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高危足月儿后颅窝畸形的超声与MRI比较

国际医学放射学杂志 2015年第6期 594-594页

作者： s.j.steggerda F.T.de Brune V.E.H.j.smits-Wintjens P.Verbon F.j.Walther G.V.Wezel-Meijler 冀晓东 Department of Neonatology Leiden University Medical Centre

摘要目的旨在评估高危新生儿后颅窝畸形的特征,以及颅脑超声联合额外的乳突囟视图检测这些畸形的诊断性能,以MRI作为参考标准。方法在这项回顾性研究中,113

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早产儿白质MR影像表现的临床意义:一项2年的随访研究

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国际医学放射学杂志 2012年第1期 86-86页

作者： F.T.de Bruine A.A.van den Berg-Huysmans L.M.Leijser M.Rijken s.j.steggerda j.van der Grond 王迪 Departments of Radiology and Pediatrics Subdivision of NeonatologyLeiden University Medical CenterAlbinusdreef 2PO Box 96002300 RCLeidenthe Netherlands

目的在等价年龄段(TEA)研究弥漫超高信号强度(DEHsI)、斑点状白质(WM)病变和脑室扩张之间的联系,并对早产儿临床随访2年,探索其对神经发育的影响。材料与方法机构审查委员会给予此项前瞻性研究伦理支持并获得

关键词：早产儿 TEA 白质髓质 MR

早产儿小脑损伤的超声与MRI检出率及影像学表现

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国际医学放射学杂志 2009年第5期32卷 489-489页

作者： s.j.steggerda L.M.Leijser F.T.Wiggers-de Brune j.van der Grond F.j.Walther G.van Wezel-Meijler 秦乃姗 Department of Pediatrics Division of NeonatologyLeiden University Medical Center

目的以MR影像为参考标准．探讨一组过早产儿经前囟（AF）常规头颅超声（Us）并补充经乳突囟（MF）和后囟（PF）的超声检查小脑损伤的检出率及其影像学特征。材料与方法此前瞻性研究经学术委员会批准并获得知情同意通知。一组77例早产儿... 详细信息

目的以MR影像为参考标准．探讨一组过早产儿经前囟（AF）常规头颅超声（Us）并补充经乳突囟（MF）和后囟（PF）的超声检查小脑损伤的检出率及其影像学特征。材料与方法此前瞻性研究经学术委员会批准并获得知情同意通知。一组77例早产儿（小于32周）在新生儿期行多次超声检查，分别采用经AF、PF和MF声窗影像。其中59例在同等月龄段行MRI检查。

关键词：影像学表现 MRI检查超声检查小脑损伤早产儿检出率影像学特征学术委员会

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António j.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

早产儿基底节和丘脑弥漫性强回声是否为生理现象?

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国际医学放射学杂志 2011年第3期 283-283页

作者： G.van Wezel-Meijler L.M.Leijser F.T.Wiggers-de Brune s.j.steggerda j.van der Grond F.j.Walther 庞国栋 Department of Pediatrics Subdivision of NeonatologyLeiden University Medical Center

目的阐明早产儿(孕期<32周)基底节和丘脑(BGT)回声(EG)是否为生理现象。材料与方法本研究经医学伦理委员会批准,获得知情同意书。130例早产儿相继行头

关键词：生理现象回声反射声基底节早产儿弥漫性间脑丘脑

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira M.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic