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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao mei Tian Jian Wang fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

Merging bound states in the continuum in an open acoustic resonator

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science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem s.Pilipchuk sibo Huang Chen shen Almas f.sadreev Yong Li Andrey E.Miroshnichenko school of Physics and Electronic sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University school of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

One kind motion of controllable constrained Birkhoffian system:the absence of constraints

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Acta Mechanica sinica 2020年第3期36卷 735-741页

作者： J.Chen f.X.mei s.X.Liu Y.X.Guo school of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China school of Physics Liaoning UniversityShenyang 110000China

This paper is devoted to discuss the motion of controllable constrained Birkhoffian system along with its absence of *** first step is to establish the autonomous and non-autonomous differential equations of motion of the system,based on Pfaff-Birkhoff ***,the existence of constraint multipliers are exhaustively ***,the definition of one kind motion of the system,called free motion,is given,which is described and analyzed by the absence of constraints that are determined by constraint *** 2 illustrates that one system can realize its free motion by selecting proper control *** particular,theorem 2 provides that one system can naturally realize free motion when we consider the integral of the unconstrained Birkhoffian system as the constraints of constrained Birkhoffian ***,the results obtained are illustrated by several examples.

关键词： Constrained Birkhoffian system Kinematic control Absence of constraint free motion

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

New methods to find solutions and analyze stability of equilibrium of nonholonomic mechanical systems

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Acta Mechanica sinica 2018年第6期34卷 1136-1144页

作者： J.Chen Y.X.Guo f.X.mei school of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China school of Physics Liaoning UniversityShenyang 110000China

A large proportion of constrained mechanical systems result in nonlinear ordinary differential equations,for which it is quite difficult to find analytical *** initial motions method proposed by Whittaker is effective to deal with such problems for various constrained mechanical systems,including the nonholonomic systems discussed in the first part of this paper,where in addition to differential equations of motion,nonholonomic constraints *** final equations of motion for these systems are obtained in the form of corresponding power ***,an alternative,direct method to determine the initial values of higher-order derivatives(q)0,(q)0,…is proposed,being different from that of *** second part of this work analyzes the stability of equilibrium of less complex,nonholonomic mechanical systems represented by gradient *** discuss the stability of equilibrium of such systems based on the properties of the gradient *** advantage of this novel method is its avoidance of the difficulty of directly establishing Lyapunov functions aimed at such unsteady nonlinear ***,these theoretical considerations are illustrated through four examples.

关键词： Nonholonomic system Initial motions Gradient system Lyapunov function stability

A framework combines supervised learning and dense subgraphs discovery to predict protein complexes

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frontiers of Computer science 2022年第1期16卷 173-186页

作者： suyu mei software College Shenyang Normal UniversityShenyang110034China

Rapidly identifying protein complexes is significant to elucidate the mechanisms of macromolecular interactions and to further investigate the overlapping clinical manifestations of *** date,existing computational methods majorly focus on developing unsupervised graph clustering algorithms,sometimes in combination with prior biological insights,to detect protein complexes from protein-protein interaction(PPI)***,the outputs of these methods are potentially structural or functional modules within PPI *** modules do not necessarily correspond to the actual protein complexes that are formed via spatiotemporal aggregation of *** this study,we propose a computational framework that combines supervised learning and dense subgraphs discovery to predict protein *** proposed framework consists of two *** first step reconstructs genome-scale protein co-complex networks via training a supervised learning model of l2-regularized logistic regression on experimentally derived co-complexed protein pairs;and the second step infers hierarchical and balanced clusters as complexes from the co-complex networks via effective but computationally intensive k-clique graph clustering method or efficient maximum modularity clustering(MMC)*** studies of cross validation and independent test show that both steps achieve encouraging *** proposed framework is fundamentally novel and excels over existing methods in that the complexes inferred from protein co-complex networks are more biologically relevant than those inferred from PPI networks,providing a new avenue for identifying novel protein complexes.

关键词： protein complexes protein co-complex networks machine learning L2-regularized logistic regression graph clustering

Cellular senescence in musculoskeletal homeostasis,diseases,and regeneration

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Bone Research 2021年第4期9卷 444-455页

作者： mei Wan Elise f.Gray-Gaillard Jennifer H.Elisseeff Department of Orthopaedic surgery The Johns Hopkins University School of MedicineBaltimoreMDUSA Translational Tissue Engineering Center Wilmer Eye Institute and the Department of Biomedical EngineeringThe Johns Hopkins UniversityBaltimoreMDUSA

Emerging insights into cellular senescence highlight the relevance of senescence in musculoskeletal disorders,which represent the leading global cause of *** senescence was initially described by Hayflick et *** 1961 as an irreversible nondividing state in in vitro cell culture *** now know that cellular senescence can occur in vivo in response to various stressors as a heterogeneous and tissue-specific cell state with a secretome phenotype acquired after the initial growth *** the past two decades,compelling evidence from preclinical models and human data show an accumulation of senescent cells in many components of the musculoskeletal *** senescence is therefore a defining feature of age-related musculoskeletal disorders,and targeted elimination of these cells has emerged recently as a promising therapeutic approach to ameliorate tissue damage and promote repair and regeneration of the skeleton and skeletal *** this review,we summarize evidence of the role of senescent cells in the maintenance of bone homeostasis during childhood and their contribution to the pathogenesis of chronic musculoskeletal disorders,including osteoporosis,osteoarthritis,and *** highlight the diversity of the senescent cells in the microenvironment of bone,joint,and skeletal muscle tissue,as well as the mechanisms by which these senescent cells are involved in musculoskeletal *** addition,we discuss how identifying and targeting senescent cells might positively affect pathologic progression and musculoskeletal system regeneration.

关键词： skeletal homeostasis dividing

Two Weighted Estimates for the Commutators of Multilinear Maximal singular Integral Operators with Dini-type Kernels

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Acta Mathematica sinica,English series 2023年第3期39卷 459-480页

作者： Chun mei ZHANG school of Mathematical sciences Beijing Normal UniversityBeijing 100875P.R.China

The main purpose of this paper is to investigate the properties of the higher order commutators of maximal Calderón-Zygmund operators with Dini-type *** weighted estimates have been established for these *** results ... 详细信息

关键词： Commutators sparse domination multlinear maximal singular integral operators Dinitype kenels two weighted boundedness

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stochastic resonance in coupled weakly-damped bistable oscillators subjected to additive and multiplicative noises

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Acta Mechanica sinica 2012年第2期28卷 505-510页

作者： Yan-mei Kang mei Wang Yong Xie Department of Applied Mathematics School of Mathematics and StatisticsXi'an Jiaotong University710049 Xi'anChina state Key Laboratory of Mechanical structure strength and Vibration School of AerospaceXi'an Jiaotong University710049 Xi'anChina

With coupled weakly-damped periodically driven bistable oscillators subjected to additive and multiplicative noises under concern, the objective of this paper is to check to what extent the resonant point predicted by the Gaussian distribution assumption can approximate the simulated one. The investigation based on the dynamical mean-field approx- imation and the direct simulation demonstrates that the pre- dicted resonant point and the simulated one are basically co- incident for the case of pure additive noise, but for the case including multiplicative noise the situation becomes some- what complex. specifically speaking, when stochastic res- onance （sR） is observed by changing the additive noise in- tensity, the predicted resonant point is lower than the sim- ulated one; nevertheless, when sR is observed by chang- ing the multiplicative noise intensity, the predicted resonant point is higher than the simulated one. Our observations im- ply that the Gaussian distribution assumption can not exactly describe the actual situation, but it is useful to some extent in predicting the low-frequency stochastic resonance of the coupled weakly-damped bistable oscillator.

关键词： stochastic resonance Dynamical mean-field approximation Direct simulation