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Nanometric Cutting Mechanism of Cerium-Lanthanum Alloy

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Chinese Journal of Mechanical Engineering 2023年第4期36卷 155-166页

作者： Chenyu Zhao Min lai Fengzhou Fang state key Laboratory of Precision Measuring Technology&Instruments Laboratory of Micro/Nano Manufacturing Technology(MNMT)Tianjin UniversityTianjin 300072China Centre of Micro/Nano Manufacturing Technology(MNMT-Dublin) University College DublinDublin 4Ireland

Cerium-lanthanum alloy is widely used in the green energy industry,and the nanoscale smooth surface of this material is in *** cutting is an effective approach to achieving the ultra-precision machining *** dynamics(MD)simulation is usually used to reveal the atomic-scale details of the material removal mechanism in nanometric *** this study,the effects of cutting speed and undeformed chip thickness(UCT)on cutting force and subsurface deformation of the cerium-lanthanum alloy during nanometric cutting are analyzed through MD *** results illustrate that the dislocations,stacking faults,and phase transitions occur in the subsurface during *** dislocations are mainly shockley partial dislocation,and the increase of temperature and pressure during the cutting process leads to the phase transformation ofγ-Ce(FCC)intoβ-Ce(HCP)andδ-Ce(BCC).β-Ce is mainly distributed in the stacking fault area,whileδ-Ce is distributed in the boundary area between the dislocation atoms andγ-Ce *** cutting speed and UCT affect the distribution of subsurface damage.A thicker deformed layer including dislocations,stacking faults and phase-transformation atoms on the machined surface is generated with the increase in the cutting speed and ***,the cutting speed and UCT significantly affect the cutting force,material removal rate,and generated subsurface *** fluctuations in the cutting force are related to the generation and disappearance of *** research first studied the nanometric cutting mechanism of the cerium-lanthanum ally,providing a theoretical basis for the development of ultra-precision machining techniques of these materials.

关键词： Cerium-lanthanum alloy Molecular dynamics simulation Nanometric cutting subsurface damage

Experimental study on Energy storage Characteristics of sintered Ore Particle Packed Beds

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Journal of Thermal science 2025年第1期 242-253页

作者： lai Zhenya DING Liwei LYU Hongkun HOU Chenglong CHEN Jiaying GUO Xutao HAN Gaoyan ZHANG kang state Grid Zhejiang Electric Power Research Institute state key Laboratory of Clean Energy Utilization Zhejiang University

The particle packed bed energy storage system has advantages such as low costs and wide temperature ranges,which can be combined with solar thermal power generation systems to solve the inherent volatility and discontinuity of renewable *** new materials with low costs and excellent storage performances is one of the eternal research hotspots in the field of energy *** paper innovatively uses sintered ore particles as energy storage material and studies the effect of particle size on the airflow resistance characteristics,energy storage characteristics,and thermocline evolution characteristics of the packed bed through thermal energy storage *** results indicate that for the particles in the macro scale,the smaller the particle,the lower the absolute permeability of the bed and the greater the airflow *** packed bed with smaller particles has a larger specific surface area,larger bulk mass,and smaller bed ***,the packed beds with smaller particles have better thermocline characteristics,less irreversible loss,and can achieve higher thermal efficiency and higher exergy efficiency in the heat storage *** cycle thermal efficiency in packed beds with 25-40 mm,16-25 mm,and 10-16 mm particles is 53.58%,56.27%,and 57.60%,respectively,and the cycle exergy efficiency is 61.81%,69.25%,and 74.13%,***,this paper also studies the effect of discharging airflow rates on thermal storage *** experimental results indicate that suitable discharging strategies should be selected based on different heat demands.

