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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Lactobionic Acid as a New synergist in Combination with Phosphonate-Zn(Ⅱ)system for Corrosion Inhibition of Carbon steel

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Journal of Materials science & Technology 2014年第1期30卷 77-89页

作者： s.srinivasa Rao b.V.Appa Rao s.Roopas Kiran b.sreedhar Department of Chemistry V.R.Siddhartha Engineering College(Autonomous) Department of Chemistry National Institute of Technology Warangal(NITW) INFN Sezione di Padova Inorganic & Physical Chemistry Division Indian Institute of Chemical Technology(IICT)

studies on lactobionic acid introduced as a synergist in the presence of phosphonobutane-1,2,4-tricarboxylic acid （PbTC） and zinc ions for corrosion control of carbon steel in aqueous environment are presented. The investigations revealed that lactobionic acid （LbA） acts as an excellent synergist in corrosion inhibition. Optimum concentrations of all the three components of the ternary formulation are established by gravimetric studies. Potentiodynamic polarization studies indicate that the new ternary system is a mixed inhibitor. Impedance studies show that a protective film is formed on the metal surface in the presence of the inhibitor formulation. The film is found to exhibit its protective nature even at higher temperatures up to 60 ~C. Analysis of the protective film by X-ray photoelectron spectroscopy （XPs） and reflection absorption Fourier transform infrared （FTIR） spectroscopy infers the presence of Zn（OH）2, oxides and hydroxides of iron and the inhibitor molecules in the surface film probably in the form of a complex, [Zn（II）-PbTC-LbA]. The morphological studies by scanning electron microscopy （sEM） and the topographical studies by atomic force microscopy （AFM） also indicate the presence of protective film on the metal surface. A plausible mechanism of corrosion inhibition is proposed.

关键词： Corrosion inhibitor Carbon steel synergism X-ray photoelectron spectroscopy Electrochemical impedance spectroscopy

Compocasting of A356-CNT composite

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Transactions of Nonferrous Metals society of China 2010年第9期20卷 1561-1566页

作者： b.AbbAsIPOUR b.NIROUM AND s.M.MONIR VAGHEFI Department of Materials Engineering Isfahan University of Technology

A356 aluminum alloys reinforced with carbon nano-tubes (CNTs) were produced by stir casting and compocasting routes and their microstructural characteristics and hardness were *** order to alleviate the problems associated with poor wettability, agglomeration and gravity segregation of CNTs in the melt, CNTs were introduced into the melts by injection of CNT deposited aluminum particles instead of raw *** particles with mean diameters of less than 100 μm were first deposited by CNTs using Ni-P electroless plating technique and then injected into the melt agitated by a mechanical *** slurry was subsequently cast at temperatures corresponding to full liquid as well as 0.15 and 0.30 solid *** results show that addition of CNTs to A356 matrix can significantly refine both full liquid and semi-solid cast *** of the samples is also significantly increased by addition of CNTs and A356-CNT composite cast at 0.3 solid fraction produces the highest hardness.

关键词： A356-CNT composite carbon nano-tube (CNT) compocasting electroless plating microstructure hardness

Artificial neural network approach for rheological characteristics of coal-water slurry using microwave pre-treatment

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International Journal of Mining science and Technology 2017年第2期27卷 379-386页

作者： b.K.sahoo s.De b.C.Meikap Department of Chemical Engineering Indian Institute of Technology Research and Development Centre for Iron and steel Steel Authority of India Limited Chemical Engineering School of Engineering Howard College University of Kwazulu-Natal

Detailed experimental investigations were carried out for microwave pre-treatment of high ash Indian coal at high power level(900 W) in microwave oven. The microwave exposure times were fixed at60 s and 120 s. A rheology characteristic for microwave pre-treatment of coal-water slurry(CWs) was performed in an online bohlin viscometer. The non-Newtonian character of the slurry follows the rheological model of Ostwald de Waele. The values of n and k vary from 0.31 to 0.64 and 0.19 to 0.81 Pa·sn,respectively. This paper presents an artificial neural network(ANN) model to predict the effects of operational parameters on apparent viscosity of CWs. A 4-2-1 topology with Levenberg-Marquardt training algorithm(trainlm) was selected as the controlled ANN. Mean squared error(MsE) of 0.002 and coefficient of multiple determinations(R^2) of 0.99 were obtained for the outperforming model. The promising values of correlation coefficient further confirm the robustness and satisfactory performance of the proposed ANN model.

关键词： Microwave pre-treatment Coal-water slurry Apparent viscosity Artificial neural network back propagation algorithm

An optimized ion trap geometry to measure quadrupole shifts of ^(171)Yb~＋ clocks

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Chinese Physics b 2016年第11期25卷 230-237页

作者： N batra b K sahoo s De Academy of scientific and Innovative Research CSIR-NPL Campus New Delhi India CsIR-National Physical Laboratory Dr. K. S. Krishnan Marg New Delhi 110012 India Theoretical Physics Division Physical Research Laboratory Navrangpura Ahmedabad 380009 India

We propose a new ion-trap geometry to carry out accurate measurements of the quadrupole shifts in the （171）Yb *** trap will minimize the quadrupole shift due to the harmonic component of the confining potential by an order of *** will be useful to reduce the uncertainties in the clock frequency measurements of the 6s 2s（1/2）→4f（13）6s2 2F（7/2）and 6s 2s（1/2）→5d2D（3/2） transitions,from which we can deduce the precise values of the quadrupole moments（0s） of the 4f（13）6s2 2F（7/2） and 5d2D（3/2） ***,it may be able to affirm the validity of the measured 0 value of the4f（13）6s22F（7/2） state,for which three independent theoretical studies defer almost by one order of magnitude from the *** also calculate 0s using the relativistic coupled-cluster（RCC） *** use these 0 values to estimate the quadrupole shift that can be measured in our proposed ion trap experiment.

