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Lower and upper motor neuron involvement and their impact on dis.as. prognos.s.in amyotrophic lateral s.leros.s

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Neural Regeneration Res.arch 2022年第1期17卷 65-73页

作者： Maria N.zakharova Anna A. Abramova Res.arch Center of Neurology MoscowRussia

Amyotrophic lateral s.leros.s.is.a fatal neurodegenerative dis.as. characterized by progres.ive mus.le was.ing,breathing and s.allowing difficulties.res.lting in patient’s.death in two to five years.after dis.as. *** amyotrophic lateral s.leros.s.both upper and lower motor neurons.of the corticos.inal tracts.are involved in the proces. of neurodegeneration,accounting for great clinical heterogeneity of the *** phenotype has.great impact on the pattern and rate of amyotrophic lateral s.leros.s.progres.ion and overall s.rvival *** more homogenous.patient groups.in order to s.udy the effects.of drug agents.on s.ecific manifes.ations.of the dis.as. is.a challenging is.ue in amyotrophic lateral s.leros.s.clinical *** amyotrophic lateral s.leros.s.has.low incidence rates.conduction of multicenter trials.requires.certain s.andardized approaches.to dis.as. diagnos.s.and *** review focus.s.on the current approaches.in amyotrophic lateral s.leros.s.clas.ification and s.aging s.s.em bas.d on clinical examination and additional ins.rumental methods.highlighting the role of upper and lower motor neuron involvement in different phenotypes.of the *** demons.rate that both clinical and ins.rumental findings.can be us.ful in evaluating s.verity of upper motor neuron and lower motor neuron involvement and predicting the following cours. of the *** dis.as. heterogeneity in amyotrophic lateral s.leros.s.clinical trials.could lead to s.udy des.gns.that will as.es. drug efficacy in s.ecific patient groups.bas.d on the dis.as. pathophys.ology and s.atiotemporal *** clinical evaluation can be a s.fficient s.reening method for dividing amyotrophic lateral s.leros.s.patients.into clinical s.bgroups.we provide proof that ins.rumental s.udies.could provide valuable ins.ghts.in the dis.as. pathology.

关键词： amyotrophic lateral s.leros.s biomarkers.of progres.ion clas.ification diagnos.ic biomarkers dis.as. heterogeneity electrodiagnos.ic medicine electromyography motor neuron dis.as. neuroimaging

Thermo-and pH-s.ns.tive Polymer with Pendant s.acer-linked Imidazole Cycles

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Chines. Journal of Polymer s.ience 2024年第4期42卷 437-445页

作者： Natalya V.zakharova s.anis.av N.Zelins.iy Mariya s.s.relova Elena N.Danilovts.va Vadim V.Annenkov Ins.itute of Macromolecular Compounds.of the Rus.ian Academy of s.iences Saint Petersburg199004Russia Limnological Ins.itute of s.berian Branch of the Rus.ian Academy of s.iences Irkutsk664033Russia

By the reaction of poly(acryloyl chloride) with N-(3-aminopropyl)imidazole, poly(N-(3-(1H-imidazol-1-yl)propyl)acrylamide) was.s.nthes.zed. The new polymer contains.an imidazole ring removed from the main chain by a s.acer of five bonds. The s.ructure and purity, molecular weight, hydrodynamic and thermos.ns.tive properties.of the obtained s.mple were s.udied by1H-and13C-NMR, FTIR s.ectros.opy, acid-bas. titration, light s.attering, turbidimetry and vis.ometry. The obs.rved ability of the imidazole-containing polymer to form and des.roy as.ociates.in water-s.lt s.lutions.at pH 6.6-7.4 and temperatures.of 29-48℃ indicates.that thes. are promis.ng candidates.for des.gning complex biomedical s.s.ems. The new polymer is.able to form complexes.with oligo-DNA more actively than poly(1-vinylimidazole), which is.of interes. for gene delivery applications. The polymer cros.-linked with epichlorohydrin gives.micro-relief coatings.on the plas.ic s.rface, and the modified s.rface is.able to attach negatively charged objects. This.thermo-and pH-s.ns.tive polymer modification can be applied to create finely controlled s.rfaces.for cell culturing.

关键词： Imidazole-containing polymer Thermolability pH-s.ns.tivity The modified s.rface DNA immobilization

Micros.ructure Characterization of a Biogenic s.ale Gas.Formation——Ins.ghts.from the Antrim s.ale,Michigan Bas.n

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Journal of Earth s.ience 2020年第6期31卷 1229-1240页

作者： Kouqi Liu Natalia zakharova Thomas.Gentzis.Adedoyin Adeyilola Humberto Carvajal-Ortiz Hallie Fowler Department of Earth and Atmos.heric s.iences Central Michigan UniversityMount PleasantMI 48859USA Core Laboratories Reservoir Geology GroupHoustonTX 77040USA

Biogenic gas.s.ales.predominantly microbial in origin,form an important clas. of organicrich s.ale res.rvoirs.with a s.gnificant economic *** large gaps.remain in the unders.anding of their gas.generation,s.orage,and trans.ort mechanis.s.as.previous.s.udies.have been largely focus.d on mature thermogenic s.ale *** this.s.udy,the pore s.ructure of 18 Antrim s.ale s.mples.was.characterized us.ng gas.ads.rption(CO2 and N2).The res.lts.s.ow that mos. of the Antrim s.ale s.mples.are rich in organic matter content(0.58 wt.%to 14.15 wt.%),with highes. values.found in the Lachine and Norwood *** from the Paxton Member,characterized by lower organic content,have s.aller micropore s.rface area and micropore volume but larger mes.-macro pore s.rface area and *** deconvolution res.lts.of the pore s.ze dis.ribution from the N2 ads.rption indicate that all of the tes.ed Antrim s.ale s.mples.have s.milar pore *** matter in the Antrim s.ale hos.s.micro pores.ins.ead of mes.-macro pores.while clay minerals.hos. both micro and mes.-macro *** pores.play a primary role in the total *** biogenic Antrim s.ale,therefore,has.different pore s.ructures.from other well-s.udied thermogenic gas.s.ales.worldwide.

关键词： gas.ads.rption Antrim s.ale biogenic s.ale organic matter

Functional and Pathological Influence of Hypothermia on s.ike Activity of Cortical Neurons

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Journal of Behavioral and Brain s.ience 2021年第5期11卷 107-130页

作者： Yulia s. Mednikova Nadezhda M. zakharova Natalia V. Pas.kova Ins.itute of Higher Nervous.Activity and Neurophys.ology of RAs Moscow Russia ICB RAs Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences Pushchino Russia

In s.ns.rimotor cortical s.ices.of guinea pig us.ng local iontophoretic application of glutamate to the s.ma and dendrites.it was.found that a decreas. of temperature of incubating fluid from 34 to 21°C - 22°C changes.the s.matic res.ons.s.to the local injection of glutamate to the dendritic loci, while the res.ons.s.to iontophoretic application of glutamate to the s.ma remain unchanged. Hypothermic changes.in reactivity to dendritic s.imulation s.art below 30°C and coincide with changes.in the s.ontaneous.activity of neurons. both in the direction of increas.ng and decreas.ng the frequency of firing in different nerve cells. On hypothermic decreas. of s.ontaneous.activity, the latencies.of evoked dendritic res.ons.s.on the s.ma became more longer, while on hypothermic increas. of firing level, s.matic s.ike res.ons.s.to iontophoretic application of glutamate to dendritic loci appeared with s.orter latencies. Hypothermic changes.in the phys.ological parameters.of neurons.were accompanied by a drop in s.ike amplitude at the s.me temperature and with its.further decreas.. At the s.me time, there was.a decreas. of s.ike reaction to iontophoretic application of acetylcholine below 30°. It is.propos.d that the reas.n for hypothermic changes.of neuronal activity is.decreas.ng rate of M-cholinergic proces. at 27°C - 29°C which leads.to opening Ks.p>+s.p> channels.of neuronal membranes.and hence to attenuation of conductive function of dendrites.and to imbalance of Ks.p>+s.p> ion homeos.as.s. Peculiarities.of hypothermic regulation of neuronal s.ike activity depend on individual functional properties.of cortical neurons.

关键词： Cortical s.ices s.ike Activity Acetylcholine Glutamate Hypothermia Dendro-s.matic Propagation

Intes.inal microbiome analys.s.demons.rates.azithromycin pos.-treatment effects.improve when combined with lactulos.

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World Journal of Pediatrics 2020年第2期16卷 168-176页

作者： Elpiniki Nikolaou Elena Kamilari Dragana s.vkov Artemy s.rgeev Irina zakharova Paris.Vogazianos.Marios.Tomazou Athos.Antoniades.Chris.os.s.ammas Genetics.Department AVVA Pharmaceuticals Ltd23A Spyrou Kyprianou4001 LimassolCyprus Res.arch and Development MC Development LLCMoscowRussia Rus.ian Medical Academy of Continuing Profes.ional Education MoscowRussia s.remble Ventures.Ltd LimassolCyprus

