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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

search for the doubly charmed baryon ■

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science China(Physics,Mechanics & Astronomy) 2020年第2期63卷 8-22页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala s.Aiola Z.Ajaltouni s.Akar P.Albicocco J.Albrecht F.Alessio M.Alexander A.Alfonso Albero G.Alkhazov P.Alvarez Cartelle A.A.Alves Jr s.Amato Y.Amhis L.An L.Anderlini G.Andreassi M.Andreotti F.Archilli J.Arnau Romeu A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier s.Bachmann J.J.Back s.Baker V.Balagura W.Baldini A.Baranov R.J.Barlow s.Barsuk W.Barter M.Bartolini F.Baryshnikov G.Bassi V.Batozskaya B.Batsukh A.Battig V.Battista A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter L.J.Bel V.Belavin s.Belin N.Beliy V.Bellee K.Belous I.Belyaev G.Bencivenni E.Ben-Haim s.benson s.Beranek A.Berezhnoy *** D.Berninghoff H.C.Bernstein E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko s.Bhasin J.Bhom M.s.Bieker s.Bifani P.Billoir A.Birnkraut A.Bizzeti M.Bjφrn M.P.Blago T.Blake F.Blanc s.Blusk D.Bobulska V.Bocci O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar s.Borghi M.Borisyak M.Borsato J.T.Borsuk T.J.V.Bowcock C.Bozzi s.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu E.Buchanan A.Buonaura C.Burr A.Bursche J.s.Butter J.Buytaert W.Byczynski s.Cadeddu H.Cai R.Calabrese s.Cali R.Calladine M.Calvi M.Calvo Gomez A.Camboni P.Campana D.H.Campora Perez L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini P.Carniti K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero R.Cenci J.Cerasoli M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis M.Chefdeville V.Chekalina C.Chen s.Chen A.Chernov s.-G.Chitic V.Chobanova M.Chrzaszcz A.Chubykin P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek F.Cindolo P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo A.Comerma-Montells A.Contu N.Cooke G.Coombs s.Coquereau G.Corti C.M.Costa sobral B.Couturier D.C.Craik J.Crkovska A.Crocombe M.Cruz Torres R.Currie C.L.Da silva E.Dall'Occo J.Dalseno C.D'Ambrosio A.Danilina P.d'Argent A.Davis O.De Aguiar Francisco K.De Bruyn s.De Capua M Centro Brasileiro de Pesquisas Fisicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina school of Physics state Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of sciences BeijingChina Institute Of High Energy Physics(IHEP) BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance LAL Univ.Paris-SudCNRS/IN2P3Universite Paris-SaclayOrsayFrance LPNHE Sorbonne Universite Paris Diderot Sorbonne Paris Cite CNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany school of Physics University College DublinDublinIreland INFN sezione di Bari BariItaly INFN sezione di Bologna BolognaItaly INFN sezione di Ferrara FerraraItaly INFN sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN sezione di Genova GenovaItaly INFN sezione di Milano-Bicocca MilanoItaly INFN sezione di Milano MilanoItaly INFN sezione di Cagliari MonserratoItaly INFN sezione di Padova PadovaItaly INFN sezione di Pisa PisaItaly INFN sezione di Roma Tor Vergata RomaItaly INFN sezione di Roma La sapienza RomaItaly Nikhef National Institute for subatomic Physics AmsterdamNetherlands Nikhef National Institute for subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of sciences KrakowPoland AGH-University of science and Technology Faculty of Physics and Applied Computer ScienceKrakowPoland Natio

A search for the doubly charmed baryon ■^+cc is performed through its decay to theΛ^+c K^-π^+ final state,using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7,8 and 13 *** data correspond to a total integrated luminosity of 9 fb^-*** significant signal is observed in the mass range from 3.4 to 3.8 GeV/c^*** limits are set at 95%credibility level on the ratio of the ■^+cc production cross-section times the branching fraction to that ofΛ^+c and ■^++cc *** limits are determined as functions of the ■^+cc mass for different lifetime hypotheses,in the rapidity range from 2.0 to 4.5 and the transverse momentum range from 4 to 15 GeV/c.