关键词： validity minimize carry clock relativistic precise deduce magnitude expectation spatially

Analysis of Mechanical Properties of Injection Molded short Glass Fibre (sGF)/Calcite/Abs Composites

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Journal of Materials science & Technology 1997年第5期13卷 389-396页

作者： Fu, s.Y. Lauke, b. Institute for Polymer Research Dresden e.V 01069 Dresden Hohe Str.6 Germany

Acrylonitrile-butadiene-styrene (Abs), with and without calcium carbonate (calcite) particles,was used as the matrix for reinforcement with as-received short-glass fibres (were originallytreated by the manufacturer) and sized short-glass fibres with two amino-silane coupling *** calcite particle content is 0, 11.7 and 23.5 vol. pct for the matrices. The glass fiber contentis 0, 10 and 15 vol. pct. The matrix materials and corresponding composites were compoundedusing a twin screw extruder and dumbbell-shaped tensile bars were prepared with an injectionmolding process. The tensile and flexural properties as well as the unnotched and notchedCharpy impact energies of short glass fibre/calcite/Abs composites were studied in this *** effects of fibres, fibre surface treatments and particles on these mechanical properties ofthe composites were discussed in detail. An importarit information was obtained, which is thatthe tensile and flexural strengths of hybrid sGF/calcite/Abs composites are the same as thoseof corresponding fibre composites when the ratio of the interfacial adhesion strength betweenparticles and matrix to that between fibres and matrix is higher than certain value. otherwise theformer are lower than the latter.

关键词： Abs Calcite/Abs Composites sGF Analysis of Mechanical Properties of Injection Molded short Glass Fibre

Microstructure,texture and mechanical behavior characterization of hot forged cast ZK60 magnesium alloy

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Journal of Materials science & Technology 2017年第9期33卷 907-918页

作者： s.M.H.Karparvarfard s.K.shaha s.b.behravesh H.Jahed b.W.Williams Department of Mechanical & Mechatronics Engineering University of Waterloo Canmet MATERIALs Natural Resources Canada

structure with a significant reduction in casting porosity, while the texture changed to sharp basaMeasured mechanical properties of the forged alloy showed that strength did not change, howductility improved by 75%. The analysis of the fracture surface of the forged alloy under tension rea ductile fracture with dimple morphology, while the as-cast alloy displayed a brittle fracture with pores. This demonstrated that the reduction of casting defects and dendritic morphology, as well evolution of recrystallized grains, enhanced ductility, while partial dynamic recrystallization throuforging process resulted in only marginal modification of strength in the forged condition.. 2017 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials sciTechno

关键词： Magnesium Forging Ductility Texture Recrystallization

Injection of N-Radicals into Diesel Engine Exhaust Treated by Plasma for Improved NO_x Removal: A Feasibility study

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Plasma science and Technology 2006年第2期8卷 202-206页

作者： b. s. RAJANIKANTH b. R. sUsHMA Dept. of High Voltage Engineering Indian Institute of Science Bangalore 560012 India

Reported in this paper is a feasibility study on the injection of plasma induced N radicals for the abatement of NO and NOx present in the actual diesel exhaust. The radical laden diesel exhaust was further treated by discharge plasma in a dielectric barrier discharge reactor. N radicals were produced in a separate plasma reactor filled with baTiO3 pellets and were then injected into the treatment zone, There was a significant improvement in the efficiency when the radicals were injected compared to that when there was no radical injection. The efficiency of NOx removal at 0 load with plasma alone was 14% whereas with the injection of N radicals it went up to 38%, The results of the experiments conducted at different loads are discussed,

关键词： N-radical diesel engine exhaust NOx removal plasma treatment

Degradation of synthetic Dyeing Wastewater by Underwater Electrical Discharge Processes

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Plasma science and Technology 2013年第7期15卷 659-665页

作者： s.D.KIM D.I.JANG b.J.LIM s.b.LEE Y.s.MOK Yeongsan River Environment Research Center National Institute of Environmental ResearchGwangju 500-480 Korea Department of Chemical and biological Engineering Jeju National UniversityJeju 690-756 Korea

Electrical discharge treatments of synthetic dyeing wastewater were carried out with two different systems： underwater pulsed electrical discharge （UPED） and underwater dielectric barrier discharge （UDbD）. Reactive blue 4 （Rb4） and Acid Red 4 （AR4） were used as model contaminants for the synthetic wastewater. The performance of the aforementioned systems was compared with respect to the chromaticity removal and the energy requirement. The results showed that the present electrical discharge systems were very effective for degradation of the dyes. The dependences of the dye degradation rate on treatment time, initial dye concentration, electrical energy, and the type of working gas including air, 02, and N2 were examined. The change in the initial dye concentration did not largely affect the degradation of either Rb4 or AR4. The energy delivered to the UPED system was only partially utilized for generating reactive species capable of degrading the dyes, leading to higher energy requirement than the UDbD system. Among the working gases, the best performance was observed with O2. As the degradation proceeded, the concentration of total dissolved solids and the solution conductivity kept increasing while pH showed a decreasing trend, revealing that the dyes were effectively mineralized.

关键词： degradation dyeing wastewater pulsed electrical discharge dielectric barrierdischarge