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The role of landscape setting in minimizing hydrogeomorphic impacts of flow regulation

International Journal of sediment Research 2013年第2期28卷 149-161页

作者： H.e.ReID G.J.BRIeRLeY K.MCFARLANe s.e.coleman s.TROWsDALe school of environment The University of Auckland Department of Civil and environmental engineering The University of Auckland

The Tongariro Power Development scheme（TPDs） is used to regulate flow in the headwaters of the largest catchment on the North Island of New Zealand（the Waikato）.Two small dams,the Rangipo Dam and the Poutu Intake Dam,were constructed in 1973 and *** flow regime of the river is managed to divert freshes into the power scheme,but allows flows larger than 100 m;s;to be released,to rework and transport sediment through the catchment. Analysis of aerial photos and maps spanning 1928 to 2007,alongside field measurements,show that there have been few hydrogeomorphic adjustments since dam *** includes limited changes to channel geometry,channel planform and bed material organization immediately downstream of the *** addition,offsite effects are minimal, both 500 m downstream of each dam,and in the more sensitive,less confined reaches in the lower catchment（11 km downstream of the Poutu Intake dam）.The limited changes can be attributed to the locations of the dams within reaches characterised by bedrock gorges and confined within *** locations act to flush sediments and impose margins that allow minimal adjustment of the *** material within this reach is characterised by the presence of a boulder *** is sourced from long-term incision into lahar deposits,and acts to limit the rate of incision, creating a steep and stable base upon which active fractions are *** as importantly,significant storage in the low-relief volcanic plateau located in the upper catchment acts to disconnect and store the high sediment yields generated by active volcanic cones in the western sub-catchment upstream of the *** limits the rate of sediment supply to regulated *** from this study show that analysis of reach-scale controls is essential in framing dam site locations in relation to the distribution of reaches and landscape units across the *** this instance, tributary inputs downstream of the dams do not repl

关键词： Flow regulation Landscape setting Landscape connectivity sediment storage Channel planform

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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAeI H.GHANDVAR e.JUMAeV s.KHATIR T.CUONG-Le school of Mechanical engineering Babol Noshirvani University of Technology Department of Mechanical engineering Faculty of Engineering New Uzbekistan University University of Business and science Center for engineering Application and Technology solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANsYs, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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Merging bound states in the continuum in an open acoustic resonator

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science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem s.Pilipchuk sibo Huang Chen shen Almas F.sadreev Yong Li Andrey e.Miroshnichenko school of Physics and electronic sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical engineering Rowan University school of engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

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Variation in Heat-shock Proteins and Photosynthetic Thermotolerance among Natural Populations of Chenopodium album *** Contrasting Thermal environments:Implications for Plant Responses to Global Warming

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Journal of Integrative Plant Biology 2008年第11期50卷 1440-1451页

作者： Deepak Barua scott A.Heckathorn James s.coleman Department of Biology Syracuse University Department of Organismic and evolutionary Biology Harvard University Department of environmental sciences University of Toledo

Production of heat-shock proteins （Hsps） is a key adaptation to acute heat stress and will be important in determining plant responses to climate change. Further, intraspecifc variation in Hsps, which will influence species-level response to global warming, has rarely been examined in naturally occurring plants. To understand intraspecific variation in plant Hsps and its relevance to global warming, we examined Hsp content and thermotolerance in five naturally occurring populations of Chenopodium album L. from contrasting thermal environments grown at low and high temperatures. As expected, Hsp accumulation varied between populations, but this was related more to habitat variability than to mean temperature. Unexpectedly, Hsp accumulation decreased with increasing variability of habitat temperatures. Hsp accumulation also decreased with increased experimental growth temperatures. Physiological thermotolerance was partitioned into basal and induced components. As with Hsps, induced thermotolerance decreased with increasing temperature variability. Thus, populations native to the more stressful habitats, or grown at higher temperatures, had lower Hsp levels and induced thermotolerance, suggesting a greater reliance on basal mechanisms for thermotolerance. These results suggest that future global climate change will differentially impact ecotypes within species, possibly by selecting for increased basal versus inducible thermotolerance.

关键词： acclimation photosynthesis stress proteins temperature.

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged fromells transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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Hepatic failure caused by plasma cell infiltration in multiple myeloma

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World Journal of Gastroenterology 2009年第16期15卷 2038-2040页

作者： Fadi e Rahhal Robert R schade Asha Nayak Teresa A coleman section of Gastroenterology Department of MedicineMedical College of GeorgiaSchool of Medicine section of Hematology/Oncology Department of MedicineMedical College of GeorgiaSchool of Medicine

Although plasma cell infiltration is not rare in autopsy of patients with multiple myeloma （MM）, it is very rarely detected in living patients. This is because MM rarely causes significant liver dysfunction that requires further evaluation. A 49-year-old man presented with acute renal failure and was diagnosed with kappa light chain MM stageⅡB. Thalidomide and dexamethasone were initiated. The patient developed a continuous increase in bilirubin that led to severe cholestasis. A liver biopsy revealed plasma cell infiltration. He then rapidly progressed to liver failure and died. Treatment options are limited in MM with significant liver dysfunction. Despite new drug therapies in MM, those patients with rapidly progressive liver failure appear to have a dismal outcome.

关键词： Hepatic failure Multiple myeloma Cell infiltration

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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Maternal body condition during latepregnancy is associated with in utero development and neonatal growth of Holstein calves

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Journal of Animal science and Biotechnology 2021年第3期12卷 984-994页

作者： A.s.Alharthi D.N.coleman I.A.Alhidary M.M.Abdelrahman e.Trevisi J.J.Loor Department of Animal Production College of Food and Agriculture SciencesKing Saud UniversityRiyadh 11451Saudi Arabia Department of Animal sciences and Division of Nutritional sciences University of IllinoisUrbanaIL 61801USA Department of Animal sciences Food and Nutrition(DIANA)Faculty of AgricultureFood and Environmental ScienceUniversitàCattolica del Sacro Cuore29122 PiacenzaItaly

Background:Nutritional management in the dry period can alter body condition score(BCs)in dairy cows,a subjective measure of body *** such,differences in BCs during late-pregnancy not only mirror nutrient utilization by fat depots,but also can play important roles on the metabolic and hormonal *** investigated the association between cow BCs during late-pregnancy on developmental parameters and blood variables of neonatal ***-nine multiparous Holstein cows were retrospectively divided by prepartal BCs into normal BCs≤3.25(NormBCs;3.02±0.17,n=30)or high BCs≥3.75(HighBCs;3.83±0.15,n=19)*** samples were collected from cows at−10 d relative to *** weight,hip and wither height,hip width and body length were measured at birth and weekly through weaning(42 d of age)and until 9 weeks of *** blood samples were collected from the jugular vein at birth(before receiving colostrum,0 d),24 h after first colostrum and at 7,21,42 and 50 d of *** data were subjected to ANOVA using the mixed procedure of *** statistical model included day,BCs,and their ***:Dry matter intake(kg/d or%of body weight)during the last 4 weeks of pregnancy was lower(P≤0.06)in HighBCs *** concentrations of fatty acids,ceruloplasmin,and nitric oxide were greater overall(Ps cows,and they tended(P=0.08)to have greater concentrations of reactive oxygen *** body weight was lower(P=0.03)in calves born to dams with *** addition,plasma concentrations of fatty acids,albumin and urea(Pere greater in those *** calves born to cows with HighBCs maintained a lower postnatal body weight(P=0.04),hip and wither height,hip width,and body length,there was no difference(P>0.05)in daily starter intake and average daily gain due to maternal ***:Overall,results highlight an association between BCs during late-gestation on in utero calf development and postna

关键词： Metabolism Neonate Nutritional programming Transition cow

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emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-eM structures drug design intramembrane proteolysis molecular dynamics Notch

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