关键词： charmed baryons limits on production of particles charmed quarks experimental tests

Controllable Fabrication of spider-Web-Like structured Anaphe Panda Regenerated silk Nanofibers / Nets via Electrospinning / Netting

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Journal of Donghua University(English Edition) 2014年第4期31卷 497-502页

作者： DULO benson 王娜李彦 OYONDI Erick MADARA s Diana 丁彬 College of Textiles Donghua University Department of Manufacturing Industrial and Textile EngineeringMoi University state Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua University

An Anaphe panda silk nanofibers / nets( NFN) membrane with attractive structures consisting of common electrospun nanofibers and two-dimensional( 2D) spider-web-like structured nano-nets were successfully fabricated via electrospinning / netting technology. The unique structures of NFN membranes such as extremely small diameter( sity,large specific surface area. and biocompatibility make this Anaphe panda silk NFN membrane a promising candidate for biomedical applications. In the present study, field emission scanning electron microscopy( FEsEM) was used to investigate the influence of polymer solution and humidity on nano-nets coverage and morphology. The FE-sEM images revealed that nano-net coverage area increased with increase in concentration of solution while lowering the humidity increased the nano-nets formation. Moreover,the mechanical properties of the membrane were also tested and the result showed that the silk NFN membrane displayed a breaking stress of 3. 7 MPa and breaking strain of 13. 8%. For further structural elucidation, Fourier transform infrared spectroscopy( FT-IR) was used to analyze the structural conformation changes from random coil to β-sheet in the NFN membrane which was an important factor effecting the usability of membrane. Thus,the results above confirmed the feasibility of Anaphe panda NFN structures applicability in cell tissue culture and other biomedical applications.

关键词： Anaphe panda silk electrospinning / netting nanofibers / nets(NFN) biocompatibility

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Measurement of Ξcc++ production in pp collisions at s1/2=13 TeV

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Chinese Physics C 2020年第2期44卷 13-23页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala s.Aiola Z.Ajaltouni s.Akar P.Albicocco J.Albrecht F.Alessio M.Alexander A.Alfonso Albero G.Alkhazov P.Alvarez Cartelle A.A.Alves Jr s.Amato Y.Amhis L.An L.Anderlini G.Andreassi M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier s.Bachmann J.J.Back s.Baker V.Balagura W.Baldini A.Baranov R.J.Barlow s.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi V.Batozskaya B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter L.J.Bel V.Belavin s.Belin V.Bellee K.Belous I.Belyaev G.Bencivenni E.Ben-Haim s.benson s.Beranek A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko s.Bhasin J.Bhom M.s.Bieker s.Bifani P.Billoir A.Bizzeti M.Bjørn M.P.Blago T.Blake F.Blanc s.Blusk D.Bobulska V.Bocci O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar s.Borghi M.Borisyak M.Borsato J.T.Borsuk T.J.V.Bowcock C.Bozzi M.J.Bradley s.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu E.Buchanan A.Buonaura C.Burr A.Bursche A.Butkevich J.s.Butter J.Buytaert W.Byczynski s.Cadeddu H.Cai R.Calabrese L.Calero Diaz s.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campoverde Quezada L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero s.Celani R.Cenci J.Cerasoli M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis M.Chefdeville V.Chekalina C.Chen s.Chen A.Chernov s.-G.Chitic V.Chobanova s.Cholak M.Chrzaszcz A.Chubykin P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek F.Cindolo P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo A.Comerma-Montells A.Contu N.Cooke G.Coombs s.Coquereau G.Corti C.M.Costa sobral B.Couturier D.C.Craik J.Crkovska A.Crocombe M.Cruz Torres R.Currie C.L.Da silva E.Dall'Occo J.Dalseno C.D' Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina school of Physics state Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of sciences BeijingChina Institute Of High Energy Physics(IHEP) BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance LAL Univ.Paris-SudCNRS/IN2P3UniversitéParis-SaclayOrsayFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany school of Physics University College DublinDublinIreland INFN sezione di Bari BariItaly INFN sezione di Bologna BolognaItaly INFN sezione di Ferrara FerraraItaly INFN sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN sezione di Genova GenovaItaly INFN sezione di Milano-Bicocca MilanoItaly INFN sezione di Milano MilanoItaly INFN sezione di Cagliari MonserratoItaly INFN sezione di Padova PadovaItaly INFN sezione di Pisa PisaItaly INFN sezione di Roma Tor Vergata RomaItaly INFN sezione di Roma La sapienza RomaItaly Nikhef National Institute for subatomic Physics AmsterdamNetherlands Nikhef National Institute for subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of sciences KrakówPoland AGH-University of science and Technology Faculty of Physics and Applied Computer ScienceKrakówPoland Nationa

The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4sed in this measuremen... 详细信息

The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4sed in this measurement correspond to an integrated luminosity of 1.7fb^-1,recorded by the LHCb experiment during *** ratio of the ■ production cross-section times the branching fraction of the■→∧^+cK^-π^+ π^+decay relative to the prompt ∧^+c production cross-section is found to be(2.22±0.27±0.29)×10^-4,assuming the central value of the measured lifetime,where the first uncertainty is statistical and the second systematic.

关键词： doubly charmed baryons hadron production QCD

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber