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Validation and application of Vierordt’’s spectrophotometric method for simultaneous estimation of tamoxifen/coenzyme Q10 in their binary mixture and pharmaceutical dosage forms

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Asian Journal of Pharmaceutical sciences 2016年第2期11卷 318-325页

作者： Eman s. El-Leithy Rania s. Abdel-Rashid Department of Pharmaceutics Faculty of Pharmacy Helwan University

For the sake of improving patient compliance and sustainability of chemotherapy healthcare system, both TC and CoQ10 were formulated as solid lipid nanoparticles (sLNs). The study was focused on establishing and validating a simple and reproducible spectrophotometric method for simultaneous determination of TC and CoQ10 in their binary mixture or pharmaceutical dosage forms. A new method based on simultaneous estimation of drug mixture without prior separation was developed. Validation parameters were checked with International Conference on Harmonization (ICH) guidelines. The accuracy and reproducibility of proposed method was statistically compared to HPLC. The TC and CoQ10 were quantified at absorptivity wavelengths of 236 nm and 275 nm, respectively. Calibration curves obeyed Beer’s law in range of 2–14 μg/ml with a correlation coefficient (R^2) of 0.999 in both methanol and simplified simulated intestinal fluid (ssIF). The %means recovery of TC and Co Q10 in pure state or binary mixture at various concentration levels were all around 100%.The low values of sD and %RsD (sion and accuracy of the proposed method. Formulated sLNs showed different %means recovery in range 81–92% for TC and 32–59% for CoQ10. The data obtained by applying simultaneous Vierordt’s equations showed no statistical significance in comparison to HPLC. Vierordt’s method was successfully applied as a simple, accurate, precise, and economical analysis method for estimating TC and CoQ10 concentrations in pure state, binary mixture and pharmaceutical dosage forms.

关键词： Tamoxifen citrate Coenzyme Q10 Binary mixture solid lipid nanoparticles Validation

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Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared s.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

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miRNA expression profiles in cerebrospinal fluid and blood of patients with Alzheimer’s disease and other types of dementia-an exploratory study

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Translational Neurodegeneration 2016年第1期5卷 40-51页

作者： sofie sølvsten sørensen Ann-Britt Nygaard Thomas Christensen Department of Neurology Copenhagen University HospitalNordsjællands HospitalDyrehavevej 293400 HillerødDenmark Department of Clinical Biochemistry Copenhagen University HospitalNordsjællands HospitalDyrehavevej 293400 HillerødDenmark

Background:MicroRNAs(miRNAs)are small non-coding RNA molecules that function as posttranscriptional regulators of gene *** of miRNAs in cerebrospinal fluid(CsF)and blood have just started gaining attention as a novel diagnostic tool for various neurological *** purpose of this exploratory investigation was to analyze the expression of miRNAs in CsF and blood of patients with Alzheimer’s disease(AD)and other neurodegenerative disorders in order to identify potential miRNA biomarker candidates able to separate AD from other types of ***:CsF was collected by lumbar puncture performed on 10 patients diagnosed with AD and 10 patients diagnosed with either vascular dementia,frontotemporal dementia or dementia with Lewy *** samples were taken immediately *** RNA was extracted from cell free fractions of CsF and plasma,and a screening for 372 known miRNA sequences was carried out by real time quantitative polymerase chain reactions(miRCURY LNA™Universal RT miRNA PCR,Polyadenylation and cDNA synthesis kit,Exiqon).Results:Fifty-two miRNAs were detected in CsF in at least nine out of ten patients in both *** these,two miRNAs(let-7i-5p and miR-15a-5p)were found significantly up-regulated and one miRNA(miR-29c-3p)was found significantly down-regulated in patients with AD compared to *** hundred and sixty-eight miRNAs were frequently detected in the blood,among which miR-590-5p and miR-142-5p were significantly up-regulated and miR-194-5p was significantly down-regulated in AD patients compared to ***:Detection of miRNA expression profiles in blood and in particular CsF of patients diagnosed with different types of dementia is feasible and it seems that several expressional differences between AD and other dementia types do exist when measured in a clinically relevant *** this explorative pilot study,the deregulated miRNAs in CsF of AD patients may be associated with relevant targ

关键词： Alzheimer’s disease Dementia Neurodegenerative disease miRNA expression Diagnostic biomarker Cerebrospinal fluid Blood

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Grounded theory qualitative approach from Foucault's ethical perspective:Deconstruction of patient self-determination in the clinical setting

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World Journal of Clinical Cases 2021年第28期9卷 8312-8326页

作者： Jesús Molina-Mula Nursing and Physiotherapy Department University of Balearics IslandPalma 07122Illes BalearsSpain

This paper aims to explain the construction of the autonomous subject from Foucault's ethical perspective for the qualitative analysis of interprofessional relationships,patient-professional relationships,and moral ethics *** tried to break loose from the self,which is merely the result of a biopol-itical subjectivation and constituted an interpersonal *** this,different elements involved in the decision-making capacity of patients in a clinical setting were ***,the context in which decision-making occurs has been explained,distinguishing between traditional practices involved in self-care and the more modern conceptions that make certain possible ***,an attempt is made to explain the formation of the medicalisation of society using the transformations of what Foucault called"techniques of the self".Finally,the ethical framework for a subject's"self-creation",insisting more on the exercises of self-subjectivation,reinforcing the ethics of the self by itself,the"care of the self",has been *** role of the patient is understood as an autonomous subject to the extent that the clinical institution and the professionals involved comprehend how the patient’s autonomy in the clinical environment is *** these elements could generate grounded theory on the qualitative methodology of this *** current ethical model based on universal principles is not useful to provide a capacity for patients decision-making,relegating to the background their opinions and ***,a new ethical perspective emerges that aims to return the patient to the fundamental axis of attention.

关键词： Decision making Personal autonomy Foucault Principle-based Ethics Bioethics,Qualitative methodology,Grounded theory

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Pathophysiology and treatment of Barrett's esophagus

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World Journal of Gastroenterology 2010年第30期16卷 3762-3772页

作者： Daniel s Oh steven R DeMeester Department of surgery The University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States

Gastroesophageal reflux disease (GERD) affects an estimated 20% of the population in the United states. About 10%-15% of patients with GERD develop Barrett’s esophagus, which can progress to adenocarcinoma, currently the most prevalent type of esophageal cancer. The esophagus is normally lined by squamous mucosa, therefore, it is clear that for adenocarcinoma to develop, there must be a sequence of events that result in transformation of the normal squamous mucosa into columnar epithelium. This sequence begins with gastroesophageal reflux, and with continued injury metaplastic columnar epithelium develops. This article reviews the pathophysiology of Barrett’s esophagus and implications for its treatment. The effect of medical and surgical therapy of Barrett’s esophagus is compared.

关键词： Gastroesophageal reflux disease Barrett’s esophagus Lower esophageal sphincter Esophageal motility Proton pump inhibitors Antireflux surgery

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A new age in understanding adult hippocampal neurogenesis in Alzheimer’s disease

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Neural Regeneration Research 2022年第12期17卷 2615-2618页

作者： Maya A.Hanspal sébastien Gillotin MRL London Discovery MSDLondon Bioscience Innovation CentreLondonUK

several lines of evidence have established that proliferation and differentiation of neural stem cells into neurons within the sub-granular zone of the dentate gyrus,a process named adult hippocampal neurogenesis,contribute to maintaining healthy cognitive functions throughout *** rate of adult hippocampal neurogenesis decreases with aging and a premature impairment of adult hippocampal neurogenesis has been observed both in animal models of Alzheimer’s disease and human post-mortem *** causal relationship between adult hippocampal neurogenesis and the development of Alzheimer’s disease pathology has,however,not been *** is partly due to the limitation of recapitulating the development of Alzheimer’s disease pathology in rodent models and the lack of translatable biomarkers to identify tractable targets in *** it is tempting to postulate that adult hippocampal neurogenesis could be leveraged to improve cognitive deficits in Alzheimer’s disease,consensual results have yet to be reached to fully explore this *** this review,we discuss how the recent progress in identifying molecular pathways in adult hippocampal neurogenesis provides a good framework to initiate strategies for drug-based intervention in neurodegenerative diseases,especially in Alzheimer’s *** outline how discrepancies in pre-clinical disease models and experimental methodology have resulted in contradictory findings and propose a shift towards using more translatable approaches to model neurogenesis in Alzheimer’s *** particular,we review how exploring novel experimental paradigms including the use of human induced pluripotent stem cells and more complex cell culture systems,as well as standardizing protocols used to investigate evidence of neurogenesis in human tissues,could deliver deeper mechanistic insights that would kick-start innovative drug discovery efforts to promote healthy aging and cellular rejuvenation.

关键词： adult hippocampal neurogenesis Alzheimer’s disease cognition human tissue induced pluripotent stem cell mouse models neurodegeneration therapeutics tractable target

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Abscisic acid, a promising therapeutic molecule to prevent Alzheimer’s and neurodegenerative diseases

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Neural Regeneration Research 2020年第6期15卷 1035-1036页

作者： Ana María sánchez-Pérez Department of Medicine Universitat Jaume I

Neuroinflammatory processes induce neuronal damage and underlie the onset of neurodegenerative pathologies,including Alzheimer’s disease(AD)(Calsolaro and Edison,2016).several conditions,ranging from emotional stress to metabolic syndrome,including traumatic brain injury,chronic infections or gut microbiota disruption can cause or aggravate ***,aging is the major factor associated with neurodegenerative diseases.

关键词： degenerative Alzheimer diseases

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sYNTHEsIs OF ORGANO sOLUBLE AROMATIC POLY(AMIDE-IMIDE)s BAsED ON 2-(5-(3,5-DINITROPHENYL)-1,3,4-OXADIAZOLE-2-YL)PYRIDINE IN AN IONIC LIQUID

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Chinese Journal of Polymer science 2011年第6期29卷 699-711页

作者： Y.Mansoori s.shah sanaei s.V.Atghia M.R.Zamanloo Gh.Imanzadeh Department of Applied Chemistry Faculty of ScienceUniversity of Mohaghegh ArdabiliArdabil 56199-11367Iran

In this work, the syntheses of new thermally stable poly（amide-imide）s with pendant 2-pyridyl-l,3,4-oxadiazole units in n-butyl methyl imidazolium bromide as reaction media have been reported. A new dicarboxylic acid has been derived from the reaction of diamine, 2-（5-（3,5-diaminophenyl）-1,3,4-oxadiazole-2-yl）pyridine （POBD）, and trimellitic acid anhydride. Polymers were prepared from the reaction of the diimide-diacid （DIDA） and different aromatic diamines in butyl methyl imidazolium bromide, [bmim] [Br], in the presence of triphenyl phosphite （TPP） as condensing agent without needing any extra components. The prepared poly（amide-imide）s were characterized by FTIR, elemental analysis, and through the synthesis of a model compound. The prepared polymers were soluble in polar and aprotic solvents, such as DMF, DMsO, NMP and DMAc. The inherent viscosity of the polymer solutions was in the range of 0.52-1.33 dL/g measured in concentrated H2sO4 at a concentration of 0.125 g/dL at （25 ± 0.5）℃. The results are compared with the results obtained from common direct polycondensation with NMP as solvent. Polymers obtained in ionic liquid showed higher inherent viscosity than that of polymers obtained via classical method in NMP. Thermal properties of the polymers were studied with DsC and TGA methods.

关键词： Poly(amide-imide) Ionic liquid Polycondensation 1,3,4-Oxadiazole

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synergistic effect of seawater's parameters on the corrosion rate of the austenitic stainless steel 304

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Acta Metallurgica sinica(English Letters) 2010年第3期23卷 161-170页

作者： s.Atashin M.Pakshir A.Yazdani Department of Materials science and Engineering Shiraz University

In this article the corrosion rate of the austenitic stainless steel type 304, under the synergistic effect of environmental factors has been assessed via potentiodynamic polarization ***, velocity, pH and temperature are the factors which induce effects on the corrosion rate of the considered *** analysis is applied using the full two-level factorial experimental design method, which results in the contribution value of each parameter in changing the quantity of average corrosion rate in both individual and synergistic *** this quantitative analysis, qualitative analysis has been used to predict the variation *** two analyses show the important role of the synergistic action, which changes the variation direction of corrosion rate and the contribution percentage of each parameter in varying the value of corrosion *** both these analyses can show the magnitude and quality of each parameter＇s effect, which is remarkably valuable in marine applications.

关键词： stainless steel 304 Environmental parameters seawater corrosion synergistic effect

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Optical theorem,crossing property,and derivative dispersion relations:implications on the asymptotic behavior of σ_(tot)(s) and ρ(s)

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Chinese Physics C 2022年第8期46卷 72-90页

作者： s.D.Campos V.A.Okorokov Applied Mathematics Laboratory-CCTs/DFQM Federal University of São CarlosSorocaba CEP 18052-780Brazil Moscow Engineering Physics Institute National Research Nuclear University MEPhI115409 MoscowRussia

In this paper,we present some results on the behavior of the total cross section and p-parameter at asymptotic energies in proton-proton(pp) and antiproton-proton(pp) ***,we consider three of the main theoretical results in high energy physics:the crossing property,derivative dispersion relation,and optical *** use of such machinery facilitates the derivation of analytic formulas for a wide set of the measured global scattering parameters and some important relations between *** suggested parameterizations approximate the energy dependence for the total cross section and ρ-parameter for pp and pp with a statistically acceptable quality in the multi-TeV ***,the qualitative description is obtained for important interrelations,namely difference,sum,and ratio of the antiparticle-particle and particle-particle total cross *** the reduced number of experimental data for the total cross section and p-parameter at the TeV-scale,which complicates any prediction for the beginning of the asymptotic domain,the fitting procedures indicates that asymptotia occur in the energy range 25.5-130 ***,in the asymptotic regime,we obtain α_(P)=1.A detailed quantitative study of the energy behavior of the measured scattering parameters and their combinations in the ultra-high energy domain indicates that the scenario with the generalized formulation of the Pomeranchuk theorem is more favorable with respect to the original formulation of this theorem.

关键词： optical theorem derivative dispersion relations asymptotic behavior Pomeranchuk theorem

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