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A novel saliva-based miRNA profile to diagnose and predict oral cancer

International Journal of Oral science 2024年第1期16卷 97-109页

作者： Jaikrishna Balakittnen Chameera Ekanayake Weeramange Daniel f.Wallace Pascal H.G.Duijf Alexandre s.Cristino Gunter Hartel Roberto A.Barrero Touraj Taheri Liz Kenny sarju Vasani Martin Batstone Omar Breik Chamindie Punyadeera saliva&Liquid Biopsy Translational Laboratory Griffith Institute for Drug DiscoveryGriffith UniversityNathanQLDAustralia Department of Medical Laboratory sciences Faculty of Allied Health SciencesUniversity of JaffnaJaffnaSri Lanka Menzies Health Institute Griffith UniversityGold CoastQLDAustralia school of Biomedical sciences Faculty of HealthQueensland University of TechnologyBrisbaneQLDAustralia Centre for Cancer Biology Clinical and Health SciencesUniversity of South Australia&SA PathologyAdelaideSAAustralia Institute of Clinical Medicine Faculty of MedicineUniversity of OsloOsloNorway Department of Medical Genetics Oslo University HospitalOsloNorway Griffith Institute for Drug Discovery Griffith UniversityNathanQLDAustralia QIMR Berghofer Medical Research Institute Statistics UnitBrisbaneQLDAustralia school of Public Health The University of QueenslandBrisbaneQLDAustralia school of Nursing Queensland University of TechnologyBrisbaneQLDAustralia eResearch Research InfrastructureAcademic DivisionQueensland University of TechnologyBrisbaneQLDAustralia Department of Anatomical Pathology Royal Brisbane and Women’s HospitalHerstonQLDAustralia faculty of Medicine The University of QueenslandBrisbaneQLDAustralia Royal Brisbane and Women’s Hospital Cancer Care ServicesHerstonQLDAustralia Department of Otolaryngology Royal Brisbane and Women’s HospitalHerstonQLDAustralia Department of Oral and Maxillofacial surgery Royal Brisbane and Women’s HospitalHerstonQLDAustralia

Oral cancer (OC) is the most common form of head and neck cancer. Despite the high incidence and unfavourable patient outcomes, currently, there are no biomarkers.f.r the early detection of OC. This study aims to discover, develop, and validate a novel saliva-based microRNA signature for early diagnosis and prediction of OC risk in oral potentially malignant disorders (OPMD).The Cancer Genome Atlas (TCGA) miRNA sequencing data and small RNA sequencing data of saliva samples were used to discover differentially expressed miRNAs. Identified miRNAs were validated in saliva samples of OC (n=50), OPMD (n=52), and controls(n=60) using quantitative real-time PCR. Eight differentially expressed miRNAs (miR-7-5p, miR-10b-5p, miR-182-5p, miR-215-5p,miR-431-5p, miR-486-3p, miR-3614-5p, and miR-4707-3p) were identified in the discovery phase and were validated. The efficiency of our eight-miRNA signature to discriminate OC and controls was:area under curve (AUC):0.954, sensitivity:86%, specificity:90%,positive predictive value (PPV):87.8%and negative predictive value (NPV):88.5%whereas between OC and OPMD was:AUC:0.911,sensitivity:90%, specificity:82.7%, PPV:74.2%and NPV:89.6%. We have developed a risk probability score to predict the presence or risk of OC in OPMD patients. We established a salivary miRNA signature that can aid in diagnosing and predicting OC,revolutionising the management of patients with OPMD. Together, our results shed new light on the management of OC by salivary miRNAs to the clinical utility of using miRNAs derived from saliva samples.

