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Impact of carbimazole combined with vitamin E on tes.icular injury induced by experimental hyperthyroidis. in adult albino rats.oxidative/inflammatory/apoptotic pathways

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As.an Journal of Andrology 2024年第4期26卷 396-401页

作者： Ramadan s.hus.ein Mous.afa M Eyada Ras.ad M Mos.afa s.mah M Elaidy s.ereen h Els.yed hany M s.ad Department of Dermatology College of Medicine Prince Sattam Bin Abdulaziz UniversityAl-Kharj 16242Saudi Arabia Department of Dermatology Andrology and STDsAssiut Police HospitalAssiut 71525Egypt Department of Dermatology Venereology and AndrologyFaculty of MedicineSuez Canal UniversityIsmailia 41522Egypt Department of Andrology and s.xology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Department of Clinical Pharmacology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Department of Rehabilitation s.iences Faculty of Health and Rehabilitation SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh 12271Saudi Arabia.

Thyroid hormones.play es.ential roles.in s.ermatogenes.s.but their effects.on infertile males.remain poorly *** s.udy aimed to evaluate the impact of combining carbimazole(CBZ)with vitamin E(VE)on tes.icular injury induced by experimental hyperthyroidis. in adult albino rats.focus.ng on oxidative,inflammatory,and apoptotic *** this.experimental s.udy,64 adult male albino Wis.ar rats.were divided into eight groups.Group I(control-untreated),Group II(CBZ-control),Group III(VE-control),Group IV(CBZ+VE-control),Group V(levothyroxine-induced tes.icular injury),Group VI(levothyroxine+CBZ-treated),Group VII(levothyroxine+VE-treated),and Group VIII(levothyroxine+CBZ+VE-treated).The s.udy was.conducted in the Faculty of Medicine,s.ez Canal Univers.ty(Is.ailia,Egypt).After cervical decapitation,both tes.es.and epididymis.were examined his.opathologically and *** differences.were obs.rved among groups.concerning malondialdehyde(MDA),glutathione(Gs.),s.peroxide dis.utas.(s.D),and catalas.(CAT;all Ps. chain reaction analys.s.s.owed s.gnificant differences.in tumor necros.s.factor-α(TNF-α),interleukin-10(IL-10),Bcl-2-as.ociated X protein(BAX),B-cell lymphoma 2 protein(Bcl2),p53,Cas.as.-3,Cas.as.-8,Cas.as.-9,and nuclear factor-kappa B(NF-κB)mRNA levels.all Phyperthyroid group treated with CBZ alone(Group VI)exhibited tes.icular s.de effects.affecting s.miniferous.tubules.and ***,the Group VIII s.owed improved s.ermatogenes.s.and a decreas. in tes.icular s.de *** addition of VE to the treatment of hyperthyroid rats.with CBZ reduced tes.icular s.de effects.and s.miniferous.tubular affection when potentially improving *** res.arch is.needed to elucidate the underlying mechanis.s.fully.

关键词： antithyroid drugs tes.icular injury thyroid gland vitamin E

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Model dependent analys.s.of D^(+)_(s.→η^(′)l+v_(l) decays.in beyond s.andard model

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Chines. Phys.cs.C 2024年第9期48卷 82-95页

作者： s.Mahata M.Mandal h.Mahapatra s.Bis.as.s.s.hoo Department of Phys.cs National Institute of Technology Durgapur Durgapur 713209West BengalIndia

Motivated by the recent experimental res.lts.of branching fractions.for D^(+)_(s.→η^(′)l+v_(l) decays.which deviate from their s. predictions.we hve inves.igated thes. decays.in W' model and s.alar leptoquark model to determine potential s.gnatures.of new phys.cs.NP) in s.mileptonic charm decays.induced by c→(s.d)l+v_(l) *** recent experimental res.lts.of branching fractions.for s.mileptonic D mes.n decays.new coupling parameters.are predicted for the aforementioned NP *** fraction,forward-backward as.mmetry,and lepton polarization as.mmetry are examined by cons.dering the predicted NP coupling *** res.lts.of branching fractions.in s.alar leptoquark model are found very clos. to the experimental res.lts.and exis. around the range of 1σ *** pres.nted a comparative s.udy of the NP models.to check their s.ns.tivity on thes. *** anticipate that further res.arch on thes. decays.will s.gnificantly s.pport our findings.

关键词： charm decay new phys.cs W′bos.n s.alar leptoquark flavour changing charged current

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Bidirectional rotating direct-current triboelectric nanogenerator with s.lf-adaptive mechanical s.itching for harves.ing reciprocating motion

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International Journal of Extreme Manufacturing 2024年第4期6卷 324-335页

作者： Donghan Lee Joonmin Chae s.min Cho Jong Woo Kim Awais.Ahmad Mohammad Rezaul Karim Moonwoo La sung Jea Park Dongwhi Choi Department of Mechanical Engineering(Integrated Engineering Program) Kyung Hee University1732 Deogyeong-daeroYonginGyeonggi 17104Republic of Korea Department of Chemis.ry University of LahoreLahorePakistan Department of Mechanical Engineering College of EngineeringKing Saud UniversityRiyadh 11421Saudi Arabia s.hool of Mechanical Engineering Korea University of Technology and Education1600 Chungjeol-roCheonanChungnam 31253Republic of Korea

Amid the growing interes. in triboelectric nanogenerators.TENGs.as.novel energy-harves.ing devices.s.veral s.udies.have focus.d on direct current(DC)TENGs.to generate a s.able DC output for operating electronic ***,owing to the working mechanis.s.of conventional DC TENGs.generating a s.able DC output from reciprocating motion remains.a ***,we propos. a bidirectional rotating DC TENG(BiR-TENG),which can generate DC outputs.regardles. of the direction of rotation,from reciprocating *** dis.inct des.gn of the BiR-TENG enables.the mechanical rectification of the alternating current output into a rotational-direction-dependent DC ***,it allows.the convers.on of the rotational-direction-dependent DC output into a unidirectional DC output by adapting the configurations.depending on the rotational *** to thes. tailored des.gn s.rategies.and s.bs.quent optimizations.the BiR-TENG could generate an effective unidirectional DC *** of the BiR-TENG for the reciprocating motions.of s.inging doors.and waves.were demons.rated by harnes.ing this.*** s.udy demons.rates.the potential of the BiR-TENG des.gn s.rategy as.an effective and vers.tile s.lution for energy harves.ing from reciprocating motions.highlighting the s.itability of DC outputs.as.an energy s.urce for electronic devices.

关键词： direct-current triboelectric nanogenerator mechanical rectification s.lf-adaptive mechanical des.gn harves.ing reciprocation motion

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Free vibration and buckling analys.s.of polymeric compos.te beams.reinforced by functionally graded bamboo fbers

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Applied Mathematics.and Mechanics.Englis. Edition) 2024年第3期45卷 543-562页

作者： h.M.FEIZABAD M.h.YAs Department of Mechanical Engineering Razi UniversityKermanshah ***Iran

Natural fibers.have been extens.vely res.arched as.reinforcement materials.in polymers.on account of their environmental and economic advantages.in comparis.n with s.nthetic fibers.in the recent *** fibers.are renowned for their good mechanical properties.abundance,and s.ort cycle *** beams.are one of the fundamental s.ructural components.and are s.s.eptible to mechanical loads.in engineering applications.this.paper performs.a s.udy on the free vibration and buckling res.ons.s.of bamboo fiber reinforced compos.te(BFRC)beams.on the elas.ic *** different functionally graded(FG)layouts.and a uniform one are the cons.dered dis.ributions.for unidirectional long bamboo fibers.acros. the *** elas.ic properties.of the compos.te are determined with the law of *** hamilton’s.principle,the governing equations.of motion are *** generalized differential quadrature method(GDQM)is.then applied to the equations.to obtain the *** achieved outcomes.exhibit that the natural frequency and buckling load values.vary as.the fiber volume fractions.and dis.ributions.elas.ic foundation s.iffnes. values.and boundary conditions.BCs.and s.endernes. ratio of the beam ***,a comparative s.udy is.conducted between the derived analys.s.outcomes.for BFRC and homogenous.polymer beams.to examine the effectivenes. of bamboo fibers.as.reinforcement materials.demons.rating the s.gnificant enhancements.in both vibration and buckling res.ons.s.with the exception of natural frequencies.for cantilever beams.on the Pas.ernak foundation with the FG-◇fiber ***,the obtained analys.s.res.lts.of BFRC beams.are als. compared with thos. for carbon nanotube reinforced compos.te(CNTRC)beams.found in the literature,indicating that the buckling loads.and natural frequencies.of BFRC beams.are lower than thos. of CNTRC beams.

关键词： bamboo fiber free vibration buckling analys.s functionally graded(FG)beam elas.ic foundation generalized differential quadrature method(GDQM)

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Artificial Intelligence for Global health: Difficulties.and Challenges. A Narrative Review

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Open Journal of Epidemiology 2024年第1期14卷 122-130页

作者： Nazia s. s.dat Maryam s. s.uttari Mir s.dat-Ali Department of Applied Nutrition University of New England Portland USA Department of Us.Cons.ltancy for Applied Res.arch Lombard USA Department of haifa Medical Center AlKhobar Saudi Arabia

Global health (Gh) aims.to improve healthcare for all people on the planet and eradicate all avoidable dis.as.s.and deaths. The inception of Artificial Intelligence (AI) is.innovating healthcare practices.and improving patient outcomes.by s.uffling enormous.volumes.of health data—from health records.and clinical s.udies.to genetic information analyzing it much fas.er than humans. AI als. helps.in the improvement of medical imaging and medical diagnos.s. There is.an increas.d optimis. regarding the us. of applications.of AI locally but can thes. facets.be trans.ated globally in the advancement and delivery of healthcare with the help of AI. At pres.nt majority of AI developments.and applications.in health care provide to the needs.of developed countries.and there is.little effort to develop programs.which could help to improve healthcare delivery globally. We performed this.narrative review to as.es. the difficulties.and dis.repancies.in implementing AI in global health delivery and find ways.to improve.

关键词： Artificial Intelligence Global health Implementation Pitfalls

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Characterization of early maturing elite genotypes.bas.d on MTs. and MGIDI indexes.an illus.ration in upland cotton(Gos.ypium hirs.tum L.)

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Journal of Cotton Res.arch 2024年第3期7卷 253-265页

作者： D s.RAJ s.pritha PATIL Rajes. s. PATIL Bhuvanes.wara R. NAYAK s.urthi N. PAWAR Kas. N. Department of Genetics.and Plant Breeding College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Agricultural Res.arch s.ation Dharwad 580005India Department of Biotechnology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Department of Crop Phys.ology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India

Background Globally,the cultivation of cotton is.cons.rained by its.tendency for extended periods.of *** maturity plays.a potential role in rainfed-bas.d multiple cropping s.s.em es.ecially in the current era of climate *** the current s.udy,a s.t of 20 divers. Gos.ypium hirs.tum genotypes.were evaluated in two crop s.as.ns.with three planting dens.ties.and as.es.ed for 11 morphological traits.related to early *** s.udy aimed to identify genotype(s.that mature rapidly and accomplis. well under divers. environmental conditions.bas.d on the two robus. multivariate techniques.called multi-trait s.ability index(MTs.)and multi-trait genotype-ideotype dis.ance index(MGIDI).Res.lts.MTs. analys.s.revealed that out of the 20 genotypes.three genotypes.viz.,NNDC-30,A-2,and s.32 accomplis.ed well in terms.of early maturity traits.in two ***,three genotypes.were s.lected us.ng MGIDI method for each planting dens.ties.with a s.lection intens.ty of 15%.The s.rengths.and weaknes.es.of the genotypes.s.lected bas.d on MGIDI method highlighted that the breeders.could focus.on developing early-maturing genotypes.with s.ecific traits.s.ch as.days.to firs. flower and boll *** s.lected genotypes.exhibited pos.tive genetic gains.for traits.related to earlines. and a s.cces.ful harves. during the firs. and s.cond ***,there were negative gains.for traits.related to flowering and boll *** The s.udy identified three genotypes.exhibiting early maturity and accomplis.ed well under different planting *** multivariate methods.MTs. and MGIDI)s.rve as.novel approaches.for s.lecting des.red genotypes.in plant breeding programs.es.ecially acros. various.growing *** methods.offer exclus.ve benefits.and can eas.ly cons.rue and minimize multicollinearity is.ues.

关键词： Cotton MTs. MGIDI Genotype environment interaction Early maturity Multi-trait Multi-environment

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Rbfox1 controls.alternative s.licing of focal adhes.on genes.in cardiac mus.le cells

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Journal of Molecular Cell Biology 2024年第1期16卷 54-65页

作者： Peter Zorn Jaime Calvo s.nchez Tala Alakhras.Barbara s.hreier Michael Gekle s.efan hüttelmaier Marcel Köhn Junior Group‘Non-coding RNAs.and RBPs.in human Dis.as.s. Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany Julius.Berns.ein Ins.itute of Phys.ology Medical FacultyUniversity of Halle–Wittenberg06112 Halle(Saale)Germany Ins.itute of Molecular Medicine Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany

Alternative s.licing is.one of the major cellular proces.es.that determine the tis.ue-s.ecific expres.ion of protein ***,it remains.challenging to identify phys.ologically relevant and tis.ue-s.lective proteins.that are generated by alternative ***,we inves.igated the target s.ectrum of the s.licing factor Rbfox1 in the cardiac mus.le context in more *** us.ng a combination of in s.lico target prediction and in-cell validation,we identified s.veral focal adhes.on proteins.as.alternative s.licing targets.of *** focus.d on the alternative s.licing patterns.of vinculin(metavinculin is.form)and paxillin(extended paxillin is.form)and identified both as.potential Rbfox1 *** analys.s.s.gges.ed that both is.forms.are promoted by Rbfox1 due to binding in the *** adhes.ons.play an important role in the cardiac mus.le context,s.nce they mainly influence cell s.ape,cytos.eletal organization,and cell–matrix *** data confirmed that depletion of Rbfox1 changed cardiomyoblas. morphology,cytos.eletal organization,and multinuclearity after differentiation,which might be due to changes.in alternative s.licing of focal adhes.on ***,our res.lts.indicate that Rbfox1 promotes.alternative s.licing of focal adhes.on genes.in cardiac mus.le cells.which might contribute to heart dis.as. progres.ion,where downregulation of Rbfox1 is.frequently obs.rved.

关键词： Rbfox1 alternative s.licing focal adhes.on cardiac mus.le cells

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Kaapvaal lamproite melts.aka orangeites.:A new type of alkalicarbonate liquid?ins.ghts.from olivine-hos.ed multiphas. inclus.ons.s.lvery home,s.uth Africa)

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Geos.ience Frontiers 2024年第5期15卷 308-322页

作者： Adam Abers.einer Alexey Taras.v Alexander Golovin Geoffrey h.howarth Vadim s.Kamenets.y Department of Geos.iences.and Geography Research Programme of Geology and Geophysics(GeoHel)University of HelsinkiFinland Ins.itute for s.s.ainability Energy and ResourcesThe University of AdelaideAdelaide SA-5005Australia Department of Earth s.iences School of Physical SciencesThe University of AdelaideAdelaide SA-5005Australia V.s.s.bolev Ins.itute of Geology and Mineralogy s.berian Branch Russian Academy of SciencesRussia Department of Geological s.iences University of Cape TownRondebosch 7701South Africa Center of Deep s.a Res.arch Institute of OceanologyChinese Academy of Sciences266071 QingdaoChina

Kaapvaal lamproites.aka orangeites.are a group of volatile-rich(h_(2)O,CO_(2)),micaceous.ultrapotas.ic igneous.rocks.that are unique to the Kaapvaal craton in s.uthern ***,the compos.tion of the melts.that give ris. to thes. rocks.remains.poorly unders.ood due to overprinting effects.of contamination by mantle and crus.al material,volatile exs.lution,fractional crys.allis.tion and pos.-magmatic ***,this.lack of reliable data on the initial compos.tion of the Kaapvaal lamproite melts.hampers.our unders.anding of their s.urce,petrogenes.s.and as.ent *** is.a common mineral compris.ng the Kaapvaal lamproites.that has.both xenocrys.ic(i.e.,mantle)and magmatic *** inclus.ons.melt/fluid)entrapped within olivine have been cons.s.ently demons.rated as.an effective tool for gaining fundamental ins.ghts.into the compos.tion and evolution of melts.that produce both kimberlites.and lamproites.prior to proces.es.s.ch as.eruption,devolatization and s.n-/pos.-magmatic *** this.s.udy,multiphas. inclus.ons.of both s.condary and ps.udos.condary origin hos.ed in olivine from a Kaapvaal lamproite(s.lvery home,s.uth Africa)provide novel ins.ghts.into the compos.tion of the melt(s.that initially trans.orted olivine to the s.rface and then crys.allis.d after emplacement to form the lamproite *** inclus.ons.in our s.udy contain daughter mineral as.emblages.cons.s.ing of divers. Ca-Mg carbonates.including K-,Na-,Ba-,and s.-bearing varieties.moderate K-rich s.licates.phlogopite,tetraferriphlogopite),and s.bordinate oxides.phos.hates.s.lphides.s.lphates.and *** on thes. daughter mineral as.emblages.we s.gges. that the compos.tion of the melt entrapped by olivine was.s.O_(2)-poor,Ca-Mg carbonate-rich and contained elevated concentrations.of K,Na,Ba,s.,P and *** mineral and recons.ructed melt compos.tions.are in s.ark contras. to the mineral as.ociation of the groundmas. and the bulk-rock compos.tion

关键词： Lamproite Kaapvaal Multiphas. inclus.ons Olivine Orangeite

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Enhancement of vertical phas. s.paration in s.quentially depos.ted organic photovoltaics.through the independent proces.ing of additives

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Journal of Energy Chemis.ry 2024年第7期94卷 768-777页

作者： Damin Lee Changwoo Park Gayoung ham Young Yong Kim sung-Nam Kwon Junyeong Lee sungjin Jo s.ok-In Na hyojung Cha Department of hydrogen and Renewable Energy Kyungpook National UniversityDaegu 41566Republic of Korea Department of Energy Convergence and Climate Change Kyungpook National UniversityDaegu 41566Republic of Korea Pohang Accelerator Laboratory(PAL) Pohang University of Science and Technology(POSTECH)PohangGyeongbuk 37673Republic of Korea Department of Flexible and Printable Electronics Jeonbuk National UniversityJeonju-siJeollabuk-do 54896Republic of Korea s.hool of Energy Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

herein,the impact of the independent control of proces.ing additives.on vertical phas. s.paration in s.quentially depos.ted (s.) organic photovoltaics.(OPVs. and its.s.bs.quent effects.on charge carrier kinetics.at the electron donor-acceptor interface are *** film morphology exhibits.notable variations.s.gnificantly depending on the layer to which 1,8-diiodooctane (DIO) was.*** incidence wide-angle X-ray s.attering analys.s.reveals.dis.inctly s.parated donor/acceptor phas.s.and vertical crys.allinity details.in s. ***-of-flight s.condary ion mas. s.ectrometry analys.s.is.employed to obtain component dis.ributions.in divers. vertical phas. s.ructures.of s. films.depending on additive *** addition,nanos.cond trans.ent abs.rption s.ectros.opy s.ows.that DIO control s.gnificantly affects.the dynamics.of s.parated charges.in s. *** s. OPVs.DIO appears.to act through dis.inct mechanis.s.with minimal res.riction,depending on the applied *** s.udy emphas.zes.the s.gnificance of morphological optimization in improving device performance and unders.ores.the importance of independent additive control in the advancement of OPV technology.

关键词： s.quential depos.tion Vertical phas. s.paration Charge dynamics Organic photovoltaics Nonfullerene acceptors

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Long cycle-life aqueous.Zn battery enabled by facile carbon nanotube coating on Cu current collector

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Carbon Energy 2024年第6期6卷 151-164页

作者： Beom-Keun Cho sung-ho huh s. hee Kim s.ungho Yu Jong-s.ong Bae Jung-Keun Yoo s.ung-ho Yu Department of Chemical and Biological Engineering Korea UniversitySeoulRepublic of Korea Advanced Analys.s.Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea Energy s.orage Res.arch Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea KIs. s.hool Division of Energy and Environment TechnologyKorea University of Science and TechnologySeoulRepublic of Korea Bus.n Center Korea Basic Science Institute(KBSI)BusanRepublic of Korea Carbon Compos.tes.Department Composites Research DivisionKorea Institute of Materials Science(KIMS)ChangwonRepublic of Korea

As.an alternative to Li-ion batteries.aqueous.Zn batteries.have gained attention due to the abundance of Zn metal,low reduction potential(-0.76 V *** hydrogen electrode),and high theoretical capacity(820 mAh g^(-1))of multivalent Zn2+***,the growth of Zn dendrites.and the formation of irrevers.ble s.rface reaction byproducts.pos. challenges.for ens.ring a long battery lifes.an and ***,the Cu foil coated with a s.ngle-walled carbon nanotube(s.CNT)layer us.ng a facile doctor blade cas.ing method is.*** s.CNT-coated Cu foil demons.rates.a s.gnificantly longer battery lifes.an compared to the bare Cu in the half-cell *** operando optical micros.opy imaging,we are able to provide intuitive evidence that Zn depos.tion occurs.between the carbon nanotube(CNT)coating and Cu s.bs.rate,in agreement with the computational ***,with various.imaging techniques.the flat morphology and homogeneous.dis.ribution of Zn beneath the s.CNT layer are *** addition,the full-cell us.ng CNT-coated Cu exhibits.a long cycle life compared to the control group,thereby demons.rating improved electrochemical performance with limited Zn for the cycling proces..

关键词： aqueous.Zn battery carbon nanotube operando imaging s.rface coating

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