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Improved measurement of electron antineutrino disappearance at Daya Bay

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Chinese Physics C 2013年第1期37卷 1-20页

作者：安丰鹏安琪白景芝 A.B.Balantekin H.R.Band W.Beriguete M.Bishai s.Blyth R.L.Brown 曹国富曹俊 R.Carr W.T.Chan 常劲帆 Y.Chang C.Chasman 陈和生 H.Y.Chen 陈申见陈少敏陈潇聪陈晓辉陈晓苏陈羽陈义学 J.J.Cherwinka 朱明中 J.P.Cummings 邓子艳丁雅韵 M.V.Diwan E.Draeger 杜小峰 D.Dwyer W.R.Edwards s.R.Ely 方绍东付金煜付在伟葛良全 R.L.Gi11 M.Gonchar 龚光华宫辉 Y.A.Gornushkin 顾文强关梦云郭新恒 R.W.Hackenburg R.L.hahn s.Hans 郝慧峰何苗贺青 k.M.Heeger 衡月昆 P.Hinrichs Y.k.Hor Y.B.Hsiung B.z.Hu 胡涛黄翰雄 H.z.Huang 黄性涛 P.Huber V.Issakov z.Isvan D.E.Jaffe s.Jetter 季筱璐季向盼姜海静焦健斌 R.A.Johnson 康丽 s.H.kettell M.kramer 关健强郭文伟郭人能 C.Y.Lai 赖万昌 W.H.Lai k.Lau L.Lebanowski J.Lee 雷瑞霆 R.Leitner 梁干庄梁嘉怡 C.A.Lewis 李飞李高嵩李秋菊李卫东李小波李小男李学潜李仪李志斌梁昊林政儒 C.L.Lin s.k.Lin 林延畅凌家杰 J.M.Link L.Littenberg B.R.Littlejohn D.W.Liu 刘金昌刘江来刘颖彪陆昌国路浩奇陆永康 k.B.Luk 马秋梅马续波马骁妍马宇蒨 k.T.McDonald M.C.McFarlane R.D.Mckeown Y.Meng D.Mohapatra Y.Nakajima J.Napolitano D.Naumov I.Nemchenok 倪浩然 W.k.Ngai 聂阳波宁哲 J.P.Ochoa-Ricoux A.Olshevski s.Patton V.Pec J.C.Peng L.E.Piilonen L.Pinsky 潘振声齐法制祁鸣钱鑫 N.Raper 任杰 R.Rosero B.Roskovec 阮锡超邵贝贝师恺 H.steiner 孙功星孙吉良 N.Tagg 谭耀豪 H.k.Tanaka 唐晓 H.Themann Y.Torun s.Trentalange O.Tsai k.V.Tsang R.H.M.Tsang C.E.Tull Y.C.Tung B.Viren V.Vorobe1 C.H.Wang 王灵淑王玲玉王龙泽王萌王乃彦王瑞光 W.Wang 王玺王贻芳王喆王铮王志民 D.M.Webber 魏瀚宇魏亚东温良剑 k.Whisnant C.G.White L.Whitehead Y.Williamson T.Wise H.L.H.Wong E.T.Worcester F.F.Wu 吴群习建博夏冬梅邢志忠徐建一徐晶徐吉磊徐晔薛涛杨长根杨雷叶梅 M.Yeh Y.s.Yeh B.L.Young 于泽源占亮 C.Zhang 章飞虹张家文张清民张书华张一纯张银鸿张一心张志坚张子平张智勇赵洁赵庆旺赵豫斌郑磊钟玮丽周莉周祖英庄红林邹佳恒 Institute of High Energy Physics Chinese Academy of Sciences University of science and Technology of China University of Wisconsin Brookhaven National Laboratory National United University California Institute of Technology Nanjing University Department of Engineering Physics Tsinghua University Chinese University of Hong kong shenzhen Univeristy North China Electric Power University siena College Department of Physics Illinois Institute of Technology Lawrence Berkeley National Laboratory Department of Physics University of California Department of Physics University of Illinois at Urbana-Champaign Chengdu University of Technology Joint Institute for Nuclear Research shanghai Jiao Tong University Beijing Normal University Joseph Henry Laboratories Princeton University Center for Neutrino Physics Virginia Tech Department of Physics National Taiwan University Institute of Physics National Chiao-Tung University China Institute of Atomic Energy University of California shandong University school of Physics Nankai University University of Cincinnati Dongguan University of Technology Department of Physics The University of Hong Kong Department of Physics University of Houston Charles University Faculty of Mathematics and Physics sun Yat-sen(Zhongshan)University College of William and Mary Rensselaer Polytechnic Institute China Guangdong Nuclear Power Group Iowa state University Xi'an Jiaotong University