关键词： specificity salivary diagnosis

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A study on the Transmission Dynamics of the Omicron Variant of COVID-19 Using Nonlinear Mathematical Models

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Computer Modeling in Engineering & sciences 2024年第6期139卷 2265-2287页

作者： s.Dickson s.Padmasekaran Pushpendra Kumar Kottakkaran sooppy Nisar Hamidreza Marasi Department of Mathematics Periyar UniversitySalemTamilnadu636011India faculty of Engineering and Natural sciences Istanbul Okan UniversityIstanbulTurkey Department of Mathematics College of Science and Humanities in AlkharjPrince Sattam Bin Abdulaziz UniversityAlkharj11942Saudi Arabia Department of Applied Mathematics Faculty of MathematicsStatistics and Computer ScienceUniversity of TabrizTabrizIran

This research examines the transmission dynamics of the Omicron variant of COVID-19 using sEIQIcRVW and sQIRV models,considering the delay in converting susceptible individuals into infected *** significant delays eventually resulted in the pandemic’s *** ensure the s.f.ty of the host population,this concept integrates quarantine and the COVID-19 *** investigate the stability of the proposed *** fundamental reproduction number influences stability *** to our findings,asymptomatic cases considerably impact the prevalence of Omicron infection in the *** real data of the Omicron variant from Chennai,Tamil Nadu,India,is used to validate the outputs.

关键词： Omicron local stability reproduction number steady states global stability

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further investigation on the fusion of ^(6)Li with ^(209)Bi target at near-barrier energies

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Chinese Physics C 2024年第7期48卷 106-117页

作者：张高龙焦振威张广鑫 M.R.Cortes 胡世鹏钱建强 D.Mengoni 屈卫卫李聪博郑云张焕乔孙慧斌王楠张春雷 J.J.Valiente-Dobón D.Testov M.Mazzocco A.Gozzelino C.Parascandolo D.Pierroutsakou M.La Commara A.Goasduff D.Bazzacco D.R.Napoli f.Galtarossa f.Recchia A.Illana s.Bakes I.Zanon s.Aydin G.de Angelis M.siciliano R.Menegazzo s.M.Lenzi J.L.ferreira J.Rangel serkan Akkoyun L.f.Canto J.Lubian school of Physics Beihang UniversityBeijing 100191China sino-french Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de física Universidade Federal Fluminense24210-340NiteróiRio de JaneiroBrazil Institute for Advanced study in Nuclear Energy&s.f.ty Shenzhen UniversityShenzhen 518060China shenzhen Key Laboratory of Research and Manufacture of High Purity Germanium Materials and fetectors Shenzhen UniversityShenzhen 518060China INfN Sezione di PadovaPadovaItaly Dipartimento di fisica Astronomia dell'Universita di padova PadovaItaly state Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key Laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China INfN Laboratori Nazionali di LegnaroI-35020 LegnaroItaly INfN Sezione di NapoliI-80126 NapoliItaly Dipartimento di farmacia Universitàdi Napoli"Federico II"I-80131 NapoliItaly Department of Natural and Mathematical sciences Faculty of EngineeringTarsus University33480 MersinTurkiye Physics Division Argonne National LaboratoryLemont-ILUSA Departamento de Matemaética Física e Computaç˜ao Universidade do Estado do Rio de JaneiroFaculdade de Tecnologia27537-000ResendeRio de JaneiroBrazil Department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de física Universidade Federal do Rio de JaneiroCP 6852821941-972Rio de JaneiroBrazil

The complete and incomplete fusion cross sections.f.r ^(6)Li+^(209)Bi were measured using the in-beamγ-ray method around the Coulomb *** cross sections of(deuteron captured)incomplete fusion(ICf)products were re-quantified experimentally for this reaction *** results reveal that the ICf cross section is equivalent to that of complete fusion(Cf)above the Coulomb barrier and dominant near or below the Coulomb barrier.A theoretical calculation based on the continuum discretized coupled channel(CDCC)method was performed for the aforementioned Cf and ICf cross sections;the result is consistent with the *** universal fusion function(Uff)was also compared with the measured Cf cross section for different barrier parameters,demonstrating that the Cf suppression factor is significantly influenced by the choice of potential,which can reflect both dynamic and static effects of breakup on the fusion process.

关键词： cross section incomplete fusion suppression factor weakly bound nuclei

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Regional anesthesia in a patient with primary ciliary dyskinesia:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3183-3187页

作者： Hyung Joon Park Ye Hwan Kim Young Joon yoon sang Yun Cho Department of Anesthesiology and Pain Medicine Hanyang University Guri HospitalGuri-si 471-701Gyeonggi-doSouth Korea

BACKGROUND Primary ciliary dyskinesia(PCD)is an inherited autosomal-recessive disorder of impaired mucociliary clearance characterized by chronic respiratory diseases,otolaryngological diseases,central nervous system abnormalities,reproductive system abnormalities,and cardiac function *** anesthesia in these patients is associated with a higher incidence of respiratory complications than in patients without the *** sUMMARY A 16-year-old male patient was referred to the emergency room complaining of right ankle pain due to distal tibiofibular *** years prior,he had been diagnosed with *** that time,he had experienced several episodes of pneumonia,sinusitis,and chronic middle ear infections.f.r which he underwent surgical *** the current admission,he presented with cough and sputum but no other respiratory symptoms.A chest computed tomography scan revealed centrilobular ground-glass opacities in both lower lobes and a calcified nodule in the left lower *** the surgical procedure and postoperative pain management,combined spinal-epidural anesthesia was *** patient’s postoperative pain score was measured by the numerical rating scale(NRs).On the day of surgery,his NRs was 5 *** the second postoperative day,the NRs score had decreased to 2–3 *** epidural catheter was removed on the fourth day following the *** patient was subsequently discharged no respiratory *** We performed combined spinal-epidural anesthesia in a patient with *** patient experienced no additional respiratory complications and was discharged with a low NRs score for pain.

关键词： Primary ciliary dyskinesia Combined spinal-epidural anesthesia Patient controlled epidural analgesia Lower limb operation Case report

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Role of climatic variability in shaping intraspecific variation of thermal tolerance in Mediterranean water beetles

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Insect science 2024年第1期31卷 285-298页

作者： susana Pallarés David Garoffolo Belén Rodríguez David sánchez-fernández Department of Zoology University of SevilleSevilleSpain faculty of Biology Department of Ecology and HydrologyUniversity of MurciaCampus EspinardoMurciaSpain

The climatic variability hypothesis(CVH)predicts that organisms in more thermally variable environments have wider thermal breadths and higher thermal plasticity than those from more stable ***,due to evolutionary trade-offs,taxa with greater absolute thermal limits may have little plasticity of such limits(trade-off hypothesis).The CVH assumes that climatic variability is the ultimate driver of thermal tolerance variation across latitudinal and altitudinal gradients,but average temperature also varies along such *** explored intraspecific variation of thermal tolerance in three typical Mediterranean saline water beetles.f.milies Hydrophilidae and Dytiscidae).for each species,we compared two populations where the species coexist,with similar annual mean temperature but contrasting thermal variability(continental *** population).We estimated thermal limits of adults.f.om each population,previously acclimated at 17,20,or 25℃.We found species-specific patterns but overall,our results agree with the CVH regarding thermal ranges,which were wider in the continental(more variable)*** the two hydrophilid species,this came at the cost of losing plasticity of the upper thermal limit in this population,supporting the trade-off hypothesis,but not in the dytiscid *** results support the role of local adaptation to thermal variability and trade-offs between basal tolerance and physiological plasticity in shaping thermal tolerance in aquatic ectotherms,but also suggest that intraspecific variation of thermal tolerance does not fit a general pattern among aquatic *** such intraspecific variation could lead to inaccurate predictions of the vulnerability of aquatic insects to global warming.

关键词： acclimation capacity aquatic insects climate change heat coma temperature supercooling point thermal plasticity

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Liquid crystal immunosensors.f.r the selective detection of Escherichia coli with a fast analysis tool

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Photonics Research 2024年第7期12卷 1564-1573页

作者： sANDRO C.OLIVEIRA MARIA s.sOAREs BÁRBARA V.GONÇALVEs ANDREIA C.M.RODRIGUEs AMADEU M.V.M.sOAREs RITA G.sOBRAL NUNO f.sANTOs JAN NEDOMA PEDRO L.ALMEIDA CARLOs MARQUEs CICECO-Aveiro Institute of Materials Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal i3N Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal Associate Laboratory i4HB-Institute for Health and Bioeconomy School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal CEsAM-Centre for Environmental and Marine studies and Department of Biology University of Aveiro3810-193 AveiroPortugal Department of Telecommunications VSB-Technical University of OstravaOstrava 70800Czech Republic i3N-CENIMAT School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal UnIRE ISELPolytechnic Institute of Lisbon1549-020 LisbonPortugal Department of Physics VSB-Technical University of OstravaOstrava 70800Czech Republic

The consumption of contaminated food may cause serious illnesses,and traditional methods to detect Escherichia coli are still associated with long waiting times and high costs given the necessity to transport samples to specialized *** is a need to develop new technologies that allow cheap,fast,and direct monitoring at the site of ***,in this work,we developed optical immunosensors.f.r the selective detection of ***,based on liquid crystal technology,whose molecules can align in different manners depending on the boundary conditions (such as substrates) as well as the environment that they *** glass substrate was.f.nctionalized with *** antibody using cysteamine as an intermediate,and a vertical alignment was imposed on the liquid crystal molecules by using DMOAP during *** presence of bacteria disrupts the alignment of the liquid crystal molecules,changing the intensity of light emerging between cross polarizers,measured using a polarized optical microscope and a *** was possible to detect *** in suspensions in the concentration range from 2.8 cells/mL to 2.8×10^(9) cells∕*** was also evaluated,and the sensors were used to analyze contaminated water samples.A prototype was developed to allow faster,in-situ,and easier analysis avoiding bulky instruments.

关键词： crystal alignment analysis

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Pre-intercalation: A valuable approach for the improvement of post-lithium battery materials

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escience 2024年第2期4卷 28-42页

作者： Charlie A.f.Nason Yang Xu Department of Chemistry University College LondonLondonWC1H 0AJUK

With the growing concern around the sustainability and supply of lithium,the need for alternative rechargeable energy storage technologies has become ever more ***-,potassium-,magnesium-,and zinc-ion batteries are fast becoming viable alternatives but are held back by capacity,rate and stability problems that have not developed comparably to lithium-ion *** overcome these shortcomings and reduce the reliance on lithium,electrode materials used for these post-lithium batteries must be ***-intercalation of foreign species into the lattice of promising electrode materials can enhance their electrochemical performance in comparison to the un-pre-intercalated counterparts,closing the performance gap with lithium-ion *** review article covers the common methods of pre-intercalating foreign species into electrode materials,the resulting structural effects and the improvements that are observed in the materials'electrochemical performance for post-lithium *** and impactful work reported previously are summarised as examples of these improvements,demonstrating the value and ever-growing importance of pre-intercalation in today's battery landscape.

关键词： Intercalation Post-lithium Batteries Energy storage Electrode materials Ion diffusion Active sites

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Proposed numerical and machine learning models.f.r fiber-reinforced polymer concrete-steel hollow and solid elliptical columns

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frontiers of structural and Civil Engineering 2024年第8期18卷 1169-1194页

作者： Tang QIONG Ishan JHA Alireza BAHRAMI Haytham f.IsLEEM Rakesh KUMAR Pijush sAMUI school of Applied Technologies Qujing Normal UniversityQujing 655011China Department of Civil Engineering Indian Institute of Technology-BHUVaranasi 221005India Department of Building Engineering Energy Systems and Sustainability ScienceFaculty of Engineering and Sustainable DevelopmentUniversity of GävleGävle 80176Sweden Department of Civil Engineering National Institute of Technology-PatnaPatna 800005India

This study employs a hybrid approach,integrating finite element method(fEM)simulations with machine learning(ML)techniques to investigate the structural performance of double-skin tubular columns(DsTCs)reinforced with glass.f.ber-reinforced polymer(GfRP).The investigation involves a comprehensive examination of critical parameters,including aspect ratio,concrete strength,number of GfRP confinement layers,and dimensions of steel tubes used in DsTCs,through comparative analyses and parametric *** ensure the credibility of the findings,the results are rigorously validated against experimental data,establishing the precision and trustworthiness of the *** present research work examines the use of the columns with elliptical cross-sections and contributes valuable insights into the application of fEM and ML in the design and evaluation of structural systems within the field of structural engineering.

关键词： elliptical column fiber-reinforced polymer machine learning finite element method ABAQUs

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Microbial,immune and antioxidant responses of Nile tilapia with dietary nano-curcumin supplements under chronic low temperatures

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Aquaculture and fisheries 2024年第1期9卷 57-65页

作者： Mohammed f.El Basuini Mohamed A.A.Zaki Abdelaziz M.El-Hais Mohamed G.Elhanafy Emad H.El-Bilawy Amr I.Zaineldin Mohamed f.A.Abdel-Aziz Ibrahim A.Abouelsaad Ibrahim TEl-Ratel Kumbukani Mzengereza Ronick s.shadrack Islam I.Teiba faculty of Agriculture Tanta UniversityTanta31527Egypt King salman International University South Sinai46618Egypt faculty of Agriculture Alexandria UniversityAlexandria21526Egypt Animal Health Research Institute(AHRI-DOKI) Agriculture Research CenterGiza12619Egypt fish Rearing Lab. Aquaculture DivisionNational Institute of Oceanography and FisheriesAlexandria21556Egypt Horticulture Department Faculty of AgricultureDamanhour UniversityDamanhur22511Egypt Department of Poultry Production Faculty of AgricultureDamietta UniversityDamietta34517Egypt Laboratory of Aquatic Animal Nutrition Faculty of FisheriesKagoshima UniversityKagoshima890-0065Japan Department of Aquatic and fisheries science Mzuzu UniversityMzuzuPrivate Bag 201Malawi faculty of Aquaculture and Marine fisheries Arish UniversityArish45516Egypt

A 56-day feeding period was performed to investigate the possible impacts of dietary nano curcumin(0,50,100,150,and 200 ppm)on the growth,nutrient utilization,non-specific immune parameters,antioxidants in Nile tilapia under chronic low temperature(21.02±0.11◦C).fishes(n=225;Initial weight=4.39±0.08 g/fish)were randomly stocked at 15 fish/tank for five experimental groups in *** low-temperature circumstances,dietary curcumin in nano form showed no notable alteration in growth variable,nutrient efficiency,digestive enzymes efficiency,biometric indices,survival rates,and hematological ***,the serum of fishes with nano curcumin diets under low-temperature stress displayed higher total protein as well as lower glucose,cortisol,and total cholesterol compared with the control ***,fish fed nano curcumin diets displayed higher lysozyme and bactericidal activities compared to the control group and the best performance was.f.und at dietary nano curcumin level of≥100 ***,groups.f.d the basal diet demonstrated the poorest antioxidant capacity,and the best superoxide dismutase(sOD)and glutathione peroxidase(GPx)existed in fish with nano curcumin diets while the best catalase(CAT)efficiency occurred at higher nano curcumin levels≥100 *** addition,higher counts of intestinal microbiota in terms of total bacterial count(TBC),total yeast and molds count(TYMC),and coliform were noticed in fish consumed the basal diet compared to groups.f.d on nano curcumin *** conclusion,incorporating nano curcumin at a level of≥100 mg/kg diet(particularly at 150 mg/kg)improved a non-specific immune response,antioxidant,and healthier gastrointestinal microbiota in Nile tilapia under chronic low-temperature stress.

关键词： Nano curcumin Gastrointestinal microbiota Antioxidants Non-specific immune responses Temperature stress

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Background removal from global auroral images:Data-driven dayglow modeling

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Earth and Planetary Physics 2024年第1期8卷 247-257页

作者： A.Ohma M.Madelaire K.M.Laundal J.P.Reistad s.M.Hatch s.Gasparini s.J.Walker Birkeland Centre for space science Department of Physics and TechnologyUniversity of BergenBergenNorway

Global images of auroras obtained by cameras on spacecraft are a key tool for studying the near-Earth ***,the cameras are sensitive not only to auroral emissions produced by precipitating particles,but also to dayglow emissions produced by photoelectrons induced by *** emissions and scattered sunlight can contribute to the background *** fully utilize such images in space science,background contamination must be removed to isolate the auroral *** we outline a data-driven approach to modeling the background intensity in multiple images by formulating linear inverse problems based on B-splines and spherical *** approach is robust,flexible,and iteratively deselects outliers,such as auroral *** final model is smooth across the terminator and accounts.f.r slow temporal variations and large-scale asymmetries in the *** demonstrate the model by using the three far ultraviolet cameras on the Imager for Magnetopause-to-Aurora Global Exploration(IMAGE)*** method can be applied to historical missions and is relevant for upcoming missions,such as the solar wind Magnetosphere Ionosphere Link Explorer(sMILE)mission.

关键词： aurora dayglow modeling global auroral images far ultraviolet images dayglow removal

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