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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang sung Gwang‑Hee Lee Byoungjoon Hwang sojung seo Ji‑Hun seo Dong‑Wan Kim Department of Materials science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea school of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(sPE)design that simultaneously mitigates solvent-related problems and improves ***-sPE exhibits high ion conductivity(2.8×10^(−3)s cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-sPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the sPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

基于肌酐和体积法GFR测量肾移植供体肾功能的比较

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国际医学放射学杂志 2016年第1期 84-84页

作者： D.K.Choi s.M.Choi B.H.Park B.C.Jeong s.i.seo s.s.Jeon 杨献峰 Department of Urology Samsung Medical CenterSungkyunkwan University School of Medicine

摘要目的评价不同方法测量肾小球滤过率(GFR)并与直接法测量GFR(d GFR)进行比较,并尝试建立一个基于CT所测肾脏体积的测量GFR的公式。材料与方法采用肌酐法(MDRD、Cockcroft-Gault公式、CKD-EPi公式和Mayo诊所公式)和Herts法(基于体积)... 详细信息

摘要目的评价不同方法测量肾小球滤过率(GFR)并与直接法测量GFR(d GFR)进行比较,并尝试建立一个基于CT所测肾脏体积的测量GFR的公式。材料与方法采用肌酐法(MDRD、Cockcroft-Gault公式、CKD-EPi公式和Mayo诊所公式)和Herts法(基于体积)测量GFR(v GFR)。比较不同的GFR评价方法并通过多元线性回归分析建立了一个新的v GFR的模型。结果基于肌酐测量GFR的结果中,MDRD和C-G公式所测值均与d GFR相关(相关性和一致系数分别为0.359、0.369和0.354、0.318)。得出的基于肾脏体积的

关键词： GFR 肾脏体积肾功能肌酐

Arctic sea-ice extent: No record minimum in 2023 or recent years

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Atmospheric and Oceanic science Letters 2025年第1期18卷 52-55页

作者： Ola M.Johannessen Tor i.Olaussen Nansen scientific society BergenNorway Nansen Environmental and Remote sensing Center BergenNorway

Arctic sea-ice extent reaches its minimum each year in september. On 11 september 2023 the minimum was 4.969 million square kilometers(***^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 ***^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. in general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing CO_(2) in the atmosphere, where the increase of CO_(2) in recent decades explains about 80% of the decrease in sea ice in september, while the remainder is caused by natural variability.

关键词： sea ice Arctic Minimum ice Climate

Work function tuned, surface Cs intercalated BiVO_(4) for enhanced photoelectrochemical water splitting reactions

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Journal of Energy Chemistry 2022年第5期31卷 612-623页

作者： shankara s.Kalanur Hyungtak seo Department of Materials science and Engineering Ajou UniversitySuwon 443-739Republic of Korea Department of Energy systems Research Ajou UniversitySuwon 443-739Republic of Korea

Monoclinic BiVO_(4) is a widely researched semiconductor in solar water splitting owing to its suitable characteristics. However, BiVO_(4) faces limitations, such as the inefficient separation and transportation of photogenerated charges in the bulk and poor catalytic water oxidation reactions at the surface that affect the water-splitting efficiency. in this work, the Cs intercalation strategy at the surface of BiVO_(4) is proposed for the enhanced water splitting to H_(2) and O_(2) productions via the effective separation and transportation photogenerated charges and improved surface catalytic water oxidation reactions. The Cs ions are found to intercalate at the surface of BiVO_(4) and regulate the oxygen vacancies to provide active O_(2) production sites and stability. The surface intercalation of Cs boosts the photocurrent to 1.89 mA cm^(-2)at 1.23 V *** hydrogen electrode(RHE). A stoichiometric evolution of H_(2) and O_(2) is recorded with a faradaic efficiency of 92%. The open-circuit voltage measurements confirmed the increase in the carrier lifetime with the work function tuning upon Cs intercalation. The proposed Cs intercalation strategy suggests an effective route to suppress the charge recombination with an increase in carrier lifetime and charge separation in BiVO_(4) for the enhanced PEC application.

关键词： Cesium BiVO_(4) Annona structure surface intercalation Photoelectrochemical water splitting

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Microstructural Evolution in Directionally solidified Ni-Base superalloy iN792+Hf

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Journal of Materials science & Technology 2008年第1期24卷 110-114页

作者： s.M.seo i.s.Kim J.H.Lee C.Y.Jo H.Miyahara K.Ogi High Temperature Materials Research Group KiMs Changwon641-010Korea Dept.of Metall.& Mater.Eng. Changwon Univ. Changwon641-773Korea Dept.of Mater.sci.& Eng. Kyushu Univ. Fukuoka819-0395Japan Oita National College of Technology Oita 870-0152Japan

Microstructural evolution during directional solidification （Ds） of Ni-base superalloy iN792＋Hf has been investigated with an emphasis on theγ′precipitates and MC-type *** quantitative image analyses revealed that the increase in the solidification rate up to 100μm/s at constant thermal gradient of 178 K/cm resulted in a fine and uniform distribution ofγ′*** relationship between the as-castγ′size and cooling rate was also determined for Ds iN792＋*** the mean time,the MC carbide size was found to be dependent both on the solidification rate and the s/L interface morphology while the area fraction of MC carbide was significantly influenced by the s/L interface morphology.

关键词： iN792 MC corbide Gamma prime solidification rate

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBi)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

statistical determination of significant curved i-girder bridge seismic response parameters

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Earthquake Engineering and Engineering Vibration 2013年第2期12卷 251-260页

作者： Junwon seo Department of Civil Construction & Environmental EngineeringIowa State University

Curved steel bridges are commonly used at interchanges in transportation networks and more of these structures continue to be designed and built in the United states. Though the use of these bridges continues to increase in locations that experience high seismicity, the effects of curvature and other parameters on their seismic behaviors have been neglected in current risk assessment tools. These tools can evaluate the seismic vulnerability of a transportation network using fragility curves. One critical component of fragility curve development for curved steel bridges is the completion of sensitivity analyses that help identify influential parameters related to their seismic response. in this study, an accessible inventory of existing curved steel girder bridges located primarily in the Mid-Atlantic United states （MAUs） was used to establish statistical characteristics used as inputs for a seismic sensitivity study. Critical seismic response quantities were captured using 3D nonlinear finite element models. influential parameters from these quantities were identified using statistical tools that incorporate experimental Plackett-Burman Design （PBD）, which included Pareto optimal plots and prediction profiler techniques. The findings revealed that the potential variation in the influential parameters included number of spans, radius of curvature, maximum span length, girder spacing, and cross-frame spacing. These parameters showed varying levels of influence on the critical bridge response.

关键词： Plackett-Burman design pareto plot prediction profiler statistical characteristics steel bridge seismic response