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supercoiled DNA Minicircles under Double-strand Breaks

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Chinese Journal of Polymer science 2024年第9期42卷 1353-1359,I0007页

作者： Ye-Peng Qiao Chun-lai Ren National Laboratory of solid state Microstructures and Department of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China

Understanding how supercoiled DNA releases intramolecular stress is essential for its functional ***,the molecular mechanism underlying the relaxation process remains insufficiently *** we employed MD simulations based on the oxDNA2 model to investigate the relaxation process of a 336-base pair supercoiled minicircular DNA under double-strand breaks with two fixed *** simulations show that the conformational changes in the DNA occur continuously,with intramolecular stress release happening abruptly only when the DNA chain traverses the breakage *** relaxation process is influenced not only by the separation distance between the fixed ends but also their ***,we observe an inhibitory effect on the relaxation characterized by small angles,where short terminal loops impede DNA conformational adjustments,preserving the supercoiled *** findings elucidate the intricate interplay between DNA conformational change,DNA motion and intramolecular stress release,shedding light on the mechanisms governing the relaxation of supercoiled DNA at the molecular level.

关键词： supercoiled DNA DNA minicircle DNA relaxation oxDNA model MD simulation

Nanostructured Mn-based oxides as high-performance cathodes for next generation Li-ion batteries

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Journal of Energy Chemistry 2021年第8期30卷 547-571,I0012页

作者： Guodong Hao Qinzhi lai Hongzhang Zhang school of Chemistry and Chemical Engineering Mudanjiang Normal UniversityMudanjiang 157011China Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China Division of Energy storage Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Mn-based oxides have been regarded as a promising family of cathode materials for high-performance lithium-ion batteries,but the practical applications have been limited because of severe capacity deterioration(such as Li Mn O_(2)and Li Mn_(2)O_(4))as well as further complications from successive structure changes during cycling,low initial coulombic efficiency(such as Li-rich cathode)and oxidization of organic carbonate solvents at high charge potential(such as Li Ni0.5 Mn1.5 O4).Large amounts of efforts have been concentrated on resolving these issues towards practical applications,and many vital progresses have been carried ***,the primary target of this review is focused on different proposed strategies and breakthroughs to enhance the rate performance and cycling stability of nanostructured Mn-based oxide cathode materials for Li-ion batteries,including morphology control,ion doping,surface coatings,composite *** combination of delicate architectures with conductive species represents the perspective ways to enhance the conductivity of the cathode materials and further buffer the structure transformation and strain during *** last,based on the elaborated progress,several perspectives of Mn-based oxide cathodes are summarized,and some possible attractive strategies and future development directions of Mn-based oxide cathodes with enhanced electrochemical properties are *** review will offer a detailed introduction of various strategies enhancing electrochemical performance and give a novel viewpoint to shed light on the future innovation in Mn-based oxide cathode materials,which benefits the design and construction of high-performance Mn-based oxide cathode materials in the future.

关键词： Mn-based oxide Cathode material Electrochemical property Modification

Epigenetic regulation of drug metabolism and transport

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Acta Pharmaceutica sinica B 2015年第2期5卷 106-112页

作者： lai Peng Xiaobo Zhong Department of Pharmaceutical sciences School of Pharmacy University of Connecticut key Laboratory of system Biomedicine Center for Comparative Biomedicine Institute of Systems BiomedicineShanghai Jiao Tong University

The drug metabolism is a biochemical process on modification of pharmaceutical substances through specialized enzymatic systems. Changes in the expression of drug-metabolizing enzyme genes can affect drug metabolism. Recently, epigenetic regulation of drug-metabolizing enzyme genes has emerged as an important mechanism. Epigenetic regulation refers to heritable factors of genomic modifications that do not involve changes in DNA sequence. Examples of such modifications include DNA methylation, histone modifications, and non-coding RNAs. This review examines the widespread effect of epigenetic regulations on genes involved in drug metabolism, and also suggests a network perspective of epigenetic regulation. The epigenetic mechanisms have important clinical implications and may provide insights into effective drug development and improve safety of drug therapy.

