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Protective effect of Prostane in experimental prostatic hyperplasia in rats

Asian Journal of Andrology 1999年第4期1卷 175-179页

作者： s.K.Mitra R.sundaram A.R.Mohan s.gopumadhavan M.V.Venkataranganna Udupa Venkatesha s.J.seshadri s.D.Autrulikar R&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 India

Aim: Prostane, a polyherbal formulation, was evaluated for its efficacy on 5α-reductase inhibition, α-adrenergic anta-gonistic activity and testosterone-induced prostatic hyperplasia. Methods: 5α-reductase inhibition was evaluated usingrat prostate homogenate as an enzyme source. Adrenergic antagonistic activity was evaluated using isolated rat vas def-erens. Experimental prostatic hyperplasia was induced in rats by giving testosterone 3 rog/kg sc for 21 days. Re-sults: Prostane dose-dependently inhibited 5α-reductase activity and exhibited α-adrenergic antagonistic activity. Treat-ment with Prostane at 250, 500 and 750 mg/kg body wt, po for 21 days significantly reduced the prostatic weight, theepithelial height and the stromal proliferation in experimental prostatic hypertrophy. Conclusion: Prostane is effectivein the treatment of experimental prostatic hypertrophy in rats and may be passed on to clinical trials on benign prostatichypertrophy after necessary toxicological evaluations. (Asian J Androl 1999 Dec; 1: 175-179)

关键词： Prostane BPH oxidoreductases adrenergic alpha-antagonists enzyme inhibitors prostate hyperplasia

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NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOs

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World Journal of Gastroenterology 2007年第7期13卷 1103-1107页

作者： MV Venkataranganna Md Rafiq s.gopumadhavan Ghouse Peer UV Babu sK Mitra R&D Center The Himalaya Drug Company Bangalore-562 123 India

AIM： To evaluate the efficacy and mechanism of action of NCB-02, a standardized Curcumin preparation, against 2, 4-dinitrochlorobenzene （DNCB）-induced ulcerative colitis in rats. METHODs： Ulcerative colitis was induced in male rats by sensitizing with topical application of DNCB in acetone for 14 d and intra-colonol challenge with DNCB on day 15. A separate group of animals with vehicle treatment in similar fashion served as control group. Colitis rats were divided into different groups and treated with NCB-02 at doses of 25, 50 and 100 mg/kg *** p.o. for 10 d. sulfasalazine at a dose of 100 mg/kg *** for 10 d served as a reference group. On day 10 after respective assigned treatment, all the animals were euthanized and the length of the colon, weight of entire colon and distal 8 cm of the colon were recorded. The distal part of the colon was immediately observed under a stereomicroscope and the degree of damage was scored. Further distal 8 cm of the colon was subject to the determination of colonic myeloperoxidase （MPO）, lipid peroxidation （LPO） and alkaline phosphatase （ALP） activities. A small piece of the sample from distal colon of each animal was fixed in 10% neutral buffered formalin and embedded in paraffin wax and sectioned for immunohistochemical examination of NFK-B and iNOs expression. REsULTs： NCB-02 showed a dose dependent protection against DNCB-induced alteration in colon length and weight. NCB-02 treatment also showed a dose dependent protection against the elevated levels of MPO, LPO and ALP, induced by DNCB. NCB-02 demonstrated a significant effect at a dose of 100 mg/kg ***., which was almost equipotent to 100 mg/kg ***. of sulfasalazine. Treatment with sulfasalazine and curcuminat a dose of 100 mg/kg ***. inhibited the DNCB-induced overexpression of NFK-B and iNOs in the colon. CONCLUsION： Curcumin treatment ameliorates colonic damage in DNCB-induced colitic rats, an effect associated with an improvement in intestinal oxidative stress and d

关键词： Curcumin Colitis Dinitrochlorobenzene NF-B iNOs

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HD-03对实验性肝硬化的抑制(英文)

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Acta Pharmacologica sinica 2000年第9期21卷 11-15页

作者： s K MITRA,U VENKATEsH UDUPA,s J sHEsHADRI,M V VENKATARANGANNA,s.gopumadhavan,s D ANTURLIKAR R&D Centre The Himalaya Drug Company Bangalore-562 123 India R&D Centre The Himalaya Drug Company Bangalore-562 123 India R&D Centre The Himalaya Drug Company Bangalore-562 123 India R&D Centre The Himalaya Drug Company Bangalore-562 123 India R&D Centre The Himalaya Drug Company Bangalore-562 123 India R&D Centre The Himalaya Drug Company Bangalore-562 123 India

AIM; To investigate the protective effect of HD-03 in experimental cirrhosis following chronic intoxication with thioacetamide (TAA). METHODs; The effect of HD-03 (750 mg/kg po) was studied in rats following TAA-induced intoxication (50 mg/kg po) for a period of 90 d. HD-03 was administered as an aqueous suspen-sion . Levels of biochemical markers indicative of hepa-totoxicity were assessed in serum and liver. Histopatho-logical evaluation of liver was also carried out to find out the protective effect of HD-03 following TAA-induced chronic intoxication. REsULTs; Administration of TAA at a dose of 50 mg/kg po for 90 d resulted in a sig-nificant derangement of serum [ serum glutamic pyruvate transaminase ( sGPT), serum glutamic oxaloacetate transaminase (sGOT) , alkaline phosphatase (ALP), al-bumin and bilirubin] and hepatic (triglycerides, protein, hydroxyproline, collagen and glycogen) biochemical pa-rameters. Histopathological evaluation of liver sections following TAA-intoxication showed necrosis and

关键词：草药医学 HD-03 肝硬化

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