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基质金属蛋白酶9基因(-8202A/G)中单核苷酸多态性与胸主动脉瘤和胸主动脉夹层形成相关

世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 57-57页

作者： Carter s.a. s.a. lemaire 张步升 Cardiovascular surgery service The Texas Heart Institute at St Luke's Episcopal Hospital The Division of Cardiothoracic Surgery Houston TX United States Dr.

Objective: Matrix metalloproteinase 9 plays.a. important role in the maintenance of the aortic extracellular matrix. Genetic variations that affect protease expression or activity might contribute to thoracic aortic dis.a.e. The purpose of this study was to determine whether 3 single nucleotide polymorphisms in the matrix metalloproteinase 9 gene are associated with thoracic aortic aneurysms.a.d dissection. Methods: Genomic DNA was isolated from blood or aortic tissue from 28 patients with degenerative thoracic aortic aneurysms, 60 patients with thoracic aortic dissection, and 111 control patients. The frequency distributions of 3 matrix metalloproteinase 9 single nucleotide polymorphisms(-8202A/G, IVs4+3G/T, and 2003A/G[Q668R]) were determined by using genotyping accomplished with a real-time detection system. Associations between polymorphisms.a.d dis.a.e were estimated with odds ratios.a.d their 95%confidence intervals. Results: The frequency of the-8202G allele was significantly higher in patients with thoracic aortic aneurysms.a.d aortic dissection(0.52 and 0.56, respectively) than in control subjects(0.36, Ps with thoracic aortic aneurysms or dissection were nearly 5 times more likely than control subjects to have the G allele(adjusted odds ratio, 4.87; 95%confidence interval, 2.04-11.64). There were no significant associations between the IVs4+3G/T or 2003A/G polymorphisms.a.d thoracic aortic dis.a.e. Conclusions: The matrix metalloproteinase 9-8202A/G polymorphism is.a.sociated with thoracic aortic aneurysms.a.d dissection. Further studies.a.e warranted to elucidate the functional role of the-8202A/G variant in matrix metalloproteinase 9 expression.

关键词：胸主动脉夹层 A/G 基质金属蛋白酶胸主动脉瘤单核苷酸多态性细胞外基质主动脉组织等位基因频

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便携式微型发射光谱仪在金属工业中的应用(英文)

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冶金分析 2007年第5期27卷 8-13页

作者： TUssET Victor lemaire Olivier ZEIMETZ Eva DUPONT Alain C.R.M. LiègeBelgium

通过有证参考物质对便携式在线发射光谱仪在不同金属类别的快速成分控制的应用进行了考察。分析了大量的不同样品(低碳和超低碳钢,不锈钢,铝、镍和铜基样品),并通过采用参考的化学分析方法如ICP-OEs,XRF,C和s的燃烧等等方法对结果进行... 详细信息

通过有证参考物质对便携式在线发射光谱仪在不同金属类别的快速成分控制的应用进行了考察。分析了大量的不同样品(低碳和超低碳钢,不锈钢,铝、镍和铜基样品),并通过采用参考的化学分析方法如ICP-OEs,XRF,C和s的燃烧等等方法对结果进行了评价。对于低碳钢中的C,s和P的分析,通过特别的校正方法,采用新型的便携式光谱仪能获得与传统的固定式光谱仪相当的分析效果。本文也列举了多种非进样直接分析的相关应用实例。

关键词：便携式在线发射光谱仪快速成分控制金属

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synthesis of(±)-phthalascidin 622

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science China Chemistry 2010年第9期53卷 1888-1898页

作者： CHRIsTIAN R.Razafindrabe sYLVAIN Aubry BENJAMIN Bourdon MARTA Andriantsiferana sTEPHANE Pellet-Ros.a.ng MARC lemaire Laboratoire de Chimie des Produits Naturels et Biotechnologie(LPNB) Université d'Antananarivo17 Cité Mahatazana-Ampandrianomby101 Antananarivo ICBMs Institut de Chimie et Biochimie Moléculaires et SupramoléculairesCNRSUMR5246Laboratoire de Catalyse et Synthèse Organique ICsM institut de Chimie Séparative de MarcouleCNRS/CEA/UM2/ENSCMUMR 5257Laboratoire de Tri Ionique par des Systèmes Moléculaires auto-assemblés

A synthesis of functionalized phenolic α-amino-alcohols(±)-8 and(±)-16 as synthetic precursors of the catechol tetrahydroisoquinoline structure of phthalascidin 650 was disclosed.(±)-8 was prepared in 5 steps from the commercially available *** from 3-methyl catechol 5,8 steps gave rise to the synthesis of phenolic α-amino-alcohol(±)-16 in 27% overall *** synthetic strategy involved the elaboration of fully functionalized aromatic aldehyde 13 and its transformation into a phenolic α-amino-alcohol(±)-16,through a Knoevenagel condensation,simultaneous reduction of nitroketene and ester functions.a.d hydrogenolysis of the benzyl protecting *** pentacycle(±)-4 was obtained after 4 additional *** Pictet-spengler cyclisation between the phenolic α-amino-alcohol(±)-16 and the N-protected α-amino-aldehyde 4 allowed to obtain(1,3')-bis-tetrahydroisoquinoline 17 with N-methylated and N-Fmoc *** last step was.a.swern oxidation allowing the expected intramolecular condensation.

关键词： phthalascidin ecteinascidin (1 3’)-bis-tetrahydroisoquinoline Pictet-spengler Bishler-Napieralsky

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The Deep Thioredoxome in Chlamydomonas reinhardtii： New Insights into Redox Regulation

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Molecular Plant 2017年第8期10卷 1107-1125页

作者： Maria Esther Perez-Perez Adeline Mauries.a.exandre Maes Nicolas J. Tourasse Marion Hamon stephane D. lemaire Christophe H. Marchand Institut de Biologie Physico-Chimique UMR8226 CNRS Sorbonne Universit6s UPMC Univ Paris 06 13 rue Pierre et Marie Curie 75005 Paris France Institut de Biologie Physico-Chimique Plateforme de Proteomique FRC550 CNRS 13 rue Pierre et Marie Curie 75005 Paris France Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientificas (CSIC)-Universidad de Sevilla Seville Spain ARNA Laboratory INSERM U1212 CNRS UMR5320 Universite Bordeaux 2 Bordeaux France

Thiol-based redox post-trans.a.ional modifications have emerged as important mechanisms of signaling and regulation in all organisms, and thioredoxin plays.a.key role by controlling the thiol-disulfide s.a.us of target proteins. Recent redox proteomic studies revealed hundreds of proteins regulated by glutathio- nylation and nitrosylation in the unicellular green alga Chlamydomonas reinhardtii, while much less is known about the thioredoxin interactome in this organism. By combining qualitative and quantitative proteomic analyses, we have comprehensively investigated the Chlamydomonas thioredoxome and 1188 targets have been identified. They participate in a wide range of metabolic pathways.a.d cellular pro- cesses. This study broadens not only the redox regulation to new enzymes involved in well-known thiore- doxin-regulated metabolic pathways but also sheds light on cellular processes for which data supporting redox regulation are s.a.ce （aromatic amino acid biosynthesis, nuclear transport, etc）. Moreover, we char- acterized 1052 thioredoxin-dependent regulatory sites.a.d showed that these data constitute a valuable resource for future functional studies in Chlamydomonas. By comparing this thioredoxome with proteomic data for glutathionylation and nitrosylation at the protein and cysteine levels, this work confirms the existence of a complex redox regulation network in Chlamydomonas.a.d provides evidence of a tremendous selectivity of redox post-trans.a.ional modifications for specific cysteine residues.