关键词： Drug metabolism DNA methylation Epigenetics Histone modification Non-coding RNA Transporter

kinetics of Mild steel Corrosion in Aqueous Acetic Acid solutions

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Journal of Materials science & Technology 2010年第3期26卷 264-269页

作者： s.k.singh A.k.Mukherjee Department of Applied Chemistry Institute of TechnologyBanaras Hindu University Department of Chemistry University of Delhi

The kinetics of mild steel corrosion in aqueous acetic acid solution has been investigated by weight loss and polarization techniques at 25,35 and 45℃.The weight loss of mild steel at room temperature （25℃） has been found to be quite significant,indicating poor corrosion resistance in acetic *** maximum corrosion rate has been observed in 25% acetic acid solution at all three experimental *** decrease in corrosion rate after attaining a maximum value has been attributed to the deposition of corrosion product on the *** polarization curves exhibit active behaviour at each concentration and temperature with a shift towards higher current density region and increased corrosion rates at higher *** cathodic polarization curves are almost identical irrespective either of the concentration of acetic acid or *** results obtained by both the techniques are in good agreement,while the surface studies support the conclusions drawn from the weight loss method.

关键词： Corrosion Mild steel Acetic acid

Accountable attribute-based authentication with fine-grained access control and its application to crowdsourcing

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Frontiers of Computer science 2023年第1期17卷 205-218页

作者： Peng LI Junzuo lai Yongdong WU College of Information science and Technology Jinan UniversityGuangzhou 510632China

We introduce a new notion called accountable attribute-based authentication with fine-grained access control (AccABA), which achieves (i) fine-grained access control that prevents ineligible users from authenticating;(ii) anonymity such that no one can recognize the identity of a user;(iii) public accountability, i.e., as long as a user authenticates two different messages, the corresponding authentications will be easily identified and linked, and anyone can reveal the user’s identity without any help from a trusted third party. Then, we formalize the security requirements in terms of unforgeability, anonymity, linkability and traceability, and give a generic construction to fulfill these requirements. Based on AccABA, we further present the first attribute-based, fair, anonymous and publicly traceable crowdsourcing scheme on blockchain, which is designed to filter qualified workers to participate in tasks, and ensures the fairness of the competition between workers, and finally balances the tension between anonymity and accountability.

关键词： fine-grained access control anonymous authentication accountability fairness crowdsourcing blockchain

The Immersed Boundary Method for Two-Dimensional Foam with Topological Changes

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Communications in Computational Physics 2012年第7期12卷 479-493页

作者： Yongsam kim Yunchang seol Ming-Chih lai Charles s.Peskin Department of Mathematics Chung-Ang UniversityDongjakgu HeukseokdongSeoul 156-756Korea Department of Applied Mathematics Center of Mathematical Modeling and Scientific ComputingNational Chiao Tung University1001Ta Hsueh RoadHsinchu 300Taiwan Courant Institute of Mathematical sciences New York University251 Mercer StreetNew YorkNY 10012 USA

We extend the immersed boundary(IB)method to simulate the dynamics of a 2D dry foam by including the topological changes of the bubble *** the article[***,M.-***,and ***,***.229:5194-5207,2010],we implemented an IB method for the foam problem in the two-dimensional case,and tested it by verifying the von Neumann relation which governs the coarsening of a two-dimensional dry ***,the method implemented in that article had an important limitation;we did not allow for the resolution of quadruple or higher order junctions into triple junctions.A total shrinkage of a bubble with more than four edges generates a quadruple or higher order *** reality,a higher order junction is unstable and resolves itself into triple *** here extend the methodology previously introduced by allowing topological changes,and we illustrate the significance of such topological changes by comparing the behaviors of foams in which topological changes are allowed to those in which they are not.

关键词： Foam permeability capillary-driven motion immersed boundary method coarsening topological changes T1 and T2 processes

NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.E.schafer sudena Wang Michael J.schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction