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Kaphta:Text mining web tool to extract information on the anticancer activity of polyphenols

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Journal of Polyphenols 2022年第2期4卷 87-100页

作者： Ramon gustavo Teodoro marques da silva samuel Lucas santos gomes Paulo Muniz deÁvila gustavo Joséda silva Ana Lucia Fachin Edilson Carlos Caritá Mozart Marins Biotechnology Unit University of Ribeirão PretoAv.Costábile Romano 2201Ribeirão PretoSP 14096-900Brazil Federal Institute of Education Science and Technology of South of Minas Gerais–IFSULDEMINASPouso AlegreMG 37550-000Brazil Medicine school University of Ribeirão PretoRibeirão PretoSP 14096-900Brazil Centro de Ciências Exatas Naturais e TecnológicasUniversidade de Ribeirão PretoRibeirão Preto SP 14096-900Brazil

In this paper,we describe the application of Kaphta architecture,a resource for text mining of the anticancer activity of *** anticancer activity of these compounds against different types of cancer has been widely reported in the literature and they are one of the most promising molecules for the development of anticancer *** architecture,which comprises four sequential and well-defined steps,uses a hybrid approach composed of a dictionary,rules and machine learning to identify abstracts containing sentences with associations between polyphenol,cancer and gene *** application of the architecture on 23826 PubMed abstracts generated a knowledge base of indexed abstracts with 172169 sentences containing,polyphenol-cancer and polyphenol-gene associations.A Web tool was implemented that allowed the user to search for information on 2006 polyphenols,240 cancers and 3121 genes entities,and 11750 polyphenol-cancer and 9160 polyphenol-gene associations indexed in the knowledge base.A ranking algorithm calculates scores for each indexed abstract considering the number and type of sentences with entities and rules recognized.A test with users demonstrated that the visualization resources on the web tool contributes to the understanding of the association between polyphenols,genes and cancers,in comparison with the PubMed *** Kaphta architecture and web tool permits to extract knowledge on the anticancer activity of polyphenols and can thus contribute to the exploration of these molecules in the development of anticancer therapies.

关键词： polyphenols cancer text-mining

C群脑膜炎奈瑟菌所致化脓性心包炎的细胞因子激活

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 39-39页

作者： de souza A.L. marques salgado M. Romano C.C. 郭俊 Intensive Care Unit Emlio Ribas Institute of InfectologySao PauloBrazil

本文报道1例5岁男性患儿,经心包液PCR检出C群脑膜炎奈瑟菌所致化脓性心包炎,该患儿既往身体健康。心包液中的白细胞介素-6。

关键词：化脓性心包炎脑膜炎奈瑟菌细胞因子激活心包液白细胞介素男性患儿 γ-干扰素胶乳凝集试验对

Endoscopic vs radiologic gastrostomy for enteral feeding:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2023年第6期11卷 277-289页

作者： Evellin souza Valentim dos santos guilherme Henrique Peixoto de Oliveira Diogo Turiani Hourneaux de Moura Bruno salomão Hirsch Roberto Paolo Trasolini Wanderley marques Bernardo Eduardo guimarãesHourneaux de Moura Department of gastroenterology Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil Department of gastroenterology and Hepatology Hospital Harvard Medical SchoolBostonMA 02115United States

BACKgROUND Percutaneous endoscopic gastrostomy(PEg)and percutaneous radiological gastrostomy(PRg)are minimally invasive techniques commonly used for prolonged enteral *** safe,both techniques may lead to complications,such as bleeding,infection,pain,peritonitis,and tube-related *** literature is unclear on which technique is the *** To establish which approach has the lowest complication *** A database search was performed from inception through November 2022,and comparative studies of PEg and PRg were selected following the Preferred Reporting Items for systematic Reviews and Meta-analyses *** included studies compared the two techniques directly and provided absolute values of the number of *** with pediatric populations were *** primary outcome of this study was infection and ***,peritonitis,pain,and mechanical complications were secondary *** risk of bias was assessed using the Cochrane risk-of-bias tool for randomized trials(RoB2)and we used The Risk of Bias in Nonrandomized studies(ROBINs-I)to analyze the retrospective *** also performed gRADE analysis to assess the quality of *** on risk differences and 95%confidence intervals were obtained using the Mantel-Haenszel *** seventeen studies were included,including two randomized controlled trials and fifteen retrospective cohort *** total population was 465218 individuals,with 273493 having undergone PEg and 191725 *** only outcome that showed a significant difference was tube related complications in retrospective studies favoring PEg(95%CI:0.03 to 0.08;Pgh this outcome did not show significant difference in randomized studies(95%CI:-0.07 to 0.04;P=0.13).There was no difference in the analyses of the following outcomes:infection in retrospective(95%CI:-0.01 to 0.00;Pstudies;bleeding in retrospective(95%CI

关键词： gastrostomy Adverse events Meta-analysis Percutaneous endoscopic Radiological gastrostomy

Transcranial direct current electrical stimulation in combination with aerobic exercise:A pilot study in post-COVID-19 systemic autoimmune rheumatic patients

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World Journal of Rheumatology 2023年第1期11卷 1-12页

作者： Rafael giovani Missé Alexandre Moura dos santos Isabela Bruna Pires Borges Marlise sítima Mendes simões Lorenza Rosa silvério Bruna Lindoso Correia Ana Wook sook Kim Aline marques Caetano sandra gofinet Pasoto Carla gonçalves schahin saad Diogo souza Domiciano Clarice Tanaka Julia Maria D’Andrea greve Abrahão Fontes Baptista samuel Katsuyuki shinjo Division of Rheumatology Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Departamento de Fisioterapia Fonoaudiologia e Terapia OcupacionalHospital das Clínicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloNúcleo de Assistência e Pesquisa em NeuromodulaçãoSao PauloBrazil Laboratório de Estudos do Movimento Instituto de Ortopedia e TraumatologiaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil

BACKgROUND systemic autoimmune rheumatic diseases(sARDs)are a group of diseases with multiorgan involvement and a high prevalence of chronic pain and *** with sARDs and post-coronavirus disease 2019(COVID-19)syndrome experience aggravation of *** this context,it is essential to establish strategies to reduce chronic pain and fatigue and improve quality of *** To assess the efficacy of transcranial direct current stimulation(tDCs)for the treatment of fatigue and pain-associated post-COVID-19 syndrome in patients with *** This study included nine patients with different types of *** patients had reverse transcription-polymerase chain reaction(RT-PCR)test confirmed COVID-19 as well as significant,persistent fatigue and pain that began to worsen after *** tDCs was administered in five daily sessions(2mA,20 min).Concomitantly,patients were involved in aerobic exercise *** participants were evaluated using specific questionnaires and strength assessment by handgrip and physical function by timed-up-and-go test and sit-to-stand test at baseline(within one week before tDCs protocol),and one week after tDCs *** all procedures,the patients’treatments remained *** The sample comprised eight women and one man with a mean age of 48.7±9.6 *** the tDCs protocol,pain and fatigue significantly improved on the visual analog scale(Psical function also improved 9.5±2.7 vs 6.8±0.8(P=0.001)for timed-up-go-test and 10.3±3.7 vs 15.1±4.0(P=0.037)for sit-to-stand *** of the patients experienced any adverse *** The present study showed that tDCs in combination with aerobic exercise was effective in improving physical function,and reducing fatigue/pain in sARDs patients with post-COVID-19 syndrome.

关键词： Autoimmune diseases COVID-19 Fatigue Neuromodulation Physical function Rheumatic diseases Pain

Treatment of Helicobacter pylori infection in children:A systematic review

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World Journal of Meta-Analysis 2020年第4期8卷 292-308页

作者： Filipe Antônio França da silva Breno Bittencourt de Brito Maria Luísa Cordeiro santos Hanna santos marques Mariana Miranda sampaio Ronaldo Teixeira da silva Júnior Jonathan santos Apolonio Lorena sousa de Carvalho Camilo santana silva Luana Kauany de sásantos Márcio Vasconcelos Oliveira gifone Aguiar Rocha Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo Horizonte 30130-100Minas GeraisBrazil

BACKgROUND Helicobacter pylori(***)infection is predominantly acquired in *** indicated,the most accepted treatment for *** eradication in this age group is first-line triple ***,the increasing resistance to clarithromycin and nitroimidazoles has been associated with treatment failure,and thus,alternative treatment regimens have been *** To perform a systematic review of randomized controlled trials on treatment regimens for *** infection in *** We surveyed relevant articles published in English from 2010 to April 2020 in the PubMed and MEDLINE *** included“Helicobacter pylori“/”children or childhood“/”treatment or eradication.”The risk of bias was evaluated according to the Cochrane Handbook of systematic Reviews for *** Among the 1144 records identified through the database,20 articles were *** studies compared the eradication rates of *** infection between standard triple therapies,changing only the main antibiotic *** studies evaluated the effectiveness of standard triple therapy with the addition of *** study investigated the relationship between the effectiveness in the eradication rates of standard triple therapy and vitamin E *** studies analyzed the eradication rates of sequential *** The findings suggest that although standard triple therapy is the most recommended regimen for children by the current guidelines,other therapeutic schemes have shown promising results and may also be recommended for clinical practice in the future.

关键词： Helicobacter pylori Children Pediatric treatment standard triple therapy Probiotics sequential therapy Eradication therapies

Relationship between Mollicutes and spontaneous abortion:An epidemiological analysis

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World Journal of Obstetrics and gynecology 2021年第1期10卷 1-15页

作者： Maria Tânia silva Oliveira Caline Novais Teixeira Oliveira Lucas santana Coelho da silva Hellen Braga Martins Oliveira Raquel sousa Freire Lucas Miranda marques Maria Luísa Cordeiro santos Fabrício Freirede Melo Cláudio Lima souza Márcio Vasconcelos Oliveira Instituto Multidisciplinar em saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil Universidade Estadual santa Cruz Universidade Estadual Santa CruzIlhéus 45662900BahiaBrazil

BACKgROUND Abortion is of great importance in public health,as it is among the main causes of maternal morbidity and *** addition to sociodemographic-and lifestylerelated factors,studies have associated infections of the genital tract with higher rates of ***,the exacerbated presence and rise of Mollicutes in the genitourinary tract may be related to higher rates of *** To perform an epidemiological analysis of women who had spontaneous abortions and placental colonization by Mollicutes in a maternity *** This cross-sectional study involved the collection of data and biological material from women hospitalized due to spontaneous abortion or term *** sample consisted of 89 women who miscarried and 20 women who had full term *** collection was carried out in three stages:(1)Conducting research on the information and clinical data in medical records of patients hospitalized due to abortion;(2)Application of a semi-structured questionnaire to identify the patient's epidemiological profile and(3)Collection of placental *** samples were collected after the curettage procedure(abortion)and after placental expulsion(delivery),both performed by an *** identification in the fragments was performed by real-time polymerase chain *** this study,the following explanatory variables were considered:(1)sociodemographic variables;(2)Variables related to access to health services;(3)Variables related to lifestyle;and(4)Variables related to sexual and reproductive health,all of which were used to perform descriptive,univariate and multivariate *** In the final model,placental colonization by Mollicutes was independently associated with the variables age[odds ratio(OR)=7.55;CI:2.37-24.03]and menarche(OR=3.43;CI:1.03-11.44).In this investigation,the prevalence of Mollicutes colonization by at least one of the following three species:Mycoplasma hominis,Ureaplasma urealyti

关键词： Miscarriage Epidemiology Mollicutes Primary prevention

冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化

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中华心血管病杂志 2019年第1期47卷 5-25页

作者： Lorenz Raber gary s Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme giulio guagliumi 瑞士伯尔尼大学医院心内科法国让·明乔兹大学医院心内科法国勃艮第弗朗什孔德大学西班牙瓦尔德里亚马克大学医院心内科西班牙圣卡洛斯临床医院和康普顿斯大学英国国王学院医院心内科意大利圣乔万尼医院心内科意大利圣拉斐尔科学研究所介入科、心胸血管科意大利卡雷奇大学医院结构介入心脏病学瑞士苏黎世大学医院心血管外科意大利卡塔尼亚大学路得里医院心胸血管和移植科、维托里奥诊所美国纽约心血管研究基金会爱尔兰萨尔塔大学医疗集团、爱尔兰戈尔韦国立大学兰贝转化医学和康复研究意大利教皇约翰二十三世医院心内科英国布里斯托尔心脏研究所、布里斯托尔大学医院国民健康基金会信托基金丹麦奥胡斯大学医院心内科荷兰鹿特丹伊拉斯姆斯大学医疗中心心脏介入科、胸部中心丹麦哥本哈根大学国王医院心脏中心德国慕尼黑技术大学德国慕尼黑心脏中心德国慕尼黑心血管研究中心、合作网站慕尼黑心脏联盟中国哈尔滨医科大学附属第二医院心内科、教育部心肌缺血重点实验室

欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUs)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUs和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的... 详细信息

欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUs)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUs和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUs或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUs和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。

关键词：冠状动脉疾病超声检查介入性体层摄影术光学相干经皮冠状动脉介入治疗

Punica granatum Leaf Lipophilic Fraction Favours Mortality by Attenuating Inflammation in Mice with Polymicrobial sepsis

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 355-367页

作者： Nagila Caroline Fialho sousa Isabella Fernandes da silva Figueiredo Mizael Calacio de Araujo Elaine Pereira de Andrade Thais Costa Alves Bruna Letícia Rosa da silva Domingos Magno santos Pereira saulo JoseFigueiredo Mendes Joao Francisco silva Rodrigues Jaqueline Pessoa Pontes simone Aparecida Teixeira AndreAlvares marques Vale Marcus Vinicius Dias-souza Lidio goncalves Lima-Neto Vera Lucia dos santos Ana Paula Azevedo-santos Marcelo Nicolas Muscara Valerio Monteiro-Neto Andrea de souza Monteiro Luis Claudio Nascimento da silva Elizabeth soares Fernandes Programa de Pos-graduacao Universidade CEUMARua JosueMontellon°1RenascencaSao LuisMA 65075-120Brazil Departamento de Farmacologia Universidade de Sao PauloAv.Prof.Lineu Prestesn°1524Sala 326ButantanSao PauloSP 05508-900Brazil Programa de Pos-graduacao em Ciências em saude Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuisMA 65080-805Brazil Departamento de Microbiologia Universidade Federal de Minas GeraisAv.Antonio Carlosn°6627PampulhaBelo HorizonteMG 31270-901Brazil Departamento de Patologia Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuísMA 65080-805Brazil

Punica granatum *** known antimicrobial and anti-inflammatory *** of different parts of this plant have been commonly used in the folk medicine to prevent and treat infections;and studies have supported the use of *** extracts for this ***,little is known of the effects of ***-derived fractions in severe infectious diseases such as ***,we investigated the actions of the hexane fraction(HF),rich in lipophilic compounds,obtained from the leaves of this plant,in a murine model of polymicrobial *** pre-treatment with HF increased mortality in septic *** same animals presented with lower levels of interleukin-6,nitric oxide and hydrogen peroxide in their peritoneal lavage samples than vehicle *** also increased polymorphonuclear cell accumulation in to the peritoneum of mice with ***-derived nitric oxide upon lipopolysaccharide stimuli was markedly reduced by incubation with ***,triterpenes,phytosterols,vitamin E and ascorbyl palmitate were detected in the *** results indicate that *** leaf lipophilic fractions may worsen sepsis *** effect may be associated with its bioactive compounds which act synergistically or not,increasing sepsis mortality in vivo.

关键词： P.granatum infection inflammation