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岩石压人硬度与声发射参数关系的研究

成都地质学院学报 1993年第1期20卷 81-86页

作者：吴光琳 s.j.jung K.A.Prisbrey 成都地质学院美国爱达荷大学

为了查明岩石压入硬度与声发射参数如累计信号数、总能量、峰值RMs(信号均方根值)、积分RMs等之间的关系,在9种不同的岩石中进行了压入试验。结果表明:岩石压入硬度与声发射信号的积分RMs有最好的相关关系。有可能利用积分RMs这一参数... 详细信息

为了查明岩石压入硬度与声发射参数如累计信号数、总能量、峰值RMs(信号均方根值)、积分RMs等之间的关系,在9种不同的岩石中进行了压入试验。结果表明:岩石压入硬度与声发射信号的积分RMs有最好的相关关系。有可能利用积分RMs这一参数来估价岩石压入硬度,并进一步预报岩石可钻性。

关键词：岩石硬度声发射参数信号

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia s.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National science Foundation(NsF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António j.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study

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World journal of Gastroenterology 2007年第47期13卷 6356-6364页

作者： EM jung DA Clevert AG schreyer s schmitt j Rennert R Kubale s Feuerbach F jung Department of Diagnostic Radiology University Hospital RegensburgFranz-Josef Strauss-Allee 11Regensburg 93043Germany Department of Radiology Ultrasound SectionGroβhadern HospitalLudwig Maximilian University of MunichMarchioninistr15Mnchen 81377Germany Department of Trauma surgery Passau HospitalInnstraβe 76Passau 94034Germany Institutes of Radiology Nuclear Medicine and UltrasoundPirmasens HospitalGermany Center for Biomaterial Development Institute of Polymer ResearchGKSSKantstr55Teltow 14513Germany

AIM: To establish the extent to which contrast enhancement with sonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODs: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL sonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. REsULTs: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUsION: The results show the poss

关键词： Liver tumors Malignant tumor Contrast harmonic imaging Quantitative contrast enhancement

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Denitrification Rates and Their Controlling Factors in streams of the Han River Basin with Different Land-Use Patterns

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Pedosphere 2014年第4期24卷 516-528页

作者： s.P.jung Y.j.KIM H.KANG school of Civil and Environmental Engineering Yonsei UniversitySeoul 120-749(Korea) River and Coastal Research Division Korea Institute of Construction TechnologyGoyang 211-712(Korea)

Land-use patterns can affect various nutrient cycles in stream ecosystems, but little information is available about the effects of urban development on denitrification processes at the watershed scale. In the presented study, we investigated the controlling factors of denitrification rates within the streams of the Han River Basin, Korea, with different land-use patterns, in order to enhance the effectiveness of water resource management strategies. Ten watersheds were classified into three land-use patterns （forest, agriculture and urban） using satellite images and geographic information system techniques, and in-situ denitrification rates were determined using an acetylene blocking method. Additionally, sediment samples were collected from each stream to analyze denitrifier communities and abundance using molecular approaches. In-situ denitrification rates were found to be in the order of agricultural streams （289.6 mg N20-N m-2 d-1）〉 urban streams （157.0 mg N20-N m-2 d-1）〉 forested streams （41.9 mg N20-N m-2 d-l）. In contrast, the average quantity of denitrifying genes was the lowest in the urban streams. Genetic diversity of denitrifying genes was not affected by watershed land-use pattern, but exhibited stream-dependent pattern. More significance factors were involved in denitrification in the sites with higher denitrification rates. Multiple linear regression analysis revealed that clay, dissolved organic carbon and water contents were the main factors controlling denitrification rate in the agricultural streams, while dissolved organic carbon was the main controlling factor in the urban streams. In contrast, temperature appeared to be the main controlling factor in the forested streams.

关键词： denitrifier communities denitrifying genes nutrient cycle stream ecosystem

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Deposition of Nano-scaled Coatings Using Inductively Coupled Plasma

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journal of Rare Earths 2004年第Z2期22卷 153-156页

作者： D H jung B Park j j Lee school of Materials science and Engineering College of EngineeringSeoul National UniversitySeoul 151-744Korea School of Materials Science and EngineeringCollege of EngineeringSeoul National UniversitySeoul 151-744Korea School of Materials Science and EngineeringCollege of EngineeringSeoul National UniversitySeoul 151-744Korea

Nano-scaled Ti-B-N coatings could be produced by inductively coupled plasma (ICP) assisted magnetron spurtering. The properties and microstructure of the coating can be changed drastically by applying ICP to conventional magnetron sputtering. In this work, an internal type rf ICP process is used. The core of this technology is the efficient production and control of self-depositing ions and reactive gas ions by an induced electric field. Ti-B-N coatings were prepared by using a TiB2 target and a gas mixture of N2 and Ar at 200 ℃ and a pressure of 60 mTorr. In addition to ICP, the effect of the substrate bias voltage on the structure and properties of the coating was investigated. By applying ICP and a bias voltage to the substrate the hardness of the Ti-B-N coating is increased by more than 75 GPa, as a result of enhanced ionization in the plasma. The Ti-B-N coating, which has the highest hardness, shows the best surface uniformity and a very dense structure with a grain size of 3 nm. This sample also shows a high crystallinity compared to the coating prepared using other deposition parameters.

关键词： nano-scaled coatings industively conpled plasma