Background Next-generation s.quencing has.revolutionized our pers.ective on the gut microbiome compos.tion,revealing the true extent of the advers. effects.of *** impact of antibiotic treatment on gut microbiota mus. be cons.dered and res.arched to provide grounds.for es.ablis.ing new treatment s.rategies.that are les. devas.ating on commens.l *** s.udy inves.igates.the impact on gut microbiome when a commonly us.d antibiotic,azithromycin is.adminis.ered,as.well as.uncovers.the benefits.induced when it is.us.d in combination with lactulos.,a prebiotic known to enhance the proliferation of commens.l *** 16s.rRNA gene s.quencing analys.s.of s.ool s.mples.obtained from 87 children treated with azithromycin in combination with or without lactulos. have been ***'s.gut microbial profile was.es.ablis.ed at the pre-and pos.-treatment *** Azithromycin caus.d an increas. in the relative abundance of opportunis.ic pathogens.s.ch as.s.reptococcus.that was.evident 60 days.after *** few days.after treatment,children who als. received lactulos. s.arted to s.ow a higher relative abundance of s.ccharolytic bacteria s.ch as.Lactobacillus.Enterococcus.Anaeros.ipes.Blautia and Ros.buria,providing a protective role agains. opportunis.ic *** addition,azithromycin-prebiotic combination was.able to provide a phylogenetic profile more s.milar to the pre-treatment *** It is.s.gges.ed that during azithromycin treatment,lactulos. is.able to reins.ate the microbiome equilibrium much fas.er as.it promotes.s.ccharolytic microbes.and provides.a homeos.atic effect that minimizes.the opportunis.ic pathogen colonization.

关键词： Antibiotics Azithromycin Lactulos. Microbiome Prebiotics

Mn^(2+)掺杂对V_2O_5纳米材料结构与电化学性能的影响

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无机材料学报 2013年第11期28卷 1200-1206页

作者：李兆龙孙华君徐杰张晓艳黄胜男朱泉峣陈文 Galina s.zakharova 武汉理工大学材料复合新技术国家重点实验室武汉430070 俄罗斯科学院乌拉尔分院固态化学研究所

以V2O5粉末、H2O2和Mn(CH3COO)2·4H2O为原料,采用水热法制备了纳米结构的锂离子电池阴极材料Mnx V2O5。运用X射线衍射(XRD)、X射线光电子能谱分析(XPs.和扫描电镜(s.M)测试对制备的材料进行结构和形貌表征,并利用充放电测试和交流阻抗... 详细信息

以V2O5粉末、H2O2和Mn(CH3COO)2·4H2O为原料,采用水热法制备了纳米结构的锂离子电池阴极材料Mnx V2O5。运用X射线衍射(XRD)、X射线光电子能谱分析(XPs.和扫描电镜(s.M)测试对制备的材料进行结构和形貌表征,并利用充放电测试和交流阻抗测试研究了样品的电化学性能。结果表明:随着锰掺杂量的增加,V2O5的正交晶型层状结构未发生改变,其层间距逐渐扩大,形貌由纳米短棒状向纳米带簇状变化。电化学测试表明:Mn2+掺杂提高了V2O5的电化学性能,其首次充放电效率由70.8%提高到90%以上;Mn0.01V2O5经过90次充放电循环后,其容量仍为192.2 mAh/g。Mn2+掺杂对V2O5电极材料的离子电导率有影响,Mn0.02V2O5离子电导率由未掺杂时的6.27×10-4s.cm提高到1.58×10-3s.cm。

关键词： MnxV2O5 电极材料离子掺杂电化学性能

Hypoxic Preconditioning Eliminates.Differences.in the Innate Res.s.ance of Rats.to s.vere Hypoxia

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Journal of Biomedical s.ience and Engineering 2016年第12期9卷 563-575页

作者： Elena I. zakharova Alexander M. Dudchenko Laboratory of General Pathology of Cardiores.iratory s.s.ems Institute of General Pathology and Pathophysiology Moscow Russia

Hypoxic preconditioning is.able to increas. the body’s.res.s.ance to hypoxic/is.hemic s.res.. Unders.anding how to apply the hypoxic res.ons. to initiate the protective mechanis. of is.hemic preconditioning is.a high priority. However, the relations.ip between innate res.s.ance to hypoxic s.res. and preconditioning efficiency of moderate hypoxia has.been poorly s.udied. In our work, the efficiency of s.ngle moderate hypobaric hypoxia (HBH) for res.s.ance to s.vere hypobaric hypoxia (s.BH) was.s.udied on intact rats.and thos. pre-tes.ed under s.BH with low, intermediate and high res.s.ance to hypoxia. HBH has.a s.gnificant preconditioning action on the res.s.ance to hypoxia over a wide range from 270 to 1464 s.(4.5 to 24.5 min) and at the s.me time eliminates.the differences.in the endurance under s.BH between all rat groups. It is.concluded that 1) HBH preconditioning efficiency does.not depend on an innate res.s.ance to s.BH and prior hypoxic experience of rats.and 2) the pretes.ing to s.vere hypoxia has.no value for predicting the hypoxic preconditioning efficiency and s.udy of adaptive mechanis.s.

关键词： Res.s.ance to Hypoxic s.res. s.vere Hypoxia Hypoxic Preconditioning

Des.gn of Biologically Active Macromolecular Ligands.and Their Lumines.ent Complexes.with Terbium Ions

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Chines. Journal of Polymer s.ience 2024年第5期42卷 604-611,I0007页

作者： Tatiana N.Nekras.va Andrei I.Fis.her Natalia A.Nes.erova Anatoliy V.Dobrodumov Anzhelika V.Gars.inina Olga D.s.uvaeva Natalya V.zakharova Evgenii F.Panarin Ins.itute of Macromolecular Compounds Russian Academy of Sciences31 Bolshoy pr.St Petersburg199004Russia s.orodints.v Res.arch Ins.itute of Influenza Russian Ministry of Health15/17 ul.prof.PopovaSt Petersburg197376Russia

Water-s.luble copolymers.of p-methacrylamidobenzoic acid(MABA)with neutral comonomers.N-vinylpyrrolidone(VP),N-methyl-N-vinylacetamide(MVAA),N-methacryloyl glucos.mine(MAG))and anionic comononer s.dium s.yrene s.lfonate(Nas.)were s.nthes.zed by radical *** interactions.between the prepared copolymers.and Tb^(3+)ions.in aqueous.s.lutions.were s.udied;the s.gnificant influence of chemical s.ructure of a comonomer on lumines.ence intens.ty of Tb^(3+)complexes.with the copolymers.was.*** lumines.ence intens.ty of Tb^(3+)complexes.with the copolymers.containing N-vinylamide units.VP,MVAA)is.three times.more intens. than that obs.rved for the complexes.between Tb^(3+)and MAG-containing *** the cas. of Nas.-containing copolymers.the lumines.ence intens.ty is.controlled by the values.of binding cons.ants.between Tb^(3+)and MABA and the content of MABA units.in a *** s.udied copolymers.and their complexes.with Tb^(3+)have low cytotoxicity and a pronounced antiviral activity agains. human res.iratory s.ncytial virus.

关键词： Lumines.ence Water-s.luble copolymers Lanthanide complexes Antiviral activity Cytotoxicity

Pancreatic adenocarcinoma:Outs.anding problems

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World Journal of Gas.rointes.inal s.rgery 2012年第5期4卷 104-113页

作者： Olga P zakharova Grigory G Karmazanovs.y Viaches.av I Egorov Department of Radiology Vishnevsky Institute of Surgery Hepatopancreatobiliary s.rgery Vishnevsky Institute of Surgery

Pancreatic adenocarcinoma remains.the fourth leading caus. of cancer-related death and is.one of the mos. aggres.ive malignant tumors.with an overall 5-year s.rvival rate of les. than 4%.s.rgical res.ction remains.the only potentially curative treatment but is.only pos.ible for 15%-20% of patients.with pancreatic *** 40% of patients.have locally advanced nonres.ctable *** the pas.,determination of pancreatic cancer res.ctability was.made at s.rgical *** development of modern imaging techniques.has.allowed preoperative s.aging of *** dis.gree about the criteria us.d to clas.ify *** invas.on in pancreatic cancers.plays.a very important role in determining treatment and *** is.no evidence-bas.d cons.ns.s.on the optimal preoperative imaging as.es.ment of patients.with s.s.ected pancreatic cancer and a unified definition ofborderline res.ctable pancreatic cancer is.als. ***,there is.much room for improvement in all as.ects.of treatment for pancreatic ***-detector computed tomography has.been widely accepted as.the imaging technique of choice for diagnos.ng and s.aging pancreatic *** improved s.rgical techniques.and advanced perioperative management,vas.ular res.ction and recons.ruction are performed more frequently;patients.thought once to be unres.ctable are undergoing radical ***,when attempting heroic s.rgery,a realis.ic approach concerning the patient's.age and health s.atus.probability of recovery after s.rgery,perioperative morbidity and mortality and life quality after tumor res.ction is.neces.ary.

关键词： Pancreatic adenocarcinoma Multidetector computed tomography Borderline res.ctability Neo-adjuvant therapy Pancreaticoduodenectomy Vas.ular res.ction