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纳米氧化铁在腹腔和盆腔的药代动力学：1.5 T和3.0 T MRI弛豫法的剂量研究

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国际医学放射学杂志 2020年第2期 234-234页

作者： s.A.Wells T.schubert U.Motosugi s.d.sharma C.A.Campo s.Kinner 朱羽苑 department of Radiology University of Wisconsin-Madison University of Wisconsin School of Medicine and Public Health

纳米氧化铁(FE)是一种用于缺铁性贫血的静脉内铁制剂,作为MRI的对比剂,增加了它的非标签使用。因此,了解FE的药代动力学十分重要。目的为评估FE在腹部和

关键词： T MRI 纳米氧化铁弛豫法剂量研究

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal sharma sehwan Kim Hyemi Eo sang Ryong Kim school of Life science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： s.sAURABH R.KIRAN d.sINGH R.VAIsH V.s.CHAUHAN school of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsdT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Vibration analysis of axisymmetric functionally graded viscothermoelastic spheres

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Acta Mechanica sinica 2014年第1期30卷 100-111页

作者： d.K.sharma J.N.sharma s.s.dhaliwal V.Walia department of Mathematics Sant Longowal Institute of Engineering and Technology department of Mathematics National Institute of Technology

The present study focuses on the analysis of free vibrations of axisymmetric functionally graded hollow spheres. The material is assumed to be graded in radial di- rection with a simple power law. Matrix Frrbenious method of extended power series is employed to derive the analytical solutions for displacement, temperature, and stresses. The dispersion relations for the existence of various types of pos- sible modes of vibrations in the considered hollow sphere are derived in a compact form. In order to explore the character- istics of vibrations, the secular equations are further solved by using fixed point iteration numerical technique with the help of MATLAB software. The numerical results have been presented graphically for polymethyl methecrylate materials in respect of natural frequencies, frequency shift, inverse quality factor, displacement, temperature change, and radial stress.

关键词： Functionally graded stresses Vibrations Fr6benius - dispersion - spherical structures

Mathematical model of micropolar fluid in two-phase immiscible fluid flow through porous channel

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Applied Mathematics and Mechanics(English Edition) 2018年第7期39卷 993-1006页

作者： P.K.YAdAV s.JAIsWAL B.d.sharma department of Mathematics Motilal Nehru National Institute of Technology Allahabad

This paper is concerned with the flow of two immiscible fluids through a porous horizontal channel. The fluid in the upper region is the micropolar fluid/the Eringen fluid, and the fluid in the lower region is the Newtonian viscous fluid. The flow is driven by a constant pressure gradient. The presence of micropolar fluids introduces additional rotational parameters. Also, the porous material considered in both regions has two different permeabilities. A direct method is used to obtain the analytical solu- tion of the concerned problem. In the present problem, the effects of the couple stress, the micropolarity parameter, the viscosity ratio, and the permeability on the velocity profile and the microrotational velocity are discussed. It is found that all the physical parameters play an important role in controlling the translational velocity profile and the microrotational velocity. In addition, numerical values of the different flow parameters are computed. The effects of the different flow parameters on the flow rate and the wall shear stress are also discussed graphically.

关键词： micropolar fluid immiscible fluid porous medium couple stress microp=olarity parameter

Boundary conditions for porous solids saturated with viscous fluid

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Applied Mathematics and Mechanics(English Edition) 2009年第7期30卷 821-832页

作者： M.d.sharma department of Mathematics Kurukshetra University

Boundary conditions are derived to represent the continuity requirements at the boundaries of a porous solid saturated with viscous fluid. They are derived from the physically grounded principles with a mathematical check on the conservation of energy. The poroelastic solid is a dissipative one for the presence of viscosity in the interstitial fluid. The dissipative stresses due to the viscosity of pore-fluid are well represented in the boundary conditions. The unequal particle motions of two constituents of porous aggre~ gate at a boundary between two solids are explained in terms of the drainage of pore-fluid leading to imperfect bonding. A mathematical model is derived for the partial connec- tion of surface pores at the porous-porous interface. At this interface, the loose-contact slipping and partial pore opening/connection may dissipate a part of strain energy. A numerical example shows that, at the interface between water and oil-saturated sandstone, the modified boundary conditions do affect the energies of the waves refracting into the isotropic porous medium.

关键词： porous solid dissipative boundary conditions

View Creation for Queriesin Object Oriented databases

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Journal of Computer science & Technology 1999年第4期14卷 349-362页

作者： RajeshNarang K.d.sharma departmentofComputerscience UniversityofDelhiDelhi110007，I departmentofComputerscience Universityof

A view in object oriented databases corresponds to virtual schemawith restructured generalization and decomposition hierarchies. Numbers of viewcreation methodologies have been proposed. A major drawback of existing method-ologies is that they do not maintain the closure property. That is, the result of aquery does not have the same semantics as embodied in the object oriented datamodel. Therefore, this paper presents a view creation methodology that derives aclass in response to a user's query, integrates derived class in global schema (i.e.,considers the problem of classes moving in class hierarchy) and selects the requiredclasses from global schema to create the view for user's query. Novel idea of viewcreation includes: (a) an object algebra for class derivation and customization (wherethe derived classes in terms of object instances and procedure/methods are studied),(b) maintenance of closure property, and (c) classification algorithm which providesmechanism to deal with the problem of a class moving in a class hierarchy.

关键词： object manipulation type level operation instance level operation,object algebra object operator operator syntax operator semantics derived class,class integration view creation algorithm

Process engineering of demineralisation of moderate to high ash Indian coals through NaOH‑HCl leaching and HF leaching

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International Journal of Coal science & Technology 2024年第2期11卷 111-122页

作者： Heena dhawan d.K.sharma ANRF Ministry of ScienceNew DelhiIndia department of Energy science and Engineering Indian Institute of Technology DelhiNew Delhi 110016India

Chemical leaching of coals would be required to produce cleaner coals for some special applications where physical benefi-ciation may not be effective *** would also help in recovering Li and rare earth metals besides in the sequestration of CO_(2).About 20 Indian coals having complexly distributed moderate to high ash contents were sequentially treated with various alkali–acid such as NaOH-HCl,HF,HCl,HCl-HF,and NaOH-HCl-HF *** aimed to establish and design the best stepwise sequential process for the highest degree of demineralisation through a chemical leaching *** and process intensification studies were carried *** than 80%demineralisation of Madhaipur and Neemcha coals was observed using the best sequential treatment designed *** repeated stepwise treatment of the alkali and the acid was also studied,which was found to significantly enhance the degree of demineralisation of *** integrated process of alkali–acid leaching followed by solvent extraction(Organo-refining)and vice versa of the treated coal was also studied for producing cleaner coals.

关键词： Alkali–acid leaching demineralisation Integrated process Rare earth elements

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive