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Effectiveness of magnetic resonance imaging and spiral computed tomography in the staging and treatment prognosis of colorectal cancer

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World Journal of Gastrointestinal surgery 2024年第7期16卷 2135-2144页

作者： Lu-na Bai Lu-Xian Zhang Department of Radiology Zhongshan Hospital Xiamen UniversityXiamen 361004Fujian ProvinceChina

BACKGROUND Colorectal cancer(CRC)is a prevalent cancer type in clinical settings;its early signs can be difficult to detect,which often results in late-stage diagnoses in many *** early detection and diagnosis of CRC are crucial for improving treatment success and patient survival ***,imaging techniques have been hypothesized to be essential in managing CRC,with magnetic resonance imaging(MRI)and spiral computed tomography(sCT)playing a significant role in enhancing diagnostic and treatment *** To explore the effectiveness of MRI and sCT in the preoperative staging of CRC and the prognosis of laparoscopic *** Ninety-five individuals admitted to Zhongshan hospital Xiamen University underwent MRI and sCT and were diagnosed with *** precision of MRI and sCT for the presurgical classification of CRC was assessed,and pathological staging was used as a *** operating characteristic curves were used to evaluate the diagnostic efficacy of blood volume,blood flow,time to peak,permeability surface,blood reflux constant,volume transfer constant,and extracellular extravascular space volume fraction on the prognosis of patients with *** Pathological biopsies confirmed the following CRC stages:23,23,32,and 17 at T1,T2,T3,and T4,*** were 39 cases at the N0 stage,22 at N1,34 at N2,44 at M0 stage,and 51 at *** pathological findings as the benchmark,the combined use of MRI and sCT for preoperative TNM staging in patients with CRC demonstrated superior sensitivity,specificity,and accuracy compared with either modality alone,with a statistically significant difference in accuracy(Pharacteristic curve analysis revealed the predictive values for laparoscopic treatment prognosis,as indicated by the areas under the curve for blood volume,blood flow,time to peak,and permeability surface,blood reflux constant,volume transfer constant,and extracellular extravascular space volu

关键词： Magnetic resonance imaging spiral computed tomography Colorectal cancer Prognosis Receiver operating characteristic curve Retrospective study

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Boosted sustained-release with iron-based MOF-derived mesoporouscarbon-spheres as a nitroimidazole drugs carrier

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Particuology 2024年第3期86卷 269-280页

作者： Danping Wu Jiaying Zou Junyi Chen Yan Li na Ma Wei Dai College of Chemistry and Materials science Zhejiang Normal UniversityJinhua321004China College of Life sciences Zhejiang Normal UniversityJinhua321004China College of Geography and Environmental sciences Zhejiang Normal UniversityJinhua321004China

Metal-organic framework(MoF)with a buildable internal structure has aroused great interest focus as self-sacrificing precursors of porous carbon(PC).however,as a drug carrier,the MOF-derived PC developed thus far are generally composed of irregular powder shape due to their crystalline nature,which consequently causing the cerebral infarction,cerebral thrombosis,and other blood *** this article,we propose a novel approach to constructing amorphous carbon microspheres(AcMs)by dis-torting the topological network through hydrothermal treatment precursors of MIL-101(Fe).Then,a distinctive MIL-101(Fe)-derived spherical porous carbons(MsPC)is achieved through high temperature calcination toward *** of the glucose initial concentration and hydrothermal treatment time on the sphericity of the as-prepared mesoporous MsPC were investigated in *** the loading capacities and sustained-release performances of nitroimidazole drugs over MsPC through simulation internal environment of human body at different ph values was systematically *** nitro-imidazole drugs loading rate and release time of MsPC are 10% and 17 h under preferred ***,the MsPC exhibited very low toxicity on hela cells and 293T cells at the concentrations tested(10-800μg mL^(-1)).This study,therefore,supports the potential of the mesoporous carbon spheres as a carrierfor nitroimidazole drug delivery.

关键词： Ornidazole Metronidazole Carbon spheres sustained-release performance Biocompatibility

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Isolated deep convections over the Tibetan Plateau in the rainy season during 2001–2020

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Atmospheric and Oceanic science Letters 2024年第5期17卷 16-21页

作者： Ying na Chaofan Li Riyu Lu school of Atmospheric science and Remote sensing Wuxi UniversityWuxiChina Key Laboratory of Ecosystem Carbon source and sink China Meteorological Administration(ECSS-CMA)Wuxi UniversityWuxiChina Center for Monsoon system Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina state Key Laboratory of Numerical Modeling for Atmospheric sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Earth and Planetary sciences University of Chinese Academy of SciencesBeijingChina

The Tibetan Plateau(TP)is a prevalent region for convection systems due to its unique thermodynamic *** study investigated isolated deep convections(IDCs),which have a smaller spatial and temporal size than mesoscale convective systems(MCss),over the TP in the rainy season(June-september)during 2001–*** authors used satellite precipitation and brightness temperature observations from the Global Precipitation Measurement *** show that IDCs mainly concentrate over the southern *** IDC number per rainy season decreases from around 140 over the southern TP to around 10 over the northern TP,with an average *** initiation time of IDCs exhibits an obvious diurnal cycle,with the peak at 1400–1500 LsT and the valley at 0900–1000 *** IDCs last less than five hours and more than half appear for only one *** generally have a cold cloud area of 7422.9 km^(2),containing a precipitation area of approximately 65%.The larger the IDC,the larger the fraction of intense precipitation it *** contribute approximately 20%–30%to total precipitation and approximately 30%–40%to extreme precipitation over the TP,with a larger percentage in July and August than in June and *** terms of spatial distribution,IDCs contribute more to both total precipitation and extreme precipitation over the TP compared to the surrounding plain *** over the TP account for a larger fraction than MCss,indicating the important role of IDCs over the region.

关键词： Isolated deep convection Tibetan plateau Climatological characteristics Precipitation contribution Extreme precipitation

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Mapping the intellectual structure and emerging trends for the application of nanomaterials in gastric cancer:A bibliometric study

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2181-2199页

作者： Bo-na Liu Xiao-Li Gao Ying Piao Department of Oncology General Hospital of Northern Theater CommandShenyang 110015Liaoning ProvinceChina

BACKGROUND Recent reviews have outlined the main nanomaterials used in relation to gastrointestinal tumors and described the basic properties of these ***,the research hotspots and trends in the application of nanomaterials in gastric cancer(GC)remain *** To demonstrate the knowledge structure and evolutionary trends of research into the application of nanomaterials in *** Publications related to the application of nanomaterials in GC were retrieved from the Web of science Core Collection for this systematic review and bibliometric *** and Citespace were used for bibliometric and visualization *** From 2000 to 2022,the application of nanomaterials in GC developed *** keyword co-occurrence analysis showed that the related research topics were divided into three clusters:(1)The application of nanomaterials in GC treatment;(2)The application and toxicity of nanomaterials in GC diagnosis;and(3)The effects of nanomaterials on the biological behavior of GC ***,silver nanoparticles,and green synthesis are the latest high-frequency keywords that represent promising future research *** The application of nanomaterials in GC diagnosis and treatment and the mechanisms of their effects on GC cells have been major themes in this field over the past 23 years.

关键词： nanomaterials Gastric cancer Bibliometrics Drug delivery VOsviewer Citespace systematic review

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Improvement of mechanical properties and investigation of strengthening mechanisms on the Ti_(3)AlC_(2) ceramic with nanosized WC addition

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Journal of Advanced Ceramics 2024年第6期13卷 861-876页

作者： Yi Zhong Ying Liu Qinkai Jiang na Jin Zifeng Lin Jinwen Ye school of Materials science&Engineering Sichuan UniversityChengdu 610065China Yibin R&D Park Yibin Industrial Technology Research InstituteSichuan UniversityYibin 644005China

Ti_(3)AlC_(2) (TAC) has great potential for use as an ablation material in aerospace applications due to its great oxidation/ablation resistance, but its high-temperature strength and thermal shock resistance still have much room for simultaneous improvement under fast temperature variation conditions. herein, we used Ti_(3)AlC_(2) and WC powders as raw materials and successfully fabricated textured (Ti,W)_(3)AlC_(2) ceramic with small amounts of TiC and Al_(2)O_(3), and room temperature mechanical properties such as flexural strength (1146±46.9 MPa), fracture toughness (11.78±0.44 MPa·m^(1/2)), and hardness (5.81±0.11 GPa) at 5 wt% WC addition were achieved. The high-temperature strength of the ceramic was significantly improved, and better thermal shock resistance from 298 to 1173 K was simultaneously acquired together with the regulation of the elastic modulus, thermal conductivity, and thermal expansion coefficient, providing (Ti,W)_(3)AlC_(2) with more possibilities for fast-temperature variation applications. strengthening and toughening mechanisms were proposed. scanning transmission electron microscopy high-angle annular dark-field imaging (sTEM-hADDF) showed that W randomly replaced the Ti1 and Ti2 sites of Ti_(3)AlC_(2), providing a good reference for establishing crystal models, and further density functional theory (DFT) calculations based on these models indicated a higher fracture energy of (Ti,W)_(3)AlC_(2) along different crystal planes, providing superior resistance to transgranular fracture;a lower mismatch degree of (Ti,W)_(3)AlC_(2)/Al_(2)O_(3) resulted in stronger interface bonding, resulting in greater resistance to intergranular fracture as well as more balanced stress distributions at different interfaces.

关键词： mechanical properties solid solution MAX phase transmission electron microscopy(TEM) ceramic atomic structure

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Carbon-based interface engineering and architecture design for high-performance lithium metal anodes

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Carbon Energy 2024年第1期6卷 207-235页

作者： na Zhu Yuxiang Yang Yu Li Ying Bai Junfeng Rong Chuan Wu sINOPEC Research Institute of Petroleum Processing Co. Ltd.BeijingChina Beijing Key Laboratory of Environmental science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijingChina Yangtze Delta Region Academy of Beijing Institute of Technology JiaxingChina

Metallic lithium(Li)is considered the“holy Grail”anode material for the nextgeneration of Li batteries with high energy density owing to the extraordinary theoretical specific capacity and the lowest negative electrochemical ***,owing to inhomogeneous Li-ion flux,Li anodes undergo uncontrollable Li deposition,leading to limited power output and practical *** materials and their composites with controllable structures and properties have received extensive attention to guide the homogeneous growth of Li to achieve high-performance Li *** this review,the correlation between the behavior of Li anode and the properties of carbon materials is ***,we review emerging strategies for rationally designing high-performance Li anodes with carbon materials,including interface engineering(stabilizing solid electrolyte interphase layer and other functionalized interfacial layer)and architecture design of host carbon(constructing three-dimension structure,preparing hollow structure,introducing lithiophilic sites,optimizing geometric effects,and compositing with Li).Based on the insights,some prospects on critical challenges and possible future research directions in this field are *** is anticipated that further innovative works on the fundamental chemistry and theoretical research of Li anodes are needed.

关键词： carbon materials dendrites hosts interfacial layers Li metal anodes

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A scalable Pillar Layered Metal-Organic Framework for natural Gas Purification

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Chemical Research in Chinese Universities 2024年第4期40卷 675-681页

作者： LU nan LAN Lan GAO Qiang LI na BU Xian-he school of Materials science and Engineering Nankai UniversityTianjin300350P.R.China state Key Laboratory of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin300071P.R.China school of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang212003P.R.China

One-step harvest of high-purity methane(Ch_(4))from ternary propane/ethane/methane(C_(3)h_(8)/C_(2)h_(6)/Ch_(4))mixtures remains a desirable yet challenging goal for natural gas ***,adsorbents either suffer from high capacity and selectivity,or are caught in a dilemma of scalable ***,we demonstrate a scalable pillar layered metal-organic framework Ni-MOF for highly efficient one-step Ch_(4)***-MOF exhibits high C_(2)h_(6)and C_(3)h_(8)uptakes of 83.3 and 86.1 cm^(3)/g at 298 K and 100 kPa and remarkable C_(2)h_(6)/Ch_(4)(50/50,volume ratio,21.5)and C_(3)h_(8)/Ch_(4)(50/50,volume ratio,212.0)***,high C_(2)h_(6)(42.2 cm^(3)/g at 10 kPa)and C_(3)h_(8)(64.7 cm^(3)/g at 5 kPa)capacities in the low-pressure region at 298 K were realized on Ni-MOF,suggesting the strong affinities of Ni-MOF towards C_(2)h_(6)and C_(3)h_(8).Furthermore,the dynamic breakthrough experiments revealed that purifying Ch_(4)from natural gas in one-step can be achieved in Ni-MOF with high-purity(>99.8%)and productivity(346.0 cm^(3)/g).Most significantly,the production of Ni-MOF can be scalably synthesized at room temperature,rendering it promising potential for industrial *** combined advantages of exceptional separation performance,scalability,and cycle stability of Ni-MOF pave the way for one-step Ch_(4)purification from natural gas.

关键词： Metal-organic framework Adsorption and separation natural gas purification scale-up synthesis

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UsP19 stabilizes TAK1 to Regulate high Glucose/Free Fatty Acid-induced Dysfunction in hK-2 Cells

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Current Medical science 2024年第4期44卷 707-717页

作者： Xiao-hui YAN Yin-na ZhU Yan-ting ZhU Kidney Disease and Dialysis Center Shaanxi Provincial People's HospitalXi'an 710068China Department of Nephrology The Third Affiliated Hospital of Xi'an Medical UniversityXi'an 710000China Nephrology and hemodialysis Center Shaanxi Provincial People's HospitalXi'an 710068China

