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Analytical investigation of steady three-dimensional problem of condensation film on inclined rotating disk by Akbari-Ganji's method

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Propulsion and Power Research 2017年第4期6卷 277-284页

作者： s.Berkan s.R.hoseini D.D.Ganji Department of Mechanical Engineering Babol University of TechnologyBabolIran

The steady three-dimensional problem of condensation film on an inclined rotating disk is illustrated in this study. The governing non-linear partial differential equations are reduced to the nonlinear ordinary differential equations system by similarity transform. The analytical solution applied to solve this system is the Akbari-Ganji's method (AGM). The velocity and temperature profiles are shown and the influence of Prandtl number and rotation ratio on the flow field, heat transfer and the Nusselt number are discussed in detail. The validity of our solutions is verified by the numerical results.

关键词： Rotating disk Condensation film Heat and mass transfer Film thickness

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Enhancement of CO_2 adsorption on nanoporous chromium terephthalate(MIL-101) by amine modification

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Journal of Natural Gas Chemistry 2012年第3期21卷 339-343页

作者： Mansoor Anbia Vahid hoseini Research Laboratory of Nanoporous Materials Faculty of ChemistryIran University of Science and TechnologyFarjam StreetNarmakTehran 16846Iran

Carbon dioxide （CO2） adsorption on a standard metal-organic framework MIL-101 and a pentaethylenehexamine modified MIL-101 （PEHA- MIL-101） are investigated and compared in this study. The adsorbent samples were characterized by XRD, FT-IR and nitrogen adsorption- desorption isotherms analysis. CO2 adsorption capacity was measured by a volumetric method. MIL-101 and PEHA-MIL-101 exhibited CO2 adsorption capacities of 0.85 and 1.3 mmO1CO2/gadsorbent at 10 bar and 298 K, respectively. It is observed that CO2 adsorption capacity was fairly improved about 50% after amine modification.

关键词： CO2 adsorption metal-organic framework MIL-101 amine modification pentaethylenehexamine (PEHA)

Fe_3O_4 nanoparticles:A powerful and magnetically recoverable catalyst for the synthesis of novel calix[4]resorcinarenes

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Chinese Chemical Letters 2012年第2期23卷 173-176页

作者： Bahador Karami s.Jafar hoseini shaghayegh Nikoseresht saeed Khodabakhshi Department of Chemistry Yasouj UniversityYasouj 75918-74831P.O.Box 353Iran Department of Chemistry Gachsaran BranchIslamic Azad UniversityGachsaran 75817lran

A simple synthesis of novel and known calix[4]resorcinarenes derivatives has been achieved by the condensation of resorcinol and different aromatic aldehydes in the presence of catalytic amounts of Fe_3O_4 nanoparticles under solvent-free *** experimental conditions have been thoroughly optimized and established,allowing significant rate enhancements and good to excellent *** reactions can be run safely without using any toxic organic solvents under mild reaction *** Fe_3O_4 nanoparticles were characterized by powdered X-ray diffraction（XRD）,transmission electron microscopy（TEM） and FT-IR spectroscopy.

关键词： Fe_3O_4 nanoparticles Calixresorcinarenes Resorcinol Arylaldehyde

Dynamic Recrystallization Behavior of a Fe-Cr-Ni super-Austenitic stainless steel

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Journal of Materials science & Technology 2009年第5期25卷 603-606页

作者： A.hoseini Asli A.Zarei-Hanzaki school of Metallurgical and Materials Engineering University of Tehran

The super-austenitic stainless steels are extensively utilized in the seamless tubes production for oil extraction industries. Due to the importance of thermo-mechanical processing in the production of these tubes, the dynamic recrystallization （DRX） characteristics of a Cr-Ni super austenitic stainless steel （1.4563） were investigated in the present study. This was performed using the hot compression testing method in the temperature range of 950-1150℃ and the strain rate of 10^-3-10^-1 s^-1. The initiation and evolution of DRX were examined through microstructural analysis. The results indicated that the recrystallized grain formed a necklace type structure at the prior austenite grain boundaries at higher strain rates. In addition, DRX nucleation occurs by bulging and successive strain induced boundary migration （sIBM）.

关键词： sanicro 28 Dynamic recrystallization super-austenitic Necklace structure

Highly efficient solvent-free synthesis of quinazolin-4(3H)-ones and 2,3-dihydroquinazolin-4(1H)-ones using tetrabutylammonium bromide as novel ionic liquid catalyst

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Chinese Chemical Letters 2010年第5期21卷 550-553页

作者： A.Davoodnia s.Allameh A.R.Fakhari N.Tavakoli-hoseini Department of Chemistry Faculty of SciencesIslamic Azad UniversityMashhad BranchMashhad 91735-413Iran

A simple and efficient procedure for the synthesis of 2-arylquinazolin-4（3H）-ones has been developed through cyclocondensation of 2-aminobenzamide with aromatic aldehydes using tetrabutylammonium bromide（TBAB） as novel neutral ionic liquid catalyst in the presence of copper（Ⅱ） chloride（CuCl;） as oxidizing agent under solvent-free conditions at 100℃.In the absence of CuCl;and under a nitrogen atmosphere,the unoxidized intermediates,2-aryl-2,3-dihydroquinazolin-4（1H）-ones,were isolated. Treatment of these intermediates with CuCl;in TBAB media gave the oxidized products 2-arylquinazolin-4（3H）-*** the other hand,cyclocondensation of 2-aminobenzamide with aromatic aldehydes in TBAB under microwave irradiation directly gave 2- arylquinazolin-4（3H）-ones.

关键词： Quinazolinones Aromatic aldehydes Tetrabutylammonium bromide(TBAB) Copper(Ⅱ) chloride(CuCl2) Microwave irradiation

Comparison the Genetic Potential of some Growth ＆ Milk Trait, s of Hybrid （Crossed） saanen with Native Goat （Lori Black Goat） versus Native Goats in Qom Province

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Journal of Agricultural science and Technology(A) 2011年第8期1卷 1297-1299页

作者： s. M. hoseini Ghazikhani M. Kalantar Department of Animal science Saveh Branch Islamic Azad University Saveh Iran Agricultural Researches Center of Qom Qom Iran

The performance of some growth and milk traits of selected Qomi native （Lori black） goats and hybrids of saanen with native goats during 2008-2010 was compared. Growth traits include birth weight （BW）, one-month weight （1 MW）, weaning weight （WW） and 6-month weight （6 MW）. Also the milk production traits was monthly milk production on 2, 3, 4, 5th months （quantitative traits） and some milk composition included dry matter （%DM）, fat （%F）, and protein （%P） percentage on during of production （qualitative traits）. There were no significant differences in sex, birth type and genetic group for BW. Also the effect of genetic groups on 1 MW, WW, and 6 MW was significant, while effects of sex and birth type on 1 MW, WW and 6 MW was not significant. Also MW （Mothe＇s weight） had no significant effect on BW, 1 MW, WW and 6 MW. The average of daily milk records was 0.48 kg for nativel and 1.1 kg for crossed goats. The maximum monthly milk records in two groups were in second month （native： 0.64 -4- 0.05, crossed： 1.44 ~： 0.12） and the minimum were in fifth month （native： 0.36 ＋ 0.03, crossed： 0.77 -4- 0.05）. %DM, %F and %P in 5th month were higher than other months in two groups. Effects of genetic groups on milk production and also on average of%F, %DM and %P were significant. This study showed that the crossbreeding has a significant effect on most milk production and growth traits in Iranian native goats.

关键词： saanen goat qomi native goat growth traits milk traits