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空中英语教室（高级版．彭蒙惠英语） 2024年第8期 20-22,43-45页

作者： Mary ann Thomas Norman Winter 不详

每个人都可以是博物学家查尔斯·毕尔是那种会把蛇放进口袋里的孩子。郊区可能会很无聊。草坪和道路无法为好奇的男孩提供多样的生物。不过,不久之前退休的宾夕法尼亚州西部自然资源保护协会保护科学资深主任毕尔却找到了在野外消磨时... 详细信息

每个人都可以是博物学家查尔斯·毕尔是那种会把蛇放进口袋里的孩子。郊区可能会很无聊。草坪和道路无法为好奇的男孩提供多样的生物。不过,不久之前退休的宾夕法尼亚州西部自然资源保护协会保护科学资深主任毕尔却找到了在野外消磨时间的方式。

关键词：自然资源保护宾夕法尼亚州博物学家大自然

持续的检查仍未缓解PW1000G机队面临的压力

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航空维修与工程 2024年第10期 25-26页

作者： Lee ann shay 赵平

目前PW1000G发动机问题导致全球机队的停飞数量已经达到顶峰，并且在未来一段时间内继续保持高位，在这期间，因为重复性检查带来的新情况和发动机本身耐久性问题也会随着发动机运行时间的累积不断暴露出来。加快备件生产和扩大PW1000G...

目前PW1000G发动机问题导致全球机队的停飞数量已经达到顶峰，并且在未来一段时间内继续保持高位，在这期间，因为重复性检查带来的新情况和发动机本身耐久性问题也会随着发动机运行时间的累积不断暴露出来。加快备件生产和扩大PW1000G全球MRO网络的维修能力成为了目前降低PW1000G发动机问题对于全球机队影响的有效手段。

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RNA m^(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

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Genes & Diseases 2024年第1期11卷 382-396页

作者： Zheng Zhang Keren Zhou Li Han Andrew small Jianhuang Xue Huilin Huang Hengyou Weng Rui su Brandon Tan Chao shen Wei Li Zhicong Zhao Ying Qing Xi Qin Kitty Wang Keith Leung Mark Boldin Chun-Wei Chen David ann Zhijian Qian Xiaolan Deng Jianjun Chen Zhenhua Chen Department of systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and Manella Graduate school of Biological sciences Beckman Research Institute of City of HopeDuarteCA 91010USA Gehr Family Center for Leukemia Research City of HopeDuarteCA 91010USA sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Guangzhou Laboratory GuangzhouGuangdong 510005China Bioland Laboratory GuangzhouGuangdong 51005China Department of Liver surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes Complications and Metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Biochemistry and Molecular Biology University of FloridaGainesvilleFL 32603USA Tongji Hospital Affiliated to Tongji University Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China school of Pharmacy China Medical UniversityShenyangLiaoning 110001China

As the most common internal modification of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play critical roles in various biological and patholog-ical processes including *** was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(METTL3)adds m^(6)A in primary microRNAs(pri-miRNAs)and fa-cilitates its processing into precursor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modification also plays a role in the maturation process of pre-miRNAs and(if so)whether such a function contributes to ***,we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia(AML)patients,especially in relapsed patients,and plays an onco-genic role in ***,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main product of precursor miR-126(pre-miR-126)),a miRNA that was reported as an oncomiRNA in AML,through facilitating the processing of pre-miR-126 into mature ***,YTHDF2 recognizes m^(6)A modification in pre-miR-126 and recruits AGO2,a regulator of pre-miRNA processing,to promote the maturation of ***2 posi-tively and negatively correlates with miR-126 and miR-126's downstream target genes,respec-tively,in AML patients,and forced expression of miR-126 could largely rescue YTHDF2/Ythdf2 depletion-mediated suppression on AML cell growth/proliferation and leukemogenesis,indi-cating that miR-126 is a functionally important target of YTHDF2 in ***,our studies not only reveal a previously unappreciated YTHDF2/miR-126 axis in AML and highlight the ther-apeutic potential of targeting this axis for AML treatment,but also suggest that m^(6)A plays a role in pre-miRNA processing that contributes to tumorigenesis.

关键词： AML miR-126 N^(6)-methyladenosine Pre-miRNA maturation YTHDF2

Efficient Object segmentation and Recognition Using Multi-Layer Perceptron Networks

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Computers, Materials & Continua 2024年第1期78卷 1381-1398页

作者： Aysha Naseer Nouf Abdullah Almujally saud s.Alotaibi Abdulwahab Alazeb Jeongmin Park Department of Computer science Air UniversityIslamabad44000Pakistan Department of Information systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Information system Department Umm Al-Qura UniversityMakkahSaudi Arabia Department of Computer science College of Computer Science and Information SystemNajran UniversityNajran55461Saudi Arabia Department of Computer Engineering Tech University of KoreaGyeonggi-do15073South Korea

Object segmentation and recognition is an imperative area of computer vision andmachine learning that identifies and separates individual objects within an image or video and determines classes or categories based on their *** proposed system presents a distinctive approach to object segmentation and recognition using Artificial Neural Networks(anns).The system takes RGB images as input and uses a k-means clustering-based segmentation technique to fragment the intended parts of the images into different regions and label thembased on their ***,two distinct kinds of features are obtained from the segmented images to help identify the objects of *** Artificial Neural Network(ann)is then used to recognize the objects based on their *** were carried out with three standard datasets,MsRC,Ms COCO,and Caltech 101 which are extensively used in object recognition research,to measure the productivity of the suggested *** findings from the experiment support the suggested system’s validity,as it achieved class recognition accuracies of 89%,83%,and 90.30% on the MsRC,Ms COCO,and Caltech 101 datasets,respectively.

关键词： K-region fusion segmentation recognition feature extraction artificial neural network computer vision

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火灾保费高企加州屋主另谋出路

商业周刊（中文版） 2024年第8期 24-25页

作者： adia Lopez John Gittelsohn ann Choi 孟洁冰(译) 不详

●在贝弗利山、贝莱尔和纳帕等富人区,找到火灾保险变得越来越难今年2月,彼得·麦克(PeterMac)即将完成一起房地产交易,这座位于好莱坞山的豪宅有四间卧室、五个浴室和无边泳池,已经挂牌上市两年时间。经过讨价还价后,房价从最初挂牌的4... 详细信息

●在贝弗利山、贝莱尔和纳帕等富人区,找到火灾保险变得越来越难今年2月,彼得·麦克(PeterMac)即将完成一起房地产交易,这座位于好莱坞山的豪宅有四间卧室、五个浴室和无边泳池,已经挂牌上市两年时间。经过讨价还价后,房价从最初挂牌的4800万美元降至2560万美元,此时交易却遇到了麻烦,麦克向买家提供了火灾保险的报价:每年20万美元。“她差点从椅子上掉下来,”The Agency的经纪人麦克说,“她想重新协商价格。”最终,买家找到了一份每年8万美元的替代保单,但是这份保险仅覆盖房屋重建成本的一小部分。

关键词：房地产交易挂牌上市富人区火灾保险讨价还价经纪人

A comprehensive review on bitter gourd (Momordica charantia L.) as a gold mine of functional bioactive components for therapeutic foods

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Food Production, Processing and Nutrition 2022年第1期4卷 107-120页

作者： K.s.Gayathry Jenny ann John Faculty of Ocean science and Technology Kerala(Department of Food Science and Technology)Kerala University of Fisheries and Ocean Studies(KUFOS)Panangad P.O.KochiKerala682506India

Bitter gourd is a tropical wine grown mainly in India, China and south East Asia. The plant is cultivated mainly for its fruit part which is edible. Bitter gourd is unaccepted widely due to its bitter taste. Nevertheless, the fruit is a source of several key nutrients. The plant, as a whole contains, more than 60 phyto-medicines that are active against more than 30 diseases, including cancer and diabetes. Currently, the incorporation of the bioactive compounds isolated from bitter gourd into functional foods and beverages finds a new horizon. Nanoencapsulation and novel green extraction methods can be employed to improve the yield and quality of extracted compounds and their stability while incorporation into food products. The present review is an attempt to throw light to nutritional aspects, various bioactive compounds present and important nutraceutical properties of the bitter gourd plant in detail.

关键词： Bitter gourd Bioactive Nutraceutical Extraction Encapsulation

miRNA expression profiles in cerebrospinal fluid and blood of patients with Alzheimer’s disease and other types of dementia-an exploratory study

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Translational Neurodegeneration 2016年第1期5卷 40-51页

作者： sofie sølvsten sørensen ann-Britt Nygaard Thomas Christensen Department of Neurology Copenhagen University HospitalNordsjællands HospitalDyrehavevej 293400 HillerødDenmark Department of Clinical Biochemistry Copenhagen University HospitalNordsjællands HospitalDyrehavevej 293400 HillerødDenmark

Background:MicroRNAs(miRNAs)are small non-coding RNA molecules that function as posttranscriptional regulators of gene *** of miRNAs in cerebrospinal fluid(CsF)and blood have just started gaining attention as a novel diagnostic tool for various neurological *** purpose of this exploratory investigation was to analyze the expression of miRNAs in CsF and blood of patients with Alzheimer’s disease(AD)and other neurodegenerative disorders in order to identify potential miRNA biomarker candidates able to separate AD from other types of ***:CsF was collected by lumbar puncture performed on 10 patients diagnosed with AD and 10 patients diagnosed with either vascular dementia,frontotemporal dementia or dementia with Lewy *** samples were taken immediately *** RNA was extracted from cell free fractions of CsF and plasma,and a screening for 372 known miRNA sequences was carried out by real time quantitative polymerase chain reactions(miRCURY LNA™Universal RT miRNA PCR,Polyadenylation and cDNA synthesis kit,Exiqon).Results:Fifty-two miRNAs were detected in CsF in at least nine out of ten patients in both *** these,two miRNAs(let-7i-5p and miR-15a-5p)were found significantly up-regulated and one miRNA(miR-29c-3p)was found significantly down-regulated in patients with AD compared to *** hundred and sixty-eight miRNAs were frequently detected in the blood,among which miR-590-5p and miR-142-5p were significantly up-regulated and miR-194-5p was significantly down-regulated in AD patients compared to ***:Detection of miRNA expression profiles in blood and in particular CsF of patients diagnosed with different types of dementia is feasible and it seems that several expressional differences between AD and other dementia types do exist when measured in a clinically relevant *** this explorative pilot study,the deregulated miRNAs in CsF of AD patients may be associated with relevant targ

关键词： Alzheimer’s disease Dementia Neurodegenerative disease miRNA expression Diagnostic biomarker Cerebrospinal fluid Blood

Mast cell activation syndrome:An up-to-date review of literature

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World Journal of Clinical Pediatrics 2024年第2期13卷 104-113页

作者： ÖnerÖzdemir Gökçe Kasımoğlu Ayşegül Bak Hüseyin sütlüoğlu süreyya savaşan Department of Pediatric Allergy and Immunology Sakarya UniversitySakaryaAdapazarı54100Türkiye Department of Pediatrics Sakarya UniversitySakaryaAdapazarı54100Türkiye Department of Pediatrics Kocaeli City HospitalKocaeli 50123Türkiye Department of Pediatrics Children’s Hospital of MichiganHematology/OncologyCentral Michigan University College of MedicineMount PleasantMI 48859United States Barbara ann Karmanos Cancer Institute Wayne State UniversityDetroitMI 12345United States

Mast cells are a subtype of white blood cells and are involved in the immune *** cells contain many chemical substances called mediators,which are involved in the allergic *** fact that mast cells play a role in many events that require urgent intervention,especially anaphylaxis,has led to a more detailed study of these *** diseases also caused by dysfunctions of mast cells have been examined in many *** instance,mast cell activation syndrome is known as an augmented number of cells due to decreased cell death,resulting in clinical symptoms affecting many *** main common symptoms include flushing,hypotension,urticaria,angioedema,headache,vomiting and *** the underlying mechanism is not yet clearly known,we aim to review the literature in a broad perspective and bring together the existing knowledge in the light of the literature due to the diversity of its involvement in the body and the fact that it is a little known syndrome.

