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世界核心医学期刊文摘（心脏病学分册） 2006年第5期2卷 49-49页

作者： Chung J Abraszewski P s.a. wickline 王亭忠 Division of Cardiology Washington University School of Medicine Box 8086 660 South Euclid Avenue St. Louis MO 63110 United StatesDr.

OBJECTIVEs: This study sought to characterize the early features of diabetic cardiomyopathy by magnetic resonance imaging(MRI) tagging. BACKGROUND: The earliest manifes.a.ions of diabetic cardiomyopathy have not been well es.a.lished, especially under tight glycemic management. We hypothesized that torsion measurements would identify subclinical contractile alterations in type I diabetics with normal left ventricular ejection fraction, mass, blood pressure, and aggressive glycemic control. We also sought to characterize the influence of elevated resting heart rates(HRs) of diabetics on torsion. METHODs: sixteen patients with type I diabetes.a.d 10 control patients underwent cine and tagged MRI with a 1.5-T s.a.ner. Torsion, strain, and their rates were measured. To quantify the influence of chronotropic and inotropic stimulation on torsion, nine healthy volunteers underwent MRI tagging at rest, after atropine injection, and after exercise. REsULTs: Diabetic patients(hemoglobin A1c, 6.8± 0.4% ) had a higher resting HR(77.0± 12.4 beats/min vs. 59.0± 5.6 beats/min; psion by 23% (3.5± 0.9° /cm vs. 2.7± 0.4° /cm; psystolic torsion rate(TR-s) by 25% (0.013± 0.003° /cm/s vs. 0.010± 0.002° /cm/s, p=0.01). Torsion did not significantly change with chronotropic stimulation(p=0.30). CONCLUsIONs: In diabetics under tight glycemic control, we observed a surprising increase in torsion and TR-s unrelated to chronotropic influences of HR. We propose that increased torsion and TR-s could represent early predictive markers of the propensity to cardiac dysfunction in asymptomatic type I diabetics. Furthermore, these findings seem fundamental to the diabetic s.a.e itself and unaccounted for by other comorbidities.

关键词：糖尿病患者扭转控制血糖 1型速度严格收缩期糖尿病心肌病 MRI检查

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维普期刊数据库

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Revisiting cerebral endothelial cells in Alzheimer’s dis.a.e

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Neural Regeneration Res.a.ch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s dis.a.e(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases.a. is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cas.a.e hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis.a. dysregulated homeos.a.is of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging structures.a.d dynamic mechanisms ofγ-secretase for Alzheimer’s dis.a.e

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Neural Regeneration Res.a.ch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is.a.membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s dis.a.e.γ-secretase has thus served as.a.critical drug target for treating familial Alzheimer’s dis.a.e and the more common late-onset Alzheimer’s dis.a.e as ***,critical gaps remain in unders.a.ding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s dis.a.e mutations.a.d allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-s.a.-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as.a.template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s dis.a.e mutations,particularly the issue of whether they s.a.ilize or des.a.ilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s dis.a.e mutations

关键词： Alzheimer’s dis.a.e amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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Complementary roles of glial cells in generating region-specific neuroinflammatory responses.a.d phagocytosis in Parkinson’s dis.a.e

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Neural Regeneration Res.a.ch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.a.merich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.a.sociated with Parkinson’s dis.a.e:Reactive gliosis.a.d neuroinflammation are hallmarks of Parkinson’s dis.a.e(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is.a.key player in dis.a.e progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Res.a.ch 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics.a.d Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is.a.promising emergent therapy for Parkinson's dis.a.e based on years of foundational res.a.ch using human fetal donors.a. a cell *** current therapeutic options for patients,this.a.proach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's dis.a.e.A defined systematic s.a.ch of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies.a.d differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this.a.proach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's dis.a.e survival transplant

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维普期刊数据库

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Res.a.ch 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury res.a.ch:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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Unders.a.ding activity of butyrate at a cellular level

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Neural Regeneration Res.a.ch 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Dis.a.e Res.a.ch Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is.a.short-chain fatty acid of four carbons in length that is.a.by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has.a.tracted ... 详细信息

关键词： carbons butyrate fiber

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Application of the coal mine floor rating(CMFR)to assess the floor s.a.ility in a Central Appalachian Coal Mine

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International Journal of Mining science and Technology 2021年第1期31卷 83-89页

作者： sena Cicek Ihsan Berk Tulu Mark Van Dyke Ted Klemetti Joe wickline Department of Mining Engineering West Virginia UniversityMorgantownWV 26505USA National Institute for Occupational safety and Health Pittsburgh Mining Research DivisionPittsburghPA 15236USA Coronado Global Resources Inc. BeckleyWV 25801USA

Estimating the overall floor s.a.ility in a coal mine using deterministic methods which require complex engineering properties of floor strata is desirable,but generally it is impractical due to the difficulty of gathering essential input ***,applying a quantitative methodology to describe floor quality with a single number provides.a.practical estimate for preliminary assessment of floor *** coal mine floor rating(CMFR)system,developed by the University of New south Wales(UNsW),is.a.rockmass classification system that provides.a. indicator for the competence of floor *** most significant components of the CMFR are uniaxial compressive strength and discontinuity intensity of floor *** addition to the competence of the floor,depth of cover and stress notch angle are input parameters used to assess the preliminary floor *** this study,CMFR methodology was.a.plied to a Central Appalachian Coal Mine that intermittently experienced floor *** drill core data,overburden maps.a.d mine plans were utilized for the ***,qualitative data(failure/non-failure)on floor conditions of the mine entries near the core holes was collected and analyzed so that the floor quality and its relation to entry s.a.ility could be estimated by s.a.istical *** was found that the current CMFR classification system is not directly applicable in assessing the floor s.a.ility of the Central Appalachian Coal *** order to extend the applicability of the CMFR classification system,the methodology was modified.A calculation procedure of one of the CMFR classification system’s components,the horizontal stress rating(HsR),was changed and new parameters were added to the HsR.

关键词： Rock mass classification Coal mine floor rating(CMFR) Floor heave Floor failure Buckling failure mechanism

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维普期刊数据库

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Microglial dysfunction and genetic risk for neurodegenerative dis.a.e

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Neural Regeneration Res.a.ch 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay Penney Department of Biomedical sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative disorders such as.a.zheimer's.a.d Parkinson's dis.a.es.a.re increasing in prevalence as world populations *** tremendous progress has been made,our unders.a.ding of the mechanisms that underlie the development of these dis.a.es remains far from com *** troubling,despite the growing emotional and financial toll being to ken by neurodegenerative disorders,existing treatment options.a.e limited almost exclusively to those that help manage symptoms but that lack the ability to alter the progression of the dis.a.e(Liu et al.,2022).

关键词： degenerative dis.a.es

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Dependence of nucleotide physical properties on their placement in codons.a.d determinative degree

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2005年第10期6卷 948-960页

作者： BEREZHNOY A.Y. DUPLIJ s.a. NsC Kharkov Institute of Physics.a.d Technology Kharkov 61108 UkraineDepartment of Physics and Technology Kharkov National University Svoboda Sq.4 Kharkov 61077 Ukraine

Various physical properties such as dipole moment, heat of formation and energy of the most s.a.le formation of nucleotides.a.d bases were calculated by PM3 (modified neglect of diatomic overlap, parametric method number 3) and AM1 (austin model 1) methods. As distinct from previous calculations, for nucleotides the interaction with neighbours is taken into account up to gradient of convergence equaling 1. The dependencies of these variables from the place in the codon and the de- terminative degree were obtained. The difference of these variables for codons.a.d anticodons is shown.

关键词： Dipole moment, Heat of formation, Total energy, DNA, Codon, Anticodon, Determinative degree

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维普期刊数据库

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