Objective Obesity-induced kidney injury contributes to the development of diabetic nephropathy(DN).here,we identified the functions of ubiquitin-specific peptidase 19(UsP19)in hK-2 cells exposed to a combination of high glucose(hG)and free fatty acid(FFA)and determined its association with TGF-beta-activated kinase 1(TAK1).Methods hK-2 cells were exposed to a combination of hG and ***19 mRna expression was detected by quantitative RT-PCR(qRT-PCR),and protein analysis was performed by immunoblotting(IB).Cell growth was assessed by Cell Counting Kit-8(CCK-8)viability and 5-ethynyl-2′-deoxyuridine(EdU)proliferation *** cycle distribution and apoptosis were detected by flow *** UsP19/TAK1 interaction and ubiquitinated TAK1 levels were assayed by coimmunoprecipitation(Co-IP)assays and *** In hG+FFA-challenged hK-2 cells,UsP19 was highly ***19 knockdown attenuated hG+FFA-triggered growth inhibition and apoptosis promotion in hK-2 ***,UsP19 knockdown alleviated hG+FFA-mediated PTEN-induced putative kinase 1(PINK1)/Parkin pathway inactivation and increased mitochondrial reactive oxygen species(ROs)generation in hK-2 ***,UsP19 stabilized the TAK1 protein through ***,increased TAK1 expression reversed the UsP19 knockdown-mediated phenotypic changes and PINK1/Parkin pathway activation in hG+FFA-challenged hK-2 *** The findings revealed that UsP19 plays a crucial role in promoting hK-2 cell dysfunction induced by combined stimulation with hG and FFAs by stabilizing TAK1,providing a potential therapeutic strategy for combating DN.

关键词： hK-2 cells high glucose free fatty acid dysfunction UsP19 deubiquitination

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Transverse mode-coupling instability with longitudinal impedance

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Nuclear science and Techniques 2024年第6期35卷 40-53页

作者： hai-sheng Xu Chun-Tao Lin na Wang Jing-Ye Xu Yuan Zhang Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of sciences Beijing 100049China Institute of Advanced science Facilities Shenzhen 518107GuangdongChina

Transverse mode-coupling instability(TMCI)is a dangerous transverse single-bunch instability that can lead to severe par-ticle *** mechanism of TMCI can be explained by the coupling of transverse coherent oscillation modes owing to the transverse short-range wakefield(i.e.,the transverse broadband impedance).Recent studies on future circular colliders,e.g.,FCC-ee,showed that the threshold of TMCI decreased significantly when both longitudinal and transverse impedances were *** performed computations for the circular electron-positron collider(CEPC)and observed a similar *** studies on the influence of longitudinal impedance on the TMCI threshold were *** concluded that the imaginary part of the longitudinal impedance,which caused a reduction in the incoherent synchrotron tune,was the primary reason for the reduction in the TMCI ***,the real part of the longitudinal impedance assists in increasing the TMCI threshold.

关键词： Transverse mode-coupling instability Longitudinal impedance

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striking stabilization Effect of spinel Cobalt Oxide Oxygen Evolution Electrocatalysts in Neutral ph by Dual-sites Iron Incorporation

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Energy & Environmental Materials 2024年第2期7卷 152-160页

作者： shuairu Zhu Xue Wang Jiabo Le na An Jianming Li Deyu Liu Yongbo Kuang Key Laboratory of Advanced Fuel Cells and Electrolyzers Technology of Zhejiang Province Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences1219 Zhongguan West RoadNingbo 315201China Zhejiang Institute of Tianjin University 85 Zhongguan West RoadNingbo 315201China Research Center of New Energy Research Institute of Petroleum Exploration&Development20 Xueyuan RoadBeijing 100083China Center of Materials science and Optoelectronics Engineering University of Chinese Academy of Sciences19(A)Yuquan RoadBeijing 100049China

Developing stable and efficient nonprecious-metal-based oxygen evolution catalysts in the neutral electrolyte is a challenging but essential goal for various electrochemical ***,cobalt-based spinels have drawn a considerable amount of attention but most of them operate in alkali ***,the frequently studied Co-Fe spinel system never exhibits appreciable stability in nonbasic conditions,not to mention attract further investigation on its key structural motif and transition states for activity ***,we report exceptional stable Co-Fe spinel oxygen evolution catalysts(~30%Fe is optimal)in a neutral electrolyte,owing to its unique metal ion arrangements in the crystal *** introduced iron content enters both the octahedral and tetrahedral sites of the spinel as Fe^(2+)and Fe^(3+)(with Co ions having mixed distribution as well).Combining density functional theory calculations,we find that the introduction of Fe to Co_(3)O_(4)lowers the covalency of metal-oxygen bonds and can help suppress the oxidation of Co^(2+/3+)and 0^(2-).It implies that the Co-Fe spinel will have minor surface reconstruction and less lattice oxygen loss during the oxygen evolution reaction process in comparison with Co_(3)O_(4)and hence show much better *** findings suggest that there is still much chance for the spinel structures,especially using reasonable sublattices engineering via multimetal doping to develop advanced oxygen evolution catalysts.

关键词： dual-sites iron electrocatalyst stability neutral electrolyte oxygen evolution reaction spinel oxides

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