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Neural Regeneration Research 2024年第3期19卷 497-498页

作者： Luís Gales i3s−Instituto de Investigação e Inovação em saúde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICbAs−Instituto de Ciências biomédicas Abel salazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly specific interactions between biomolecules,such as antigen-antibody,protein-ligand,or nucleic acid base pair complementary are on the basis of the organization of complex *** same principles may be tentatively used in molecular medicine for diagnosis and therapeutics.A molecule can be designed to selectively bind a protease and thereby inhibit the production of a peptide that forms toxic aggregates in the brain or an antibody may be produced to bind specifically to that peptide for detection or clearance ***,interference in biological systems is not that *** a start there is the inhibition of the physiological role of the protease;moreover,several cleavage fragments may be produced,which may continue to diverge due to putative post-translational modification and self-assembly processes,hiding the toxic target in a“soup”of peptide species varying in size,structure and chemical composition.A perspective of the current status and challenges in targeting peptide species for diagnosis and treatment in the context of Alzheimer’s disease is given.

关键词： Alzheimer diagnosis thereby

Quantum correlations and entanglement in coupled optomechanical resonators with photon hopping via Gaussian interferometric power analysis

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Chinese Physics b 2024年第5期33卷 204-211页

作者： Y.Lahlou b.Maroufi M.Daoud LPHE-Ms Department of PhysicsFaculty of SciencesMohammed V UniversityRabatMorocco LPMs Department of PhysicsFaculty of SciencesIbn Tofail UniversityKénitraMorocco

Quantum correlations that surpass entanglement are of great importance in the realms of quantum information processing and quantum ***,for quantum systems prepared in pure states,it is difficult to differentiate between quantum entanglement and quantum ***,this indistinguishability is no longer holds for mixed *** contribute to a better understanding of this differentiation,we have explored a simple model for both generating and measuring these quantum *** study concerns two macroscopic mechanical resonators placed in separate Fabry–Pérot cavities,coupled through the photon hopping *** system offers a comprehensively way to investigate and quantify quantum correlations beyond entanglement between these mechanical *** key ingredient in analyzing quantum correlation in this system is the global covariance *** forms the basis for computing two essential metrics:the logarithmic negativity(E_(N)^(m))and the Gaussian interferometric power(P_(G)^(m)).These metrics provide the tools to measure the degree of quantum entanglement and quantum correlations,*** study reveals that the Gaussian interferometric power(P_(G)^(m))proves to be a more suitable metric for characterizing quantum correlations among the mechanical modes in an optomechanical quantum system,particularly in scenarios featuring resilient photon hopping.

关键词： quantum correlations entanglement Gaussian interferometric power logarithmic negativity optomechanics photon hopping

The great catastrophe: causes of the Permo-Triassic marine mass extinction

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National science Review 2024年第1期11卷 37-50页

作者： Paul b.Wignall David P.G.bond school of Earth & Environment University of Leeds school of Environmental sciences University of Hull

The marine losses during the Permo-Triassic mass extinction were the worst ever experienced. All groups were badly affected, especially amongst the benthos(e.g. brachiopods, corals, bryozoans, foraminifers,ostracods). Planktonic populations underwent a fundamental change with eukaryotic algae being replaced by nitrogen-fixing bacteria, green-sulphur bacteria, sulphate-reducing bacteria and prasinophytes. Detailed studies of boundary sections, especially those in south China, have resolved the crisis to a ～55 kyr interval straddling the Permo-Triassic boundary. Many of the losses occur at the beginning and end of this interval painting a picture of a two-phase extinction. Improved knowledge of the extinction has been supported by numerous geochemical studies that allow diverse proposed extinction mechanisms to be studied. A transition from oxygenated to anoxic-euxinic conditions is seen in most sections globally, although the intensity and timing shows regional variability. Decreased ocean ventilation coincides with rapidly rising temperatures and many extinction scenarios attribute the losses to both anoxia and high *** kill mechanisms include ocean acidification for which there is conflicting support from geochemical proxies and, even less likely, siltation(burial under a massive influx of terrigenous sediment) which lacks substantive sedimentological evidence. The ultimate driver of the catastrophic changes at the end of the Permian was likely siberian Trap eruptions and their associated carbon dioxide emissions with consequences such as warming, ocean stagnation and acidification. Volcanic winter episodes stemming from siberian volcanism have also been linked to the crisis, but the short-term nature of these episodes(s) and the overwhelming evidence for rapid warming during the crisis makes this an unlikely cause. Finally, whilst the extinction is well studied in equatorial latitudes, a different history is found in northern boreal latitudes

关键词： ocean anoxia ocean acidification siltation productivity collapse volcanic winter

soil resilience assessment using soil profile descriptions and Analytic Hierarchy Process in Mediterranean mountains considering diverse fire occurrences

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Journal of Mountain science 2024年第8期21卷 2517-2532页

作者： Jesús RODRIGO-COMINO Departamento de Análisis Geográfico Regional y Geografía Física Facultad de Filosofía y LetrasCampus Universitario de CartujaUniversidad de GranadaGranada 18071Spain

Wildfires are complex natural phenomena that exert significant impacts on landscapes,societies,and *** the concept of resilience is crucial in mitigating its possible negative impacts,as it involves preparing for,responding to,and recovering from *** research aims to demonstrate the utility of in situ soil profile description in assessing land use resilience using an Analytic Hierarchy Process(AHP)through an expert panel *** study examines a catchment located in the balearic Islands,considering two fire occurrences(once and twice),comparing abandoned agricultural terraces and natural *** results demonstrated that the priority ranking of variables to assess soil profile resilience against wildfires,determined by a panel of 10 experts,identified horizon depth(25.1%),slope inclination(21.5%),and hydrological connectivity(16.6%)as the most crucial *** variables,such as number and size of roots,structure of pedal soil material,size class structure,and rock fragments,also contributed to resilience but to a lesser extent,with scores ranging from 5.7%to 9.6%.Analyzing the priorities established by the experts using AHP,the results showed that the least resilient soil horizon was H1 of the control hillslope,especially under high and low connectivity processes,which aligned with the loss of superficial soil horizons after one and two *** showed greater changes in resilience after occurring wildfires compared to terraces,with the most significant alterations occurring after the second wildfire *** study addresses a significant knowledge gap in the field by highlighting the interconnectedness of wildfires,resilience,and land use,providing insights into land management strategies for wildfire-prone regions.

关键词： soil profiles soil geography Wildfires AHP Land management Expert panel survey

Electron kinetic effects in back-stimulated Raman scattering bursts driven by broadband laser pulses

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Matter and Radiation at Extremes 2024年第4期9卷 54-67页

作者： Q.K.Liu L.Deng Q.Wang X.Zhang F.Q.Meng Y.P.Wang Y.Q.Gao H.b.Cai s.P.Zhu Graduate school China Academy of Engineering PhysicsBeijing 100088China Institute of Applied Physics and Computational Mathematics Beijing 100094China school of Nuclear science and Technology University of Science and Technology of ChinaHefei 230026China shanghai Institute of Laser Plasma Shanghai 201800China HEDPs Center for Applied Physics and TechnologyPeking UniversityBeijing 100871China school of Physics Zhejiang UniversityHangzhou 310027China

We examine electron kinetic effects in broadband-laser-driven back-stimulated Raman scattering(bsRs)bursts using particle-in-cell *** bursts occur during the nonlinear stage,causing reflectivity spikes and generating large numbers of hot ***-duration simulations are performed to observe burst events,and a simplified model is developed to eliminate the interference of the broadband laser’s random intensity *** the simplified model,we isolate and characterize the spectrum of electron plasma *** spectrum changes from a sideband structure to a turbulence-like structure during the burst.A significant asymmetry in the spectrum is *** asymmetry is amplified and transferred to electron phase space by high-intensity broadband laser pulses,leading to violent vortex-merging and generation of hot *** proportion of hot electrons increases from 6.76%to 14.7%during a single violent burst *** demonstrate that kinetic effects profoundly influence the bsRs evolution driven by broadband lasers.

关键词： scattering kinetic simplified

Cross-method Analysis of Corotation Radii Data set for spiral Galaxies

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Research in Astronomy and Astrophysics 2024年第7期24卷 98-113页

作者： V.s.Kostiuk A.A.Marchuk A.s.Gusev sternberg Astronomical Institute Lomonosov Moscow State University Central (Pulkovo) Astronomical Observatory Russian Academy of Sciences saint Petersburg state University

A corotation radius is a key characteristic of disk galaxies that is essential to determine the angular speed of the spiral structure Ωp, and therefore understand its nature. In the literature, there are plenty of methods to estimate this value, but do these measurements have any consistency? In this work, we collected a data set of corotation radius measurements for 547 galaxies, 300 of which had at least two values. An initial analysis reveals that most objects have rather inconsistent corotation radius positions. Moreover, a significant fraction of galactic disks is distinguished by a large error coverage and almost uniform distribution of measurements. These findings do not have any relation to spiral type, Hubble classification, or presence of a bar. Among other reasons, obtained results could be explained by the transient nature of spirals in a considerable part of galaxies. We have made our collected data sample publicly available, and have demonstrated on one example how it could be useful for future research by investigating a winding time value for a sample of galaxies with possible multiple spiral arm patterns.

