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Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease

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World Journal of Gastroenterology 2000年第1期6卷 49-52页

作者： Indaram AVK Nandi s Weissman s Lam s Bailey B Blumstein M greenberg R Bank s Division of Gastroenterology Long Island Jewish Medical CenterAlbert Einstein College of MedicineNew YorkUSA

AIM To determine levels of cytokines incolonic mucosa of asymptomatic first degreerelatives of Crohn’s disease *** Cytokines(Interleukin(IL)1-Beta,IL-2,IL-5 and IL-8)were measured using ELIsAin biopsy samples of normal looking colonicmucosa of first degree relatives of Crohn’sdisease patients(n = 9)and from normalcontrols(n = 10)with no family history ofCrohn’s *** Asymptomatic first degree relativesof patients with Crohn’s disease had significantlyhigher levels of basal intestinal mucosalcytokines(IL-2,IL-5 and IL-8)than *** these increased cytokinelevels serve as phenotypic markers for a geneticpredisposition to developing Crohns diseaselater on,or whether they indicate early(pre-clinical)damage has yet to be further *** Asymptomatic first degreerelatives of Crohn’s disease patients have higherlevels of cytokines in their normal-lookingintestinal mucosa compared to normal controls,This supports the hypothesis that increasedcytokines may be a cause or an early event inthe inflammatory cascade of Crohns disease andare not merely a result of the inflammatoryprocess.

关键词： subject headings crohns disease cytokine/analysis intestinal mucosa

Analyzing the extent and use of impervious land in rural landscapes

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Geography and sustainability 2024年第4期5卷 625-636页

作者： Andreas Moser Jasper van Vliet Ulrike Wissen Hayek Adrienne grêt-Regamey Planning of Landscape and Urban systems(PLUs) ETH ZurichStefano-Franscini-Platz 5ZurichSwitzerland Institute for Environmental studies(IVM) Vrije Universiteit AmsterdamDe Boelelaan 1111Amsterdamthe Netherlands

The amount of impervious surface is increasing rapidly *** urban expansion has been studied extensively,the alteration of impervious land cover in rural regions remains *** particular,insights into the utilization of these sealed surfaces are crucially needed to unravel the underlying dynamics of land use changes beyond urban *** study focuses on rural regions from a swiss case study and presents an analysis of the use of sealed surfaces in such regions,rather than solely quantifying the extent of sealed *** a synergistic approach that merges detailed cadastral plans with very-high-resolution remote sensing imagery and sophisticated deep learning algorithms,we characterized the uses of sealed surfaces,including buildings and their *** findings reveal that 2.1%of the study area’s rural regions comprises sealed surfaces-an area comparable to the sealed surfaces in the urban *** these rural regions,transport infrastructure represents 68%of this impervious *** account for 12%,and their surroundings,constituting 13%,are utilized primarily for agricultural purposes,including farming and livestock *** deep learning approach achieved a classification accuracy of 72%for a shallow model and 79%for a deeper model,indicating that mapping building types is possible with reasonable *** outcomes of this study underscore the critical need to factor in the presence and utilization of impervious land cover within rural regions for the sustainable management of land resources.

关键词： soil sealing Rural areas Very-high-resolution aerial imagery Building types Convolutional neural networks Cadastral data

Detection and clearance in Alzheimer’s disease: leading with illusive chemical, structural and morphological features of the targets

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Neural Regeneration Research 2024年第3期19卷 497-498页

作者： Luís Gales i3s−Instituto de Investigação e Inovação em saúde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs−Instituto de Ciências Biomédicas Abel salazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly specific interactions between biomolecules,such as antigen-antibody,protein-ligand,or nucleic acid base pair complementary are on the basis of the organization of complex *** same principles may be tentatively used in molecular medicine for diagnosis and therapeutics.A molecule can be designed to selectively bind a protease and thereby inhibit the production of a peptide that forms toxic aggregates in the brain or an antibody may be produced to bind specifically to that peptide for detection or clearance ***,interference in biological systems is not that *** a start there is the inhibition of the physiological role of the protease;moreover,several cleavage fragments may be produced,which may continue to diverge due to putative post-translational modification and self-assembly processes,hiding the toxic target in a“soup”of peptide species varying in size,structure and chemical composition.A perspective of the current status and challenges in targeting peptide species for diagnosis and treatment in the context of Alzheimer’s disease is given.

关键词： Alzheimer diagnosis thereby

Influence of structural depth of laser-patterned steel surfaces on the solid lubricity of carbon nanoparticle coatings

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Friction 2023年第7期11卷 1276-1291页

作者： Timothy MACLUCAs Lukas DAUT Philipp grÜTZMACHER Maria Agustina GUITAR Volker PREssER Carsten GACHOT sebastian sUAREZ Frank MÜCKLICH Chair of Functional Materials Saarland UniversitySaarbrücken 66123Germany Institute for Engineering Design and Product Development TU WienWien 1060Austria INM–Leibniz Institute for New Materials Saarbrücken 66123Germany Department of Materials science&Engineering Saarland UniversitySaarbrücken 66123Germany saarene-saarland Center for Energy Materials and sustainability Saarbrücken 66123Germany

Carbon nanoparticle coatings on laser-patterned stainless-steel surfaces present a solid lubrication system where the pattern's recessions act as lubricant-retaining *** study investigates the influence of the structural depth of line patterns coated with multi-walled carbon nanotubes(CNTs)and carbon onions(COs)on their respective potential to reduce friction and *** laser interference patterning(DLIP)with a pulse duration of 12 ps is used to create line patterns with three different structural depths at a periodicity of 3.5μm on AIsI 304 steel ***,electrophoretic deposition(EPD)is applied to form homogeneous carbon nanoparticle coatings on the patterned *** ball-on-disc experiments are conducted on the as-described surfaces with an alumina counter body at a load of 100 *** results show that the shallower the coated structure,the lower its coefficient of friction(COF),regardless of the particle ***,with a minimum of just below 0.20,CNTs reach lower COF values than COs over most of the testing *** resulting wear tracks are characterized by scanning electron microscopy,transmission electron microscopy,and energy-dispersive X-ray *** friction testing,the CNTs remain in contact,and the immediate proximity,whereas the CO coating is largely *** of structural depth,no oxidation occurs on CNT-coated surfaces,whereas minor oxidation is detected on CO-coated wear tracks.

关键词： solid lubricant coatings carbon nanotubes carbon onions direct laser interference patterning(DLIP)surface structuring electrophoretic deposition(EPD)

starburst amacrine cells,involved in visual motion perception,lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients

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Translational Neurodegeneration 2023年第1期12卷 638-653页

作者： Xavier sánchez-sáez Isabel Ortuño-Lizarán Carla sánchez-Castillo Pedro Lax Nicolás Cuenca Department of Physiology Genetics and MicrobiologyUniversity of AlicanteSan Vicente del RaspeigSpain Alicante Institute for Health and Biomedi-cal Research(IsABIAL) AlicanteSpain Ramón Margalef Institute University of AlicanteSan Vicente del RaspeigSpain.

Background The main clinical symptoms characteristic of Parkinson’s disease(PD)are bradykinesia,tremor,and other motor ***,non-motor symptoms,such as visual disturbances,can be identified at early stages of the *** of these symptoms is the impairment of visual motion ***,we sought to determine if the starburst amacrine cells,which are the main cellular type involved in motion direction selectivity,are degenerated in PD and if the dopaminergic system is related to this *** Human eyes from control(n=10)and PD(n=9)donors were available for this *** immunohistochemistry and confocal microscopy,we quantified starburst amacrine cell density(choline acetyltransferase[ChAT]-positive cells)and the relationship between these cells and dopaminergic amacrine cells(tyrosine hydroxylase-positive cells and vesicular monoamine transporter-2-positive presynapses)in cross-sections and wholemount *** First,we found two different ChAT amacrine populations in the human retina that presented different ChAT immunoreactivity intensity and different expression of calcium-binding *** populations are affected in PD and their density is reduced compared to ***,we report,for the first time,synaptic contacts between dopaminergic amacrine cells and ChAT-positive cells in the human *** found that,in PD retinas,there is a reduction of the dopaminergic synaptic contacts into ChAT *** Taken together,this work indicates degeneration of starburst amacrine cells in PD related to dopaminergic degeneration and that dopaminergic amacrine cells could modulate the function of starburst amacrine *** motion perception circuitries are affected in PD,their assessment using visual tests could provide new insights into the diagnosis of PD.

关键词： Parkinson’s disease Retinal neurodegeneration Human retina ChAT amacrine cells Dopaminergic amacrine cells

sparse current source reconstruction in MCG

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science Bulletin 2015年第14期60卷 1235-1240页

作者： Mengpei Chen shiqin Jiang Lu Bing Chen Zhao Birgit Hailer Dietrich gr nemeyer Peter Van Leeuwen school of Electronics and Information Engineering Tongji University Department of Internal Medicine Philippusstift University Witten/Herdecke Faculty of Health Gro¨ nemeyer Institute for MicrotherapyUniversity Witten/Herdecke

Cardiac current source reconstruction is investigated by a fast greedy sparse(FGs) method applied to simulated and real magnetocardiography(MCG) data measured using 61-channel superconducting quantum interference device. The approach reduces the size of the lead field matrix based on a priori knowledge of dipolar magnetic field map. Consequently, the computational demands and the accuracy of sparse source reconstruction are improved simultaneously. The simulation results demonstrate that the FGs method is capable of reconstructing sparse equivalent current sources using the magnetic field data generated by a single current source with varying orientation or multiple current sources generated randomly. In addition, we analyze the cardiac current source reconstructed with real MCG data at typical instants and discuss the electrical excitation conduction during the QRs complex based on moving sparse source imaging.

关键词： Magnetocardiography (MCG) sparsedecomposition Current source reconstruction Cardiac electrical activity signal processing

sYNTHEsEs AND CHARACTERIZATIONs OF OLIGO(AZOMETHINE ETHER)s DERIVED FROM 2,2'-[1,4-ENYLENEBIs(METHYLENEOXY)]DIBENZALDEHYDE AND 2,2'-[1,2-PHENYLENEBIs(METHYLENEOXY)]DIBENZALDEHYDE

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Chinese Journal of Polymer science 2012年第5期30卷 682-693页

作者： Ismet Kaya süleyman Culhaoglu Canakkale Onsekiz Mart University Faculty of Science and ArtsDepartment of ChemistryCanakkale 17020Turkey

The oligo（azomethine ether）s were synthesized via polycondensation of alkyl diamines with aromatic dialdehydes. Two series of dialdehydes, namely 2,2＇-[1,2-phenylenebis（methyleneoxy）]dibenzaldehyde [2,2＇-1,2-（PBMODB）] and 2,2＇- [1,4-phenylenebis（methyleneoxy）]dibenzaldehyde [2,2＇-I,4-（PBMODB）] were prepared from the condensation reactions of salicylaldehyde with o-xylenedibromide and p-xylenedibromide, respectively. The structures of dialdehydes and oligomers were determined by FT-IR, 1H-NMR and 13C-NMR. The thermal analyses of oligomers were conducted by DsC and TG/DTA techniques, respectively. size exclusion chromatography （sEC） technique was also used to determine molecular weights and molecular weight distributions of oligomers. Electrochemical properties of the synthesized products were investigated.

关键词： Polyazomethine Thermal analysis Dialdehyde Oligoazomethine.

Model dependent analysis of D^(+)_(s)→η^(′)l+v_(l) decays in beyond standard model

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Chinese Physics C 2024年第9期48卷 82-95页

作者： s.Mahata M.Mandal H.Mahapatra s.Biswas s.sahoo Department of Physics National Institute of Technology Durgapur Durgapur 713209West BengalIndia

Motivated by the recent experimental results of branching fractions for D^(+)_(s)→η^(′)l+v_(l) decays,which deviate from their sM predictions,we hve investigated these decays in W' model and scalar leptoquark model to determine potential signatures of new physics(NP) in semileptonic charm decays induced by c→(s,d)l+v_(l) *** recent experimental results of branching fractions for semileptonic D meson decays,new coupling parameters are predicted for the aforementioned NP *** fraction,forward-backward asymmetry,and lepton polarization asymmetry are examined by considering the predicted NP coupling *** results of branching fractions in scalar leptoquark model are found very close to the experimental results and exist around the range of 1σ *** presented a comparative study of the NP models to check their sensitivity on these *** anticipate that further research on these decays will significantly support our findings.

关键词： charm decay new physics W′boson scalar leptoquark flavour changing charged current

Neumann＇s method for boundary problems of thin elastic shells

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Applied Mathematics and Mechanics(English Edition) 2017年第4期38卷 543-556页

作者： Y. s. NEUsTADT Department of Civil Engineering Samara State Architectural and Building University Samara 443001 Russia

The possibility of using Neumann＇s method to solve the boundary problems for thin elastic shells is studied. The variational statement of the static problems for the shells allows for a problem examination within the distribution space. The convergence of Neumann＇s method is proven for the shells with holes when the boundary of the domain is not completely fixed. The numerical implementation of Neumann＇s method normally requires significant time before any reliable results can be achieved. This paper suggests a way to improve the convergence of the process, and allows for parallel computing and evaluation during the calculations.

关键词： boundary problem thin elastic shell theory Neumann's method variational principle Korn's inequality distribution embedding theorem green tensor