We report an improved measurement of the neutrino mixing angle θ13 from the Daya Bay Reactor Neutrino Experiment. We exclude a zero value for sin22θ13 with a significance of 7.7 standard deviations. Electron antineutrinos from six reactors of 2.9 GWm th were detected in six antineutrino detectors deployed in two near （flux-weighted baselines of 470 m and 576 m） and one far （1648 m） underground experimental halls. Using 139 days of data, 28909 （205308） electron antineutrino candidates were detected at the far hall （near halls）. The ratio of the observed to the expected number of antineutrinos assuming no oscillations at the far hall is 0.944± 0.007（stat.） ± 0.003（syst.）. An analysis of the relative rates in six detectors finds sin22θ13=0.089± 0.010（stat.）±0.005（syst.） in a three-neutrino framework.

关键词： neutrino oscillation neutrino mixing reactor Daya Bay

加巴喷丁治疗疼痛性HIV相关感觉神经病的安慰剂对照试验

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世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 35-35页

作者： hahn k. Arendt G. Braun J.s. 江山 Department of Neurology Charité Campus Mitte Schumannstr. 20/21 D- 10117 Berlin Germany Dr

Background: Painful HIV- associated sensory neuropathies (HIV- sN) are a common complication of HIV infection. The pathogenesis is unknown and the treatment very limited. Gabapentin (GBP) is effective in painful diabetic neuropathy and postherpetic neuralgia and its effectiveness on painful HIV- sN has been reported anecdotally. Design: Multicenter, prospective, randomised, double- blind, placebo- controlled study. Methods: Patients were followed for a 1- week screening, a 4- week double- blind and a 2- week open treatment phase. GBP was initiated at 400 mg/d, titrated over 2 weeks to 1200 mg/d, and then either maintained at this level or - if not beneficial - titrated to 2400 mg/d. After 4 weeks the medication was unblinded and the patient had the choice to begin, to maintain or to increase GBP to 3600 mg/d. The primary outcome measure was an improvement in median pain on the Visual Analogue scale (VAs) from the screening week compared to the 4th treatment week. A secondary efficacy measure was the median sleep score (VAs). Results: 15 patients received GBP and 11 placebo. In each group one patient dropped out during the double- blind phase. Median pain (GBP 5.1; placebo 4.7) and sleep score (GBP 4.5; placebo 5.6) did not differ between both groups at baseline. In the GBP- group there was a significant decrease of the pain to 2.85 (- 44.1 % ) as well as of the sleep VAs to 2.3 (- 48.9 % ). No significant decrease in the pain (median VAs = 3.3, - 29.8 % ) as well as in the sleep score (median VAs = 4.95, - 11.6% ) was observed in the placebo- group. GBP was generally well tolerated. The most frequent side effect was somnolence reported in 80 % of GBP- treated patients. Conclusions: GBP was more effective than placebo in reducing pain and sleep interference in patients with HIV- sN.

关键词： HIV相关疼痛性加巴喷丁安慰剂对照维持剂量睡眠障碍视觉模拟发病机制

Combined Add-on supplementation of Omega-3 Fatty Acids, Vitamin E, Vitamin A, Copper, and selenium in Rheumatoid Arthritis

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Food and Nutrition sciences 2011年第7期2卷 714-723页

作者： Janina Willers sabine Fasse Nils Putschky Henning Zeidler Hans-Georg Pott Michael Bernateck Winfried Demary Reinhard Hein Vu Vi Pham Rainer stange Bernhard Uehleke Heike Franziska Weidemann Guido Hoese Ralf Lichtinghagen Andreas hahn 不详

Objectives: The present study evaluated the effects of a combined nutritional supplement, containing omega-3 fatty acids (ω-3 FA) and different antioxidative micronutrients on nutrient status and disease activity in patients with rheumatoid arthritis (RA). Methods: The study was conducted as a double-blind, randomised placebo-controlled trial. A hundred patients with defined RA were allocated to the verum or placebo group. During a period of twelve weeks they were given three capsules of their specific study supplementation every day. The daily dosage of ω-3 FA was 1.35 g (thereof 900 mg eicosapentaenoic acid, EPA), 90 mg vitamin E, 600 μg vitamin A, 3 mg copper, and 75 μg selenium, or soy oil (placebo), respectively. Outcome variables were the changes in DAs 28, the number of tender and swollen joints, morning stiffness, and supply with different nutrients (e.g. serum concentration of EPA, AA and vitamin E), as well as blood lipid levels. Results: sixty-four participants were included in this analysis: 30 receiving verum and 34 placebo. After twelve weeks of intervention, little but not significant improvements were observed in the DAs 28 and other clinical factors. subgroup analysis revealed that the effect was much more pronounced in patients who were at least at a moderate activity of illness. Regarding the nutritional status, the serum concentration of EPA (P sOD (P sed significantly, while AA (P sed after supplementation. The concentration of triglycerides decreased significantly in the verum group (P sions: A twelve week add-on supplementation of a combined food supplement (ω-3 FA + antioxidants) effected modest but not significant changes in the clinical parameters in RA. Though vitamin E, sOD and GPx improved significantly, equivalent to an increased antioxidant defence. This supplementation was dedicated to enhance the nutritional s

关键词： Rheumatoid Arthritis Nutrition Omega-3 Fatty Acids Antioxidants Lipid Profil

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结肠直肠癌姑息治疗的改进

德国医学 2001年第4期18卷 220-221页

作者： A.Wein C.Riedel B.Hanke s.Lampert W.Brückl B.Reingruber W.Hohenberger E.G.hahn 张林 Medizinischeklinik I mit Poliklinik Friedrich-Alexander-Universitat Erlangen-NumbergKrankenhausstrabe 12D-91054 ErlangenGermany Medizinischeklinik I mit Poliklinik Friedrich-Alexander-Universitat Erlangen-Numberg 华中科技大学同济医学院附属同济医院

结肠直肠癌的发病率约为50/100?000,占女性肿瘤的第二位和男性肿瘤的第三位.约20?000例病人可以形成同时或异时的转移,最常见为肝转移.这类病人是行转移灶切除术的绝对适应证,因为根治手术的5年生存率可以达到25%～38%.如果不能切除的话... 详细信息

结肠直肠癌的发病率约为50/100?000,占女性肿瘤的第二位和男性肿瘤的第三位.约20?000例病人可以形成同时或异时的转移,最常见为肝转移.这类病人是行转移灶切除术的绝对适应证,因为根治手术的5年生存率可以达到25%～38%.如果不能切除的话,应该进行其他的姑息治疗,本文对此综述如下.

关键词：结肠直肠癌外科切除术治疗方法药物治疗化疗

IPNA临床实践建议:儿童激素敏感型肾病综合征的诊断和治疗

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中国合理用药探索 2023年第2期20卷 1-35页

作者： Agnes Trautmann Olivia Boyer Elisabeth Hodson Arvind Bagga Debbie s.Gipson susan samuel Jack Wetzels khalid Alhas an sushmita Banerjee Rajendra Bhimma Melvin Bonilla-Felix Francisco Cano Martin Christian Deirdre hahn Hee Gyung kang koichi Nakanishi Hesham safouh Howard Trachtman Hong Xu Wendy Cook Marina Vivarelli Dieter Hafner on behalf of the International Pediatric Nephrology Association 韩思雨(翻译) 季丽娜(翻译) 不详清华大学附属北京清华长庚医院儿科北京102218

特发性肾病综合征是最常见的儿童肾小球疾病,其特征是大量蛋白尿、低蛋白血症和(或)伴有水肿,全球每年儿童患病率为(1.15~16.90)每10万例。约有85%~90%的患者在接受糖皮质激素治疗的4~6周内可达到蛋白尿完全缓解,表现为激素敏感型肾病... 详细信息

特发性肾病综合征是最常见的儿童肾小球疾病,其特征是大量蛋白尿、低蛋白血症和(或)伴有水肿,全球每年儿童患病率为(1.15~16.90)每10万例。约有85%~90%的患者在接受糖皮质激素治疗的4~6周内可达到蛋白尿完全缓解,表现为激素敏感型肾病综合征(ssNs)。约70%~80%的ssNs患者在随访期间至少复发1次,其中多达50%的患者出现频繁复发或依赖糖皮质激素以维持蛋白尿缓解。为延长复发间隔时间,激素治疗的用药剂量和用药时长始终是热点问题之一,且患者出现激素相关并发症的概率较高。临床已应用多种激素助减药物(免疫抑制药物),但在疾病治疗过程中这些药物的选择和用药时机存在明显差异。因此,需要国际循证临床实践建议(CPRs)来指导临床实践、减少实践差异。国际儿科肾脏病学会(IPNA)召集专家小组通过对12个临床相关PICO(研究对象、干预措施、对照、结果/结局)问题进行系统的文献回顾,制定了关于儿童ssNs诊断和治疗的建议和分级。对治疗转归提出了新的定义,有助于指导治疗改变,并为重要的研究问题提供了参考。

关键词：激素敏感型肾病综合征儿童频复发型肾病综合征激素依赖型肾病综合征激素毒性儿科免疫抑制治疗

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光动力疗法治疗非小细胞肺癌

国际病理科学与临床杂志 2013年第3期33卷 185-197页

作者： Charles B simone II Joseph s Friedberg Eli Glatstein James P stevenson Daniel H sterman stephen M hahn keith A Cengel 袁光金李金銮朱宇熹凌扬 Department of Radiation Oncology Department of surgery Division of Thoracic Surgery Department of Medicine Division ofMedical Oncology Department of Medicine Division of PulmonaryAllergy and Critical CareHospital of the University of PennsylvaniaPhiladelphiaPAUSA 解放军第82医院肿瘤内科江苏淮安215008 福建省肿瘤医院放疗科福州350014 重庆医科大学附一院肿瘤科重庆400042 日本京都大学附属病院放射性肿瘤科苏州大学附属常州肿瘤医院肿瘤内科常州江苏213001

光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软... 详细信息

光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软骨外浸润的肺部肿瘤的最有效方法。对于晚期非小细胞癌患者,光动力治疗可以作为综合根治疗法的一部分,用于减轻阻塞性支气管内病变,增加可手术性或缩小所需手术范围。本文对现有发表的应用光动力疗法治疗至少10例以上非小细胞肺癌病例的研究文献进行综述,提出了光动力疗法应用的治疗建议并进行了总结。

关键词：光动力疗法肺癌支气管内姑息疗法非小细胞肺癌

丙型肝炎病毒核蛋白与转录调节因子NFAT1C和YY1的结合位点分析

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肝脏 2001年第S1期6卷 114-页

作者：黄长形 hahn Y s 西安第四军医大学唐都医院全军感染病诊疗中心 710038 Berine

Indoor Air Mycological survey and Occupational Exposure in Libraries in Mato Grosso-Central Region—Brazil

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Advances in Microbiology 2018年第4期8卷 324-353页

作者： Diniz Pereira Leite Júnior Ronaldo sousa Pereira Washington santos de Almeida sara de Almeida Alves simoes Ana Caroline Akeme Yamamoto Janaina Vasconcellos Ribeiro de souza Evelin Rodrigues Martins Fábio Alexandre Leal dos santos Rosane Christine hahn Faculty of Medicine Post Graduate Course in Health Sciences-Federal University of Mato Grosso(UFMT)CuiabáMTBrazil specialized Medical Mycology Center Federal University of Mato Grosso(UFMT)CuiabáMTBrazil University Center of Várzea Grande(UNIVAG) Várzea GrandeMGBrazil Faculty of Medicine of sao Josédo Rio Preto(FAMERP) Sao PauloSPBrazil

Background: Indoor air quality in environments where there is great circulation of people, posing risks to the health of its occupants, including allergic problems, infections and contaminations, can be aided by climatic factors, chemicals and biological agents housed in these environments, influencing the location and providing favorable conditions for the degradation of bibliographic collections. The present study investigated the presence of fungi in indoor environments in seven public and private libraries in the central region of Brazil, Mato Grosso, and verified the impact on occupational health. Results: A total of 26,194 fungal specimens were isolated from 342 dust samples collected using three techniques: Andersen’s sampler (12.3%), exposure plate dish (25.1%) and sterile swab (62.6%). A total of 184 fungal species were identified: 156 (84.8%) mycelial fungi and 28 (15.2%) yeast fungi, belonging 54 fungal genera, 43 (79.6%) mycelial fungi and 11 (20.4%) yeast fungi. The genus Aspergillus (40.6%) was one of the main fungi present in indoor air. Aspergillus niger (12.3%) was identified as the most prevalent species in literary environments, followed by Cryptococcus spp. (7.1%) and Cladosporium cladosporioides (7.0%). In relation to seasonal distribution, there was a greater fungal isolation in the dry season (54%);followed by the rainy season (46%). Conclusion: These results suggest the substrates researched in the evaluated environments presented in the form of documents, books and papers associated with dust and air humidity become suitable for microbiological proliferation. These findings highlight the importance of minimizing the risk of exposure to fungal agents, identified in pathogenic and toxigenic microenvironments in library collections.

关键词： Biological Hazards Library Collections Anemophilous Fungi Indoor Air Quality

Lancet Infect Dis:DTPa-HBV-IPV/Hib疫苗治疗侵袭性b型流感嗜血杆菌的有效性研究

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疾病监测 2018年第7期33卷 558-558页

作者： Monge s hahné sJ de Melker HE

2016年,荷兰报告该国5岁以下儿童患侵袭性b型流感嗜血杆菌（b,Hib）疾病的发病率升高。自2011年开始,荷兰引入了六价白喉、破伤风和无细胞百日咳–乙型肝炎病毒–灭活脊髓灰质炎病毒/Hib疫苗（DTPa-HBV-IPV/Hib）。2018年7月刊载了一项... 详细信息

2016年,荷兰报告该国5岁以下儿童患侵袭性b型流感嗜血杆菌（b,Hib）疾病的发病率升高。自2011年开始,荷兰引入了六价白喉、破伤风和无细胞百日咳–乙型肝炎病毒–灭活脊髓灰质炎病毒/Hib疫苗（DTPa-HBV-IPV/Hib）。2018年7月刊载了一项研究,旨在评估该六价疫苗的有效性,以进一步判断侵袭性Hib疾病发病率的增加是否与该疫苗的有效性降低有关系。

关键词： b型流感嗜血杆菌疫苗治疗 Lancet 有效性侵袭性疾病发病率脊髓灰质炎病毒 Hib疫苗