关键词： Chlamydomonas reinhardtii disulfide bond isotope-coded affinity tag redox proteomics redox regulation thioredoxin targets

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High-Resolution Crys.a. structure and Redox Properties of Chloroplastic Triosephosphate Isomerase from Chlamydomonas reinhardtii

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Molecular Plant 2014年第1期7卷 101-120页

作者： Mirko Zaffagnini Laure Michelet Chiara sciabolini Nas.a.ia Di Giacinto samuel Morisse Christophe H. Marchand Paolo Trost simona Fermani stephane D lemaire Laboratoire de Biologie Moleculaire et Cellulaire des Eucaryotes FRE3354 Centre National de la Recherche Scientifique Universite Pierre et Marie Curie Institut de Biologie Physico-Chimique 13 rue Pierre et Marie Curie 75005 Paris France Laboratory of Plant Redox Biology Department of Pharmacy and Biotechnology (FaBiT) University of Bologna via Irnerio 42 40126 Bologna Italy Department of Chemistry 'G. Ciamician' University of Bologna via Selmi 2 40126 Bologna Italy

Triosephosphate isomerase （TPI） catalyzes the interconversion of glyceraldehyde-3-phosphate to dihydroxyacetone phosphate. Photosynthetic organisms generally contain two isoforms of TPI located in both cytoplasm and chloroplasts. While the cytoplasmic TPI is involved in the glycolysis, the chloroplastic isoform participates in the Calvin-Benson cycle, a key photosynthetic process responsible for carbon fixation. Compared with its cytoplasmic counterpart, the functional features of chloroplastic TPI have been poorly investigated and its three-dimensional structure has not been solved. Recently, several studies proposed TPI as.a.potential target of different redox modifications including dithiol/disulfide interchanges, glutathionylation, and nitrosylation. However, neither the effects on protein activity nor the molecular mechanisms underlying these redox modifications have been investigated. Here, we have produced recombinantly and purified TPI from the unicellular green alga Chlamydomonas reinhardtii （Cr）. The biochemical properties of the enzyme were delineated and its crys.a.lographic structure was determined at a resolution of 1.1 A. CrTPI is.a.homodimer with subunits containing the typical （β/α）8-barrel fold. Although no evidence for TRX regulation was obtained, CrTPI was found to undergo glutathionylation by oxidized glutathione and trans-nitrosylation by nitrosoglutathione, confirming its sensitivity to multiple redox modifications.

关键词： triosephosphate isomerase three-dimensional structure TIM-barrel thiol-based redox regulation transnitrosylation.

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sweet syndrome as.a.paraneoplastic manifes.a.ion of cholangiocarcinoma:A case report

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World Journal of Clinical Cases 2020年第18期8卷 4122-4127页

作者： Camille Carneiro lemaire Ana Luisa Carvalho Portilho Luciana V Pinheiro Rafael Alves Vivas Maíra Britto Melaine Montenegro Luiz Felipe de Farias Rodrigues sérgio Arruda AndréCastro Lyra Lourianne Nascimento Cavalcante Department of Internal Medicine Escola Bahiana de Medicina e Saúde PúblicaSalvador 40290-000BahiaBrazil Department of Internal Medicine Hospital Geral Roberto SantosSalvador 41180-780BahiaBrazil Department of surgery Hospital Geral Roberto SantosSalvador 41180-780BahiaBrazil Department of Gastroenterology and Hepatology Hospital Geral Roberto SantosSalvador 41180-780BahiaBrazil Department of Radiology Hospital Geral Roberto SantosSalvador 41180-780BahiaBrazil Pathological Anatomy Fiocruz-BahiaUniversidade Estadual da BahiaSalvador 40000-000BahiaBrazil Department of Medicine Division of Gastroenterology and HepatologyFederal University of Bahia and Gastro-Hepatology ServiceSalvador 40295-050BahiaBrazil Department of Medicine Division of Gastroenterology and HepatologyFederal University of Bahia and SED-CHD Hospital Geral Roberto SantosSalvador 40295-050BahiaBrazil

BACKGROUND sweet’s syndrome,also known as.a.ute febrile neutrophilic dermatosis,is.a.rare skin disorder that may be associated with *** sUMMARY A 58-year-old female presented with a choles.a.ic syndrome and significant weight loss three months before *** months earlier,she had abruptly developed skin lesions with erythematous papules that evolved to erythematous *** evaluation and laboratory tests confirmed hepatic *** lesions histopathological findings showed neutrophilic dermatosis,massive edema,fibrin,necrosis.a.d *** results,in association with the macroscopic aspects of the findings,led to the diagnosis of paraneoplastic sweet’s syndrome due to *** s.a.ing was consistent with an advanced tumor without a cure perspective,we opted to perform percutaneous biliary drainage,and subsequently,palliative ***,after a few weeks,the patient *** In conclusion,the diagnosis of the underlying dis.a.e-causing sweet’s syndrome must be accurate,and patients need to be followed-up,as neoplas.a.such as cholangiocarcinoma may be a later manifes.a.ion.

关键词： Cholangiocarcinoma Paraneoplastic syndrome sweet syndrome Case report Bullous lesions Choles.a.is

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sexuality of Repartnered Men and Women in France: sexual Behaviors, Perceptions, Expectations.a.d sexual Dysfunctions

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Advances in sexual Medicine 2012年第1期2卷 10-19页

作者： Marie-Helene Colson Antoine lemaire Patrick Klein 不详

Introduction. Although many epidemiological studies on sexuality have been published, none have specifically addressed male and female sexuality in repartnered couples. Aim. To investigate men and women’s sexual behaviors, perceptions.a.d expectations, and the frequency of their sexual dysfunctions, with a focus on repartnered couples, i.e, subjects living with a partner in a s.a.le relationship after divorce or widowhood (including both remarried couples.a.d cohabitating unmarried couples). Methods. Analysis of telephone survey data collected from 1,002 French subjects (483 men, 519 women) ≥35years. Of these, 748 were living with their partner as part of a heterosexual couple. For these subjects, the sexuality of 149 repartnered subjects was compared to that of the other 599 subjects. Main Outcome Measures. A 39-item questionnaire assessing subjects' perceptions, expectations, sexual behaviors.a.d dysfunctions. Results. Compared with other subjects, men and women in repartnered couples had more active sexuality and more interest in sexuality (men 93% vs 80%, P s 65%, P sensitive to feelings.a.d emotions linked to their sexuality, and these feelings seemed to increase steadily with age. Their sexuality was more attuned to their partner’s pleasure (men 79% vs. 59% P s. 34% P ship and for sexuality was equally present for both groups, although repartnered couples were more often concerned about potential inadequacy and conflicts between the two partners. Although repartnered men seemed to be less.a.fected by diminished desire, they had slightly higher rates of premature ejaculation and erectile dysfunction, and considered their quality of life to be more affected by these problems. Conclusion. The sexuality of repartnered couples remains poorly studied, but seems to differ from that of non-repartnered couples. Our findings open interesting avenues of

关键词： Repartnered Couples Remarried Couples sexual Behavior sexual Inadequency Marital Relationship

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继发于慢性血管夹层的Ⅱ型胸腹主动脉瘤的修复术

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中国普通外科杂志 2013年第6期22卷 677-680页

作者： Joseph s.Coselli scott A.lemaire scott A.Weldon 美国特克萨斯洲贝勒医学院 Michael E.DeBakey外科心胸外科分部

1引言Crawford II型胸腹主动脉瘤（TAAA）修复通常包括用合成的血管取代从左锁骨下动脉至肾下腹主动脉分叉的胸腹主动脉全长血管。因为行广泛的动脉替换,II型修复出现术后并发症有极高风险[1-6]。为了减少这些并发症,我们常规在术中采... 详细信息

1引言Crawford II型胸腹主动脉瘤（TAAA）修复通常包括用合成的血管取代从左锁骨下动脉至肾下腹主动脉分叉的胸腹主动脉全长血管。因为行广泛的动脉替换,II型修复出现术后并发症有极高风险[1-6]。为了减少这些并发症,我们常规在术中采用联合方法保护相应器官[7-9]。

关键词：主动脉瘤修复术视频

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Methods for Analysis of Protein Glutathionylation and their Application to Photosynthetic Organisms

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Molecular Plant 2009年第2期2卷 218-235页

作者： Xing-Huang Gao Mariette Bedhomme Daniel Veyel Mirko Zaffagnini stephane D. lemaire Institut de Biotechnologie des Plantes UMR 8618 CNRS/Universite Paris-Sud 11 Batiment 630 Orsay 91405 Cedex France

Protein s-glutathionylation, the reversible formation of a mixed-disulfide between glutathione and protein thiols, is involved in protection of protein cysteines from irreversible oxidation, but also in protein redox regulation. Recent studies have implicated s-glutathionylation as.a.cellular response to oxidative/nitrosative stress, likely playing an important role in signaling. Considering the potential importance of glutathionylation, a number of methods have been developed for identifying proteins undergoing glutathionylation. These methods, ranging from analysis of purified proteins in vitro to large-s.a.e proteomic analyses in vivo, allowed identification of nearly 200 targets in mammals. By contrast, the number of known glutathionylated proteins is more limited in photosynthetic organisms, although they are severely exposed to oxidative stress. The aim of this review is to detail the methods.a.ailable for identification and analysis of glutathionylated proteins in vivo and in vitro. The advantages.a.d drawbacks of each technique will be discussed as well as their application to photosynthetic organisms. Furthermore, an overview of known glutathionylated proteins in photosynthetic organisms is provided and the physiological importance of this post-trans.a.ional modification is discussed.

关键词： environmental signals oxidative and photo-oxidative stress proteomics signal transduction Glutathionylation Methods Glutaredoxin Glutathione.

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氯化咪唑基离子液体对柴油中含氮化合物选择性脱除作用研究

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无机化学学报 2008年第6期24卷 919-925页

作者：谢莉莉陈旬王绪绪付贤智 Alain Favre-Reguillon stephane Pellet-Ros.a.ng Marc lemaire 福州大学光催化研究所福建省光催化重点实验室-省部共建国家重点实验室培育基地福州350002 ICBMs Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Laboratoire de Catalyse et Synthèse Organique 43 Boulevard du 11 Novembre 1918 Villeurbanne F-69622 France CNRs UMR5246 Université Lyon 1

通过N-甲基咪唑和烷基氯的季铵化反应合成出了咪唑环N上烷基取代基碳链长度或者饱和度不同的4种离子液体:氯化1-丁基-3-甲基咪唑(BMImCl)、氯化1-烯丙基-3-甲基咪唑(AlMImCl)、氯化1-苯甲基-3-甲基咪唑(BzMImCl)和氯化-1-辛基-3-甲基咪... 详细信息

通过N-甲基咪唑和烷基氯的季铵化反应合成出了咪唑环N上烷基取代基碳链长度或者饱和度不同的4种离子液体:氯化1-丁基-3-甲基咪唑(BMImCl)、氯化1-烯丙基-3-甲基咪唑(AlMImCl)、氯化1-苯甲基-3-甲基咪唑(BzMImCl)和氯化-1-辛基-3-甲基咪唑(OcMImCl)。以含咔唑(CAR)和二苯并噻吩(DBT)的甲苯-正十二烷烃溶液作为模拟柴油,测定CAR和DBT在这些离子液体中的相对分配系数,考察了离子液体对氮和硫化物的萃取脱除选择性。结果表明,在这些离子液体中CAR比DBT有更高的分配系数;4种离子液体比较,BMImCl和AlMImCl对CAR的分配系数分别达46和14,对氮和硫化合物的萃取脱除选择性sN/s分别达到125和38。测定了离子液体在模拟柴油的溶解度,发现这4种离子液体在甲苯和正十二烷烃模拟柴油中的溶解度有显著的差别,其中BMImCl和AlMImCl的溶解度相当且都很小。综合结果显示BMImCl具有最佳性能。实验还比较了BMImCl对不同碱性氮杂环化合物的萃取效果,发现其对含硫化合物和碱性含氮化合物的萃取效率随着模拟柴油中甲苯的质量分数的增加而降低,而对中性含氮化合物表现出高萃取效率,且几乎不受甲苯质量分数的影响。对一种含有361 mg·kg-1N和3598 mg·kg-1s的工业柴油,BMImCl对其对中性含氮化合物的萃取效率达到38%,而对相对含量高约十倍的含硫化合物的萃取率仅约有1.7%。综合上述结果表明,氯化1-丁基-3-甲基咪唑盐离子液体对柴油中的中性含氮化合物具有高选择性脱除作用。

关键词：离子液体中性氮化物萃取柴油

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