检索结果-南通市图书馆

MAIPFE:An Efficient Multimodal Approach Integrating Pre-Emptive Analysis,Personalized Feature selection,and Explainable AI

在线全文

学校读者我要写书评

暂无评论

computers, Materials & continua 2024年第5期79卷 2229-2251页

作者： Moshe Dayan sirapangi s.Gopikrishnan school of computer science and Engineering VIT-AP UniversityAmaravathiAndhra Pradesh522241India

Medical Internet of Things(IoT)devices are becoming more and more common in *** has.c.eated a huge need for advanced predictive health modeling strategies that can make good use of the growing amount of multimodal data to find potential health risks early and help individuals in a personalized *** methods,while useful,have limitations in predictive accuracy,delay,personalization,and user interpretability,requiring a more comprehensive and efficient approach to harness modern medical IoT *** is a multimodal approach integrating pre-emptive analysis,personalized feature selection,and explainable AI for real-time health monitoring and disease *** using AI for early disease detection,personalized health recommendations,and transparency,healthcare will be *** Multimodal Approach Integrating Pre-emptive Analysis,Personalized Feature selection,and Explainable AI(MAIPFE)framework,which combines Firefly Optimizer,Recurrent Neural Network(RNN),Fuzzy c Means(FcM),and Explainable AI,improves disease detection precision over existing *** metrics show the model’s superiority in real-time health *** proposed framework outperformed existing models by 8.3%in disease detection classification precision,8.5%in accuracy,5.5%in recall,2.9%in specificity,4.5%in AUc(Area Under the curve),and 4.9%in delay *** prediction precision increased by 4.5%,accuracy by 3.9%,recall by 2.5%,specificity by 3.5%,AUc by 1.9%,and delay levels decreased by 9.4%.MAIPFE can revolutionize healthcare with preemptive analysis,personalized health insights,and actionable *** research shows that this innovative approach improves patient outcomes and healthcare efficiency in the real world.

关键词： Predictive health modeling Medical Internet of Things explainable artificial intelligence personalized feature selection preemptive analysis

GRP7 phase separation as an interpreter of temperature cues

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2024年第6期17卷 842-844页

作者： sunita Pathak Lucia c.strader Department of Biology Duke UniversityDurhamNCUSA

Plants are exposed to a range of daily and seasonal temperatures and thus are required to regulate their cellular processes under fluctuating temperature *** various temperature-responsive genes,GLYcINE-RIcH RNA BINDING PROTEIN7(GRP7)encodes a glycine-rich RNA-binding protein that provides freezing tolerance to plants.c.rpenter et al.,1994;Kim et al.,2008)by acting as an RNA chaperone(Kwak et al.,2011).

关键词： conditions. separation

Effects of interlayer spacing and applied pressure on the lanthanide transport in Mos2-based two-dimensional channels

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of smart and Nano Materials 2024年第3期15卷 579-592页

作者： Qinsi Xiong chong Liu George c.schatz Department of chemistry Northwestern UniversityEvanstonILUSA Pritzker school of Molecular Engineering University of ChicagoChicagoILUSA

Rare-earth elements(REEs)are critical to modern industry but difficult to separate due to their subtle and monotonic changes in phys.c.-chemical ***2-based two-dimensional(2D)materials offer novel opportunities for enhancing REE separation,exhibiting a distinct volcano-shaped transport performance distribution that peaks at sm3+.However,the specific contributions of thermodynamic and kinetic factors to ion transport within 2D confinement remain *** this study,we conducted a series of non-equilibrium all-atom molecular dynamics(MD)simulations to explore the effects of interlayer spacing and external pressure on the transport of lanthanide ions inÅ-scale acetate functionalized 2D Mos2(Mos2-cOOH)*** examined ion entry and permeation rates,water flux,dehydration,and binding *** simulation results reveal that the transport trends of lanthanide ions are jointly driven by the dehydration degree and the relative-binding strengths of ions to water and to the acetate within the 2D ***,the dehydration pattern of lanthanide ions during permeation is.c.osely linked to kinetic ***,this study provides a detailed atomistic understanding of the mechanisms under-lying lanthanide ion transport under *** findings point to the significant potential for tuning confinement and chemical functionalization withinÅ-scale channels for more efficient REE separation.

关键词： Mos_(2) 2D channels Lanthanide ions ion transport nanofluidics

Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

cellular & Molecular Immunology 2024年第4期21卷 362-373页

作者： Zeguang Wu Qiezhong Lamao Meichao Gu Xuanxuan Jin Ying Liu Feng Tian Ying Yu Pengfei Yuan shuaixin Gao Thomas s.Fulford Adam P.Uldrich catherine c.L Wong Wensheng Wei Biomedical Pioneering Innovation center Peking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking University100871BeijingChina EdiGene Inc. Life Science ParkChangping District102206BeijingChina center for Precision Medicine Multi-Omics Research Peking University Health Science CenterPeking University100191BeijingChina Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity The University of MelbourneParkvilleVIC3010Australia cancer Immunology Program Peter MacCallum Cancer CentreMelbourneVICAustralia state Key Laboratory for complex Severe and Rare DiseasesClinical Research InstitutePeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegePeking-Tsinghua Center for Life Sciences100871BeijingChina

Vγ9Vδ2 T cells are specialized effector cells that have gained prominence as immunotherapy agents due to their ability to target and kill cells with altered pyrophosphate *** our effort to understand how cancer cells evade the cell-killing activity of Vγ9Vδ2 T cells,we performed a comprehensive genome-scale cRIsPR screening of cancer *** found that four molecules belonging to the butyrophilin(BTN)family,specifically BTN2A1,BTN3A1,BTN3A2,and BTN3A3,are critically important and play unique,nonoverlapping roles in facilitating the destruction of cancer cells by primary Vγ9Vδ2 T *** coordinated function of these BTN molecules was driven by synchronized gene expression,which was regulated by IFN-γsignaling and the RFX ***,an enzyme called QPcTL was shown to play a key role in modifying the N-terminal glutamine of these BTN proteins and was found to be a crucial factor in Vγ9Vδ2 T cell killing of cancer *** our research,we offer a detailed overview of the functional genomic mechanisms that underlie how cancer cells escape Vγ9Vδ2 T ***,our findings shed light on the importance of the harmonized expression and function of gene family members in modulating T-cell activity.

关键词： Butyrophilin Vγ9Vδ2 T-cell cancer-specific immune evasion Glutaminyl-peptide cyclotransferase-like Pyrophosphate metabolite Immunotherapy

Hierarchical control strategy for Load Regulation Based on stackelberg Game Theory considering Randomness

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

csEE Journal of Power and Energy systems 2024年第3期10卷 929-941页

作者： Tingyu Jiang Ping Ju c.Y.chung Yuzhong Gong college of Energy and Electrical Engineering Hohai UniversityNanjing 211100China Department of Electrical Engineering City University of Hong KongHong Kong CF624China Department of Electrical and computer Engineering University of SaskatchewanSaskatoonSK S7N 5A9Canada csEE IEEE

Demand response has been recognized as a valuable functionality of power systems for mitigating power *** paper proposes a hierarchical control strategy among the distribution system operator(DsO),load aggregators(LAs),and thermostatically controlled loads(TcLs);the strategy includes a scheduling layer and an executive layer to provide load *** the scheduling layer,the DsO(leader)offers.c.mpensation price(cP)strategies,and the LAs(followers)respond to cP strategies with available regulation power(ARP)*** of the DsO and LAs are modeled according to their behaviors during the load regulation *** game is adopted to capture interactions among the players and leader and to obtain the optimal strategy for each participant to achieve ***,considering inevitable random factors in practice,e.g.,renewable generation and behavior of users,two different stochastic models based on sample average approximation(sAA)and parameter modification are formulated with improved scheduling *** the executive layer,distributed TcLs are triggered based on strategies determined in the scheduling layer.A self-triggering method that does not violate user privacy is presented,where TcLs receive external signals from the LA and independently determine whether to alter their operation *** simulations are performed on the modified IEEE-24 bus system to verify effectiveness of the proposed strategy.

关键词： Demand response hierarchical control load regulation self-triggering method stackelberg game

Generalized polynomial chaos expansion by reanalysis using static condensation based on substructuring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 819-836页

作者： D.LEE s.c.ANG J.LEE Department of Automotive Engineering Hanyang UniversitySeoul 04763Republic of Korea school of Mechanical Engineering Chungnam National UniversityDaejeon 34134Republic of Korea Department of Mechanical Robotics and Energy EngineeringDongguk UniversitySeoul 04620Republic of Korea

This paper presents a new computational method for forward uncertainty quantification(UQ)analyses on large-scale structural systems in the presence of arbitrary and dependent random *** method consists of a generalized polynomial chaos expansion(GPcE)for statistical moment and reliability analyses ass.c.ated with the stochastic output and a static reanalysis method to generate the input-output data *** the reanalysis,we employ substructuring for a structure to isolate its local regions that vary due to random *** allows for avoiding repeated computations of invariant substructures while generating the input-output data *** substructuring with static condensation further improves the computational efficiency of the reanalysis without losing ***,the GPcE with the static reanalysis method can achieve significant computational saving,thus mitigating the curse of dimensionality to some degree for UQ under high-dimensional *** numerical results obtained from a simple structure indicate that the proposed method for UQ produces accurate solutions more efficiently than the GPcE using full finite element analyses(FEAs).We also demonstrate the efficiency and scalability of the proposed method by executing UQ for a large-scale wing-box structure under ten-dimensional(all-dependent)random inputs.

关键词： forward uncertainty quantification(UQ) generalized polynomial chaos expansion(GPcE) static reanalysis method static condensation substructuring

Property enhancement of cast iron used for nuclear casks

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2016年第1期23卷 40-48页

作者： R.K. Behera B.P. Mahto J.s. Dubey s.c. Mishra s. sen Department of Metallurgical and Materials Engineering National Institute of Technology Rourkela Odisha 769008 India Bhaba Atomic Research centre (Post Irradiation Examination Division) Mumbai 400085 India

Ductile iron （DI） is a preferred material for use in various structural, automotive, and engineering fields because of its excellent combination of strength, toughness, and ductility. In the current investigation, we elucidate the relationship between the morphological and mechanical properties of DI intended for use in safety applications in the nuclear industry. DI specimens with various alloying elements were subjected to annealing and austempering heat treatment processes. A faster cooling rate appeared to increase the nodule count in austempered specimens, compensating for their nodularity value and subsequently decreasing their ductility and impact strength. The ductility and impact energy values of annealed specimens increased with increasing ferrite area fraction and nodularity, whereas an increase in the amounts of Ni and cr resulted in an increase of hardness via solid solution strengthening. Austempered specimens were observed to be stronger than an- nealed specimens and failed in a somewhat brittle manner characterized by a river pattern, whereas the ductile failure mode was.c.aracter- ized by the presence of dimples.

关键词： ductile iron nodularity mechanical properties failure modes nuclear industry

A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

在线全文

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos santos P.J.Dijkstra c.Mota J.Bauer H.Ferreira Rui L.Reis N.Neves s.c.marero-Espinosa M.B.Baker L.Moroni Department of complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal IcVs/3B’s-PT Government Ass.c.ate Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBAsQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrins.c.biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PcL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PcL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PcL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).subsequently,a bone morphogenetic protein 2(BMP-2)-derived peptide was grafted onto the films.c.mprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMscs)was *** two weeks of culturing in a bas.c.medium,cells expressed higher levels of BMP receptor II(BMPRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films.c.ntain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending surface functionalization surface density click chemistry Human

Metrology for sub-Rayleigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

在线全文

学校读者我要写书评

暂无评论

High Power Laser science and Engineering 2024年第3期12卷 90-105页

作者： E.A.Vishnyakov A.sagisaka K.Ogura T.Zh.Esirkepov B.Gonzalez-Izquierdo c.D.Armstrong T.A.Pikuz s.A.Pikuz W.Yan T.M.Jeong s.singh P.Hadjisolomou O.Finke G.M.Grittani M.Nevrkla c.M.Lazzarini A.Velyhan T.Hayakawa Y.Fukuda J.K.Koga M.Ishino K.Kondo Y.Miyasaka A.Kon M.Nishikino Y.V.Nos.c. D.Khikhlukha I.P.Tsygvintsev D.Kumar J.Nejdl D.Margarone P.V.sasorov s.Weber M.Kando H.Kiriyama Y.Kato G.Korn K.Kondo s.V.Bulanov T.Kawachi A.s.Pirozhkov ELI Beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon science(KPsI) QSTKyotoJapan central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary Research Initiatives Osaka UniversityOsakaJapan HB11 Energy Holdings FreshwaterAustralia Key Laboratory for Laser Plasmas(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina collaborative Innovation center of IFsA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Phys.c. AscR PragueCzech Republic FZU-Institute of Phys.c. AscR PragueCzech Republic czech Technical University in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Phys.c. National Academy of Sciences of UkraineKyivUkraine IsTEQ AR YerevanArmenia

Tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a~10^(22)W/cm^(2)laser±plasma *** used nearly 10 J total energy femtos.c.nd laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy(i.e.,around half of the short Rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays.c.n ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-rays