关键词： galaxies: fundamental parameters galaxies: kinematics and dynamics galaxies: structure

A Hybrid Machine Learning Approach for Improvised QoE in Video services over 5G Wireless Networks

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Computers, Materials & Continua 2024年第3期78卷 3195-3213页

作者： K.b.Ajeyprasaath P.Vetrivelan school of Electronics Engineering Vellore Institute of TechnologyChennaiTamil Nadu600127India

Video streaming applications have grown considerably in recent *** a result,this becomes one of the most significant contributors to global internet *** to recent studies,the telecommunications industry loses millions of dollars due to poor video Quality of Experience(QoE)for *** the standard proposals for standardizing the quality of video streaming over internet service providers(IsPs)is the Mean Opinion score(MOs).However,the accurate finding of QoE by MOs is subjective and laborious,and it varies depending on the user.A fully automated data analytics framework is required to reduce the inter-operator variability characteristic in QoE *** work addresses this concern by suggesting a novel hybrid XGbstackQoE analytical model using a two-level layering *** one combines multiple Machine Learning(ML)models via a layer one Hybrid *** ML models at level one are trained using the entire training data *** level two Hybrid XGbstackQoE-Model is fitted using the outputs(meta-features)of the layer one ML *** proposed model outperformed the conventional models,with an accuracy improvement of 4 to 5 percent,which is still higher than the current traditional *** proposed framework could significantly improve video QoE accuracy.

关键词： Hybrid XGbstackQoE-model machine learning MOs performance metrics QoE 5G video services

Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability:Insights from McArdle disease

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Journal of sport and Health science 2024年第3期13卷 398-408页

作者： Pedro L.Valenzuela Alfredo santalla Lidia b.Alejo Andrea Merlo Asuncion bustos Laura Castellote-belles Roser Ferrer-Costa Nicola A.Maffiuletti David barranco-Gil Tomas Pinos Alejandro Lucia Physical Activity and Health Research Group(“PaHerg”) Research Institute of Hospital“12 de Octubre”(“imas12”)Madrid 28041Spain Department of systems biology University of AlcalaMadrid 28871Spain Department of sport and Computer science Section of Physical Education and SportsFaculty of SportUniversidad Pablo de OlavideSevilla 41013Spain EVOPRED Research Group Universidad Europea de CanariasTenerife 38300Spain Faculty of sport sciences Universidad Europea de MadridMadrid 28670Spain Gait&Motion Analysis Laboratory Sol et Salus HospitalTorre Pedrera di Rimini(RN)47922Italy Department of Clinical biochemistry Laboratoris ClınicsHospital Universitari Vall d’HebronBarcelona 08035Spain Human Performance Lab Schulthess ClinicZurich 8008Switzerland biomedical Research Networking Center on Rare Disorders(CIbERER) Barcelona 08035Spain Mitochondrial and Neuromuscular Disorders Unit Vall d’Hebron Institut de RecercaUniversitat Autonoma de BarcelonaBarcelona 08035Spain

background:This study aimed to determine the effect of different carbohydrate(CHO)doses on exercise capacity in patients with McArdle disease—the paradigm of“exercise intolerance”,characterized by complete muscle glycogen unavailability—and to determine whether higher exogenous glucose levels affect metabolic responses at the McArdle muscle cell(in vitro)***:Patients with McArdle disease(n=8)and healthy controls(n=9)underwent a 12-min submaximal cycling constant-load bout followed by a maximal ramp test 15 min after ingesting a non-caloric *** a randomized,double-blinded,cross-over design,patients repeated the tests after consuming either 75 g or 150 g of CHO(glucose:fructose=2:1).Cardiorespiratory,biochemical,perceptual,and electromyographic(EMG)variables were ***,glucose uptake and lactate appearance were studied in vitro in wild-type and McArdle mouse myotubes cultured with increasing glucose concentrations(0.35,1.00,4.50,and 10.00 g/L).Results:Compared with controls,patients showed the“classical”second-wind phenomenon(after prior disproportionate tachycardia,myalgia,and excess electromyographic activity during submaximal exercise,all pse capacity(-51%ventilatory threshold and55%peak power output,both pss of the CHO dose(pboth doses compared with the placebo),CHO intake increased blood glucose and lactate levels,decreased fat oxidation rates,and attenuated the second wind in the ***,only the higher dose increased ventilatory threshold(+27%,p=0.010)and peak power output(+18%,p=0.007).In vitro analyses revealed no differences in lactate levels across glucose concentrations in wild-type myotubes,whereas a doseresponse effect was observed in McArdle ***:CHO intake exerts beneficial effects on exercise capacity in McArdle disease,a condition associated with total muscle glycogen *** of these benefits are dose dependent.

关键词： Endurance Glycogen storage disease Glycogenosis Nutrition supplement

There is more to the knee joint than just the quadriceps:A systematic review with meta-analysis and evidence gap map of hamstring strength,flexibility,and morphology in individuals with gradual-onset knee disorders

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Journal of sport and Health science 2024年第4期13卷 521-536页

作者： Helder s.Lopes Marina C.Waiteman Liliam b.Priore Neal R.Glaviano David M.bazett-Jones Ronaldo V.briani Fabio M.Azevedo school of science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA school of Exercise and Rehabilitation sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

background:Impairments in hamstring strength,flexibility,and morphology have been associated with altered knee biomechanics,pain,and *** the presence of these impairments in individuals with gradual-onset knee disorders is important and may indicate targets for assessment and *** systematic review aimed to synthesize the literature to determine the presence of impairments in hamstring strength,flexibility,and morphology in individuals with gradual-onset knee ***:Five databases(MEDLINE,Embase,CINAHL,sPORTDiscus,and Web of science)were searched from inception to september *** studies comparing hamstring outcomes(e.g.,strength,flexibility,and/or morphology)between individuals with gradual-onset knee disorders and their unaffected limbs or pain-free controls were ***-analyses for each knee disorder were ***-level certainty was assessed using the Grading of Recommendations Assessment,Development,and Evaluation,and evidence gap maps were ***:seventy-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofemoral pain(PFP),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced hamstring strength compared to pain-free controls during isometric(standard mean difference(sMD)=-0.76,95%confidence interval(95%CI):-1.32 to-0.21)and concentric contractions(sMD=-0.97,95%CI:-1.49 to-0.45).Individuals with PFP presented with reduced hamstring strength compared to painfree controls during isometric(sMD=-0.48,95%CI:-0.82 to-0.14),concentric(sMD=-1.07,95%CI:-2.08 to-0.06),and eccentric contractions(sMD=-0.59,95%CI:-0.97 to-0.21).No differences were observed in individuals with patellar *** with PFP presented with reduced hamstring flexibility when compared to pain-free controls(sMD=-0.76,95%CI:-1.15 to-0.36).Evidence gap maps identified insufficient evidence for chondromalacia patel

关键词： Chondromalacia patellae Knee flexors Knee osteoarthritis Patellar tendinopathy Patellofemoral pain

Function and dysfunction of GEMIN5:understanding a novel neurodevelopmental disorder

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Neural Regeneration Research 2024年第11期19卷 2377-2386页

作者： Charles H.Nelson Udai b.Pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Children’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

The recent identification of a neurodevelopmental disorder with cerebellar atrophy and motor dysfunction(NEDCAM)has resulted in an increased interest in GEMIN5,a multifunction RNA-binding *** the largest member of the survival motor neuron complex,GEMIN5 plays a key role in the biogenesis of small nuclear ribonucleoproteins while also exhibiting translational regulatory functions as an independent *** many questions remain regarding both the pathogenesis and pathophysiology of this new disorder,considerable progress has been made in the brief time since its *** this review,we examine GEMIN5 within the context of NEDCAM,focusing on the structure,function,and expression of the protein specifically in regard to the disorder ***,we explore the current animal models of NEDCAM,as well as potential molecular pathways for treatment and future directions of *** review provides a comprehensive overview of recent advances in our understanding of this unique member of the survival motor neuron complex.

关键词： cerebellar atrophy GEMIN5 neurodevelopmental disorder neurological disease sMN complex