关键词： Mast cell Mast cell activation syndrome Tryptase Histamine

Innovation in pathogenesis and management of aortic aneurysm

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World Journal of Experimental Medicine 2024年第2期14卷 35-45页

作者： Maryam Barkhordarian Hadrian Hoang-Vu Tran Aiswarya Menon sai Priyanka Pulipaka Izage Kianifar Aguilar Axel Fuertes shraboni Dey Angel ann Chacko Tanni sethi Ayrton Bangolo simcha Weissman Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States

Aortic aneurysm(AA)refers to the persistent dilatation of the aorta,exceeding three *** the pathophysiology of this condition is important for its prevention and management,given its responsibility for more than 25000 deaths in the United *** are classified based on their location or *** pathophysiologic pathways including inflammation,the immune system and atherosclerosis have been implicated in its *** markers such as transforming growth factorβ,interleukin-1β,tumor necrosis factor-α,matrix metalloproteinase-2 and many more may contribute to this *** genetic disorders such as Marfan syndrome,Ehler-Danlos syndrome and Loeys-Dietz syndrome have also been associated with this *** years has seen the investigation of novel management of AA,exploring the implication of different immune suppressors,the role of radiation in shrinkage and prevention,as well as minimally invasive and newly hypothesized surgical *** this narrative review,we aim to present the new contributing factors involved in pathophysiology of *** also highlighted the novel management methods that have demonstrated promising benefits in clinical outcomes of the AA.

关键词： Aortic aneurysm Abdominal aneurysm Thoracic aneurysm Immunotherapy surgical management Pathophysiology Inflammation and molecular pathways

Holistic Acupuncture approach to idiopathic refractory nausea,abdominal pain and bloating

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World Journal of Gastroenterology 2007年第40期13卷 5360-5366页

作者： ann Ouyang Division of Gastroenterology Hepatology Department of MedicineThe Milton S.Hershey Medical CenterCollege of MedicinePennsylvania State UniversityHersheyPA 17033United States

AIM： To evaluate the effectiveness of a holistic acupuncture approach on nausea, pain, bloating and electrogastrogram （EGG） parameters in patients with intractable symptoms.METHODs： Twelve patients with no or mild nausea （those without nausea had bloating or pain） and 10 with a histool of moderate to severe nausea were referred for acupuncture. All underwent an EGG and were treated at acupuncture points PC6, sP4 and DU20. Visual analog scales （VAs） assessing severity of nausea, pain and bloating were obtained before and after acupuncture treatment. Nineteen patients received three and three patients received two treatments.REsULTs： VAs scores for nausea reflected the clinical assessment and differed significantly between mild and moderate/severe nausea groups. Acupuncture significantly improved severity of nausea in both groups with improved pre-treatment nausea between the first and third treatments in the moderate/severe nausea group. Pain scores improved with acupuncture in the mild nausea group only and bloating improved only with the first treatment in this group. Patients with bloating with VAs scores greater than 35 pre-treatment improved with acupuncture and over all VAs scores for pain improved with treatment. Acupuncture increased the power in the 2.7 to 3.5 cpm range in the EGG.CONCLUsION： In this uncontrolled clinical study, a holistic acupuncture approach significantly improved nausea in patients with refractory symptoms and increased the power in the 2,7-3,5 cpm component of the electrogastrogram, Bloating and pain VAs scores improved acutely with treatment, This study suggests that acupuncture may be effective in this refractory group of patients and further study using appropriate controls is warranted,

关键词： Acupuncture Functional bowel disorder nausea Pain Holistic medicine