively new class of materials that combines the attractive properties of ionic liquids(ILs)and polyelectrolytes and finds wide *** backbone of this PIL is composed of quaternary imidazolium salts,which are among the most promising and popular ***,little is known about the physicochemical characteristics of the aqueous solutions of this *** this study,we synthesized and characterized samples of this PIL and obtained experimental data on the viscosity,static and dynamic light scattering,and nuclear magnetic resonance diffusometry for aqueous and aqueous KBr solutions with varying polymer contents at T=298.15 *** discuss the effects of the polymer concentration and salinity on the behavior of the solution.

关键词： Polymerized ionic liquid Polyelectrolyte solutions Viscosity Light scattering NMR diffusometry

Electrocardiogram signal Denoising Using Optimized Adaptive Hybrid Filter with Empirical Wavelet Transform

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of shanghai Jiaotong university(science) 2025年第1期30卷 66-80页

作者： BALAsUBRAMANIAN s NARUKA Mahaveer singh TTEWARI Gaurau Department of Electronics and Communication Engineering Maharishi University of Information TechnologyMaharishi Vidya MandirLucknow226013India Department of Electronics and Communication Engineering IEC College of Engineering and TechnologyGreater Noida201310India Department of Electrical Communication Engineering School of Information and Communication TechnologyGautam Buddha UniversityGreater Noida201310India

Cardiovascular diseases are the world’s leading cause of death;therefore cardiac health of the human heart has been a fascinating topic for *** electrocardiogram(ECG)signal is a comprehensive non-invasive method for determining cardiac *** health practitioners use the ECG signal to ascertain critical information about the human *** this article,swarm intelligence approaches are used in the biomedical signal processing sector to enhance adaptive hybrid filters and empirical wavelet transforms(EWTs).At first,the white Gaussian noise is added to the input ECG signal and then applied to the *** ECG signals are denoised by the proposed adaptive hybrid *** honey badge optimization(HBO)algorithm is utilized to optimize the EWT window function and adaptive hybrid filter weight *** proposed approach is simulated by MATLAB 2018a using the MIT-BIH dataset with white Gaussian,electromyogram and electrode motion artifact noises.A comparison of the HBO approach with recursive least square-based adaptive filter,multichannel least means square,and discrete wavelet transform methods has been done in order to show the efficiency of the proposed adaptive hybrid *** experimental results show that the HBO approach supported by EWT and adaptive hybrid filter can be employed efficiently for cardiovascular signal denoising.

关键词： electrocardiogram(ECG)signal denoising empirical wavelet transform(EWT) honey badge optimization(HBO) adaptive hybrid filter window function

Intrumer:A Multi Module Distributed Explainable IDs/IPs for securing Cloud Environment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A s.K.B.sangeetha Department of Computer science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDs,have been developed to tackle these ***,most conventional Intrusion Detection system(IDs)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDsmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDs datasets CICIDs 2017,Honeypots,and NsL-KDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

Innovative dispersion techniques of graphene nanoplatelets(GNPs)through mechanical stirring and ultrasonication:Impact on morphological,mechanical,and thermal properties of epoxy nanocomposites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology(防务技术) 2025年第1期43卷 13-25页

作者： Vasi Uddin siddiqui s.M.sapuan Mohd Roshdi Hassan Advanced Engineering Materials and Composites Research Centre(AEMC) Department of Mechanical and Manufacturing EngineeringUniversiti Putra MalaysiaUPM SerdangSelangor 43400Malaysia Department of Mechanical and Manufacturing Engineering Universiti Putra MalaysiaUPM SerdangSelangor 43400Malaysia

Graphene nanoplatelets(GNPs)have attracted tremendous interest due to their unique properties and bonding *** study focuses on the effect of GNP dispersion on the mechanical,thermal,and morphological behavior of GNP/epoxy *** study aims to understand how the dispersion of GNPs affects the properties of epoxy nanocomposite and to identify the best dispersion approach for improving mechanical performance.A solvent mixing technique that includes mechanical stirring and ultrasonication was used for producing the *** transform infrared spectroscopy was used to investigate the interaction between GNPs and the epoxy *** measurements of density and moisture content were used to confirm that GNPs were successfully incorporated into the *** findings showed that GNPs are successfully dispersed in the epoxy matrix by combining mechanical stirring and ultrasonication in a single step,producing well-dispersed nanocomposites with improved mechanical ***,the nanocomposites at a low GNP loading of 0.1 wt%,demonstrate superior mechanical strength,as shown by increased tensile properties,including improved Young's modulus(1.86 GPa),strength(57.31 MPa),and elongation at break(4.98).The nanocomposite with 0.25 wt%GNP loading performs better,according to the viscoelastic analysis and flexural properties(113.18 MPa).Except for the nanocomposite with a 0.5 wt%GNP loading,which has a higher thermal breakdown temperature,the thermal characteristics do not significantly *** effective dispersion of GNPs in the epoxy matrix and low agglomeration is confirmed by the morphological *** findings help with filler selection and identifying the best dispersion approach,which improves mechanical *** effective integration of GNPs and their interaction with the epoxy matrix provides the doorway for additional investigation and the development of sophisticated *** fiel

关键词： Graphene nanoplatelets Epoxy Nanocomposites Mechanical properties Thermal properties Mechanical stirrer sonication

Measurement of the integrated luminosity of the Phase 2 data of the Belle Ⅱ experiment

