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Microsystems & Nanoengineering 2023年第3期9卷 159-170页

作者： Y.Hori s.konishi Graduate school of science and Engineering Ritsumeikan UniversityShigaJapan Department of Mechanical Engineering Ritsumeikan UniversityShigaJapan Ritsumeikan Advanced Research Academy KyotoJapan Ritsumeikan Global Innovation Research Organization KyotoJapan

Various soft actuators have been investigated to overcome the drawbacks of conventional solid machines and explore the applications of soft *** particular,and because they are expected to be applicable in minimally invasive medicine because of their safety,soft inflatable microactuators using an actuation conversion mechanism from balloon inflation to bending motion have been proposed for high-output bending *** microactuators could be applied to create an operation space by safely moving organs and tissues;however,the conversion efficiency could be further *** study aimed to improve conversion efficiency by investigating the design of the conversion *** contact conditions between the inflated balloon and conversion film were examined to improve the contact area for force transmission,with the contact area dependent on the length of the contact arc between the balloon and force conversion mechanism and on the amount of balloon *** addition,surface contact friction between the balloon and film,which affects actuator performance,was also *** generated force of the improved device is 1.21 N at 80 kPa when it bends 10 mm,which is 2.2 times the generated force of the previous *** improved soft inflatable microactuator is expected to assist in performing operations in a limited space,such as in endoscopic or laparoscopic operations.

关键词： film mechanism operations

茶园中泡囊—灌木状菌根(VAM)侵染百分率与土壤磷含量的关系

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福建热作科技 1990年第3期15卷 47-48,F003页

作者： A.Morita s.konishi 丁文

在日本的大部分茶园,PH值低于5.0的酸性土壤,都能适应茶树生长.在酸性土壤中,铝被解离并具有一定的生理活性.因此,许多植物受到铝解离后的毒性影响.由于铝和磷形成化合物导致植物缺磷症是毒性影响之一.但茶树却未发现有铝中毒现象.如果... 详细信息

在日本的大部分茶园,PH值低于5.0的酸性土壤,都能适应茶树生长.在酸性土壤中,铝被解离并具有一定的生理活性.因此,许多植物受到铝解离后的毒性影响.由于铝和磷形成化合物导致植物缺磷症是毒性影响之一.但茶树却未发现有铝中毒现象.如果它们之间有差异的话,这可能是铝的存在刺激了茶树生长和磷的吸收的原因(Kon-ishi et al.1985).

关键词：茶园泡囊灌木状菌根侵染百分率土壤磷含量

simultaneous detection of the shuttling motion of liquid metal droplets in channels under alternating pressure and capacitive sensor signals

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Microsystems & Nanoengineering 2024年第2期10卷 83-90页

作者： shinji Bono Ryotaro Nakai satoshi konishi Research Organization of science and Technology Ritsumeikan UniversityShigaJapan Ritsumeikan Advanced Research Academy KyotoJapan Ritsumeikan Global Innovation Research Organization Ritsumeikan UniversityShigaJapan Graduate school of science and Engineering Ritsumeikan UniversityShigaJapan

Implementing a signal-switching mechanism for the selective use of integrated sensors and actuators plays a crucial role in streamlining the functionality of miniaturized ***,a liquid metal droplet(LMD)-based signal-switching mechanism is introduced to achieve such *** modulation with a 100-μm spatial resolution enabled precise control of the position of the LMDs within a *** integrating the channel with asymmetrically structured electrodes,the effect of the shuttle-like movement of LMD on the temporal changes in the overall capacitance was ***,analysis of the capacitive peaks revealed the directional movement of the LMDs,enabling estimation of the position of the LMDs without direct *** addition,we achieved successful signal extraction from the capacitive sensor that was linked to the activated electrodes,thereby enabling selective data *** proposed signal-switching mechanism method achieved a detection accuracy of~0.1 *** sensor’s ability to simultaneously detect the LMD position and generate a signal underscores its significant potential for multiplexing in multisensing systems,particularly in concealed environments,such as in vivo settings.

关键词： liquid thereby integrating

Observation of Inception of sheet Cavitation from Free Nuclei

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Journal of Thermal science 2017年第3期26卷 223-228页

作者： Wakana TsURU Takafumi konishi satoshi WATANABE shin-ichi TsUDA Graduate school of Engineering Kyushu University Japan Department of Mechanical Engineering Kyushu University Japan

Prediction of inception of sheet cavitation on solid walls has been recognized to be very difficult, since it is significantly affected by the boundary layer flow characteristics, the population of free nuclei, the nuclei held in the wall roughness, the amount of dissolved air in liquid and so on. It has not sufficiently been made clear how the inception is affected by the conditions of water qualities and background flow characteristics. In this study, high speed observation of inception of sheet cavity from free nuclei is conducted for a two-dimensional convergent-divergent nozzle flow, where the sheet cavity forms just downstream of the nozzle throat. The effects of the amount of dissolved air and the free stream velocity on the inception process of sheet cavitation is examined. In addition, the bubble nuclei density, which is well known to be important factor for cavitation inception, is passively controlled by the filter installed in the tunnel. From the observations, it is confirmed that the nuclei number density significantly affects the formation of sheet cavity rather than the other two parameters. In conditions with large nuclei number density, the sheet cavity does not form, and bubbly cavitation appears instead. In the case with small nuclei number density, the sheet cavity forms from a single flowing nucleus and develops streamwisely and spanwisely. In the conditions with medium nuclei number density, the sheet cavity also forms but is shorter/narrower streamwisely/spanwisely, due to interaction of other nuclei flowing near the formed sheet cavity.

关键词： Cavitation inception sheet cavity Nuclei distribution Dissolved air

PROTEOME ANALYsIs OF RICE ROOT PROTEINs REGULATED BY GIBBERELLIN

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Genomics, Proteomics & Bioinformatics 2005年第3期3卷 132-142页

作者： sETsUKO KOMATsU HIROsATO konishi DEPARTMENT OF MOLECULAR GENETICs NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES TSUKUBA 305-8602 JAPAN

To gain an enhanced understanding of the mechanism by which gibberellins （GAs） regulate the growth and development of plants, it is necessary to identify proteins regulated by GA. Proteome analysis techniques have been applied as a direct, effective, and reliable tool in differential protein expressions. In previous studies, sixteen proteins showed differences in accumulation levels as a result of treatment with GA3, uniconazole, or abscisic acid （ABA）, and/or the differences between the GA-deficient semi-dwarf mutant, Tan-ginbozu, and normal cultivars. Among these proteins, aldolase increased in roots treated with GA3, was present at low levels in Tan-ginbozu roots, and decreased in roots treated with uniconazole or ABA. In a root elongation assay, the growth of aldolase-antisense transgenic rice was half of that of vector control transgenic rice. These results indicate that increases in aldolase activity stimulate the glycolytic in the GA-induced growth of roots. In among GA, aldolase, and root growth. pathway and may play an important role this review, we discuss the relationship among GA, aldolase, and root growth.

关键词： aldolase gibberellin proteome rice

Coupled alkali feldspar dissolution and secondary mineral precipitation in batch systems: 5. Results of K-feldspar hydrolysis experiments

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Chinese Journal Of Geochemistry 2015年第1期34卷 1-12页

作者： Peng Lu Hiromi konishi Eric Oelkers Chen Zhu Department of Geological sciences Indiana University EXPEC Advance Research Center Saudi Aramco Oil Company Department of Geology Faculty of Science Niigata University Laboratoire de Geochimie CNRS 38 Rue Des Trente-Six Ponts31400 Toulouse France Earth sciences University College London Department of Earth sciences Zhejiang University

This paper explores how dissolution and precipitation reactions are coupled in batch reactor experimental systems at elevated temperatures. This is the fifth paper in our series of ‘‘Coupled Alkali Feldspar Dissolution and secondary Mineral Precipitation in Batch systems.'' In the previous four papers we presented batch experiments of alkali-feldspar hydrolysis and explored the coupling of dissolution and precipitation reactions(Fu et al. in Chem Geol91:955–964, 2009; Zhu and Lu in Geochim Cosmochim Acta 73:3171–3200, 2009; Zhu et *** Geochim Cosmochim Acta 74:3963–3983, 2010; Lu et al. in Appl Geochem30:75–90, 2013). Here, we present the results of additionalK-rich feldspar hydrolysis experiments at 150 °C. Our solution chemistry measurements have constrained feldspar dissolution rates, and our high resolution transmission electron microscopy work has identified boehmite precipitation. Reaction path modeling of K-feldspar dissolution and boehmite precipitation simulated the coupled reactions, but only with forced changes of boehmite rate law in the middle of experimental duration. The results which are reported in this article lend further support to our hypothesis that slow secondary mineral precipitation explains part of the wellknown apparent discrepancy between lab measured and field estimated feldspar dissolution rates(Zhu et al. in Water–rock interaction, 2004).

关键词：沉淀反应水解实验长石溶解批处理系统次生矿物碱性长石钾长石高分辨透射电子显微镜

Data-driven derivation of partial differential equations using neural network model

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International Journal of Modeling, simulation, and scientific Computing 2021年第2期12卷 1-19页

作者： Koji Koyamada Yu Long Graduate Takuma Kawamura Katsumi konishi Academic Center for Computing and Media studies Kyoto University Yoshida-honnmachi Sakyo-kuKyoto 606-8501Japan school of Engineering Kyoto University Yoshida-honnmachi Sakyo-kuKyoto 606-8501Japan Center for Computational science and e-systems Japan Atomic Energy Research Institute 148-4 Kashiwanoha Campus 178-4 WakashibaKashiwa-CityChiba 277-0871Japan Faculty of Computer and Information sciences Hosei University 3-7-2Tajino-cho Koganei-shiTokyo 184-8584Japan

It has become critical to develop explanatory models using partial differential equations(PDEs)for big data from interesting scientific phenomena,e.g.,fluids,atmosphere,and cosmic *** data are often measured at discrete spatiotemporal *** this paper,we assume a PDE and consider a set of the PDE solution data at multiple discrete points as pseudo-measurement *** a data-driven PDE derivation,it is assumed that the PDE is a linear regression model comprising partial temporal and spatial differential terms,where the coefficients are estimated using regression analysis techniques,and the PDE derivation accuracy is defined as the difference(i.e.,error)between the exact and estimated coefficients.A spatiotemporal model is required to calculate the partial temporal and spatial differential terms;thus,we employ a spatiotemporal model based on a neural network(NN)obtained from big *** develop the data-driven PDE derivation technique,we employ PDEs with exact solutions such that we can calculate the differential terms by differentiating them analytically at multiple discrete *** we assume an activation function in the NN model,the partial differential term can be derived using a chain *** NN model accuracy is measured by the loss function and error between the exact and estimated partial differential *** addition,we clarify a requirement for an NN structure that can maximize the PDE derivation and NN model accuracy by varying the NN meta-parameters,i.e.,the numbers of NN layers and neurons.

关键词： Neural network partial differential equation regression analysis

Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma

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Protein & Cell 2010年第8期1卷 711-717页

作者： Takuma Hayashi Akiko Horiuchi Kenji sano Nobuyoshi Hiraoka Yae Kanai Tanri shiozawa susumu Tonegawa Ikuo konishi Department of Immunology and Infectious Disease Shinshu University Graduate School of MedicineMatsumotoNagano 390-8621Japan Department of Obstetrics and Gynecology Shinshu University School of MedicineMatsumotoNagano 390-8621Japan Department of Laboratory Medicine Shinshu University HospitalMatsumotoNagano 390-8621Japan Pathology Division National Cancer Center Research InstituteTokyo 104-0045Japan Picower Institution and Department of Biology Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA Department of Obstetrics and Gynecology Kyoto University Graduate School of MedicineSakyo-kuKyoto 606-8501Japan Promoting Business using Advanced Technology Japan Science and Technology Agency(JST)Kawaguchi-shiSaitama 332-0012Japan

Uterine tumors are the most common type of gynecologic *** leiomyosarcoma(LMs)is rare,accounting for 2%to 5%of tumors of the uterine *** LMs develops more often in the muscle tissue layer of the uterine body than in the uterine *** development of gynecologic tumors is often correlated with female hormone secretion;however,the development of uterine LMs is not substantially correlated with hormonal conditions,and the risk factors are not yet *** evaluation combined with PET/CT can be useless in the diagnosis and surveillance of uterine ***,a diagnostic biomarker,which distinguishes malignant LMs and benign tumor leiomyoma(LMA)is yet to be ***,it is necessary to analyze risk factors associated with uterine LMs in order to establish a method of ***2-deficient mice spontaneously develop uterine LMs,with a disease prevalence of~40%by 14 months of *** is therefore of interest whether human uterine LMs shows a loss of LMP2 *** found LMP2 expression is absent in human LMs,but present in human ***,defective LMP2 expression may be one of the risk factors for ***2 is potentially a diagnostic biomarker for uterine LMs,and gene therapy with LMP2-encording DNA may be a new therapeutic approach.

关键词： LMP2 uterine leiomyosarcoma uterine leiomyoma diagnostic biomarker

Analysis of Field Emission Properties of Carbon Nanocoils for Imaging Materials

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仪器仪表学报 2004年第S3期 72-75+115页

作者： Yasumoto konishi,Hiroyoshi Tanaka,Yoshikazu Nakayama,Osamu suekane,Toshikazu Nosaka Department of Physics and Electronics Osaka Prefecture University sakai Osaka 599-8531 Japan Department of Physics and Electronics Osaka Prefecture University sakai Osaka 599-8531 Japan Department of Physics and Electronics Osaka Prefecture University sakai Osaka 599-8531 Japan Innovation Plaza Osaka Japan science and Technology Agency Izumi Osaka 594-1144 Japan Handai Frontier Research Center Graduate school of Engineering Osaka University Osaka 565-0871 Japan Handai Frontier Research Center Graduate school of Engineering Osaka University Osaka 565-0871 Japan Innovation Plaza Osaka Japan science and Technology Agency Izumi Osaka 594-1144 Japan Technology Research Institute of Osaka Prefecture Izumi Osaka 594-1157 Japan

Carbon nanotubes and nanocoils are expected as the charging materials and electron gun for the imaging devices. It is synthesized for carbon nanocoils with different diameters by the catalytic thermal decomposition of acetylene using iron-indium-tin-oxide catalysts. It is found that the turn-on voltage is decreased by decreasing the average diameter of the grown carbon nanocoils. The turn on voltage of as low as 30 V at the electrodes' gap of 130 μm has been achieved when the coil diameter is decreased to 60 nm. The calculation for the concentration of the electric field on the coil surface has been performed using a finite element method. It is obtained that the strength of electric field around the top ring of a coil is increased with the decrease of the tubular diameter of the coil and has a similar value for that at the tip of a carbon nanotube, suggesting that the efficiency of the field emission from nanocoils would be higher than that from nanotubes. These results can explain the good stability of field emission from carbon nanocoils.

关键词： Carbon nanocoil Field emission Carbon nanotube Finite element method

Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer

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World Journal of Gastroenterology 2022年第32期28卷 4649-4667页

作者： Tomoyuki Fukami Atsushi shiozaki Toshiyuki Kosuga Michihiro Kudou Hiroki shimizu Takuma Ohashi Tomohiro Arita Hirotaka konishi shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Yukiko Morinaga Eiichi konishi Eigo Otsuji Division of Digestive surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Pathology Kyoto City HospitalKyoto 604-8845Japan Department of Pathology Kyoto Prefectural University of MedicineKyoto 602-8566Japan

BACKGROUND Anoctamin 5(ANO5)/transmembrane protein 16E belongs to the ANO/transmembrane protein 16 anion channel *** comprise a family of plasma membrane proteins that mediate ion transport and phospholipid scrambling and regulate other membrane proteins in numerous cell *** studies have elucidated the roles and mechanisms of ANO5 activation in various cancer ***,it remains unclear whether ANO5 acts as a plasma membrane chloride channel,and its expression and functions in gastric cancer(GC)have not been *** To examine the role of ANO5 in the regulation of tumor progression and clinicopathological significance of its expression in *** Knockdown experiments using ANO5 small interfering RNA were conducted in human GC cell lines,and changes in cell proliferation,cell cycle progression,apoptosis,and cellular movement were *** gene expression profiles of GC cells were investigated following ANO5 silencing by microarray *** staining of ANO5 was performed on 195 primary tumor samples obtained from patients with GC who underwent curative gastrectomy between 2011 and 2013 at our *** Reverse transcription-quantitative polymerase chain reaction(PCR)and western blotting demonstrated high ANO5 mRNA and protein expression,respectively,in NUGC4 and MKN45 *** these cells,ANO5 silencing inhibited cell proliferation and induced *** addition,the knockdown of ANO5 inhibited G1-s phase progression,invasion,and *** results of the microarray analysis revealed changes in the expression levels of several cyclin-associated genes,such as CDKN1A,CDK2/4/6,CCNE2,and E2F1,in ANO5-depleted NUGC4 *** expression of these genes was verified using reverse transcription-quantitative *** staining revealed that high ANO5 expression levels were associated with a poor *** analysis identified high ANO5 expression as an independent prognostic fa

关键词： Anoctamin 5 Gastric cancer Cell cycle G1/s checkpoint Cell proliferation