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Optical high-resolution spectroscopic study of Tm^(3+) crystal-field levels in LiLuF_4

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Journal of Rare Earths 2009年第4期27卷 624-626页

作者： D.s.Pytalev s.a.klimin M.N.Popova Institute of spectroscopy Russian Academy of Sciences 5 Fizicheskaya St. Troitsk Moscow region 142190 Russia

We report on the fast high-resohition study of LiLuF4：Tm3＋. The accurate energy level scheme of Tm3＋ in the LiLuF4 matrix was obtained for the 3H6.5.4, 3F4.3.2, and ^1G4 multiplets. It was shown that electric-dipol... 详细信息

关键词： Fourier-transform spectroscopy Tm^3+ crystal-field levels LiLuF4 rare earths

Evidences for non-equivalent centers in mixed chain nickelates (Nd_xY_(1-x))_2BaNiO_5

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Journal of Rare Earths 2009年第4期27卷 603-606页

作者： M.V.Narozhnyy s.a.klimin E.A.Popova G.Dhalenne Institute of spectroscopy Russian Academy of sciences 5 Fizicheskaya Str. Troitsk Moscow region 142190 Russia Moscow state Institute of Electronics and Mathematics 109028 Moscow Russia Laboratoire de Physico-Chimie de l'état solide Université Paris-Sud F-91405 Orsay France

Absorption spectra of the mixed chain nickelates （（NdxY1-x）2BaNiO5 were measured for different x. Experimentally two evidences for the presence of non-equivalent rare-earth centers （NEREC） were found. First, the linewidths show a very strong broadening for x when the calculated distribution over NEREC is wide. second, a compficated lineshape of the lowest-frequency line in the region of the 4I9/2→4I1/2 electronic lransition is in good agreement with statistics of NEREC. A simple modeling for the line broadening due to NEREC is suggested.

关键词： Haldane chains non-equivalent rare-earth centers Fourier-lransform spectroscopy

Crystal-field levels of Nd3+ in a new langasite compound Nd3CrGe3Be2O14

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Journal of Rare Earths 2019年第11期37卷 1250-1254页

作者： sergei A.klimin Boris V.Mill Marina N.Popova Institute of spectroscopy Russian Academy of SciencesTroitskMoscow 108840Russia Faculty of Physics M.V.Lomonosov Moscow State UniversityMoscow 119991Russia

We report on the crystal-field(CF)levels of Nd^3+in Nd3CrGe3Be2O14,a representative of recently synthesized Be-containing *** are the first in the family to contain two magnetic subsystems,1 D chromium and Kagome-like rare-earth ***-resolution broad-band temperature-dependent spectra allow us to find all five CF Kramers doublets of the ground 4I9/2 CF multiplet and 38 levels of the excited 4I11/2,13/2,15/2,4F3/2,4F5/2+2H9/2,4F7/2+4s3/2 and 4F9/2 CF *** data form a basis for a future exploration of this interesting two-sublattice magnet with frustrated *** transitions between Kramers doublets of Nd^3+indicate magnetic activity of 1D-chromium chains at T<20 K.

关键词： Langasite Two magnetic subsystems High-resolution spectroscopy Crystal-field levels Magnetic correlations Rare earths

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber