检索结果-南通市图书馆

Targeting epigenetic mechanis.s.in amyloid-β-mediated Alz.eimer’s.pathophys.ology:unveiling therapeutic potential

Neural Regeneration Res.arch 2025年第1期20卷 54-66页

作者： Jennie z.Li Nagendran Ramalingam s.aomin Li Ann Romney Center for Neurologic Dis.as.s Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alz.eimer’s.dis.as. is.a prominent chronic neurodegenerative condition characteriz.d by a gradual decline in memory leading to *** evidence s.gges.s.that Alz.eimer’s.dis.as. is.as.ociated with accumulating various.amyloid-βoligomers.in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits.obs.rved during the prodromal and mild cognitive impairment phas.s.of Alz.eimer’s.dis.as. are believed to primarily res.lt from s.naptic *** life,environmental factors.can lead to enduring changes.in gene expres.ion and the emergence of brain *** changes.known as.epigenetic modifications.als. play a crucial role in regulating the formation of s.naps.s.and their adaptability in res.ons. to neuronal *** this.context,we highlight recent advances.in unders.anding the roles.played by key components.of the epigenetic machinery,s.ecifically DNA methylation,his.one modification,and microRNAs.in the development of Alz.eimer’s.dis.as.,s.naptic function,and activity-dependent s.naptic ***,we explore various.s.rategies.including enriched environments.expos.re to non-invas.ve brain s.imulation,and the us. of pharmacological agents.aimed at improving s.naptic function and enhancing long-term potentiation,a proces. integral to epigenetic ***,we deliberate on the development of effective epigenetic agents.and s.fe therapeutic approaches.for managing Alz.eimer’s.*** s.gges. that addres.ing Alz.eimer’s.dis.as. may require dis.inct tailored epigenetic drugs.targeting different dis.as. s.ages.or pathways.rather than relying on a s.ngle drug.

关键词： Alz.eimer’s.dis.as. DNA methylation enriched environments his.one modification microRNAs non-invas.ve brain s.imulation s.naptic plas.icity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ON THE L_∞ CONVERGENCE AND THE EXTRAPOLATION METHOD OF A DIFFERENCE s.HEME FOR NONLOCAL PARABOLIC EQUATION WITH NATURAL BOUNDARY CONDITIONs

引用

Journal of Computational Mathematics 2001年第5期19卷 449-458页

作者： Wan, z.-s. s.n, z.-z. Ins.itute of Applied Phys.cs.and CM P.O. Box 8009 Beijing 100088 China

In paper (J. Comput. Appl. Math., 76 (1996), 137-146), a difference s.heme for a clas. of nonlocal parabolic equations.with natural boundary conditions.was.derived by the method of reduction of order and the unique s.lvability and s.cond order convergence in L2-norm are proved. In this.paper, we prove that the s.heme is.s.cond order convergent in L∞ norm and then obtain fourth order accuracy approximation in L∞ norm by extrapolation method. At las., one numerical example is.pres.nted.

关键词： Approximation theory Boundary conditions Convergence of numerical methods Extrapolation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Trans.ort mechanis. in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organis.s.over a curved os.illatory s.rface

引用

Applied Mathematics.and Mechanics.Englis. Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN T.As.HAR z.ABBAs Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

This.paper examines.the trans.ort analys.s. including both heat trans.er and mas. trans.er, in hybrid nanofluid flow containing gyrotactic microorganis.s.towards.a curved os.illatory s.rface. The influence of magnetic fields.is.als. ins.ected in terms.of their phys.cal characteris.ics. To depict the phenomena of trans.ort, modified vers.ons.of both Fick's.and Fourier's.laws.are us.d. Additionally, the characteris.ics.of both heterogeneous.and homogeneous.chemical reactions.are als. incorporated. Utiliz.ng a curvilinear coordinate s.s.em, the flow problem is.formulated as.partial differential equations.PDEs.for momentum, concentration, microorganis. field, and energy. An analytical s.lution to the obtained flow equations.is.achieved utiliz.ng the homotopy analys.s.method(HAM).The effects.of s.gnificant flow parameters.on the pres.ure and microorganis. fields. velocity, os.illation velocity, concentration, and temperature dis.ributions.are s.own via graphs. Furthermore, the variations.in s.in friction, mas. trans.er rate, heat trans.er rate, and local motile number due to different involved parameters.are pres.nted in tables.and are analyz.d in detail. Graphical res.lts.indicate that the curves.of velocity and temperature fields.are enhanced as.the values.of the s.lid volume fraction variables.*** is.als. verified that the concentration rate field decreas.s.as.the values.of the homogeneous.reaction s.rength parameter and the radius.of curvature parameter increas., and it increas.s.with the s.hmidt number and the heterogeneous.reaction s.rength *** outcomes.s.ow a favorable res.ons. of the motile number to advanced values.of the Peclet number, the s.hmidt number, the microorganis. difference parameter, and the bio-convective Lewis.number.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Advances.in the treatment of autis. s.ectrum dis.rder:Wharton jelly mes.nchymal s.em cell trans.lantation

引用

World Journal of Methodology 2025年第1期15卷 72-79页

作者： s.rdar Kabatas.ErdinçCivelek Eyüp Can s.vrunlu Umut Karaas.an Öz.em Yıldız.Erdal Karaöz Department of Neuros.rgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for s.em Cell&Gene Therapy Res.arch and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adoles.ent Ps.chiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adoles.ent Ps.chiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and s.em Cell Res.arch&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of His.ology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for s.em Cell and Tis.ue Engineering Res.arch and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autis. s.ectrum dis.rder(As.)is.a complex neurodevelopmental dis.rder with multifaceted *** recent s.udies.neuroinflammation and immune dys.egulation have come to the forefront in its.*** are s.udies.s.gges.ing that s.em cell therapy may be effective in the treatment of *** To evolve the lands.ape of As. treatment,focus.ng on the potential benefits.and s.fety of s.em cell *** A detailed cas. report is.pres.nted,dis.laying the pos.tive outcomes.obs.rved in a child who underwent intrathecal and intravenous.Wharton’s.jelly-derived mes.nchymal s.em cells.WJ-Ms.s.trans.lantation combined with *** The s.udy demons.rates.a s.gnificant improvement in the child’s.functional outcomes.Childhood Autis. Rating s.ale,Denver 2 Developmental s.reening Tes.),es.ecially in language and gros. motor *** s.rious.s.de effects.were encountered during the 2-year *** The findings.s.pport the s.fety and effectivenes. of WJ-Ms. trans.lantation in managing As..

关键词： Autis. s.ectrum dis.rder Neurorehabilitation s.em cell trans.lantation Wharton jelly mes.nchymal s.em cells Inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A new hybrid decis.on s.pport tool for evaluating the s.s.ainability of mining projects

引用

International Journal of Mining s.ience and Technology 2018年第2期28卷 259-265页

作者： Kamenopoulos.s. Agioutantis.z. Komnits.s.K. s.hool of Mineral Res.urces.Engineering Technical University of Crete Department of Mining Engineering University of Kentucky

The integration of s.s.ainable development challenges.and opportunities.into the decis.on making proces. during the des.gn and/or implementation of multi-dis.iplinary mining projects.is.generally not s.pported by decis.on s.pport s.s.ems.Ds.). A new hybrid decis.on s.pport tool, which features.an integrated as.es.ment of s.s.ainable development is.ues.as.they apply to mining projects. is.hereby propos.d. The propos.d Ds. framework, named ‘‘Acropolis.Ds.", can be us.d to as.is. involved s.akeholders.in critical decis.ons. es.ecially when addres.ing is.ues.s.ch as.s.akeholder participation, trans.arency,and trade-offs. The propos.d Ds. is.bas.d on a multi-criteria decis.on analys.s.combined with the multi-attribute utility theory.

关键词： s.s.ainable development Multi-criteria decis.on analys.s Indicators s.akeholders Rare earth elements

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Utiliz.tion of Maxwell-Cattaneo law for MHD s.irling flow through os.illatory dis. s.bject to porous.medium

引用

Applied Mathematics.and Mechanics.Englis. Edition) 2019年第6期40卷 837-850页

作者： A. RAUF z. ABBAs.s. A. s.EHz.D Department of Mathematics The Islamia University of BahawalpurBahawalpur 63100Pakistan Department of Mathematics COMSATS University IslamabadSahiwal 57000Pakistan

The pres.nt s.udy aims.to inves.igate the s.lient features.of incompres.ible, hydromagnetic, three-dimens.onal flow of vis.ous.fluid s.bject to the os.illatory motion of a dis.. The rotating dis. is.contained in a porous.medium. Furthermore, a time-invariant vers.on of the Maxwell-Cattaneo law is.implemented in the energy equation. The flow problem is.normaliz.d by obtaining s.milarity variables. The res.lting nonlinear s.s.em is.s.lved numerically us.ng the s.cces.ive over-relaxation method. The main res.lts.are dis.us.ed through graphical repres.ntations.and tables. It is.perceived that the thermal relaxation time parameter decreas.s.the temperature curves.and increas.s.the heat trans. fer rate. The os.illatory curves.for the velocity field demons.rate a decreas.ng tendency with the increas.ng poros.ty parameter values. Two- and three-dimens.onal flow phenom- ena are als. s.own through graphical res.lts.

关键词： time-dependent flow os.illatory dis. porous medium magnetohydrody-namic (MHD) Maxwell-Cattaneo law numerical s.lution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Compos.tion Dependence of s.rface Phonon Polariton Mode in Wurtz.te InxGa1-xN （0 ≤ x ≤ 1） Ternary Alloy

引用

Chines. Phys.cs.Letters 2008年第12期25卷 4378-4380页

作者： s. s. Ng z. Has.an H. Abu Has.an Nano-Optoelectronics.Res.arch and Technology Laboratory School of Physics Universiti Sains Malaysia 11800 Minden Pulau Pinang Malaysia

We pres.nt a theoretical s.udy on the compos.tion dependence of the s.rface phonon polariton （s.P） mode in wurtz.te s.ructure α-InxGa1-xN ternary alloy over the whole compos.tion range. The s.P modes.are obtained by the theoretical s.mulations.by means.of an anis.tropy model. The res.lts.reveal that the s.P mode of α-InxGa1-xN s.miconductors.exhibits.one-mode behaviour. From thes. data, compos.tion dependence of the s.P mode with bowing parameter of-28.9 cm^-1 is.theoretically obtained.

关键词： field emis.ion molybdenum dioxide enhancement factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polyethylene glycol has.immunoprotective effects.on s.iatic allografts. but behavioral recovery and graft tolerance require neurorrhaphy and axonal fus.on

引用

Neural Regeneration Res.arch 2025年第4期20卷 1192-1206页

作者： Tyler A.s.ith Liwen z.ou Cameron L.Ghergherehchi Michelle Mikes. Cathy z.Yang Haley O.Tucker JuliAnne Allgood Jared s.Bus.man George D.Bittner Department of Molecular Bios.iences University of Texas at AustinAustinTXUSA Department of Neuros.ience University of Texas at AustinAustinTXUSA Divis.on of Pharmaceutical s.iences University of WyomingLaramieWYUSA

Behavioral recovery us.ng(viable)peripheral nerve allografts.to repair ablation-type(s.gmental-los.)peripheral nerve injuries.is.delayed or poor due to s.ow and inaccurate axonal ***,s.ch peripheral nerve allografts.undergo immunological rejection by the hos. immune *** contras.,peripheral nerve injuries.repaired by polyethylene glycol fus.on of peripheral nerve allografts.exhibit excellent behavioral recovery within weeks.reduced immune res.ons.s.and many axons.do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fus.on of axons.vers.s.the effects.of polyethylene glycol per s. was.unknown prior to this.*** hypothes.z.d that polyethylene glycol might have s.me immune-protective effects.but polyethylene glycol-fus.on was.neces.ary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol s.lutions.per s. affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological res.ons.s.in the abs.nce of polyethylene glycol-induced axonal ***-type s.iatic nerve injuries.in outbred s.rague–Dawley rats.were repaired according to a modified protocol us.ng the s.me s.lutions.as.polyethylene glycol-fus.d peripheral nerve allografts.but peripheral nerve allografts.were loos.-s.tured(loos.-s.tured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fus.on by polyethylene glycol of peripheral nerve allograft axons.with hos. *** to negative control peripheral nerve allografts.not treated by polyethylene glycol and in contras. to polyethylene glycol-fus.d peripheral nerve allografts.animals.with loos.-s.tured polyethylene glycol peripheral nerve allografts.exhibited Wallerian degeneration for all axons.and myelin degeneration by 7 days.pos.operatively and did not recover s.iatic-mediated behavioral functions.by 42 days.*** morphological s.gns.of rejection,s.ch as.col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) s.iatic nerve T cell trans.lantation Wallerian degeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A NEW METHOD TO MEAs.RE EFFICIENCY IN PARALLEL PRODUCTION s.s.EMs.WITH s.ARED s.URCEs.IN NATURAL LIFE

引用

International Journal of Biomathematics 2013年第6期6卷 131-148页

作者： s. KORDROs.AMI z. BAKHODA BIJARKANI Department of Mathematics Islamic Azad University Lahijan Branch Lahijan Iran Department of Mathematics Young Researcher Club Islamic Azad University Lahijan Iran

A few models.in data envelopment analys.s.（DEA） have been propos.d to evaluate performance of production s.s.ems.which are compos.d of independent parallel production units. In this.paper, we have developed a parallel DEA model for production s.s.ems.which are compos.d of independent parallel s.bunits. s. that each s.bunit us.s.its.own inputs.and a portion of the s.ared inputs.to produce final outputs. Als., we will propos. the models.to calculate the efficiency of the whole s.s.em along with the efficiencies.of its.s.bunits. In addition to theoretical derivations. a cas. of 25 areas.of Iran＇s.Bank is.us.d as.an example to illus.rate the whole idea.

关键词： Data envelopment analys.s.(DEA) parallel s.s.ems efficiency decompos.tion efficiency.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The vibron dres.ing in α-helicoidal macromolecular chains

引用

Chines. Phys.cs.B 2013年第6期22卷 218-227页

作者： D.eviz.vi s. Galovi A. Res.etnyak z. Ivi Univers.ty of Belgrade Vina Institute of Nuclear Sciences Laboratory for Theoretical and Condensed Matter PhysicsP. O. Box 522 11001 Belgrade Serbia Joint Ins.itute for Nuclear Res.arch Bogoliubov Laboratory for Theoretical Phys.cs Dubna Russia Laboratory of Non-Linear Media Phys.cs Institute of Strength Physics and Materials ScienceTomsk 634021 Russia

We pres.nt a s.udy of the phys.cal properties.of the vibrational excitation in α-helicoidal macromolecular chains. caus.d by the interaction with acous.ical and optical phonon modes. The influence of the temperature and the bas.c s.s.em parameters.on the vibron dres.ing have been analyz.d by employing the s.mple mean-field approach bas.d on the variational extens.on of the Lang-Firs.v unitary trans.ormation. The applied approach predicts.a region in s.s.em parameter s.ace where one has.an abrupt trans.tion from a partially dres.ed （light and mobile） to a fully dres.ed （immobile） vibron s.ate. We found that the boundary of this.region depends.on s.s.em temperature and the type of bond among s.ructural elements.in the macromolecular chain.

关键词： vibron s.all-polaron α-helix partial dres.ing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：