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协同运用高新科技优化矿山生产管理(一)

国外金属矿山 2002年第2期27卷 17-24页

作者： s.d.德苏罗 M.斯科布尔 s.邓巴冀湘苏悦加拿大不列颠哥伦比亚大学采矿与选矿工程系

其他产业中开发出来并且已臻完善的各种新技术、新信息源与新经营手段也应当能够为矿山企业提供以前是不可行的优化机遇。露天开采业的优化机遇包括 :优化矿岩爆破破碎质量、磨矿前矿石混匀和短期生产计划。要使这些机遇得以成功地实现 ... 详细信息

其他产业中开发出来并且已臻完善的各种新技术、新信息源与新经营手段也应当能够为矿山企业提供以前是不可行的优化机遇。露天开采业的优化机遇包括 :优化矿岩爆破破碎质量、磨矿前矿石混匀和短期生产计划。要使这些机遇得以成功地实现 ,关键在于 :不能只凭采用某一单项的新技术、新经营手段或者新信息源 ,而是要靠这三者相结合的协同作用。数据处理分析手段以及管理机制为各种新技术与新信息的协同运用提供了所需的“粘合剂”。这些优化机遇可使矿山企业增加赢利 ,灵活经营。

关键词：现代矿业高新技术信息源经营手段生产系统生产管理

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协同运用高新科技优化矿山生产管理(二)

国外金属矿山 2002年第3期27卷 12-17页

作者： s.d.德苏罗 M.斯科布尔 s.邓巴冀湘苏悦加拿大不列颠哥伦比亚大学采矿与选矿工程系

4.3 库存管理在控制存货成本方面,供应公司可起着关键作用[20].随着供应商与矿山公司的关系从对手转变为伙伴,相互合作便开始给双方公司增加利润.矿山公司已经开始同供应公司订立设备维修与炸药供应的协约.通过与供应公司实行生产进度... 详细信息

4.3 库存管理在控制存货成本方面,供应公司可起着关键作用[20].随着供应商与矿山公司的关系从对手转变为伙伴,相互合作便开始给双方公司增加利润.矿山公司已经开始同供应公司订立设备维修与炸药供应的协约.通过与供应公司实行生产进度计划责任分担的办法,租赁设备可由供应公司负责维修.炸药公司通过亲自参加爆破设计,便可以利用设在现场的炸药加工厂或当地的炸药分发站准时供应炸药.这就避免了矿山和制造厂的炸药贮备量过多.可以应用在零售业中已十分成熟的信息系统准时将所需炸药送到指定的工作台阶.这种变革方式要求(从矿山公司方面)与供应公司建立紧密的非对手关系,需要有一致的计划编制方法和可靠的信息系统.对于供应公司来说,微观管理各项少量库存,是不经济的.这个责任将落到矿山公司的有关负责人的身上.

关键词：成本水泵库存管理备件配件矿山生产管理

重组线虫抗凝血蛋白c2治疗非sT段抬高型急性冠状动脉综合征:ANTHEM-TIMI 32试验

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世界核心医学期刊文摘（心脏病学分册） 2007年第10期3卷 52-53页

作者： Giugliano R.P. Wiviott s.d. stone P.H. 孙凯 TIMI study Group BostonMAUnited States Dr.

目的:评价重组线虫抗凝血蛋白c2(rNAPc2)治疗非sT段抬高型急性冠状动脉综合征(nsTE-ACs)患者的安全性和有效性。背景:rNAPc2是一种组织因子/VⅡa因子复合物的强抑制剂。

关键词：急性冠状动脉综合征 ANTHEM-TIMI 32 c2 抗凝血蛋白线虫蠕虫 sT

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在后退式长壁工作面采用穿层钻孔抽放瓦斯

矿业安全与环保 1987年第2期 57-62页

作者： P.C.撒克 ,s.d.劳尔 ,J.舍维克 ,余荣鑫

在后退式长壁开采作业中,只要条件允许,可用穿层钻孔代替地面垂直钻孔抽放采空区瓦斯.这是西弗吉尼亚北部开采匹兹堡煤层的一个煤矿与美国矿业局签订合同进行的研究项目.这项研究首次将这一技术用于匹兹堡煤层.从后退式长壁采区的平巷... 详细信息

在后退式长壁开采作业中,只要条件允许,可用穿层钻孔代替地面垂直钻孔抽放采空区瓦斯.这是西弗吉尼亚北部开采匹兹堡煤层的一个煤矿与美国矿业局签订合同进行的研究项目.这项研究首次将这一技术用于匹兹堡煤层.从后退式长壁采区的平巷向采区上方打14个小直径斜钻孔,贯穿上覆煤层.所有钻孔均与瓦斯抽放管连接,由地面的瓦斯泵将采空区瓦斯抽出.在各个不同的长壁盘区开采阶段,穿层钻孔的瓦斯抽放率分别为7%至18%,而地面垂直钻孔的瓦斯抽放率是20%.穿层钻孔瓦斯抽放率低的原因是由于钻孔周围有裂隙,产生泄漏现象.

关键词：穿层钻孔瓦斯浓度采空区瓦斯抽放率长壁工作面回采工作面地面垂直钻孔瓦斯流量抽放瓦斯后退式

肝性脑病患者大脑“外周型苯二氮结合位点”的体内成像

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世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 39-40页

作者： Cagnin A. Taylor-Robinson s.d. Forton d.M. Banati R.B. 陈瑜 school of Medical Radiation sciences Ramaciotti Centre for Brain ImagingUniversity of SydneyEast St PO Box 170LidcombeNSW 1825Australia.Prof

Background and aim: One propos.d.mechanism whereby hepatic encephalopathy (HE) leads to loss of brain function is.d.sregulated synthesis of neurosteroids. Mitochondrial synthesis of neurosteroids is regulated by “peripheral benzodiazepine binding sites" (PBBs). Express.d.in the brain by activated glial cells, PBBs can be measured in vivo by the specific ligand [11C](R)-PK11195 and positron emission tomography (PET). Recently, it has been suggested that PBBs expressing glial cells may play a role in the general inflammatory responses seen in HE. Therefore, we measured PBBs in vivo in the brains of patients with minimal HE using [11C](R)-PK11195 PET. Methods: Five patients with minimal HE and biopsy proven cirrhosis of differing aetiology were assess.d.with a neuropsychometric battery. Regional expression of PBBs in the brain was.d.tected by [11C](R)-PK11195 PET. Results: All patients showed brain regions with increas.d.[11C](R)-PK11195 binding. significant increases in glial [11C](R)-PK11195 binding were found bilaterally in the pallidum, right putamen, and right dorsolateral prefrontal region. The patient with the most severe cognitive impairment had the highest increases in regional [11C](R)-PK11195 binding. Conclusion: HE is associated with increas.d.cerebral binding of [11C](R)-PK11195 in vivo, reflecting increas.d.expression of PBBs by glial cells. This supports earlier experimental evidence in rodent models of liver failure, suggesting that an altered glial cell state, as evidenced by the increase in cerebral PBBs, might be causally related to impaired brain functioning in HE.

关键词：肝性脑病苯二氮外周型胶质细胞神经甾体苍白球认知障碍脑功能壳核特异性配体

原发性膀胱输尿管反流患儿的排泄式膀胱尿道造影的随访时间:一个临床方案的研发与应用

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世界核心医学期刊文摘（儿科学分册） 2006年第9期2卷 52-53页

作者： Thompson M. simon s.d. sharma V. Alon U.s. 郭战宏 section of Nephrology Children's Mercy Hospital2401 Gillham RdKansas CityMO 64108United States Dr.

Background and Objectives. Of children diagnos.d.with urinary tract infection,30% to 40% have primary vesicoureteral reflux (VUR). For the majority of these children,treatment involves long-term prophylactic antibiotics (ABX) and a periodic voiding cystourethrogram (VCUG) until resolution of VUR as.d.tected by VCUG. Radiation exposure and cons.d.rable discomfort have been associated with VCUG. To date,no clear guidelines exist regarding the timing of follow-up VCUGs. The objective of this study was to develop a clinically applicable algorithm for the optimal timing of repeat VCUGs and validate this algorithm in a retrospective cohort of children with VUR. Methods. Bas.d.on previously published data regarding the probability of resolution of VUR over time,a decision-tree model (dTM) was.d.veloped. The dTM compared the differential impact of 3 timing schedules of VCUGs (yearly,every 2 years,and every 3 years) on the average numbers of VCUGs performed,years of ABX exposure,and overall costs. Bas.d.on the dTM,an algorithmoptimizing the timing of VCUG was.d.veloped. The algorithm then was validated in a retrospective cohort of patients at an urban pediatric referral center. data were extracted from the medical records regarding number of VCUGs,time of ABX prophylaxis,and complications associated with either. VUR in patients in the cohort was grouped into mild VUR (grades I and II and unilateral grade III for those ≤ 2 years old),and moderate/ severe VUR (other grade III and grade IV). Kaplan-Meier survival curves were created from the cohort data. From the survival curves,the median times to resolution of VUR were determined for the cohort,and these times were compared with the median times to VUR resolution of the data us.d.for the dTM. The numbers of VCUGs performed,time of ABX exposure,and costs in the cohort were compared with those that would have occurred if the algorithm had been applied to both mild and moderate/severe VUR groups. Results. Using an algorithm that

关键词：膀胱尿道造影膀胱输尿管反流预防性抗生素总体费用重度患儿生存曲线检查次数方案应用决策树

磁共振成像技术及多普勒超声在量化测定狭窄的二尖瓣面积时的比较

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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 45-46页

作者： Lin s.J. Brown P.A. Watkins M.P. s.d. Caruthers 刘豫 Cardiovascular di vision Washington Univ. School of Medicine St. Louis MO United StatesDr.

Objectives The purpose of this study was to evaluate the reliability of the pr essure half-time(PHT) method for estimating mitral valve areas(MVAs) by velocit y-encoded cardiovascular magnetic resonance(VE-CMR) and to compare the method with paired doppler ultrasound. Background The pressure halftime doppler echocar diography method is a practical technique for clinical evaluation of mitral sten osis. As CMR continues evolving as a routine clinical tool, its use for estimati ng MVA requires thorough evaluation. Methods seventeen patients with mitral sten osis underwent echocardiography and CMR. Using VE-CMR, MVA was estimated by PHT method. Additionally, peak E and peak A velocities were defined. Interobserver repeatability of VE-CMR was evaluated. Results By doppler, MVAs ranged from 0.8 7 to 4.49 cm2; by CMR, 0.91 to 2.70 cm2, correlating well between modalities (r= 0.86). The correlation coefficient for peak E and peak A between modalities was 0.81 and 0.89, respectively. Velocity-encoded CMR data analysis provided robust , repeatable estimates of peak E, peak A, and MVA (r=0.99, 0.99, and 0.96, respe ctively). Conclusions Velocity-encoded cardiovascular magnetic resonance can be us.d.routinely as a robust tool to quantify MVA via mitral flow velocity analys is with PHT method.

关键词：磁共振成像技术二尖瓣面积血流速度可重复性多普勒超声法二尖瓣血流通过速度峰流速常用技术数据分析

A型肉毒杆菌毒素预防治疗慢性紧张型头痛的多中心、双盲、随机、安慰剂对照、平行分组研究

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世界核心医学期刊文摘(神经病学分册) 2006年第10期 13-14页

作者： silberstein s.d. Gbel H. Jensen R. 樊慧婷 department of Neurology Jefferson Headache Center Thomas Jefferson University Hospital 111 South 11th Street Philadelphia PA19107United States Dr.

We studied the safety and efficacy of 0 U, 50 U, 100 U, 150 U (five sites), 86 Usub and 100 Usub (three sites) botulinum toxin type A (BoNTA; BOTOX ; Allergan, Inc., Irvine, CA, UsA)- for the prophylaxis of chronic tension- type headache (CTTH). Three hundred patients (62.3% female; mean age 42.6 years)- enrolled. For the primary endpoint, the mean change from baseline in the number of TTH- free days per month, there was no statistically significant difference between placebo and four BoNTA groups, but a significant difference favouring placebo vs. BoNTA 150 was observed (4.5 vs. 2.8 tension headachefree days/month; P = 0.007). All treatment groups improved at day 60. Although efficacy was not demonstrated for the primary endpoint, at day 90, more patients in three BoNTA groups had ≥ 50% decrease in tension headache days than did placebo (P ≤ 0.024). Most treatment- related adverse events were mild or moderate, and transient. BoNZA was safe and well- tolerated in the study.

关键词：肉毒杆菌毒素紧张型安慰剂空白剂预防治疗头痛头疼疼痛

依诺肝素与普通肝素在应用替罗非班、阿司匹林治疗的患者中的作用与早期保守初始治疗策略:A-to-Z试验的A期结果

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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 29-30页

作者： de Lemos J.A. Blazing M.A. Wiviott s.d. 王永兴

In high risk patients with non sT elevation acute coronary syndromes(ACs), en oxaparin is generally preferred to unfractionated heparin(UFH). However, less is known about the relative merits of these two forms of heparin in patients recei ving concomitant glycoprotein IIb/IIIa inhibitors. The A phase of the A to Z t rial was an open label non inferiority trial in which 3987 patients with non s T elevation ACs were randomis.d.to receive either enoxaparin or UFH in combinati on with aspirin and tirofiban. Inclusion required either sT depression or cardia c biomarker elevation. While the selection of an early management strategy (inva sive or conservative) was at the discretion of the local investigator, investiga tors were asked to designate their plans for an invasive or conservative strateg y on the case record form. An early conservative strategy was specified for 1778 patients(45%); this subgroup forms the population for the present analyses. Am ong patients with a planned conservative strategy, baseline characteristics were similar between those randomis.d.to UFH (n=872) and those randomis.d.to enoxapa rin (n=906). The primary endpoint of death, new MI, or documented refractory isc haemia within 7 days of randomisation occurred in 10.6%of patients randomis.d.t o UFH and 7.7%of patients randomis.d.to enoxaparin (HR 0.72; 95%CI 0.53-0.99; p=0.04). The combined rate of TIMI major, minor, or loss no site bleeding was 1.3%in patients treated with UFH and 1.8%in those treated with enoxaparin (p=n s). When a conservative approach to catheterisation and PCI was planned for ACs patients receiving tirofiban and aspirin, enoxaparin was associated with superio r efficacy and similar bleeding vs UFH.

关键词：依诺肝素 A-to-Z 普通肝素阿司匹林治疗替罗非班初始治疗急性冠脉综合征心脏标志物难治性缺血亚组