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Total nasal septal reconstruction using costal cartilage in difficult cases of secondary septoplasty

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Plastic and Aesthetic Research 2016年第1期3卷 306-310页

作者： Kapil s.agrawal Raghav shrotriya Department of Plastic and Reconstructive surgery Seth GS Medical College and KEM HospitalMumbai 400012India

Rhinoplasty and septal reconstruction often require the use of cartilage *** nasal septal reconstruction may be required in very specific situations like difficult secondary septoplasty or severely deformed post traumatic *** in these cases the septal cartilage or bone is insufficient for septal *** authors hereby describe a new technique of complete septal reconstruction by using the 7th rib(costal)cartilage combined with author’s ingenious technique to prevent warping.

关键词： Rhinoplasty nasal septum reconstruction costal cartilage graft

Adoption of green finance and green innovation for achieving circularity:An exploratory review and future directions

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Geoscience Frontiers 2024年第4期15卷 333-346页

作者： Rohit agrawal shruti agrawal Ashutosh samadhiya Anil Kumar sunil Luthra Vranda Jain Operations Management and Quantitative Techniques Indian Institute of ManagementBodhgaya 824234BiharIndia Department of Humanities and social sciences Malaviya National Institute of Technology Jaipur RajasthanIndia Jindal Global Business school OP Jindal Global UniversitySonipatIndia Guildhall school of Business and Law London Metropolitan UniversityLondonUK AICTE Training and Learning(ATAL) All India Council for Technical EducationDelhiIndia Economics and International Business Jaipuria Institute of ManagementNoidaIndia

There is growing attention from governments and regulators towards crucial matters such as climate change and global warming,resulting in a pressing need to investigate the factors that make it possible for businesses to engage in green finance(GF).The externality of environmental pollution prioritizes the need of green innovation(GI)in public *** distributes financial resources to the research and development(R&D)of clean energy and environmentally friendly goods and processes;it is complementary to the GI process for environmental *** policies help to alleviate the impacts of financial constraints and GI impaired industries involving new products,processes,services and the global *** better understand how GF and GI have functioned as a catalyst for circular economy practices,this paper seeks to present a historical and contemporary overview of these *** research is thoroughly dissected by a systematic literature evaluation of articles from 2016 to 2023 that appear in peer-reviewed journals and are indexed in the sCOPUs *** attain supply chain circularity,this article encompasses four major research themes concerning the adoption of GF and green *** research also includes a network analysis of shortlisted articles to examine the overall citation *** is shown that several institutional theories are associated with the investigated *** a final step,a framework is provided to illustrate how GF and GIs might be used to achieve supply chain *** research findings provide a novel concept related to GF within the context of GI which are significant for environmentalists,policymakers,green investors,and *** its findings,the study provides a conceptual framework that promotes sustainable strategies to effectively balance financial considerations and environmental *** helps to leverage the potential of green research and practice to create value for businesses and to benefi

关键词： Green finance Green innovation systematic literature review Environmental protection Climate change

Unveiling childhood asthma:Exploring biomarkers,zinc,and beyond

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World Journal of Clinical Pediatrics 2024年第2期13卷 7-10页

作者： Amit agrawal Department of Pediatrics Gandhi Medical CollegeHamidia Hospital CampusBhopal 462022India

This editorial discusses a case-control study by Ibrahim et al,published in the recent issue of the World Journal of Clinical *** bronchial asthma is a chronic inflammatory respiratory *** was found that an increase in oxidative stress leads to a decrease in antioxidants causing oxidative damage to mitochondrial respiratory chain complexes resulting in the inflammation of the airway,hypersecretion of mucus causing a cascade of clinical manifestations ranging from recurrent episodes of coughing,wheezing,and breathlessness to shortness of *** oxidative stress mediates the inflammatory response in asthma,the supplementation of anti-oxidants can be one strategy to manage this *** is one such antioxidant that has attracted much attention about asthma and airway *** is a crucial trace element for human metabolism that helps to regulate gene expression,enzyme activity,and protein *** from zinc,free serum ferritin levels are also elevated in case of *** previous studies found that ferritin levels may also help determine the pathology of disease and predict prognosis in addition to tracking disease ***,this study's results were different from the findings of the previous studies and the zinc levels did not show a significant difference between asthmatic children and non-asthmatic children but ferritin levels were significantly high in asthmatic children as compared to the ***,the possible role of the biochemical nutritional assessment including zinc and ferritin as biomarkers for asthma severity should be assessed in the future.

关键词： Asthma Biomarker Children Zinc Ferritin Immunoglobulin E

WHO/IUATLD关于对固定剂量复合制剂中利福平生物当量的评价推荐的方案

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国际结核病与肺部疾病杂志 2001年第1期 16-18页

作者： R.Panchagnula s.agrawal K.J.Kaur I.singh C.L.Kaul 丁北川 Department of Pharmaceutics National Institute of Pharmaceutical Education and Research (NIPER) SAS Nagar Punjab. India

为了对固定剂量复合制剂(fixed-dosecombinations,FDCs)中利福平生物当量(bioequivalence)精确地检验,并减少与生物当量研究有关的时间及成本的制约,世界卫生组织及国际防痨和肺部疾病联合会推出一项简化的筛查方案。此项研究承担了该... 详细信息

为了对固定剂量复合制剂(fixed-dosecombinations,FDCs)中利福平生物当量(bioequivalence)精确地检验,并减少与生物当量研究有关的时间及成本的制约,世界卫生组织及国际防痨和肺部疾病联合会推出一项简化的筛查方案。此项研究承担了该方案对所有类型FDCs测试其适用性的目的。普通志愿者获得的三项研究数据,及药代动力学参数经不同的统计检测予以评价。从结果上看,已证实简化的筛查方案对在市场上可获得的所有类型FDCs中利福平的生物当量予以评价是合适的。

关键词：结核病固定剂量复合制剂生物当量 WHO/IUATLD方案

A comprehensive review on pharmacognosy, phytochemistry and pharmacological activities of 8 potent Prunus species of southeast Asia

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Journal of Traditional Chinese Medicine 2024年第3期44卷 620-628页

作者： shikha agrawal Adarsh Kumar Ankit Kumar singh Harshwardhan singh suresh Thareja Pradeep Kumar Department of Pharmaceutical sciences and Natural Products Central University of PunjabBathinda 151401India

Genus Prunus comprising around 430 species is a vast important genus of family Rosaceae, subfamily amygdalaoidae. Among all 430 species, around 19 important species are commonly found in Indian subcontinent due to their broad nutritional and economic importance. some most common species of genus Prunus are Prunus amygdalus, Prunus persica, Prunus armeniaca, Prunus avium, Prunus cerasus, Prunus cerasoides, Prunus domestica, Prunus mahaleb, etc. A newly introduced species of Prunus i.e Prunus sunhangii is recently discovered which is morphologically very similar to Prunus cerasoides. Plants of Prunus species are short to medium-sized deciduous trees mainly found in the northern hemisphere. In India and its subcontinent,it extends from the Himalayas to sikkim, Meghalaya,Bhutan, Myanmar etc. Different Prunus species have been extensively studied for their morphological,microscopic, pharmacological and phytoconstituents characteristics. Total phenolic content of Prunus species explains the presence of phenols in high quantity and pharmacological activity due to phenols. Phytochemical screening of species of genus Prunus shows the presence of wide phytoconstituents which contributes in their pharmacological significance and reveals the therapeutic potential and traditional medicinal significance of this genus. Genus Prunus showed a potent antioxidant activity analyzed by 1,1-diphenyl-2-picryl-hydrazyl radical assay. Plant species belonging to the genus Prunus is widely used traditionally for the treatment of various disorders. some specific Prunus species possess potent anticancer, anti-inflammatory,hypoglycemic etc. activity which makes the genus more interesting for further research and findings. This review is an attempt to summarize the comprehensive study of Prunus species from its distribution, morphological characters to phytoconstituents, and pharmacological activity.

关键词： Rosaceae Prunus antineoplastic agents hypoglycemic agents distribution phytochemistry review

Transcranial direct current stimulation as early augmentation in adolescent obsessive compulsive disorder:A pilot proof-of-concept randomized control trial

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World Journal of Clinical Pediatrics 2024年第2期13卷 161-170页

作者： Aditya agrawal Vivek Agarwal sujita Kumar Kar Amit Arya Department of Psychiatry King George Medical UniversityUttar PradeshLucknow 226003India

BACKGROUND Transcranial direct current stimulation(tDCs)is proven to be safe in treating various neurological conditions in children and *** is also an effective method in the treatment of OCD in *** To assess the safety and efficacy of tDCs as an add-on therapy in drug-naive adolescents with *** We studied drug-naïve adolescents with OCD,using a Children’s Yale-Brown obsessive-compulsive scale(CY-BOCs)scale to assess their *** active and sham groups were given fluoxetine,and we applied cathode and anode over the supplementary motor area and deltoid for 20 min in 10 *** occurred at 2,6,and 12 wk using *** Eighteen adolescents completed the study(10-active,8-sham group).CY-BOCs scores from baseline to 12 wk reduced significantly in both groups but change at baseline to 2 wk was significant in the active group *** mean change at 2 wk was more in the active group(11.8±7.77 vs 5.25±2.22,P=0.056).Adverse effects between the groups were *** tDCs is safe and well tolerated for the treatment of OCD in ***,there is a need for further studies with a larger sample population to confirm the effectiveness of tDCs as early augmentation in OCD in this population.

关键词： Adolescents Early augmentation Obsessive compulsive disorder safety Transcranial direct current stimulation

A transient shift in equatorial hydrology and vegetation during the Eocene Thermal Maximum 2

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Geoscience Frontiers 2024年第5期15卷 174-181页

作者： Gaurav srivastava Harshita Bhatia Poonam Verma Yogesh P.singh shailesh agrawal Torsten Utescher R.C.Mehrotra Birbal sahni Institute of Palaeosciences 53 University RoadLucknow 226007India Academy of scientific and Innovative Research(AcsIR) Ghaziabad 201002India senckenberg Research Institute and Natural History Museum Frankfurt/M.Senckenberg Research Station of Quaternary PalaeontologyWeimerGermany Institute for Geosciences University of BonnNussallee 853115 BonnGermany

The equatorial evergreen forests nourish the world’s biodiversity hotspots and are considered the lungs of the ***,their future survival is uncertain,due to anthropogenically increased carbon emissions and changes in the hydrological *** the changes in the hydrological cycle in the equatorial region due to an increase in carbon emission is of prime *** early Paleogene hyperthermal events are potential analogs to understand the consequences of high carbon emission on the hydrological *** this communication,we quantify the terrestrial seasonal climate using the plant proxy and infer that during the Eocene Thermal Maximum 2 when atmospheric carbon dioxide concentration was>1000 ppmv near the palaeo-equator(~0.6°N),the rainfall decreased significantly,leading to the expansion of deciduous *** study raises important questions about the future survival of equatorial rainforests and biodiversity hotspots under increased carbon emissions.

关键词： Coexistence approach Climate ETM-2 Global warming Hyperthermal Paleogene

Explainable Artificial Intelligence(XAI)Model for Cancer Image Classification

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Computer Modeling in Engineering & sciences 2024年第10期141卷 401-441页

作者： Amit singhal Krishna Kant agrawal Angeles Quezada Adrian Rodriguez Aguiñaga samantha Jiménez satya Prakash Yadav Department of Computer science&Engineering Raj Kumar Goel Institute of TechnologyGhaziabad201017India Department of school of Computing science and Engineering Galgotias UniversityGreater Noida203201India Tecnológico Nacional de México Campus Tijuana Baja California22414México Universidad Autónoma de Baja California TijuanaBaja California22414México Department of Computer science and Engineering G.LBajaj Institute of Technology and Management(GLBITM)Affiliated to Dr.A.P.J.Abdul Kalam Technical UniversityLucknow201306India school of Computer science Engineering and Technology(sCsET) Bennett UniversityGreater Noida201310India

The use of Explainable Artificial Intelligence(XAI)models becomes increasingly important for making decisions in smart healthcare *** is to make sure that decisions are based on trustworthy algorithms and that healthcare workers understand the decisions made by these *** models can potentially enhance interpretability and explainability in decision-making processes that rely on artificial ***,the intricate nature of the healthcare field necessitates the utilization of sophisticated models to classify cancer *** research presents an advanced investigation of XAI models to classify cancer *** describes the different levels of explainability and interpretability associated with XAI models and the challenges faced in deploying them in healthcare *** addition,this study proposes a novel framework for cancer image classification that incorporates XAI models with deep learning and advanced medical imaging *** proposed model integrates several techniques,including end-to-end explainable evaluation,rule-based explanation,and useradaptive *** proposed XAI reaches 97.72%accuracy,90.72%precision,93.72%recall,96.72%F1-score,9.55%FDR,9.66%FOR,and 91.18%*** will discuss the potential applications of the proposed XAI models in the smart healthcare *** will help ensure trust and accountability in AI-based decisions,which is essential for achieving a safe and reliable smart healthcare environment.

关键词： Explainable artificial intelligence artificial intelligence XAI healthcare cancer image classification

Patient-centric periodontal research:A pioneering application of patient-reported outcome measures

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World Journal of Clinical Cases 2024年第18期12卷 3281-3284页

作者： Amit Arvind agrawal Department of Peridontology and Implantology Mahatma Gandhi Vidyamandir’s Karmaveer Bhausaheb Hiray Dental College and HospitalNasik 422003India

Conventional dentistry or periodontal research often ignores the human component in favor of clinical outcomes and biological *** research is driven by the statistical significance of outcome parameters rather than the satisfaction level of the *** this context,patient-centric periodontal research(PCPR)is an approach that considers the patient´s feedback concerning their functional status,experience,clinical outcomes,and accessibility to their *** is argued that data self-reported by the patient might have low reliability owing to the confounding effect of their personal belief,cultural background,and social and economic ***,literature has shown that the incorporation of“patient-centric outcome”components considerably enhances the validity and applicability of research *** in the results of different studies might be due to the use of different and non-standardized assessment *** overcome this problem,this editorial enlists various reliable tools available in the *** conclusion,we advocate that the focus of researchers should shift from mere periodontal research to PCPR so that the results can be effectively applied in clinical settings and the therapeutic strategy can also change from mere periodontal therapy to patient-centric periodontal therapy.

关键词： Patient-centered care Clinical research surrogate endpoints Quality of life Oral health Patient reported treatment outcomes