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A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in Er+breast cancer cells

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Microsystems & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ortega Quesada Jonathan cuccia rachael coates Blake Nassar Ethan Littlefield Elizabeth c.Martin Adam T.Melvin cain Department of chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA Department Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metastatic breast cancer leads to poor prognoses and worse outcomes in patients due to its invasive behavior and poor response to *** is still unclear what biophysical and biochemical factors drive this more aggressive phenotype in metastatic cancer;however recent studies have suggested that exposure to fluid shear stress in the vasculature could cause *** this study a modular microfluidic platform capable of mimicking the magnitude of fluid shear stress(Fss)found in human vasculature was designed and *** device provides a platform to evaluate the effects of Fss on McF-7 cell line,an estrogen receptor positive(Er+)breast cancer cell line,during circulation in the *** of the effects of Fss on McF-7 cells was carried out utilizing two approaches:single cell analysis and bulk *** single cell analysis,cells were trapped in a microarray after exiting the serpentine channel and followed by immunostaining on the device(on-chip).Bulk analysis was performed after cells were collected in a microtube at the outlet of the microfluidic serpentine channel for western blotting(off-chip).It was found that cells exposed to an Fss magnitude of 10 dyn/cm^(2) with a residence time of 60 s enhanced expression of the proliferation marker Ki67 in the McF-7 cell line at a single cell *** understand possible mechanisms for enhanced Ki67 expression,on-chip and off-chip analyses were performed for pro-growth and survival pathways ErK,AKT,and JAK/*** demonstrated that after shearing the cells phosphorylation of p-AKT,p-mTOr,and p-sTAT3 were ***,there was no change in p-ErK1/*** is a mediator of Er rapid signaling,analysis of phosphorylated Erαwas carried out and no significant differences between sheared and non-sheared populations were *** together these results demonstrate that Fss can increase phosphorylation of proteins associated with a more aggressive phenotype in circulating cancer *** findin

关键词： fluid breast estrogen

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Effect of coenzyme Q10 supplementation on post-vitrification mouse embryo development

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Asian pacific Journal of reproduction 2024年第3期13卷 126-132页

作者： Anisa-Annur s Wan-Hafizah WJ Nor-Ashikin MNK Muhammad-Zaki r Faculty of Pharmacy and Health sciences Royal College of Medicine PerakUniversiti Kuala Lumpur30450 IpohPerakMalaysia Maternofetal and Embryo research Group Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh Campus47000 Sungai BulohSelangorMalaysia

Objective:To investigate the effects of coenzyme Q10(coQ10)supplementation on post-vitrification embryo development and gross ***:Balb/c mouse embryos were cultured in potassium simplex optimised medium(KsOM)with varying coQ10 concentrations[0(control),20,40,and 60μM].The most effective coQ10 concentration(40μM)was selected for subsequent post-vitrification morphology *** were randomly divided into four groups:Group A(non-vitrified without coQ10),Group B(non-vitrified with coQ10),Group c(vitrified without coQ10),and Group D(vitrified with coQ10),followed by vitrification at the 8-cell *** rates and development until the blastocyst stage were evaluated through morphological examinations using AsEBIr's system,distinguishing normal and abnormal ***:supplementation of 40μM coQ10 significantly increased blastocyst formation(95%)compared to the control group(92%),20μM(62%),and 60μM(56%)(Prification,Group D exhibited a significant increase in blastocyst formation(92%)compared to Group c(82%)(Prphological assessments indicated superior embryo quality in Group B over Group D during the cleavage stage,morula,and blastocyst(Pconclusions:coQ10 supplementation exhibits promising potential to enhance preimplantation embryo development,increase blastocyst formation rates,and improve embryo quality *** offers a promising approach to mitigate oxidative stress on embryos,potentially improving overall assisted reproductive technology outcomes.

关键词： coenzyme Q10 Antioxidant Embryo development Vitrification Morphology Assisted reproductive technology

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single atom cu-N-c catalysts for the electro-reduction of cO_(2) to cO assessed by rotating ring-disc electrode

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Journal of Energy chemistry 2024年第1期88卷 169-182,I0004页

作者： s.Pérez-rodríguez M.Gutiérrez-roa c.Giménez-rubio D.ríos-ruiz P.Arévalo-cid M.V.Martínez-Huerta A.Zitolo M.J.Lázaro D.sebastián Instituto de carboquímica(csIc) Miguel Luesma Castán 450018 ZaragozaSpain Instituto de catálisis y Petroleoquímica(csIc) Marie Curie 228049 MadridSpain synchrotron sOLEIL L’Orme des MerisiersDépartementale 12891190France

The electrochemical cO_(2) reduction reaction(cO_(2)rr) to controllable chemicals is considered as a promising pathway to store intermittent renewable energy. Herein, a set of catalysts based on copper-nitrogendoped carbon xerogel(cu-N-c) are successfully developed varying the copper amount and the nature of the copper precursor, for the efficient cO_(2)rr. The electrocatalytic performance of cu-N-c materials is assessed by a rotating ring-disc electrode(rrDE), technique still rarely explored for cO_(2)rr. For comparison, products are also characterized by online gas chromatography in a H-cell. The as-synthesized cu-Nc catalysts are found to be active and highly cO selective at low overpotentials(from -0.6 to -0.8 V ***) in 0.1 M KHcO_(3), while H_(2) from the competitive water reduction appears at larger overpotentials(-0.9 V vs. rHE). The optimum copper acetate-derived catalyst containing cu-N_(4) moieties exhibits a cO_(2)-to-cO turnover frequency of 997 h^(-1) at -0.9 V vs. rHE with a H_(2)/cO ratio of 1.8. These results demonstrate that rrDE configuration can be used as a feasible approach for identifying electrolysis products from cO_(2)rr.

关键词： cu-N-c carbon xerogel rotating ring disc electrode carbon dioxide reduction reaction carbon monoxide

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Polio eradication surveillance in sri Lanka,2019-2023

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Asian Pacific Journal of Tropical Medicine 2024年第6期17卷 268-272页

作者： M.A.Y.Fernando N.s.Madarasinghe c.rangana N.Weerasinghe D.c.U.D.Weligamage J.I.Abeynayake Department of Medical Microbiology and Immunology Faculty of MedicineUniversity of ColomboSri Lanka Department of Virology Medical Research InstituteColombo 08Sri Lanka Medical research Institute Colombo 08Sri Lanka

Objective:To evaluate the polio laboratory surveillance carried out from January,2019 to May,2023 by the Polio regional reference Laboratory,sri ***:This retrospective study analyzed all stool samples received under the acute flaccid paralysis(AFP)and immunodeficient vaccine-derived poliovirus(VDPV)surveillance at Polio regional reference Laboratory,sri Lanka from January,2019 to May,*** results of the testing methodologies were extracted from the laboratory data system,i.e.,poliovirus virus isolation,intra-typic differentiation/VDPV real time reverse transcriptase polymerase chain reaction(ITD/VDPV rrTPcr)and sequencing,along with the data on timing of reporting results,stool adequacy and *** was analyzed using descriptive ***:A total of 2141 stool samples from 1644 cases were received for AFP surveillance from sri Lanka(93.61%),Maldives(1.52%),and immunodeficient VDPV(4.86%)*** polioviruses(19/1644,1.15%)and non-polio enteroviruses(73/1644,4.44%)were isolated,while sabin-like 3 virus was detected in majority(12/19,63.15%)among the poliovirus *** polioviruses or circulating VDPVs were not detected among the *** all years of the study,the non-polio AFP detection rate was>1/100000 in children aged less than 15 years,whereas stool adequacy rate was>80%.All results were reported within 14 days of receipt,ensuring timely reporting as per global ***:The Polio regional reference Laboratory,sri Lanka plays a vital role in maintaining the polio-free status in the country through its robust laboratory surveillance,while adhering to the surveillance ***-detection of wild polioviruses and circulating VDPV during the study period reinforces the polio-free status in the country.

关键词： Poliovirus Polio laboratory surveillance regional reference laboratory Polio eradication

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The ccD instrument background of the sMILE sXI

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Earth and Planetary Physics 2024年第1期8卷 15-24页

作者： M.W.J.Hubbard O.Hetherington D.J.Hall T.W.Buggey s.Parsons T.Arnold A.Holland c.Pagani s.sembay centre for Electronic Imaging The Open UniversityMilton KeynesMK76AAUK X-ray and Observational Astronomy Group Department of Physics&AstronomyUniversity of LeicesterLE17RHUK

The EsA and cAs sMILE mission orbit is highly elliptical and will pass through multiple radiation *** soft X-ray Imager(sXI)instrument aboard has a radiation shutter door designed to close when the surrounding radiation flux is *** shutter door will close when passing below an altitude threshold to protect against trapped particles in the Earth’s Van Allen ***,two radiation environments can be approximated based on the shutter door position:open and *** instrument background for the ccDs(charge-coupled Devices)that form the focal plane array of the sXI were evaluated for the two *** to the correlation of the space environment with the solar cycle,the solar minima and maxima,the background was also evaluated at these two *** results demonstrated that the highest instrument background will occur during solar minima due to the main contributing source being Galactic cosmic rays(Gcrs).It was also found that the open background was highest for solar minima and that the closed background was highest during solar *** is due to the radiation shutter door acting as a scattering centre and the changes in the energy flux distribution of the Gcrs between the two solar extremes.

关键词： instrument background X-ray astronomy space radiation

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Magnesium oxide(MgO)nanoadsorbents in wastewater treatment:A comprehensive review

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Journal of Magnesium and Alloys 2024年第5期12卷 1709-1773页

作者： H.c.s.Perera V.Gurunanthanan Anoop singh M.M.M.G.P.G.Mantilaka G.Das sandeep Arya Department of Physics Khalifa UniversityAbu Dhabi12788United Arab Emirates Postgraduate Institute of science University of PeradeniyaPeradeniyaSri Lanka Department of Humanities and sciences Guru Nanak Institutions Technical CampusIbrahimpatnamHyderabad501506India centre for Global Health research Saveetha Medical College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai602105Tamil NaduIndia Department of Physics University of JammuJammu and Kashmir180006India

Wastewater contamination by heavy metals and synthetic dyes presents a significant environmental challenge,necessitating effective and sustainable separation *** review article provides a detailed examination of magnesium oxide(MgO)nanoparticles as an innovative nanoadsorbent for wastewater treatment,with a specific focus on heavy metal and dye *** review comprehensively explores various aspects of MgO nanoparticles,including their structural characteristics and synthesis *** article delves into the morphology and crystallographic arrangement of MgO nanoparticles,offering insights into their structural *** the complexity of adsorption processes,the review identifies and analyzes parameters influencing the adsorption efficiency of MgO nanoparticles,such as temperature,pH,contact time,initial concentration,and co-existing *** interplay between these parameters and the adsorption capability of MgO nanoparticles emphasizes the importance of optimizing operational ***,the review assesses various synthesis methods for MgO nanoparticles,including sol-gel,hydrothermal,precipitation,green synthesis,solvothermal,and template-assisted *** discusses the advantages,limitations,and resulting nanoparticle characteristics of each method,enabling readers to grasp the implications of synthesis processes on adsorption *** comprehensive review consolidates current insights into the effectiveness of MgO nanoparticles as a potent nanoadsorbent for removing heavy metals and dyes from wastewater covering a wide spectrum of aspects related to MgO ***,there is a need to investigate the use of MgO in the treatment of actual wastewater or river water,in order to leverage its cost-effectiveness and high efficiency for practical water treatment applications in real-time.

关键词： MgO nanoparticles Nanoadsorbent Wastewater treatment Heavy metals Dye separation Adsorption synthesis methods

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collisionless shock acceleration of protons in a plasma slab produced in a gas jet by the collision of two laser-driven hydrodynamic shockwaves

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Matter and radiation at Extremes 2024年第2期9卷 12-25页

作者： J.-r.Marquès L.Lancia P.Loiseau P.Forestier-colleoni M.Tarisien E.Atukpor V.Bagnoud c.Brabetz F.consoli J.Domange F.Hannachi P.Nicolaï M.salvadori B.Zielbauer LULI CNRSÉcole PolytechniqueCEASorbonne UniversitéInstitut Polytechnique de Paris91128 Palaiseau CedexFrance cEA DAMDIF91297 Arpajon CedexFrance UniversitéParis-saclay CEALMCE91680 Bruyères-le-ChatelFrance cENBG CNRS-IN2P3Universitéde Bordeaux33175 Gradignan CedexFrance GsI Helmholtzzentrum für schwerionenforschung GmbH Planckstraße 164291 DarmstadtGermany University of Darmstadt Schloßgartenstr.764289 DarmstadtGermany ENEA Fusion and Technologies for Nuclear safety Department C.R.FrascatiVia Enrico Fermi 45FrascatiRomeItaly cELIA Universitéde Bordeaux–CNRS–CEA33405 TalenceFrance UniversitéParis-saclay CEALIDYL91191 Gif-sur-YvetteFrance

We have recently proposed a new technique of plasma tailoring by laser-driven hydrodynamic shockwaves generated on both sides of a gas jet[Marquès et al.,*** 28,023103(2021)].In a continuation of this numerical work,we study experimentally the influence of the tailoring on proton acceleration driven by a high-intensity picosecond laser in three cases:without tailoring,by tailoring only the entrance side of the picosecond laser,and by tailoring both sides of the gas *** tailoring,the acceleration is transverse to the laser axis,with a low-energy exponential spectrum,produced by coulomb *** the front side of the gas jet is tailored,a forward acceleration appears,which is significantly enhanced when both the front and back sides of the plasma are *** forward acceleration produces higher-energy protons,with a peaked spectrum,and is in good agreement with the mechanism of collisionless shock acceleration(csA).The spatiotemporal evolution of the plasma profile is characterized by optical shadowgraphy of a probe *** refraction and absorption of this beam are simulated by post-processing 3D hydrodynamic simulations of the plasma *** with the experimental results allows estimation of the thickness and near-critical density of the plasma slab produced by tailoring both sides of the gas *** parameters are in good agreement with those required for csA.

关键词： acceleration hydrodynamic collision

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Impact of sex on the outcomes of deceased donor liver transplantation

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World Journal of Transplantation 2024年第1期14卷 120-129页

作者： Oya M Andacoglu Isabel s Dennahy Nicole c Mountz Luisa Wilschrey Arzu Oezcelik Division of Transplantation and Advanced Hepatobiliary surgery University of UtahSalt Lake CityUT 84112United States Department of surgery University of EssenEssen D-45122Germany Department of surgery The University of Oklahoma Health Sciences CenterOklahoma CityOK 73117United States Department of surgery University of Oklahoma College of MedicineOklahoma CityOK 73117United States

BAcKGrOUND Data examining the impact of sex on liver transplant(LT)outcomes are *** is clear that further research into sex-related differences in transplant patients is necessary to identify areas for *** of these differences may help to identify specific areas of focus to improve on the organ matching process,as well as the peri-and post-operative care of these *** To utilize data from a high-volume Eurotransplant center to compare characteristics of male and female patients undergoing liver transplant and assess association between sex-specific variables with short-and long-term post-transplant *** A retrospective review of the University of Essen’s transplant database was performed with collection of baseline patient characteristics,transplant-related data,and short-term *** of these data were made with shapiro-Wilk,Mann-Whitney U,χ2 and Bonferroni tests applied where appropriate.A P value ofs accepted as statistically *** Of the total 779 LT recipients,261(33.5%)were *** patients suffered higher incidences of acute liver failure and lower incidences of alcohol-related or viremic liver disease(P=0.001).Female patients were more likely to have received an organ from a female donor with a higher donor risk index score,and as a high urgency offer(all Pseline characteristics of male and female recipients were also significantly *** multivariate hazard regression analysis,recipient lab-Model for End-stage Liver Disease score and donor cause of death were associated with long-term outcomes in ***-operative diagnosis of hepatocellular carcinoma,age at time of listing,duration of surgery,and units transfused during surgery,were associated with long-term outcomes in *** of complications was associated with long-term outcomes in both *** survival was similar in both males and females;however,when stratified by age,females<50 y

关键词： Liver transplant Outcomes survival Peri-and post-operative care

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c19Mc mirNA-520G induces sP100 antiviral gene transcription and inhibits melanin production in skin cutaneous melanoma

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Genes & Diseases 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh Marian T.smallin Nino Mtchedlidze Isha Godwin Marco Napoli Nicole Hackel Manali s.Phadke Avani A.Deshpande Xiaobo Li John H.Lockhart Jaden r.Baldwin suehelay Acevedo-Acevedo Yifeng Gao Michelle A.reiser Keiran s.M.smalley Elsa r.Flores Andrew s.Brohl Department of Molecular Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Molecular Medicine Program H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA saveetha Medical college ChennaiTamil Nadu 602105India Tumor Biology Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA sarcoma Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

sP100 is an antiviral protein that restricts the productive stage of human papillomavirus(HPV)and multiple other viruses,and viruses in turn block sUMO-1-mediated stabilization of sP100 and promotes its degradation(Table s1).Interferon(IFN)signaling could still produce more sP100 through transcription to counteract viruses.1 Viruses also disable the transcriptional up-regulation of sP100 to achieve persistent infection in hosts.

关键词： sP100 melanoma stabilization

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Effect of solidification cooling rate on microstructure and tribology characteristics of Zn-4si alloy

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 362-373页

作者： F.Akbari M.Golkaram s.Beyrami G.shirazi K.Mantashloo r.Taghiabadi M.saghafi Yazdi I.Ansarian Department of Metallurgy and Material science Imam Khomeini International University(IKIU)Qazvin ***Iran

The main objective of this work was to modify the microstructure and enhance the tribological properties of a new Zn-4si al-loy through a high solidification cooling rate(scr).According to the results,by increasing the scr from 2.0 to 59.5℃/s the average size of primary si particles and that of the grains reduced from 76.1 and 3780μm to less than about 14.6 and 460μm,***-ing the scr also enhanced the microstructural homogeneity,decreased the porosity content(by 50%),and increased the matrix hardness(by 36%).These microstructural changes enhanced the tribological *** instance,under the applied pressure of 0.5 MPa,an in-crease in the scr from 2.0 to 59.5℃/s decreased the wear rate and the average friction coefficient of the alloy by 57%and 23%,*** wear mechanism was also changed from the severe delamination,adhesion,and abrasion in the slowly-cooled alloy to the mild tribolayer delamination/abrasion in the high-cooling-rate-solidified sample.

关键词： zinc-silicon alloy primary silicon solidification cooling rate tribology sliding wear

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