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An Analog of Einstein’s General Relativity Emerging from classical Finite Elasticity Theory:Analytical and computational Issues

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communications in computational Physics 2013年第8期14卷 801-818页

作者： c.cherubini s.Filippi Nonlinear Physics andMathematicalModeling Lab University Campus Bio-MedicoI-00128Via A.del Portillo 21RomeItaly International center for Relativistic Astrophysics-I.c.R.A. University of Rome“La Sapienza”I-00185 RomeItaly

The“analogue gravity formalism”,an interdisciplinary theoretical scheme developed in the past for studying several non relativistic classical and quantum systems through effective relativistic curved space-times,is here applied to largely deformable elastic bodies described by the nonlinear theory of solid *** the simplest nonlinear constitutive relation for the elastic material given by a Kirchhoff-st Venant strain-energy density function,it is possible to write for the perturbations an effective space-time metric if the deformation is purely longitudinal and depends on one spatial coordinate *** and numerical studies of the corresponding dynamics are performed in selected cases and physical implications of the results obtained are finally discussed.

关键词： Finite elasticity general relativity analogue gravity finite elements method

A Rule-Based Approach for Grey Hole Attack Prediction in Wireless sensor Networks

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Intelligent Automation & soft computing 2023年第3期35卷 3815-3827页

作者： c.Gowdham s.Nithyanandam Department of computer science and Engineering PRIST Deemed to be UniversityThanjavur613403TamilnaduIndia

The Wireless sensor Networks(WsN)are vulnerable to assaults due to the fact that the devices connected to them have a reliable connection to the inter-net.A malicious node acts as the controller and uses a grey hole attack to get the data from all of the other nodes in the ***,the nodes are dis-carding and modifying the data packets according to the requirements of the *** assault modiﬁes the fundamental concept of the WsNs,which is that different devices should communicate with one *** the proposed system,there is a fuzzy idea offered for the purpose of preventing the grey hole attack from making effective communication among the WsN *** currently available model is unable to recognise the myriad of different kinds of *** fuzzy engine identiﬁed suspicious actions by utilising the rules that were gen-erated to make a prediction about the malicious node that would halt the *** conducted using simulation are used to determine delay,accuracy,energy consumption,throughput,and the ratio of packets successfully *** stands in contrast to the model that was suggested,as well as the methodologies that are currently being used,and analogue behavioural *** comparison to the existing method,the proposed model achieves an accuracy rate of 45 per-cent,a packet delivery ratio of 79 percent,and a reduction in energy usage of around 35.6 *** results from the simulation demonstrate that the fuzzy grey detection technique that was presented has the potential to increase the net-work’s capability of detecting grey hole assaults.

关键词： Attack prediction grey hole wireless sensor networks rule-based model grey attack

Endoscopic ultrasound-guided techniques for diagnosing pancreatic mass lesions: can we do better?

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World Journal of Gastroenterology 2016年第39期22卷 8658-8669页

作者： Andrew c storm Linda s Lee Division of Gastroenterology Hepatology and Endoscopy Brigham and Women’s Hospital Harvard Medical School

The diagnostic approach to a possible pancreatic mass lesion relies first upon various non-invasive imaging modalities, including computed tomography, ultrasound, and magnetic resonance imaging techniques. Once a suspect lesion has been identified, tissue acquisition for characterization of the lesion is often paramount in developing an individualized therapeutic approach. Given the high prevalence and mortality associated with pancreatic cancer, an ideal approach to diagnosing pancreatic mass lesions would be safe, highly sensitive, and reproducible across various practice settings. Tools, in addition to radiologic imaging, currently employed in the initial evaluation of a patient with a pancreatic mass lesion include serum tumor markers, endoscopic retrograde cholangiopancreatography, and endoscopic ultrasound-guided fine needle aspiration(EUs-FNA). EUs-FNA has grown to become the gold standard in tissue diagnosis of pancreatic lesions.

关键词： Endoscopic ultrasound Fine needle aspiration Pancreatic cancer Pancreatic mass Endoscopy

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse school of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Reproductive fluids,used for the in vitro production of pig embryos,result in healthy offspring and avoid aberrant placental expression of PEG3 and LUM

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Journal of Animal science and Biotechnology 2021年第3期12卷 972-983页

作者： E.París-Oller s.Navarro-serna c.soriano-Úbeda J.s.Lopes c.Matás s.Ruiz R.Latorre O.López-Albors R.Romar s.cánovas P.coy Department of Physiology-Faculty of Veterinary University of Murcia-Campus Mare Nostrum30100 MurciaSpain Institute for Biomedical Research of Murcia IMIB-ArrixacaMurciaSpain Department of Anatomy and comparartive Pathology Faculty of Veterinary MedicineUniversity of Murcia-Campus Mare Nostrum30100 MurciaSpain

Background:In vitro embryo production(IVP)and embryo transfer(ET)are two very common assisted reproductive technologies(ART)in human and ***,in pig,the combination of either procedures,or even their use separately,is still considered suboptimal due to the low efficiency of IVP plus the difficulty of performing ET in the long and contorted uterus of the *** addition,the potential impact of these two ART on the health of the offspring is *** investigated here if the use of a modified IVP system,with natural reproductive fluids(RF)as supplements to the culture media,combined with a minimally invasive surgery to perform ET,affects the output of the own IVP system as well as the reproductive performance of the mother and placental molecular ***:The blastocyst rates obtained by both in vitro systems,conventional(c-IVP)and modified(RF-IVP),were *** and farrowing rates were also ***,when compared to in vivo control(artificial insemination,AI),litter sizes of both IVP groups were lower,while placental efficiency was higher in AI than in *** expression studies revealed aberrant expression levels for PEG3 and LUM in placental tissue for c-IVP group when compared to AI,but not for RF-IVP ***:The use of reproductive fluids as additives for the culture media in pig IVP does not improve reproductive performance of recipient mothers but could mitigate the impact of artificial procedures in the offspring.

关键词： Assisted reproductive technologies Embryo transfer In vitro embryo production Placenta Reproductive fluids

Effect of solar wind plasma parameters on space weather

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Research in Astronomy and Astrophysics 2015年第1期15卷 85-106页

作者： Balveer s.Rathore Dinesh c.Gupta subhash c.Kaushik school of study in Physics Jiwaji UniversityGwalior Madhya Pradesh India

Today’s challenge for space weather research is to quantitatively predict the dynamics of the magnetosphere from measured solar wind and interplanetary magnetic field（IMF） conditions. correlative studies between geomagnetic storms（GMss）and the various interplanetary（IP） field/plasma parameters have been performed to search for the causes of geomagnetic activity and develop models for predicting the occurrence of GMss, which are important for space weather predictions. We find a possible relation between GMss and solar wind and IMF parameters in three different situations and also derived the linear relation for all parameters in three *** the basis of the present statistical study, we develop an empirical model. With the help of this model, we can predict all categories of GMss. This model is based on the following fact： the total IMF Btotalcan be used to trigger an alarm for GMss, when sudden changes in total magnetic field Btotaloccur. This is the first alarm condition for a storm’s arrival. It is observed in the present study that the southward Bzcomponent of the IMF is an important factor for describing GMss. A result of the paper is that the magnitude of Bzis maximum neither during the initial phase（at the instant of the IP shock） nor during the main phase（at the instant of Disturbance storm time（Dst） minimum）. It is seen in this study that there is a time delay between the maximum value of southward Bzand the Dst minimum, and this time delay can be used in the prediction of the intensity of a magnetic storm two-three hours before the main phase of a GMs. A linear relation has been derived between the maximum value of the southward component of Bzand the Dst, which is Dst =（-0.06）＋（7.65）Bz＋ *** auxiliary conditions should be fulfilled with this, for example the speed of the solar wind should, on average, be 350 km s-1 to 750 km s-1, plasma β should be low and, most importantly, plasma temperature should be low for intense storms. If the plasma tem

关键词： solar wind geomagnetic storms(GMss) interplanetary magnetic field(IMF)

soil Organic carbon Loss and Turnover Resulting from Forest conversion to Maize Fields in Eastern Thailand

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Pedosphere 2011年第5期21卷 581-590页

作者： s.JAIARREE A.cHIDTHAIsONG N.TANGTHAM c.POLPRAsERT E.sAROBOL s.c.TYLER Joint Graduate school of Energy and Environment King Mongkut's University of Technology Thonburi Faculty of Forestry Kasetsart University sirindhorn International Institute of Technology Thammasat University Faculty of Agriculture Kasetsart University Department of chemistry Norco College

soil organic carbon(sOc) content and its stable carbon isotopic composition(within the upper 1 m) were measured to determine the e?ect of land-use changes from dry evergreen forest to maize fields in eastern *** land cover maps,derived from aerial photography and satellite images for years 1989,1996,and 2002 were used in association with field surveys and farmer interviews to derive land-use history and to assist in study site *** from forest to maize cultivation for the duration of 12 years reduced sOc stocks at the rate of 6.97 Mg c ha-1 *** was most pronounced in the top 10 cm soil layer,which was 47% after 12 years of *** carbon isotope data revealed that the main fraction lost was forest-derived *** low input rates of maize-derived c were not sufficient to maintain sOc at the level prior to forest *** 12 years of continuous maize cultivation,the maize-derived c fraction made up about 20% of total sOc(5 Mg ha-1 of the total 25.31 Mg ha-1).

关键词： c stocks forest-derived c land-use change maize-derived c stable carbon isotope

Local heroes or villains:tissue-resident memory T cells in human health and disease

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cellular & Molecular Immunology 2020年第2期17卷 113-122页

作者： s.c.sasson c.L.Gordon s.N.christo P.Klenerman L.K.Mackay Translational Gastroenterology Unit Nuffield Department of MedicineUniversity of OxfordOxfordUK Department of Microbiology and Immunology Peter Doherty Institute for Infection and ImmunityUniversity of MelbourneMelbourneVICAustralia Department of Infectious Diseases Austin HealthMelbourneVICAustralia Peter Medawar Building for Pathogen Research University of OxfordOxfordUK

Tissue-resident memory T(T_(RM))cells are increasingly associated with the outcomes of health and disease.T_(RM) cells can mediate local immune protection against infections and cancer,which has led to interest in T_(RM) cells as targets for vaccination and ***,these cells have also been implicated in mediating detrimental pro-inflammatory responses in autoimmune skin diseases such as psoriasis,alopecia areata,and ***,we summarize the biology of T_(RM) cells established in animal models and in translational human *** review the beneficial effects of T_(RM) cells in mediating protective responses against infection and cancer and the adverse role of T_(RM) cells in driving pathology in autoimmunity.A further understanding of the breadth and mechanisms of T_(RM) cell activity is essential for the safe design of strategies that manipulate T_(RM) cells,such that protective responses can be enhanced without unwanted tissue damage,and pathogenic T_(RM) cells can be eliminated without losing local immunity.

关键词： human T cells tissue-resident memory immunity

A new way to construct topological invariants of non-Hermitian systems with the non-Hermitian skin effect

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chinese Physics B 2020年第1期29卷 119-123页

作者： J s Liu Y Z Han c s Liu Hebei Key Laboratory of Microstructural Material Physics School of ScienceYanshan UniversityQinhuangdao 066004China

The non-Hermitian skin effect breaks the conventional bulk–boundary correspondence and leads to non-Bloch topological *** by the fact that the topological protected zero modes are immune to perturbations,we construct a partner of a non-Hermitian system by getting rid of the non-Hermitian skin *** adjusting the imbalance hopping,we find that the existence of zero-energy boundary states still dictate the bulk topological invariants based on the band-theory *** non-Hermitian su–schrieffer–Heeger(ssH)models are used to illuminate the ***,we obtain the winding numbers in analytical form without the introduction of the generalized Brillouin *** work gives an alternative method to calculate the topological invariants of non-Hermitian systems.

关键词： non-Hermitian skin effect su–schrieffer–Heeger(ssH)model bulk–boundary correspondence topological invariant