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EFNs偏头痛药物治疗指南 EFNs特别工作组的报告

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国际脑血管病杂志 2007年第12期15卷 881-890页

作者： s.evers J.fra A.Frese P.J.Goadsby M.Linde A.May P.s.sándor 张现伟张敏吴宣富 Department of Neurology University of MünsterMünsterGermany National Institute of Neurosurgery BudapestHungary Headache Group Institute of NeurologyThe National Hospital for Neurology and NeurosurgeryLondonUK Cephalea Pain Center Lkarhnset Sdra vgenGothenburgGothenburgSweden Department of Neurology University of HamburgHamburgGermany Department of Neurology University of ZurichZurichSwitzerland 广州中医药大学第一附属医院神经内科 510405

偏头痛是最常见的功能障碍性神经疾病之一,会对患者的生活质量造成严重影响。为了在文献检索和专家组共识基础上对不同类型偏头痛综合征的各种药物治疗方案提供循证或专家推荐,我们从现有的所有医学参考文献系统中筛选出关于有先兆型或... 详细信息

偏头痛是最常见的功能障碍性神经疾病之一,会对患者的生活质量造成严重影响。为了在文献检索和专家组共识基础上对不同类型偏头痛综合征的各种药物治疗方案提供循证或专家推荐,我们从现有的所有医学参考文献系统中筛选出关于有先兆型或无先兆型偏头痛以及偏头痛样综合征等各种类型临床资料进行分析。根据欧洲神经病学学会联盟(European Federation of Neurological ***)制定的推荐意见分级方案对这些研究结果进行评价从而确定A级、B级或C级推荐和良好的临床实践要点。对于偏头痛急性发作期的治疗,推荐口服非甾体消炎药(NsAID)和曲坦类药物。用药方案应遵循分层治疗的观念。在服用NsAID和曲坦类药物之前,推荐口服甲氧氯普胺或多潘立酮。极重度发作的首选药物为静脉注射乙酰水杨酸或皮下注射舒马曲坦。偏头痛持续状态或许可用类固醇治疗。对于偏头痛的预防性治疗,β-受体阻断药(普萘洛尔和美托洛尔)、氟桂利嗪、丙戊酸和托吡酯可作为首选用药,其次可选择阿米替林、萘普生、蜂斗菜烯碱和比索洛尔。

关键词：指南头痛偏头痛预防曲坦类药物

Capturing Hormonal and Light Interactions in a simulation Model of shoot Branching

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Capturing Hormonal and Light Interactions in a Simulation Mo...

2012 IEEE 4th International symposium on Plant Growth Modeling,simulation,Visualization and Applications(PMA 2012)

作者： J.B.evers A.R.van der Krol Centre for Crop systems Analysis Wageningen UR Wageningen the Netherlands Laboratory of Plant Physiology Wageningen UR Wageningen the Netherlands

shoot branching,*** bud break and subsequent branch outgrowth,is a key determinant of overall aboveground plant *** plant development,the number of branches formed strongly influences the amount of light absorbed by the plant,and thus the plant's competitive strength in terms of light capture in relation to neighbouring *** branching is regulated by genetic and physiological factors such as hormones and *** turn,these internal factors are modulated by environmental signals such as light intensity,light spectral composition and *** internal and environmental factors are part of a complex feedback system that operates at several levels of biological ***,we present a modelling approach that captures the interactions between hormones and light in the case of shoot *** simulated Arabidopsis individually and in a plot at different ratios of ambient red and far-red light(R:FR).A low R:FR resulted in low *** individual plants experienced slightly higher R:FR values and produced more branches as a result,depending on ambient R:*** model serves a useful scientific tool to integrate knowledge and to improve experimental approaches on shoot branching.

关键词： shoot branching red / far-red ratio plant hormones bud break Arabidopsis

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丛集性头痛患者的药物过用性头痛

世界核心医学期刊文摘(神经病学分册) 2006年第12期 17-18页

作者： Paemeleire K. Bahra A. evers s. P.J.Goadsby 郭俊 Dr.Headache Group Institute of NeurologyQueen SquareLondon WC1N 3BGUnited Kingdom

OBJECTIVE:Medication-overuse headache(MOH)in cluster headache(CH)patients is incompletely described,perhaps because of the relatively low prevalence of ***:The authors describe a retrospective series of 17 patients(13 men,4 women)with CH who developed MOH in association with overuse of a wide range of monotherapies or varying combinations of simple analgesics(n = 9),caffeine(n = 1),opioids(n = 10),ergotamine(n = 3),and triptans(n = 14).The series includes both episodic(n = 7)and chronic(n = 10)CH ***:A specific triptan-overuse headache diagnosis was made in 3 patients,an opioid-overuse headache diagnosis was made in 1 patient,and an ergotamine-overuse headache diagnosis was made in 1 *** approximately half of the patients(n = 8),the MOH phenotype was a bilateral,dull,and featureless daily *** the other 9 patients,the MOH was characterized by at least one associated feature,most commonly nausea(n = 6),exacerbation with head movement(n = 5),or throbbing character of the pain(n = 5).The common denominator in 15 patients was a personal or family history,or both,of *** 2 other patients gave a family history of unspecified *** withdrawal was attempted and successful in 13 ***:Medication-overuse headache is a previously underrecognized and treatable problem associated with cluster headache(CH).CH patients should be carefully monitored,especially those with a personal or family history of migraine.

关键词：丛集性患者头痛头疼疼痛药物

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慢性继发性头痛或口面部疼痛

中国疼痛医学杂志 2021年第8期27卷 561-567页

作者：于生元(编译) 何绵旺(编译) 袁文茜(编译) 曹伯旭(编译) 袁慧娟(编译) 江姣锦(编译) 别智(编译) 那伟楠(编译) 赵赫(编译) 宋学军(审校) 刘小立(审校) 万有(审校) 樊碧发(审校) 韩济生(审校) Benoliela R svenssonb P stefan evers s 中国人民解放军总医院第一医学中心神经内科医学部北京100853 南方科技大学疼痛医学中心和南方科技大学围术期医学研究中心深圳518055 北京大学医学部疼痛医学中心北京100191 河北医科大学第四医院疼痛科石家庄050011 北京大学神经科学研究所北京100191 国家卫健委中日友好医院疼痛科北京100029 不详

本文介绍了世界卫生组织(WHO)国际疾病分类-11(international classification of diseases-11,ICD-11)中有关慢性继发性头痛和慢性口面部疼痛的诊断标准,该标准主要参考国际头痛学会(InternationalHeadache society,HIs)发布的第3版国际头痛分类标准(ICHD-3,ICD-11的神经系统疾病章节)。ICHD-3将头痛分为三大类:原发性头痛(特发性头痛)、继发性头痛(症状性头痛)和口面部疼痛(包括颅神经痛)。头痛或口面部疼痛在3个月或更长时间内有一半以上的天数发作,每天持续时间超过2个小时,应诊断为慢性头痛或慢性口面部疼痛。慢性原发性头痛和慢性原发性口面部疼痛属于慢性原发性疼痛综合征,在之前的文章中已有描述,本文仅涉及慢性继发性头痛和慢性继发性口面部疼痛。ICHD-3慢性继发性口面部疼痛次级分类中增加了颞下颌关节紊乱诊断标准和慢性牙痛的疾病分类,以及国际疼痛学会(International Association for the study of Pain,IAsP)口面部疼痛和头痛兴趣小组的贡献。本文描述的ICD-11编码将与基础疾病的编码联合使用,以识别需要疼痛管理的病人。此外,这些编码将提高此类疾病在疾病统计中的可见性,并促进对其机制的研究。

关键词： ICD-11 ICHD-3 WHO 慢性继发性头痛慢性口面部疼痛颞下颌关节紊乱面部疼痛牙痛诊断

前庭性偏头痛:诊断标准——Barany学会及国际头痛学会共识文件

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神经病学与神经康复学杂志 2013年第3期10卷 176-178页

作者：华驾略李焰生 Lempert T Olesen J Furman J Waterston J seemungal B Carey J Bisdorff A Versino M evers s Newman-Toker D 上海交通大学医学院附属仁济医院神经内科上海200127

本文提供了前庭性偏头痛的诊断标准,由Barany学会前庭疾患分类委员会及国际头痛学会(IHs)偏头痛分类分委员会共同制定。分类包括前庭性偏头痛及很可能的前庭性偏头痛。与IHs的常规程序相同,前庭性偏头痛作为一种新分类,将首先出现在第3... 详细信息

本文提供了前庭性偏头痛的诊断标准,由Barany学会前庭疾患分类委员会及国际头痛学会(IHs)偏头痛分类分委员会共同制定。分类包括前庭性偏头痛及很可能的前庭性偏头痛。与IHs的常规程序相同,前庭性偏头痛作为一种新分类,将首先出现在第3版国际头痛分类(ICHD-3)的附录中。若积累了进一步的证据,很可能的前庭性偏头痛也许会纳入更晚的ICHD版本中。前庭性偏头痛的诊断建立在反复发作的前庭症状、具有偏头痛病史、前庭症状与偏头痛症状间存在时间上的相关性,并排除其他可导致前庭症状的病因。符合前庭性偏头痛诊断的症状包括不同类型的眩晕及头部活动诱发的头晕伴恶心。症状的严重程度必须为中重度。急性发作的持续时间限于5 min^72 h的时间窗内。

关键词：偏头痛眩晕头晕前庭诊断标准 Barany学会国际头痛学会

Global Wheat Head Detection 2021:An Improved Dataset for Benchmarking Wheat Head Detection Methods

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Plant Phenomics 2021年第1期3卷 277-285页

作者： Etienne David Mario serouart Daniel smith simon Madec Kaaviya Velumani shouyang Liu Xu Wang Francisco Pinto shahameh shafiee Izzat sATahir Hisashi Tsujimoto shuhei Nasuda Bangyou Zheng Norbert Kirchgessner Helge Aasen Andreas Hund Pouria sadhegi-Tehran Koichi Nagasawa Goro Ishikawa sébastien Dandrifosse Alexis Carlier Benjamin Dumont Benoit Mercatoris Byron evers Ken Kuroki Haozhou Wang Masanori Ishii Minhajul ABadhon Curtis Pozniak David shaner LeBauer Morten Lillemo Jesse Poland scott Chapman Benoit de solan Frédéric Baret Ian stavness Wei Guo Arvalis Institut du Végétal3 Rue Joseph et Marie Hackin75116 ParisFrance UMR1114 EMMAH INRAECentre PACABâtiment ClimatDomaine Saint-Paul228 Route de l’AérodromeCS 4050984914 Avignon CedexFrance school of Food and Agricultural sciences The University of QueenslandGatton4343 QLDAustralia Hiphen sAs 120 Rue Jean DaussetAgroparcBâtiment Technicité84140 AvignonFrance Plant Phenomics Research Center Nanjing Agricultural UniversityNanjingChina Wheat Genetics Resource Center Dep.of Plant PathologyKansas State Univ.4024 Throckmorton Plant Sciences CenterManhattanKansasUSA Global Wheat Program International Maize and Wheat Improvement Centre(CIMMYT)MexicoD.F.Mexico Faculty of Biosciences Norwegian University of Life SciencesP.O.Box 5003NO-1432ÅsNorway Agricultural Research Corporation Wheat Research ProgramP.O.Box 126Wad MedaniSudan Arid Land Research Center Tottori UniversityTottori 680-0001Japan Laboratories of Plant Genetics and Plant Breeding Graduate School of AgricultureKyoto UniversityJapan CsIRO Agriculture and Food Queensland Biosciences Precinct306 Carmody RoadSt Lucia4067 QLDAustralia Institute of Agricultural sciences ETH ZurichUniversitätstrasse 28092 ZurichSwitzerland Plant sciences Department Rothamsted ResearchHarpendenUK Institute of Crop science National Agriculture and Food Research OrganizationJapan Hokkaido Agricultural Research Center National Agriculture and Food Research OrganizationJapan Biosystems Dynamics and Exchanges TERRA Teaching and Research CenterGembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium Plant sciences TERRA Teaching and Research CenterGembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium Graduate school of Agricultural and Life sciences The University of Tokyo1-1-1 Midori-choNishitokyo CityTokyoJapan Department of Computer science University of SaskatchewanCanada Department of Plant sciences University of SaskatchewanCanada College of Agriculture and Life sciences University of ArizonaTucsonArizona

The Global Wheat Head Detection(GWHD)dataset was created in 2020 and has assembled 193,634 labelled wheat heads from 4700 RGB images acquired from various acquisition platforms and 7 countries/*** an associated competition hosted in Kaggle,GWHD_2020 has successfully attracted attention from both the computer vision and agricultural science *** this first experience,a few avenues for improvements have been identified regarding data size,head diversity,and label *** address these issues,the 2020 dataset has been reexamined,relabeled,and complemented by adding 1722 images from 5 additional countries,allowing for 81,553 additional wheat *** now release in 2021 a new version of the Global Wheat Head Detection dataset,which is bigger,more diverse,and less noisy than the GWHD_2020 version.

关键词： Wheat adding release