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2020年第2期44卷 1-12页

作者： F.Abudinén I.Adachi P.Ahlburg H.Aihara N.Akopov A.Aloisio F.Ameli L.Andricek N.Anh Ky D.M.Asner H.Atmacan T.Aushev V.Aushev T.Aziz K.Azmi V.Babu s.Baehr s.Bahinipati A.M.Bakich P.Bambade sw.Banerjee s.Bansal V.Bansal M.Barrett J.Baudot A.Beaulieu J.Becker P.K.Behera J.V.Bennett E.Bernieri F.U.Bernlochner M.Bertemes M.Bessner s.Bettarini V.Bhardwaj F.Bianchi T.Bilka s.Bilokin D.Biswas G.Bonvicini A.Bozek M.Bračko P.Branchini N.Braun T.E.Browder A.Budano s.Bussino M.Campajola L.Cao G.Casarosa C.Cecchi D.Červenkov M.-C.Chang P.Chang R.Cheaib V.Chekelian Y.Q.Chen Y.-T.Chen B.G.Cheon K.Chilikin H.-E.Cho K.Cho s.Cho s.-K.Choi s.Choudhury D.Cinabro L.Corona L.M.Cremaldi s.Cunliffe T.Czank F.Dattola E.De La Cruz-Burelo G.De Nardo M.De Nuccio G.De Pietro R.de sangro M.Destefanis s.Dey A.De Yta-Hernandez F.Di Capua s.Di Carlo J.Dingfelder Z.Doležal I.Domínguez Jiménez T.V.Dong K.Dort s.Dubey s.Duell s.Eidelman M.Eliachevitch T.Ferber D.Ferlewicz G.Finocchiaro s.Fiore A.Fodor F.Forti A.Frey B.G.Fulsom M.Gabriel E.Ganiev M.Garcia-Hernandez R.Garg A.Garmash V.Gaur A.Gaz U.Gebauer A.Gellrich J.Gemmler T.Geßler R.Giordano A.Giri B.Gobbo R.Godang P.Goldenzweig B.Golob P.Gomis P.Grace W.Gradl E.Graziani D.Greenwald C.Hadjivasiliou s.Halder K.Hara T.Hara O.Hartbrich K.Hayasaka H.Hayashii C.Hearty M.T.Hedges I.Heredia de la Cruz M.Hernández Villanueva A.Hershenhorn T.Higuchi E.C.Hill H.Hirata M.Hoek s.Hollitt T.Hotta C.-L.Hsu Y.Hu K.Huang T.Iijima K.Inami G.Inguglia J.Irakkathil Jabbar A.Ishikawa R.Itoh M.Iwasaki Y.Iwasaki s.Iwata P.Jackson W.W.Jacobs D.E.Jaffe E.-J.Jang H.B.Jeon s.Jia Y.Jin C.Joo J.Kahn H.Kakuno A.B.Kaliyar G.Karyan Y.Kato T.Kawasaki H.Kichimi C.Kiesling B.H.Kim C.-H.Kim D.Y.Kim s.-H.Kim Y.K.Kim Y.Kim T.D.Kimmel K.Kinoshita C.Kleinwort B.Knysh P.Kodyš T.Koga I.Komarov T.Konno s.Korpar D.Kotchetkov N.Kovalchuk T.M.G.Kraetzschmar P.Križan R.Kroeger J.F.Krohn P.Krokovny W.Kuehn T.Kuhr M.Kumar R.Kumar K.Kumara s.kurz A.Kuzmin Y.-J.Kwon s.Lacaprara Y.-T.Lai C.La Licata K.Lalwani L.Lanceri J.s.Lange K.Lautenbach I.-s.Le Beihang University Beijing 100191 Brookhaven National Laboratory UptonNew York 11973 Budker Institute of Nuclear Physics sB RAs Novosibirsk 630090 Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional Mexico City 07360 Faculty of Mathematics and Physics Charles University12116 Prague Chiba University Chiba 263-8522 Consejo Nacional de Ciencia y Tecnología Mexico City 03940 Deutsches Elektronen–synchrotron 22607 Hamburg Duke University DurhamNorth Carolina 27708 Earthquake Research Institute University of TokyoTokyo 113-0032 Forschungszentrum Jülich 52425 Jülich Department of Physics Fu Jen Catholic UniversityTaipei 24205 Key Laboratory of Nuclear Physics and Ion-beam Application(MOE)and Institute of Modern Physics Fudan UniversityShanghai 200443 II.Physikalisches Institut Georg-August-Universität Göttingen37073 Göttingen Gifu University Gifu 501-1193 The Graduate University for Advanced studies(sOKENDAI) Hayama 240-0193 Gyeongsang National University Jinju 52828 Department of Physics and Institute of Natural sciences Hanyang UniversitySeoul 04763 High Energy Accelerator Research Organization(KEK) Tsukuba 305-0801 J-PARC Branch KEK Theory CenterHigh Energy Accelerator Research Organization(KEK)Tsukuba 305-0801 Indian Institute of science Education and Research Mohali SAS Nagar140306 Indian Institute of Technology Bhubaneswar Satya Nagar 751007 Indian Institute of Technology Hyderabad Telangana 502285 Indian Institute of Technology Madras Chennai 600036 Indiana University BloomingtonIndiana 47408 Institute for High Energy Physics Protvino 142281 Institute of High Energy Physics Vienna 1050 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049 Institute of Particle Physics(Canada) VictoriaBritish Columbia V8W 2Y2 Institute of Physics Hanoi Instituto de Fisica Corpuscular Paterna 46980 INFN Laboratori Nazionali di Frascati I-00044 Frascati INFN sezione di Napoli I-80126 Napoli INFN sezione di Padova I-35131 Padova INFN sezione di Perugia I-06123 Perugia

From April to July 2018,a data sample at the peak energy of the T(4 s) resonance was collected with the Belle Ⅱ detector at the superKEKB electron-positron *** is the first data sample of the Belle Ⅱ *** Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is *** work provides a basis for future luminosity measurements at Belle Ⅱ.

关键词： luminosity Bhabha digamma Belle II

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina silvera-simón Manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB